Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance

Wouamba SCN, Happi Mouthe G, Lenta BN, Sewald N, Kouam SF (2020)
BIOCHEMICAL SYSTEMATICS AND ECOLOGY 88: UNSP 103988.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Wouamba, Steven Collins N.; Happi Mouthe, GervaisUniBi; Lenta, Bruno N.; Sewald, NorbertUniBi ; Kouam, Simeon Fogue
Abstract / Bemerkung
The chemical investigation of the roots of Vernonia guineensis Benth. (Asteraceae) resulted in the isolation of a new ceramide, named vernoguinamide (1), together with fifteen known compounds, including three anthraquinones, physion (2), erythroglaucin (3) and emodin (4), three triterpenoids, hop-17(21)-en-3 beta-yl acetate (5), lupeol (6) and betulinic acid (7), six steroids, vernoguinoside A (8), vernoguinoside (9), beta-sitosterol 3-O-beta-D-glucoside (10), stigmasterol 3-O-beta-D-glucoside (11), stigmasterol (12) and beta-sitosterol (13) and three fatty acid derivatives, tetracosanoic acid (14), tricosanic acid (15) and arachidic acid glycerol ester (16). The structure of the new compound as well as those of the known compounds were established by spectrometric analysis including HRESI-MS, 1D and 2D-NMR and by comparison with the previously reported data. Among these compounds, the anthraquinones 2-4 and the triterpene 5 were isolated for the first time from Vernonia genus and compounds 6, 7 and 14-16 were extracted for the first time from the species. The isolated compounds were tested for their antibacterial activity and 3, 8 and 9 were the most active compounds against the tested bacteria. Furthermore, the chemophenetic relationships of the isolated compounds and their significance were also discussed.
Stichworte
Vemonia guineensis Benth.; Asteraceae; Chemophenetic significance; Ceramide; Anthraquinone; Antibacterial
Erscheinungsjahr
2020
Zeitschriftentitel
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
Band
88
Art.-Nr.
UNSP 103988
ISSN
0305-1978
eISSN
1873-2925
Page URI
https://pub.uni-bielefeld.de/record/2942909

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Wouamba SCN, Happi Mouthe G, Lenta BN, Sewald N, Kouam SF. Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance. BIOCHEMICAL SYSTEMATICS AND ECOLOGY. 2020;88: UNSP 103988.
Wouamba, S. C. N., Happi Mouthe, G., Lenta, B. N., Sewald, N., & Kouam, S. F. (2020). Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 88, UNSP 103988. doi:10.1016/j.bse.2019.103988
Wouamba, S. C. N., Happi Mouthe, G., Lenta, B. N., Sewald, N., and Kouam, S. F. (2020). Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance. BIOCHEMICAL SYSTEMATICS AND ECOLOGY 88:UNSP 103988.
Wouamba, S.C.N., et al., 2020. Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 88: UNSP 103988.
S.C.N. Wouamba, et al., “Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance”, BIOCHEMICAL SYSTEMATICS AND ECOLOGY, vol. 88, 2020, : UNSP 103988.
Wouamba, S.C.N., Happi Mouthe, G., Lenta, B.N., Sewald, N., Kouam, S.F.: Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance. BIOCHEMICAL SYSTEMATICS AND ECOLOGY. 88, : UNSP 103988 (2020).
Wouamba, Steven Collins N., Happi Mouthe, Gervais, Lenta, Bruno N., Sewald, Norbert, and Kouam, Simeon Fogue. “Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance”. BIOCHEMICAL SYSTEMATICS AND ECOLOGY 88 (2020): UNSP 103988.