Noncoding regions underpin avian bill shape diversification at macroevolutionary scales.

Yusuf L, Heatley MC, Palmer JPG, Barton HJ, Cooney CR, Goßmann T (2020)
Genome research 30(4): 553-565.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Yusuf, Leeban; Heatley, Matthew C; Palmer, Joseph P G; Barton, Henry J; Cooney, Christopher R; Goßmann, ToniUniBi
Abstract / Bemerkung
Recent progress has been made in identifying genomic regions implicated in trait evolution on a microevolutionary scale in many species, but whether these are relevant over macroevolutionary time remains unclear. Here, we directly address this fundamental question using bird beak shape, a key evolutionary innovation linked to patterns of resource use, divergence, and speciation, as a model trait. We integrate class-wide geometric-morphometric analyses with evolutionary sequence analyses of 10,322 protein-coding genes as well as 229,001 genomic regions spanning 72 species. We identify 1434 protein-coding genes and 39,806 noncoding regions for which molecular rates were significantly related to rates of bill shape evolution. We show that homologs of the identified protein-coding genes as well as genes in close proximity to the identified noncoding regions are involved in craniofacial embryo development in mammals. They are associated with embryonic stem cell pathways, including BMP and Wnt signaling, both of which have repeatedly been implicated in the morphological development of avian beaks. This suggests that identifying genotype-phenotype association on a genome-wide scale over macroevolutionary time is feasible. Although the coding and noncoding gene sets are associated with similar pathways, the actual genes are highly distinct, with significantly reduced overlap between them and bill-related phenotype associations specific to noncoding loci. Evidence for signatures of recent diversifying selection on our identified noncoding loci in Darwin finch populations further suggests that regulatory rather than coding changes are major drivers of morphological diversification over macroevolutionary times. © 2020 Yusuf et al.; Published by Cold Spring Harbor Laboratory Press.
Erscheinungsjahr
2020
Zeitschriftentitel
Genome research
Band
30
Ausgabe
4
Seite(n)
553-565
eISSN
1549-5469
Page URI
https://pub.uni-bielefeld.de/record/2942703

Zitieren

Yusuf L, Heatley MC, Palmer JPG, Barton HJ, Cooney CR, Goßmann T. Noncoding regions underpin avian bill shape diversification at macroevolutionary scales. Genome research. 2020;30(4):553-565.
Yusuf, L., Heatley, M. C., Palmer, J. P. G., Barton, H. J., Cooney, C. R., & Goßmann, T. (2020). Noncoding regions underpin avian bill shape diversification at macroevolutionary scales. Genome research, 30(4), 553-565. doi:10.1101/gr.255752.119
Yusuf, L., Heatley, M. C., Palmer, J. P. G., Barton, H. J., Cooney, C. R., and Goßmann, T. (2020). Noncoding regions underpin avian bill shape diversification at macroevolutionary scales. Genome research 30, 553-565.
Yusuf, L., et al., 2020. Noncoding regions underpin avian bill shape diversification at macroevolutionary scales. Genome research, 30(4), p 553-565.
L. Yusuf, et al., “Noncoding regions underpin avian bill shape diversification at macroevolutionary scales.”, Genome research, vol. 30, 2020, pp. 553-565.
Yusuf, L., Heatley, M.C., Palmer, J.P.G., Barton, H.J., Cooney, C.R., Goßmann, T.: Noncoding regions underpin avian bill shape diversification at macroevolutionary scales. Genome research. 30, 553-565 (2020).
Yusuf, Leeban, Heatley, Matthew C, Palmer, Joseph P G, Barton, Henry J, Cooney, Christopher R, and Goßmann, Toni. “Noncoding regions underpin avian bill shape diversification at macroevolutionary scales.”. Genome research 30.4 (2020): 553-565.

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