Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.

Hamed, Abdelaaty; Abdel-Razek, Ahmed S; Araby, Mariam; Abu-Elghait, Mohammed; El-Hosari, Doaa G; Frese, Marcel; Soliman, Hesham S M; Stammler, Hans-Georg; Sewald, Norbert; Shaaban, Mohamed

Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.

Hamed A, Abdel-Razek AS, Araby M, Abu-Elghait M, El-Hosari DG, Frese M, Soliman HSM, Stammler H-G, Sewald N, Shaaban M (2020)
Natural product research: 1-9.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch

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DOI

https://doi.org/10.1080/14786419.2020.1741583

Autor*in

Hamed, Abdelaaty; Abdel-Razek, Ahmed S; Araby, Mariam; Abu-Elghait, Mohammed; El-Hosari, Doaa G; Frese, Marcel^UniBi ; Soliman, Hesham S M; Stammler, Hans-Georg^UniBi; Sewald, Norbert^UniBi ; Shaaban, Mohamed

Einrichtung

Fakultät für Chemie > Anorganische Chemie und Strukturchemie
Fakultät für Chemie > Organische Chemie III

Abstract / Bemerkung

The crystal structure and unambiguous absolute configuration of meleagrin (1) isolated from fungus Emericella dentata Nq45 is reported herein to first time on the bases of single crystal X-ray diffraction. Together with 1, haenamindole (2), isorugulosuvine (3), secalonic acid D (4), ergosterol (5) and cerebroside A (6) were obtained and their structures were determined by ESI MS and NMR data analysis. Diverse biological activity of meleagrin (1) was investigated. Compound 1 pronounced potent cytotoxicity against the human cervix carcinoma cell line KB-3-1 and its multidrug resistant sub-clone KB-V1 of IC50 3.07 and 6.07M, respectively, in comparison with the reference (+) - griseofulvin (IC50 19, 19.5M). Based on the antibiofilm activity, compound 1 displayed as well potent activity against Staphylococcus aureus with an MIC of 0.25mg/mL. Isolation of the producing fungus and taxonomical characterization is stated as well.

Erscheinungsjahr

2020

Zeitschriftentitel

Natural product research

Seite(n)

1-9

ISSN

1478-6419

eISSN

1478-6427

Page URI

https://pub.uni-bielefeld.de/record/2942000

Zitieren

Hamed A, Abdel-Razek AS, Araby M, et al. Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Natural product research. 2020:1-9.

Hamed, A., Abdel-Razek, A. S., Araby, M., Abu-Elghait, M., El-Hosari, D. G., Frese, M., Soliman, H. S. M., et al. (2020). Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Natural product research, 1-9. doi:10.1080/14786419.2020.1741583

Hamed, Abdelaaty, Abdel-Razek, Ahmed S, Araby, Mariam, Abu-Elghait, Mohammed, El-Hosari, Doaa G, Frese, Marcel, Soliman, Hesham S M, Stammler, Hans-Georg, Sewald, Norbert, and Shaaban, Mohamed. 2020. “Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.”. Natural product research, 1-9.

Hamed, A., Abdel-Razek, A. S., Araby, M., Abu-Elghait, M., El-Hosari, D. G., Frese, M., Soliman, H. S. M., Stammler, H. - G., Sewald, N., and Shaaban, M. (2020). Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Natural product research, 1-9.

Hamed, A., et al., 2020. Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Natural product research, , p 1-9.

A. Hamed, et al., “Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.”, Natural product research, 2020, pp. 1-9.

Hamed, A., Abdel-Razek, A.S., Araby, M., Abu-Elghait, M., El-Hosari, D.G., Frese, M., Soliman, H.S.M., Stammler, H.-G., Sewald, N., Shaaban, M.: Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies. Natural product research. 1-9 (2020).

Hamed, Abdelaaty, Abdel-Razek, Ahmed S, Araby, Mariam, Abu-Elghait, Mohammed, El-Hosari, Doaa G, Frese, Marcel, Soliman, Hesham S M, Stammler, Hans-Georg, Sewald, Norbert, and Shaaban, Mohamed. “Meleagrin from marine fungus Emericella dentata Nq45: crystal structure and diverse biological activity studies.”. Natural product research (2020): 1-9.

Daten bereitgestellt von European Bioinformatics Institute (EBI)