Late-Stage Diversification of Tryptophan-Derived Biomolecules.

Gruß H, Sewald N (2020)
Chemistry - A European Journal 26(24): 5328-5340.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Pd-mediated reactions have emerged as a powerful tool for the site-selective and bioorthogonal late-stage diversification of amino acids, peptides and related compounds. Indole moieties of tryptophan derivatives are susceptible to C2 H-activation, whereas halogenated aromatic amino acids such as halophenylalanines or halotryptophans provide a broad spectrum of different functionalisations. The compatibility of transition-metal-catalysed cross-couplings with functional groups in peptides, other biologically active compounds and even proteins has been demonstrated. This Review primarily compiles the application of different cross-coupling reactions to modify halotryptophans, halotryptophan containing peptides or halogenated, biologically active compounds derived from tryptophan. Modern approaches use regio- and stereoselective biocatalytic strategies to generate halotryptophans and derivatives on a preparative scale. The combination of bio- and chemocatalysis in cascade reactions is given by the biocompatibility and bioorthogonality of Pd-mediated reactions. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Erscheinungsjahr
2020
Zeitschriftentitel
Chemistry - A European Journal
Band
26
Ausgabe
24
Seite(n)
5328-5340
ISSN
0947-6539
eISSN
1521-3765
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2941720

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Gruß H, Sewald N. Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal. 2020;26(24):5328-5340.
Gruß, H., & Sewald, N. (2020). Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal, 26(24), 5328-5340. https://doi.org/10.1002/chem.201903756
Gruß, Hendrik, and Sewald, Norbert. 2020. “Late-Stage Diversification of Tryptophan-Derived Biomolecules.”. Chemistry - A European Journal 26 (24): 5328-5340.
Gruß, H., and Sewald, N. (2020). Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal 26, 5328-5340.
Gruß, H., & Sewald, N., 2020. Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal, 26(24), p 5328-5340.
H. Gruß and N. Sewald, “Late-Stage Diversification of Tryptophan-Derived Biomolecules.”, Chemistry - A European Journal, vol. 26, 2020, pp. 5328-5340.
Gruß, H., Sewald, N.: Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal. 26, 5328-5340 (2020).
Gruß, Hendrik, and Sewald, Norbert. “Late-Stage Diversification of Tryptophan-Derived Biomolecules.”. Chemistry - A European Journal 26.24 (2020): 5328-5340.
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2020-10-09T09:45:57Z
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