Late-Stage Diversification of Tryptophan-Derived Biomolecules.

Gruß H, Sewald N (2019)
Chemistry - A European Journal: chem.201903756.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Abstract / Bemerkung
Pd-mediated reactions have emerged as a powerful tool for the site-selective and bioorthogonal late-stage diversification of amino acids, peptides and related compounds. Indole moieties of tryptophan derivatives are susceptible to C2 H-activation, whereas halogenated aromatic amino acids such as halophenylalanines or halotryptophans provide a broad spectrum of different functionalisations. The compatibility of transition-metal-catalysed cross-couplings with functional groups in peptides, other biologically active compounds and even proteins has been demonstrated. This Review primarily compiles the application of different cross-coupling reactions to modify halotryptophans, halotryptophan containing peptides or halogenated, biologically active compounds derived from tryptophan. Modern approaches use regio- and stereoselective biocatalytic strategies to generate halotryptophans and derivatives on a preparative scale. The combination of bio- and chemocatalysis in cascade reactions is given by the biocompatibility and bioorthogonality of Pd-mediated reactions. © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Erscheinungsjahr
2019
Zeitschriftentitel
Chemistry - A European Journal
Art.-Nr.
chem.201903756
ISSN
0947-6539
eISSN
1521-3765
Page URI
https://pub.uni-bielefeld.de/record/2941720

Zitieren

Gruß H, Sewald N. Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal. 2019: chem.201903756.
Gruß, H., & Sewald, N. (2019). Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal, chem.201903756. doi:10.1002/chem.201903756
Gruß, H., and Sewald, N. (2019). Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal:chem.201903756.
Gruß, H., & Sewald, N., 2019. Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal, : chem.201903756.
H. Gruß and N. Sewald, “Late-Stage Diversification of Tryptophan-Derived Biomolecules.”, Chemistry - A European Journal, 2019, : chem.201903756.
Gruß, H., Sewald, N.: Late-Stage Diversification of Tryptophan-Derived Biomolecules. Chemistry - A European Journal. : chem.201903756 (2019).
Gruß, Hendrik, and Sewald, Norbert. “Late-Stage Diversification of Tryptophan-Derived Biomolecules.”. Chemistry - A European Journal (2019): chem.201903756.

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