Microbial engineering for production of N-functionalized amino acids and amines

Mindt M, Walter T, Kugler P, Wendisch VF (2020)
Biotechnology Journal 15(7): 1900451.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 723.69 KB
Abstract / Bemerkung
N‐ functionalized amines play important roles in nature and occur, for example, in the antibiotic vancomycin, the immunosuppressant cyclosporine, the cytostatic actinomycin, the siderophore aerobactin, the cyanogenic glucoside linamarin, and the polyamine spermidine. In the pharmaceutical and fine‐chemical industries N‐ functionalized amines are used as building blocks for the preparation of bioactive molecules. Processes based on fermentation and on enzyme catalysis have been developed to provide sustainable manufacturing routes to N‐ alkylated, N‐ hydroxylated, N‐ acylated, or other N‐ functionalized amines including polyamines. Metabolic engineering for provision of precursor metabolites is combined with heterologous N‐ functionalizing enzymes such as imine or ketimine reductases, opine or amino acid dehydrogenases, N‐ hydroxylases, N‐ acyltransferase, or polyamine synthetases. Recent progress and applications of fermentative processes using metabolically engineered bacteria and yeasts along with the employed enzymes are reviewed and the perspectives on developing new fermentative processes based on insight from enzyme catalysis are discussed.
Erscheinungsjahr
2020
Zeitschriftentitel
Biotechnology Journal
Band
15
Ausgabe
7
Art.-Nr.
1900451
ISSN
1860-6768
eISSN
1860-7314
Page URI
https://pub.uni-bielefeld.de/record/2941687

Zitieren

Mindt M, Walter T, Kugler P, Wendisch VF. Microbial engineering for production of N-functionalized amino acids and amines. Biotechnology Journal . 2020;15(7): 1900451.
Mindt, M., Walter, T., Kugler, P., & Wendisch, V. F. (2020). Microbial engineering for production of N-functionalized amino acids and amines. Biotechnology Journal , 15(7), 1900451. doi:10.1002/biot.201900451
Mindt, M., Walter, T., Kugler, P., and Wendisch, V. F. (2020). Microbial engineering for production of N-functionalized amino acids and amines. Biotechnology Journal 15:1900451.
Mindt, M., et al., 2020. Microbial engineering for production of N-functionalized amino acids and amines. Biotechnology Journal , 15(7): 1900451.
M. Mindt, et al., “Microbial engineering for production of N-functionalized amino acids and amines”, Biotechnology Journal , vol. 15, 2020, : 1900451.
Mindt, M., Walter, T., Kugler, P., Wendisch, V.F.: Microbial engineering for production of N-functionalized amino acids and amines. Biotechnology Journal . 15, : 1900451 (2020).
Mindt, Melanie, Walter, Tatjana, Kugler, Pierre, and Wendisch, Volker F. “Microbial engineering for production of N-functionalized amino acids and amines”. Biotechnology Journal 15.7 (2020): 1900451.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International (CC BY-NC-ND 4.0):
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2020-07-31T11:21:54Z
MD5 Prüfsumme
ce32f499a7693ee7f1cce05196d2ad7c

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 32170807
PubMed | Europe PMC

Suchen in

Google Scholar