Advances in the Evolutionary Understanding of MHC Polymorphism.

Radwan J, Babik W, Kaufman J, Lenz TL, Winternitz J (2020)
Trends in genetics 36(4): 298-311.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Radwan, Jacek; Babik, Wieslaw; Kaufman, Jim; Lenz, Tobias L; Winternitz, JamieUniBi
Abstract / Bemerkung
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes: extreme polymorphism, excess of nonsynonymous changes in peptide-binding domains, and long gene genealogies. Recent studies provide evidence that these features may arise due to pathogens evolving ways to evade immune response guided by the locally common MHC alleles. However, complexities of selection on MHC genes are simultaneously being revealed that need to be incorporated into existing theory. These include pathogen-driven selection for antigen-binding breadth and expansion of the MHC gene family, associated autoimmunity trade-offs, hitchhiking of deleterious mutations linked to the MHC, geographic subdivision, and adaptive introgression. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Erscheinungsjahr
2020
Zeitschriftentitel
Trends in genetics
Band
36
Ausgabe
4
Seite(n)
298-311
ISSN
0168-9525
eISSN
1362-4555
Page URI
https://pub.uni-bielefeld.de/record/2941493

Zitieren

Radwan J, Babik W, Kaufman J, Lenz TL, Winternitz J. Advances in the Evolutionary Understanding of MHC Polymorphism. Trends in genetics. 2020;36(4):298-311.
Radwan, J., Babik, W., Kaufman, J., Lenz, T. L., & Winternitz, J. (2020). Advances in the Evolutionary Understanding of MHC Polymorphism. Trends in genetics, 36(4), 298-311. doi:10.1016/j.tig.2020.01.008
Radwan, J., Babik, W., Kaufman, J., Lenz, T. L., and Winternitz, J. (2020). Advances in the Evolutionary Understanding of MHC Polymorphism. Trends in genetics 36, 298-311.
Radwan, J., et al., 2020. Advances in the Evolutionary Understanding of MHC Polymorphism. Trends in genetics, 36(4), p 298-311.
J. Radwan, et al., “Advances in the Evolutionary Understanding of MHC Polymorphism.”, Trends in genetics, vol. 36, 2020, pp. 298-311.
Radwan, J., Babik, W., Kaufman, J., Lenz, T.L., Winternitz, J.: Advances in the Evolutionary Understanding of MHC Polymorphism. Trends in genetics. 36, 298-311 (2020).
Radwan, Jacek, Babik, Wieslaw, Kaufman, Jim, Lenz, Tobias L, and Winternitz, Jamie. “Advances in the Evolutionary Understanding of MHC Polymorphism.”. Trends in genetics 36.4 (2020): 298-311.

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