Programmed DNA elimination of germline development genes in songbirds

Kinsella CM, Ruiz-Ruano FJ, Dion-Côté A-M, Charles AJ, Goßmann T, Cabrero J, Kappei D, Hemmings N, Simons MJP, Camacho JPM, Forstmeier W, et al. (2019)
Nature Communications 10(1): 5468.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Autor*in
Kinsella, Cormac M.; Ruiz-Ruano, Francisco J.; Dion-Côté, Anne-Marie; Charles, Alexander J.; Goßmann, ToniUniBi ; Cabrero, Josefa; Kappei, Dennis; Hemmings, Nicola; Simons, Mirre J. P.; Camacho, Juan Pedro M.; Forstmeier, Wolfgang; Suh, Alexander
Alle
Abstract / Bemerkung
In some eukaryotes, germline and somatic genomes differ dramatically in their composition. Here we characterise a major germline–soma dissimilarity caused by a germline-restricted chromosome (GRC) in songbirds. We show that the zebra finch GRC contains >115 genes paralogous to single-copy genes on 18 autosomes and the Z chromosome, and is enriched in genes involved in female gonad development. Many genes are likely functional, evidenced by expression in testes and ovaries at the RNA and protein level. Using comparative genomics, we show that genes have been added to the GRC over millions of years of evolution, with embryonic development genes bicc1 and trim71 dating to the ancestor of songbirds and dozens of other genes added very recently. The somatic elimination of this evolutionarily dynamic chromosome in songbirds implies a unique mechanism to minimise genetic conflict between germline and soma, relevant to antagonistic pleiotropy, an evolutionary process underlying ageing and sexual traits.
Erscheinungsjahr
2019
Zeitschriftentitel
Nature Communications
Band
10
Ausgabe
1
Art.-Nr.
5468
ISSN
2041-1723
Page URI
https://pub.uni-bielefeld.de/record/2941285

Zitieren

Kinsella CM, Ruiz-Ruano FJ, Dion-Côté A-M, et al. Programmed DNA elimination of germline development genes in songbirds. Nature Communications. 2019;10(1): 5468.
Kinsella, C. M., Ruiz-Ruano, F. J., Dion-Côté, A. - M., Charles, A. J., Goßmann, T., Cabrero, J., Kappei, D., et al. (2019). Programmed DNA elimination of germline development genes in songbirds. Nature Communications, 10(1), 5468. doi:10.1038/s41467-019-13427-4
Kinsella, C. M., Ruiz-Ruano, F. J., Dion-Côté, A. - M., Charles, A. J., Goßmann, T., Cabrero, J., Kappei, D., Hemmings, N., Simons, M. J. P., Camacho, J. P. M., et al. (2019). Programmed DNA elimination of germline development genes in songbirds. Nature Communications 10:5468.
Kinsella, C.M., et al., 2019. Programmed DNA elimination of germline development genes in songbirds. Nature Communications, 10(1): 5468.
C.M. Kinsella, et al., “Programmed DNA elimination of germline development genes in songbirds”, Nature Communications, vol. 10, 2019, : 5468.
Kinsella, C.M., Ruiz-Ruano, F.J., Dion-Côté, A.-M., Charles, A.J., Goßmann, T., Cabrero, J., Kappei, D., Hemmings, N., Simons, M.J.P., Camacho, J.P.M., Forstmeier, W., Suh, A.: Programmed DNA elimination of germline development genes in songbirds. Nature Communications. 10, : 5468 (2019).
Kinsella, Cormac M., Ruiz-Ruano, Francisco J., Dion-Côté, Anne-Marie, Charles, Alexander J., Goßmann, Toni, Cabrero, Josefa, Kappei, Dennis, Hemmings, Nicola, Simons, Mirre J. P., Camacho, Juan Pedro M., Forstmeier, Wolfgang, and Suh, Alexander. “Programmed DNA elimination of germline development genes in songbirds”. Nature Communications 10.1 (2019): 5468.
Link(s) zu Volltext(en)
Access Level
OA Open Access

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 31784533
PubMed | Europe PMC

Suchen in

Google Scholar