Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense.

Happi GM, Wouamba SCN, Ismail M, Kouam SF, Frese M, Lenta BN, Sewald N (2020)
Steroids.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Happi, Gervais Mouthe; Wouamba, Steven Collins N; Ismail, Mohamed; Kouam, Simeon Fogue; Frese, Marcel; Lenta, Bruno Ndjakou; Sewald, NorbertUniBi
Abstract / Bemerkung
Two new ergostane-type steroids named tiamenones A and B (1-2) were isolated from the bark of Entandrophragma angolense (Meliaceae) along with ten known compounds identified as 20S-hydroxy-4,6,24(28)-ergostatrien-3-one (3), 3beta,7alpha,20beta-trihydroxyergosta-5,24(28)-diene (4), 3beta,5alpha-dihydroxyergosta-7,22-diene (5), stigmasterol, beta-sitosterol, beta-amyrin, oleanolic acid, asperphenamate, sucrose and daucosterol. The structures of the isolated compounds have been established using NMR spectroscopic and mass spectrometric analyses. The assignment of relative and absolute configurations of compound 1 was achieved by a NOESY experiment and comparison of its NMR data with those of known compound reported in literature. Compounds 1-3, beta-amyrin and asperphenamate were evaluated for their antibacterial potencies against five bacterial model strains viz. Escherichia coli DSMZ 1058, Pseudomonas agarici DSMZ 11810, Bacillus subtilis DSMZ 704, Micrococcus luteus DMSZ 1605 and Staphylococcus warneri DSMZ 20036 and their cytotoxicity on two cell lines KB3-1 and HT-29. No potencies were exhibited by the tested compounds even at the highest concentration of 0.5 mg/mL. Compounds 1-3 were found to be potential HIV-1 inhibitors based on their molecular docking analyses. Copyright © 2020. Published by Elsevier Inc.
Erscheinungsjahr
2020
Zeitschriftentitel
Steroids
eISSN
1878-5867
Page URI
https://pub.uni-bielefeld.de/record/2941089

Zitieren

Happi GM, Wouamba SCN, Ismail M, et al. Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense. Steroids. 2020.
Happi, G. M., Wouamba, S. C. N., Ismail, M., Kouam, S. F., Frese, M., Lenta, B. N., & Sewald, N. (2020). Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense. Steroids. doi:10.1016/j.steroids.2020.108584
Happi, G. M., Wouamba, S. C. N., Ismail, M., Kouam, S. F., Frese, M., Lenta, B. N., and Sewald, N. (2020). Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense. Steroids.
Happi, G.M., et al., 2020. Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense. Steroids.
G.M. Happi, et al., “Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense.”, Steroids, 2020.
Happi, G.M., Wouamba, S.C.N., Ismail, M., Kouam, S.F., Frese, M., Lenta, B.N., Sewald, N.: Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense. Steroids. (2020).
Happi, Gervais Mouthe, Wouamba, Steven Collins N, Ismail, Mohamed, Kouam, Simeon Fogue, Frese, Marcel, Lenta, Bruno Ndjakou, and Sewald, Norbert. “Ergostane-type steroids from the Cameroonian 'white tiama' Entandrophragma angolense.”. Steroids (2020).

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