Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl.

Akosung E, Kenmogne SB, Lobe Songue J, Longue Ekon JP, Lateef M, Ngeufa Happi E, Langat MK, Tabekoueng GB, Toze FAA, Stammler H-G, Ndjakou Lenta B, et al. (2020)
Natural product research: 1-10.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Akosung, Emmanuel; Kenmogne, Sidonie Beactrice; Lobe Songue, Jules; Longue Ekon, Jean Pierre; Lateef, Mehreen; Ngeufa Happi, Emmanuel; Langat, Moses Kiprotich; Tabekoueng, Georges Bellier; Toze, Flavien Aristide Alfred; Stammler, Hans-GeorgUniBi; Ndjakou Lenta, Bruno; Wansi, Jean Duplex
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Abstract / Bemerkung
The phytochemical investigation of the methanolic extracts of roots, stem bark, leaves and twigs of Manilkara obovata has led to the isolation of one new friedelane triterpene, lacefriedelic acid or 3beta,23-dihydroxy D:A-friedooleanan-28-oic acid (1) and one new prenylated xanthone, lacexanthone or 4,7-dihydroxy-2,3,3,9,9-pentamethyl-2,2-dihydrofurano[2,3-a]pyrano[2,3-i]xanthen-13(9H)-one (2) alongside twenty-four known compounds. Compounds 1-11 are reported here for the first time from the genus Manilkara. The structures of all compounds were determined by spectroscopic analyses and X-ray crystallography. The methanolic extracts of twigs and leaves showed anti-oxidant activity of 93.2 and 91.1%, respectively, at 100g/mL when measured by DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate), while the twig extract displayed 86.3% at 100g/mL against the urease inhibition assay. Some isolated compounds (1-4, 15 and 20) showed significant to moderate anti-oxidant activity and urease inhibition assay. It is estimated that significantly active anti-oxidants and urease inhibitors metabolized by the plant may find future application in food industry.
Erscheinungsjahr
2020
Zeitschriftentitel
Natural product research
Seite(n)
1-10
ISSN
1478-6419
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2940377

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Akosung E, Kenmogne SB, Lobe Songue J, et al. Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. Natural product research. 2020:1-10.
Akosung, E., Kenmogne, S. B., Lobe Songue, J., Longue Ekon, J. P., Lateef, M., Ngeufa Happi, E., Langat, M. K., et al. (2020). Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. Natural product research, 1-10. doi:10.1080/14786419.2020.1713123
Akosung, E., Kenmogne, S. B., Lobe Songue, J., Longue Ekon, J. P., Lateef, M., Ngeufa Happi, E., Langat, M. K., Tabekoueng, G. B., Toze, F. A. A., Stammler, H. - G., et al. (2020). Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. Natural product research, 1-10.
Akosung, E., et al., 2020. Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. Natural product research, , p 1-10.
E. Akosung, et al., “Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl.”, Natural product research, 2020, pp. 1-10.
Akosung, E., Kenmogne, S.B., Lobe Songue, J., Longue Ekon, J.P., Lateef, M., Ngeufa Happi, E., Langat, M.K., Tabekoueng, G.B., Toze, F.A.A., Stammler, H.-G., Ndjakou Lenta, B., Wansi, J.D., Sewald, N., Ali, M.S., Kamdem Waffo, A.F.: Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. Natural product research. 1-10 (2020).
Akosung, Emmanuel, Kenmogne, Sidonie Beactrice, Lobe Songue, Jules, Longue Ekon, Jean Pierre, Lateef, Mehreen, Ngeufa Happi, Emmanuel, Langat, Moses Kiprotich, Tabekoueng, Georges Bellier, Toze, Flavien Aristide Alfred, Stammler, Hans-Georg, Ndjakou Lenta, Bruno, Wansi, Jean Duplex, Sewald, Norbert, Ali, Muhammad Shaiq, and Kamdem Waffo, Alain Francois. “Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl.”. Natural product research (2020): 1-10.

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