Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017

Troeger CE, Khalil IA, Blacker BF, Biehl MH, Albertson SB, Zimsen SRM, Rao PC, Abate D, Ahmadi A, Ahmed MLCB, Akal CG, et al. (2020)
LANCET INFECTIOUS DISEASES 20(1): 37-59.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Troeger, Christopher E.; Khalil, Ibrahim A.; Blacker, Brigette F.; Biehl, Molly H.; Albertson, Samuel B.; Zimsen, Stephanie R. M.; Rao, Puja C.; Abate, Degu; Ahmadi, Alireza; Ahmed, Mohamed Lemine Cheikh Brahim; Akal, Chalachew Genet; Alahdab, Fares
Alle
Abstract / Bemerkung
Background Many countries have shown marked declines in diarrhoea! disease mortality among children younger than 5 years. With this analysis, we provide updated results on diarrhoeal disease mortality among children younger than 5 years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) and use the study's comparative risk assessment to quantify trends and effects of risk factors, interventions, and broader sociodemographic development on mortality changes in 195 countries and territories from 1990 to 2017. Methods This analysis for GBD 2017 had three main components. Diarrhoea mortality was modelled using vital registration data, demographic surveillance data, and verbal autopsy data in a predictive, Bayesian, ensemble modelling tool; and the attribution of risk factors and interventions for diarrhoea were modelled in a counterfactual framework that combines modelled population-level prevalence of the exposure to each risk or intervention with the relative risk of diarrhoea given exposure to that factor. We assessed the relative and absolute change in diarrhoea mortality rate between 1990 and 2017, and used the change in risk factor exposure and sociodemographic status to explain differences in the trends of diarrhoea mortality among children younger than 5 years. Findings Diarrhoea was responsible for an estimated 533 768 deaths (95% uncertainty interval 477 162-593 145) among children younger than 5 years globally in 2017, a rate of 78.4 deaths (70.1-87.1) per 100 000 children. The diarrhoea mortality rate ranged between countries by over 685 deaths per 100 000 children. Diarrhoea mortality per 100 000 globally decreased by 69.6% (63.1-74.6) between 1990 and 2017. Among the risk factors considered in this study, those responsible for the largest declines in the diarrhoea mortality rate were reduction in exposure to unsafe sanitation (13.3% decrease, 11.2-15.5), childhood wasting (9.9% decrease, 9.6-10.2), and low use of oral rehydration solution (6.9% decrease, 4-8-8-4). Interpretation Diarrhoea mortality has declined substantially since 1990, although there are variations by country. Improvements in sociodemographic indicators might explain some of these trends, but changes in exposure to risk factors-particularly unsafe sanitation, childhood growth failure, and low use of oral rehydration solution-appear to be related to the relative and absolute rates of decline in diarrhoea mortality. Although the most effective interventions might vary by country or region, identifying and scaling up the interventions aimed at preventing and protecting against diarrhoea that have already reduced diarrhoea mortality could further avert many thousands of deaths due to this illness. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.
Erscheinungsjahr
2020
Zeitschriftentitel
LANCET INFECTIOUS DISEASES
Band
20
Ausgabe
1
Seite(n)
37-59
ISSN
1473-3099
eISSN
1474-4457
Page URI
https://pub.uni-bielefeld.de/record/2940094

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Troeger CE, Khalil IA, Blacker BF, et al. Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. LANCET INFECTIOUS DISEASES. 2020;20(1):37-59.
Troeger, C. E., Khalil, I. A., Blacker, B. F., Biehl, M. H., Albertson, S. B., Zimsen, S. R. M., Rao, P. C., et al. (2020). Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. LANCET INFECTIOUS DISEASES, 20(1), 37-59. doi:10.1016/S1473-3099(19)30401-3
Troeger, C. E., Khalil, I. A., Blacker, B. F., Biehl, M. H., Albertson, S. B., Zimsen, S. R. M., Rao, P. C., Abate, D., Ahmadi, A., Ahmed, M. L. C. B., et al. (2020). Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. LANCET INFECTIOUS DISEASES 20, 37-59.
Troeger, C.E., et al., 2020. Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. LANCET INFECTIOUS DISEASES, 20(1), p 37-59.
C.E. Troeger, et al., “Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017”, LANCET INFECTIOUS DISEASES, vol. 20, 2020, pp. 37-59.
Troeger, C.E., Khalil, I.A., Blacker, B.F., Biehl, M.H., Albertson, S.B., Zimsen, S.R.M., Rao, P.C., Abate, D., Ahmadi, A., Ahmed, M.L.C.B., Akal, C.G., Alahdab, F., Alam, N., Alene, K.A., Alipour, V., Aljunid, S.M., Al-Raddadi, R.M., Alvis-Guzman, N., Amini, S., Anber, N.H., Anjomshoa, M., Antonio, C.A.T., Arabloo, J., Aremu, O., Atalay, H.T., Atique, S., Avokpaho, E.F.G.A., Awad, S., Awasthi, A., Badawi, A., Balakrishnan, K., Banoub, J.A.M., Barac, A., Bassat, Q., Bedi, N., Bennett, D.A., Bhattacharyya, K., Bhutta, Z.A., Bijani, A., Car, J., Carvalho, F., Castaneda-Orjuela, C.A., Christopher, D.J., Dandona, L., Dandona, R., Daryani, A., Demeke, F.M., Deshpande, A., Djalalinia, S., Dubey, M., Dubljanin, E., Duken, E.E., Zaki, M.E.S., Endries, A.Y., Fernandes, E., Fischer, F., Fullman, N., Gardner, W.M., Geta, B., Ghadiri, K., Gorini, G., Goulart, A.C., Guo, Y., Hailu, G.B., Haj-Mirzaian, A., Haj-Mirzaian, A., Hamidi, S., Hassen, H.Y., Chi Linh Hoang, C.L.H., Hostiuc, M., Hussain, Z., Irvani, S.S.N., James, S.L., Jha, R.P., Jonas, J.B., Karch, A., Kasaeian, A., Kassa, T.D., Kassebaum, N.J., Kefale, A.T., Khader, Y.S., Khan, E.A., Khan, M.N., Khang, Y.-H., Khoja, A.T., Kimokoti, R.W., Kisa, A., Kisa, S., Kissoon, N., Kochhar, S., Kosen, S., Koyanagi, A., Defo, B.K., Kumar, G.A., Lal, D.K., Leshargie, C.T., Li, S., Lodha, R., Macarayan, E.R.K., Majdan, M., Mamun, A.A., Manguerra, H., Melese, A., Memish, Z.A., Mengistu, D.T., Meretoja, T.J., Mestrovic, T., Miazgowski, B., Mirrakhimov, E.M., Moazen, B., Mohammad, K.A., Mohammed, S., Monasta, L., Moore, C.E., Mosser, J.F., Mousavi, S.M., Murthy, S., Mustafa, G., Nazari, J., Cuong Tat Nguyen, C.T.N., Long Hoang Nguyen, L.H.N., Nisar, M.I., Nixon, M.R., Ogbo, F.A., Okoro, A., Olagunju, A.T., Olagunju, T.O., Mahesh, P.A., Pakhale, S., Postma, M.J., Qorbani, M., Quansah, R., Rafiei, A., Rahim, F., Rahimi-Movaghar, V., Rai, R.K., Rezai, M.S., Rezapour, A., Jesus Rios-Blancas, M., Ronfani, L., Rosettie, K., Rothenbacher, D., Safari, S., Saleem, Z., Sambala, E.Z., Samy, A.M., Milicevic, M.M.S., Sartorius, B., Sawhney, M., Seyedmousavi, S., Shaikh, M.A., Sheikh, A., Shigematsu, M., Smith, D.L., Soriano, J.B., Sreeramareddy, C.T., Stanaway, J.D., Sufiyan, M.'awiyyah B., Teklu, T.G.E., Temsah, M.-H., Tessema, B., Bach Xuan Tran, B.X.T., Khanh Bao Tran, K.B.T., Ullah, I., Updike, R.L., Vasankari, T.J., Veisani, Y., Wada, F.W., Waheed, Y., Weaver, M., Wiens, K.E., Wiysonge, C.S., Yimer, E.M., Yonemoto, N., Zaidi, Z., Zar, H.J., Zarghi, A., Lim, S.S., Vos, T., Mokdad, A.H., Murray, C.J.L., Kyu, H.H., Hay, S.I., Reiner, Robert C., J.: Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. LANCET INFECTIOUS DISEASES. 20, 37-59 (2020).
Troeger, Christopher E., Khalil, Ibrahim A., Blacker, Brigette F., Biehl, Molly H., Albertson, Samuel B., Zimsen, Stephanie R. M., Rao, Puja C., Abate, Degu, Ahmadi, Alireza, Ahmed, Mohamed Lemine Cheikh Brahim, Akal, Chalachew Genet, Alahdab, Fares, Alam, Noore, Alene, Kefyalew Addis, Alipour, Vahid, Aljunid, Syed Mohamed, Al-Raddadi, Rajaa M., Alvis-Guzman, Nelson, Amini, Saeed, Anber, Nahla Hamed, Anjomshoa, Mina, Antonio, Carl Abelardo T., Arabloo, Jalal, Aremu, Olatunde, Atalay, Hagos Tasew, Atique, Suleman, Avokpaho, Euripide F. G. A., Awad, Samah, Awasthi, Ashish, Badawi, Alaa, Balakrishnan, Kalpana, Banoub, Joseph Adel Mattar, Barac, Aleksandra, Bassat, Quique, Bedi, Neeraj, Bennett, Derrick A., Bhattacharyya, Krittika, Bhutta, Zulfiqar A., Bijani, Ali, Car, Josip, Carvalho, Felix, Castaneda-Orjuela, Carlos A., Christopher, Devasahayam J., Dandona, Lalit, Dandona, Rakhi, Daryani, Ahmad, Demeke, Feleke Mekonnen, Deshpande, Aniruddha, Djalalinia, Shirin, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Zaki, Maysaa El Sayed, Endries, Aman Yesuf, Fernandes, Eduarda, Fischer, Florian, Fullman, Nancy, Gardner, William M., Geta, Birhanu, Ghadiri, Keyghobad, Gorini, Giuseppe, Goulart, Alessandra C., Guo, Yuming, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamidi, Samer, Hassen, Hamid Yimam, Chi Linh Hoang, Chi Linh Hoang, Hostiuc, Mihaela, Hussain, Zakir, Irvani, Seyed Sina Naghibi, James, Spencer L., Jha, Ravi Prakash, Jonas, Jost B., Karch, Andre, Kasaeian, Amir, Kassa, Tesfaye Dessale, Kassebaum, Nicholas J., Kefale, Adane Teshome, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khan, Md Nuruzzaman, Khang, Young-Ho, Khoja, Abdullah T., Kimokoti, Ruth W., Kisa, Adnan, Kisa, Sezer, Kissoon, Niranjan, Kochhar, Sonali, Kosen, Soewarta, Koyanagi, Ai, Defo, Barthelemy Kuate, Kumar, G. Anil, Lal, Dharmesh Kumar, Leshargie, Cheru Tesema, Li, Shanshan, Lodha, Rakesh, Macarayan, Erlyn Rachelle King, Majdan, Marek, Mamun, Abdullah A., Manguerra, H., Melese, Addisu, Memish, Ziad A., Mengistu, Desalegn Tadese, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Mirrakhimov, Erkin M., Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammed, Shafiu, Monasta, Lorenzo, Moore, Catrin E., Mosser, Jonathan F., Mousavi, Seyyed Meysam, Murthy, Srinivas, Mustafa, Ghulam, Nazari, Javad, Cuong Tat Nguyen, Cuong Tat Nguyen, Long Hoang Nguyen, Long Hoang Nguyen, Nisar, Muhammad Imran, Nixon, Molly R., Ogbo, Felix Akpojene, Okoro, Anselm, Olagunju, Andrew T., Olagunju, Tinuke O., Mahesh, P. A., Pakhale, Smita, Postma, Maarten J., Qorbani, Mostafa, Quansah, Reginald, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rai, Rajesh Kumar, Rezai, Mohammad Sadegh, Rezapour, Aziz, Jesus Rios-Blancas, Maria, Ronfani, Luca, Rosettie, Katherine, Rothenbacher, Dietrich, Safari, Saeed, Saleem, Zikria, Sambala, Evanson Zondani, Samy, Abdallah M., Milicevic, Milena M. Santric, Sartorius, Benn, Sawhney, Monika, Seyedmousavi, Seyedmojtaba, Shaikh, Masood Ali, Sheikh, Aziz, Shigematsu, Mika, Smith, David L., Soriano, Joan B., Sreeramareddy, Chandrashekhar T., Stanaway, Jeffrey D., Sufiyan, Mu'awiyyah Babale, Teklu, Teklay G. E., Temsah, Mohamad-Hani, Tessema, Belay, Bach Xuan Tran, Bach Xuan Tran, Khanh Bao Tran, Khanh Bao Tran, Ullah, Irfan, Updike, Rachel L., Vasankari, Tommi Juhani, Veisani, Yousef, Wada, Fiseha Wadilo, Waheed, Yasir, Weaver, Marcia, Wiens, Kirsten E., Wiysonge, Charles Shey, Yimer, Ebrahim M., Yonemoto, Naohiro, Zaidi, Zoubida, Zar, Heather J., Zarghi, Afshin, Lim, Stephen S., Vos, Theo, Mokdad, Ali H., Murray, Christopher J. L., Kyu, Hmwe Hmwe, Hay, Simon I., and Reiner, Robert C., Jr. “Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017”. LANCET INFECTIOUS DISEASES 20.1 (2020): 37-59.

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