Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)

Makong YS, Mouthé Happi G, Djouaka Bavoua JL, Wansi JD, Nahar L, Kamdem Waffo AF, Martin C, Sewald N, Sarker SD (2019)
Molecules 24(23): 4412.

Zeitschriftenaufsatz | Veröffentlicht| Englisch
 
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Autor*in
Makong, Yves Salomon; Mouthé Happi, Gervais; Djouaka Bavoua, Judith Liliane; Wansi, Jean Duplex; Nahar, Lutfun; Kamdem Waffo, Alain François; Martin, Claire; Sewald, NorbertUniBi ; Sarker, Satyajit Dey
Abstract / Bemerkung
A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.
Stichworte
Brucea antidysenterica; Simaroubaceae; bruceanoside A; bruceacanthinones A–B; cytotoxicity
Erscheinungsjahr
2019
Zeitschriftentitel
Molecules
Band
24
Ausgabe
23
Art.-Nr.
4412
ISSN
1420-3049
Finanzierungs-Informationen
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
Page URI
https://pub.uni-bielefeld.de/record/2939318

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Makong YS, Mouthé Happi G, Djouaka Bavoua JL, et al. Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules. 2019;24(23): 4412.
Makong, Y. S., Mouthé Happi, G., Djouaka Bavoua, J. L., Wansi, J. D., Nahar, L., Kamdem Waffo, A. F., Martin, C., et al. (2019). Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules, 24(23), 4412. doi:10.3390/molecules24234412
Makong, Y. S., Mouthé Happi, G., Djouaka Bavoua, J. L., Wansi, J. D., Nahar, L., Kamdem Waffo, A. F., Martin, C., Sewald, N., and Sarker, S. D. (2019). Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules 24:4412.
Makong, Y.S., et al., 2019. Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules, 24(23): 4412.
Y.S. Makong, et al., “Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)”, Molecules, vol. 24, 2019, : 4412.
Makong, Y.S., Mouthé Happi, G., Djouaka Bavoua, J.L., Wansi, J.D., Nahar, L., Kamdem Waffo, A.F., Martin, C., Sewald, N., Sarker, S.D.: Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules. 24, : 4412 (2019).
Makong, Yves Salomon, Mouthé Happi, Gervais, Djouaka Bavoua, Judith Liliane, Wansi, Jean Duplex, Nahar, Lutfun, Kamdem Waffo, Alain François, Martin, Claire, Sewald, Norbert, and Sarker, Satyajit Dey. “Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)”. Molecules 24.23 (2019): 4412.
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2019-12-03T12:05:07Z
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