Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects

Zolotareva O, Saik OV, Königs C, Bragina EY, Goncharova IA, Freidin MB, Dosenko VE, Ivanisenko VA, Hofestädt R (2019)
Scientific Reports 9(1): 16302: 16302.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Zolotareva, OlgaUniBi; Saik, Olga V.; Königs, CassandraUniBi; Bragina, Elena Yu.; Goncharova, Irina A.; Freidin, Maxim B.; Dosenko, Victor E.; Ivanisenko, Vladimir A.; Hofestädt, RalfUniBi
Abstract / Bemerkung
Asthma and hypertension are complex diseases coinciding more frequently than expected by chance. Unraveling the mechanisms of comorbidity of asthma and hypertension is necessary for choosing the most appropriate treatment plan for patients with this comorbidity. Since both diseases have a strong genetic component in this article we aimed to find and study genes simultaneously associated with asthma and hypertension. We identified 330 shared genes and found that they form six modules on the interaction network. A strong overlap between genes associated with asthma and hypertension was found on the level of eQTL regulated genes and between targets of drugs relevant for asthma and hypertension. This suggests that the phenomenon of comorbidity of asthma and hypertension may be explained by altered genetic regulation or result from drug side effects. In this work we also demonstrate that not only drug indications but also contraindications provide an important source of molecular evidence helpful to uncover disease mechanisms. These findings give a clue to the possible mechanisms of comorbidity and highlight the direction for future research.
Erscheinungsjahr
2019
Zeitschriftentitel
Scientific Reports
Band
9
Ausgabe
1
Art.-Nr.
16302
Seite(n)
16302
ISSN
2045-2322
eISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2938765

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Zolotareva O, Saik OV, Königs C, et al. Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports. 2019;9(1):16302: 16302.
Zolotareva, O., Saik, O. V., Königs, C., Bragina, E. Y., Goncharova, I. A., Freidin, M. B., Dosenko, V. E., et al. (2019). Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports, 9(1), 16302., 16302. doi:10.1038/s41598-019-52762-w
Zolotareva, O., Saik, O. V., Königs, C., Bragina, E. Y., Goncharova, I. A., Freidin, M. B., Dosenko, V. E., Ivanisenko, V. A., and Hofestädt, R. (2019). Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports 9, 16302:16302.
Zolotareva, O., et al., 2019. Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports, 9(1), p 16302: 16302.
O. Zolotareva, et al., “Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects”, Scientific Reports, vol. 9, 2019, pp. 16302, : 16302.
Zolotareva, O., Saik, O.V., Königs, C., Bragina, E.Y., Goncharova, I.A., Freidin, M.B., Dosenko, V.E., Ivanisenko, V.A., Hofestädt, R.: Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects. Scientific Reports. 9, 16302 : 16302 (2019).
Zolotareva, Olga, Saik, Olga V., Königs, Cassandra, Bragina, Elena Yu., Goncharova, Irina A., Freidin, Maxim B., Dosenko, Victor E., Ivanisenko, Vladimir A., and Hofestädt, Ralf. “Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects”. Scientific Reports 9.1 (2019): 16302: 16302.
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2019-11-12T07:59:28Z
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