A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.

Zolotareva O, Kleine M (2019)
Journal of integrative bioinformatics 16(4): 20180069.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Abstract / Bemerkung
Modern high-throughput experiments provide us with numerous potential associations between genes and diseases. Experimental validation of all the discovered associations, let alone all the possible interactions between them, is time-consuming and expensive. To facilitate the discovery of causative genes, various approaches for prioritization of genes according to their relevance for a given disease have been developed. In this article, we explain the gene prioritization problem and provide an overview of computational tools for gene prioritization. Among about a hundred of published gene prioritization tools, we select and briefly describe 14 most up-to-date and user-friendly. Also, we discuss the advantages and disadvantages of existing tools, challenges of their validation, and the directions for future research.
Erscheinungsjahr
2019
Zeitschriftentitel
Journal of integrative bioinformatics
Band
16
Ausgabe
4
Art.-Nr.
20180069
ISSN
1613-4516
eISSN
1613-4516
Page URI
https://pub.uni-bielefeld.de/record/2937582

Zitieren

Zolotareva O, Kleine M. A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics. 2019;16(4): 20180069.
Zolotareva, O., & Kleine, M. (2019). A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics, 16(4), 20180069. doi:10.1515/jib-2018-0069
Zolotareva, O., and Kleine, M. (2019). A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics 16:20180069.
Zolotareva, O., & Kleine, M., 2019. A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics, 16(4): 20180069.
O. Zolotareva and M. Kleine, “A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.”, Journal of integrative bioinformatics, vol. 16, 2019, : 20180069.
Zolotareva, O., Kleine, M.: A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics. 16, : 20180069 (2019).
Zolotareva, Olga, and Kleine, Maren. “A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.”. Journal of integrative bioinformatics 16.4 (2019): 20180069.

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