A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.

Zolotareva O, Kleine M (2019)
Journal of integrative bioinformatics.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck| Englisch
 
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Abstract / Bemerkung
Modern high-throughput experiments provide us with numerous potential associations between genes and diseases. Experimental validation of all the discovered associations, let alone all the possible interactions between them, is time-consuming and expensive. To facilitate the discovery of causative genes, various approaches for prioritization of genes according to their relevance for a given disease have been developed. In this article, we explain the gene prioritization problem and provide an overview of computational tools for gene prioritization. Among about a hundred of published gene prioritization tools, we select and briefly describe 14 most up-to-date and user-friendly. Also, we discuss the advantages and disadvantages of existing tools, challenges of their validation, and the directions for future research.
Erscheinungsjahr
2019
Zeitschriftentitel
Journal of integrative bioinformatics
eISSN
1613-4516
Page URI
https://pub.uni-bielefeld.de/record/2937582

Zitieren

Zolotareva O, Kleine M. A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics. 2019.
Zolotareva, O., & Kleine, M. (2019). A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics. doi:10.1515/jib-2018-0069
Zolotareva, O., and Kleine, M. (2019). A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics.
Zolotareva, O., & Kleine, M., 2019. A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics.
O. Zolotareva and M. Kleine, “A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.”, Journal of integrative bioinformatics, 2019.
Zolotareva, O., Kleine, M.: A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases. Journal of integrative bioinformatics. (2019).
Zolotareva, Olga, and Kleine, Maren. “A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases.”. Journal of integrative bioinformatics (2019).

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