Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells.

Greiner J, Merten M, Kaltschmidt C, Kaltschmidt B (2019)
FEBS letters.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck| Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Abstract / Bemerkung
Sexual dimorphisms contribute, at least in part, to the severity and occurrence of a broad range of neurodegenerative, cardiovascular, and bone disorders. In addition to hormonal factors, increasing evidence suggests that stem cell-intrinsic mechanisms account for sex-specific differences in human physiology and pathology. Here, we discuss sex-related intrinsic mechanisms in adult stem cell populations, namely mesoderm-derived stem cells, neural stem cells (NSCs) and neural crest-derived stem cells (NCSCs), and their implications for stem-cell differentiation and regeneration. We particularly focus on sex-specific differences in stem cell-mediated bone regeneration, in neuronal development and NSC-mediated neuroprotection. Moreover, we review our own recently published observations regarding the sex-dependent role of NF-kappaB-p65 in neuroprotection of human NCSC-derived neurons and sex-differences in NCSC-related disorders, so called neurocristopathies. These observations are in accordance with the increasing evidence pointing towards sex-specific differences in neurocristopathies and degenerative diseases like Parkinson's disease or osteoporosis. All findings discussed here indicate that sex-specific variability in stem-cell biology may become a crucial parameter for the design of future treatment strategies. © 2019 Federation of European Biochemical Societies.
Erscheinungsjahr
2019
Zeitschriftentitel
FEBS letters
eISSN
1873-3468
Page URI
https://pub.uni-bielefeld.de/record/2937576

Zitieren

Greiner J, Merten M, Kaltschmidt C, Kaltschmidt B. Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells. FEBS letters. 2019.
Greiner, J., Merten, M., Kaltschmidt, C., & Kaltschmidt, B. (2019). Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells. FEBS letters. doi:10.1002/1873-3468.13606
Greiner, J., Merten, M., Kaltschmidt, C., and Kaltschmidt, B. (2019). Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells. FEBS letters.
Greiner, J., et al., 2019. Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells. FEBS letters.
J. Greiner, et al., “Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells.”, FEBS letters, 2019.
Greiner, J., Merten, M., Kaltschmidt, C., Kaltschmidt, B.: Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells. FEBS letters. (2019).
Greiner, Johannes, Merten, Madlen, Kaltschmidt, Christian, and Kaltschmidt, Barbara. “Sexual dimorphisms in adult human neural, mesoderm-derived, and neural crest-derived stem cells.”. FEBS letters (2019).

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 31529465
PubMed | Europe PMC

Suchen in

Google Scholar