Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae).

Makong YS, Fotso GW, Mouthe GH, Lenta B, Rennert R, Sewald N, Arnold N, Wansi JD, Ngadjui BT (2019)
Natural product research.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Abstract / Bemerkung
The chemical investigation of the root barks leaves and stem barks of Brucea antidysenterica J. F. Mill. (Simaroubaceae) led to the isolation of a new pregnane glycoside, named Bruceadysentoside A or 3-O-beta-L-arabinopyranosyl-pregn-5-en-20-one (1) together with seventeen known compounds. Their structures were established from spectral data, mainly HRESIMS, 1D and 2D NMR and by comparison with literature data. Compounds 1, 2, 5, 6, 8, 10, 12 and 13 were tested in vitro for their effects on the viability of two different human cancer cell lines, namely prostate PC-3 adenocarcinoma cells and colorectal HT-29 adenocarcinoma cells. No substantial activities were recorded for 2, 10, 12 and 13 (up to 10muM concentration). 1, 5 and 8 did not show strong anti-proliferative effects up to 100muM, however, 6 exhibited a stronger anti-proliferative effect with IC50 values of 100muM against PC-3 and 200muM against HT-29.
Erscheinungsjahr
2019
Zeitschriftentitel
Natural product research
eISSN
1478-6427
Page URI
https://pub.uni-bielefeld.de/record/2937245

Zitieren

Makong YS, Fotso GW, Mouthe GH, et al. Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae). Natural product research. 2019.
Makong, Y. S., Fotso, G. W., Mouthe, G. H., Lenta, B., Rennert, R., Sewald, N., Arnold, N., et al. (2019). Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae). Natural product research. doi:10.1080/14786419.2019.1655024
Makong, Y. S., Fotso, G. W., Mouthe, G. H., Lenta, B., Rennert, R., Sewald, N., Arnold, N., Wansi, J. D., and Ngadjui, B. T. (2019). Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae). Natural product research.
Makong, Y.S., et al., 2019. Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae). Natural product research.
Y.S. Makong, et al., “Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae).”, Natural product research, 2019.
Makong, Y.S., Fotso, G.W., Mouthe, G.H., Lenta, B., Rennert, R., Sewald, N., Arnold, N., Wansi, J.D., Ngadjui, B.T.: Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae). Natural product research. (2019).
Makong, Yves Salomon, Fotso, Ghislain Wabo, Mouthe, Gervais Happi, Lenta, Bruno, Rennert, Robert, Sewald, Norbert, Arnold, Norbert, Wansi, Jean Duplex, and Ngadjui, Bonaventure Tchaleu. “Bruceadysentoside A, a new pregnane glycoside and others secondary metabolites with cytotoxic activity from brucea antidysenterica J. F. Mill. (simaroubaceae).”. Natural product research (2019).

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