Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.
Litzke V, Ottensmann M, Forcada J, Heitzmann L, Hoffman J (2019)
Ecology and evolution 9(14): 7985-7996.
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Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity-fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations have been widely reported at both neutral and functional loci, yet few studies have directly compared the two, making it difficult to gauge the relative contributions of genome-wide inbreeding and specific functional genes to fitness. Here, we compared the effects of neutral and immune gene heterozygosity on death from bacterial infection in Antarctic fur seal (Arctocephalus gazella) pups. We specifically developed a panel of 13 microsatellites from expressed immune genes and genotyped these together with 48 neutral loci in 234 individuals, comprising 39 pups that were classified at necropsy as having most likely died of bacterial infection together with a five times larger matched sample of healthy surviving pups. Identity disequilibrium quantified from the neutral markers was positive and significant, indicative of variance in inbreeding within the study population. However, multilocus heterozygosity did not differ significantly between healthy and infected pups at either class of marker, and little evidence was found for fitness associations at individual loci. These results support a previous study of Antarctic fur seals that found no effects of heterozygosity at nine neutral microsatellites on neonatal survival and thereby help to refine our understanding of how HFCs vary across the life cycle. Given that nonsignificant HFCs are underreported in the literature, we also hope that our study will contribute toward a more balanced understanding of the wider importance of this phenomenon.
Erscheinungsjahr
2019
Zeitschriftentitel
Ecology and evolution
Band
9
Ausgabe
14
Seite(n)
7985-7996
Urheberrecht / Lizenzen
ISSN
2045-7758
eISSN
2045-7758
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Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
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Litzke V, Ottensmann M, Forcada J, Heitzmann L, Hoffman J. Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and evolution. 2019;9(14):7985-7996.
Litzke, V., Ottensmann, M., Forcada, J., Heitzmann, L., & Hoffman, J. (2019). Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and evolution, 9(14), 7985-7996. doi:10.1002/ece3.5317
Litzke, Vivienne, Ottensmann, Meinolf, Forcada, Jaume, Heitzmann, Louise, and Hoffman, Joseph. 2019. “Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.”. Ecology and evolution 9 (14): 7985-7996.
Litzke, V., Ottensmann, M., Forcada, J., Heitzmann, L., and Hoffman, J. (2019). Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and evolution 9, 7985-7996.
Litzke, V., et al., 2019. Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and evolution, 9(14), p 7985-7996.
V. Litzke, et al., “Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.”, Ecology and evolution, vol. 9, 2019, pp. 7985-7996.
Litzke, V., Ottensmann, M., Forcada, J., Heitzmann, L., Hoffman, J.: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals. Ecology and evolution. 9, 7985-7996 (2019).
Litzke, Vivienne, Ottensmann, Meinolf, Forcada, Jaume, Heitzmann, Louise, and Hoffman, Joseph. “Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.”. Ecology and evolution 9.14 (2019): 7985-7996.
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Szulkin M, Bierne N, David P., Evolution 64(5), 2010
PMID: 20148954
Inbreeding coefficient and heterozygosity-fitness correlations in unhatched and hatched song sparrow nestmates.
Taylor SS, Sardell RJ, Reid JM, Bucher T, Taylor NG, Arcese P, Keller LF., Mol. Ecol. 19(20), 2010
PMID: 20854411
Taylor SS, Sardell RJ, Reid JM, Bucher T, Taylor NG, Arcese P, Keller LF., Mol. Ecol. 19(20), 2010
PMID: 20854411
AUTHOR UNKNOWN, 2003
Primer3Plus, an enhanced web interface to Primer3.
Untergasser A, Nijveen H, Rao X, Bisseling T, Geurts R, Leunissen JA., Nucleic Acids Res. 35(Web Server issue), 2007
PMID: 17485472
Untergasser A, Nijveen H, Rao X, Bisseling T, Geurts R, Leunissen JA., Nucleic Acids Res. 35(Web Server issue), 2007
PMID: 17485472
Reduced microsatellite heterozygosity does not affect natal dispersal in three contrasting roe deer populations.
Vanpe C, Debeffe L, Hewison AJM, Quemere E, Lemaitre JF, Galan M, Amblard B, Klein F, Cargnelutti B, Capron G, Merlet J, Warnant C, Gaillard JM., Oecologia 177(3), 2014
PMID: 25388875
Vanpe C, Debeffe L, Hewison AJM, Quemere E, Lemaitre JF, Galan M, Amblard B, Klein F, Cargnelutti B, Capron G, Merlet J, Warnant C, Gaillard JM., Oecologia 177(3), 2014
PMID: 25388875
No correlation between neonatal fitness and heterozygosity in a reintroduced population of Père David's deer
AUTHOR UNKNOWN, 2013
AUTHOR UNKNOWN, 2013
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