Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia.

Jacob C, Altevers J, Barck I, Hardt T, Braun S, Greiner W (2019)
ESC heart failure 6(4): 840-855.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Jacob, Christian; Altevers, Julia; Barck, Isabella; Hardt, Thomas; Braun, Sebastian; Greiner, WolfgangUniBi
Abstract / Bemerkung
AIMS: The aim of this study was to assess the burden of heart failure (HF) patients with/without iron deficiency/iron deficiency anaemia (ID/A) from the health insurance perspective.; METHODS AND RESULTS: We conducted a retrospective claims database analysis using the Institut fur angewandte Gesundheitsforschung Berlin research database. The study period spanned from 1 January 2012 to 31 December 2014. HF patients were identified by International Statistical Classification of Diseases and Related Health Problems, 10th revision, German Modification codes (I50.-, I50.0-, I50.00, I50.01, I50.1-, I50.11, I50.12, I50.13, I50.14, I50.19, and I50.9). HF patients were stratified into HF patients without ID/A and HF patients with ID/A (D50.-, D50.0, D50.8, D50.9, and E61.1). HF patients with ID/A were stratified into three subgroups: no iron treatment, oral iron treatment, and intravenous iron treatment. A matching approach was applied to compare outcomes for HF patients without ID/A vs. HF patient with untreated incident ID/A without iron treatment and for HF patients receiving no iron treatment vs. oral iron treatment vs. intravenous iron treatment. Matching parameters included exact age, sex, and New York Heart Association functional class. An optimization algorithm was used to balance total health care costs in the baseline period for the potential matched pairs without sample size reduction. In total, 172394 (4537.4 per 100000) HF patients were identified in the Institut fur angewandte Gesundheitsforschung Berlin research database in 2013. Of these, 11.1% (19070; 501.9 per 100000) were diagnosed with ID/A and/or had a prescription for iron medication in 2013. The mean age of HF patients was 77.0years (±12.0years). Women were more frequently diagnosed with HF (54.6%). HF patients with untreated incident ID/A (1.77%) had a significantly higher all-cause mortality than HF patients without ID/A (33.1% vs. 24.1%, P<0.01). The analysis of health care utilization revealed significant differences in the rate of all-cause hospitalization (72.9% vs. 50.5%, P<0.01). The annual health care costs for HF patients with untreated incident ID/A amounted to 17347 with incremental costs of 849 (P<0.01) attributed to ID/A.; CONCLUSIONS: Heart failure is associated with a major burden for patients and the health care system in terms of health care resource utilization, costs, and mortality. Our findings suggest that there is an unmet need for treating more HF patients with ID/A with iron medication. © 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
Erscheinungsjahr
2019
Zeitschriftentitel
ESC heart failure
Band
6
Ausgabe
4
Seite(n)
840-855
ISSN
2055-5822
Page URI
https://pub.uni-bielefeld.de/record/2936485

Zitieren

Jacob C, Altevers J, Barck I, Hardt T, Braun S, Greiner W. Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia. ESC heart failure. 2019;6(4):840-855.
Jacob, C., Altevers, J., Barck, I., Hardt, T., Braun, S., & Greiner, W. (2019). Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia. ESC heart failure, 6(4), 840-855. doi:10.1002/ehf2.12485
Jacob, Christian, Altevers, Julia, Barck, Isabella, Hardt, Thomas, Braun, Sebastian, and Greiner, Wolfgang. 2019. “Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia.”. ESC heart failure 6 (4): 840-855.
Jacob, C., Altevers, J., Barck, I., Hardt, T., Braun, S., and Greiner, W. (2019). Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia. ESC heart failure 6, 840-855.
Jacob, C., et al., 2019. Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia. ESC heart failure, 6(4), p 840-855.
C. Jacob, et al., “Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia.”, ESC heart failure, vol. 6, 2019, pp. 840-855.
Jacob, C., Altevers, J., Barck, I., Hardt, T., Braun, S., Greiner, W.: Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia. ESC heart failure. 6, 840-855 (2019).
Jacob, Christian, Altevers, Julia, Barck, Isabella, Hardt, Thomas, Braun, Sebastian, and Greiner, Wolfgang. “Retrospective analysis into differences in heart failure patients with and without iron deficiency or anaemia.”. ESC heart failure 6.4 (2019): 840-855.

33 References

Daten bereitgestellt von Europe PubMed Central.

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; ESC Scientific Document Group, Filippatos G, McMurray JJV, Aboyans V, Achenbach S, Agewall S, Al-Attar N, Atherton JJ, Bauersachs J, John Camm A, Carerj S, Ceconi C, Coca A, Elliott P, Erol C, Ezekowitz J, Fernandez-Golfin C, Fitzsimons D, Guazzi M, Guenoun M, Hasenfuss G, Hindricks G, Hoes AW, Iung B, Jaarsma T, Kirchhof P, Knuuti J, Kolh P, Konstantinides S, Lainscak M, Lancellotti P, Lip GYH, Maisano F, Mueller C, Petrie MC, Piepoli MF, Priori SG, Torbicki A, Tsutsui H, van Veldhuisen DJ, Windecker S, Yancy C, Zamorano JL, Zamorano JL, Aboyans V, Achenbach S, Agewall S, Badimon L, Baron-Esquivias G, Baumgartner H, Bax JJ, Bueno H, Carerj S, Dean V, Erol C, Fitzsimons D, Gaemperli O, Kirchhof P, Kolh P, Lancellotti P, Lip GYH, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Roffi M, Torbicki A, Vaz Carneiro A, Windecker S, Sisakian HS, Isayev E, Kurlianskaya A, Mullens W, Tokmakova M, Agathangelou P, Melenovsky V, Wiggers H, Hassanein M, Uuetoa T, Lommi J, Kostovska ES, Juilliere Y, Aladashvili A, Luchner A, Chrysohoou C, Nyolczas N, Thorgeirsson G, Marc Weinstein J, Di Lenarda A, Aidargaliyeva N, Bajraktari G, Beishenkulov M, Kamzola G, Abdel-Massih T, Celutkiene J, Noppe S, Cassar A, Vataman E, Abir-Khalil S, van Pol P, Mo R, Straburzynska-Migaj E, Fonseca C, Chioncel O, Shlyakhto E, Otasevic P, Goncalvesova E, Lainscak M, Diaz Molina B, Schaufelberger M, Suter T, Yilmaz MB, Voronkov L, Davies C., Eur. Heart J. 37(27), 2016
PMID: 27206819

AUTHOR UNKNOWN, 1994
Leitlinie Nr. 9: Herzinsuffizienz. Langfassung
AUTHOR UNKNOWN, 2006
Epidemiology of heart failure in Germany: a retrospective database study.
Stork S, Handrock R, Jacob J, Walker J, Calado F, Lahoz R, Hupfer S, Klebs S., Clin Res Cardiol 106(11), 2017
PMID: 28748265
Regional Differences in the Prevalence of Cardiovascular Disease.
Dornquast C, Kroll LE, Neuhauser HK, Willich SN, Reinhold T, Busch MA., Dtsch Arztebl Int 113(42), 2016
PMID: 27866565
Gesundheit Todesursachen in Deutschland 2015, Fachserie 12 Reihe
AUTHOR UNKNOWN, 2017
Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status.
Comin-Colet J, Enjuanes C, Gonzalez G, Torrens A, Cladellas M, Merono O, Ribas N, Ruiz S, Gomez M, Verdu JM, Bruguera J., Eur. J. Heart Fail. 15(10), 2013
PMID: 23703106
Iron deficiency: an ominous sign in patients with systolic chronic heart failure.
Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B, Borodulin-Nadzieja L, Banasiak W, Polonski L, Filippatos G, McMurray JJ, Anker SD, Ponikowski P., Eur. Heart J. 31(15), 2010
PMID: 20570952
Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure.
Jankowska EA, Rozentryt P, Witkowska A, Nowak J, Hartmann O, Ponikowska B, Borodulin-Nadzieja L, von Haehling S, Doehner W, Banasiak W, Polonski L, Filippatos G, Anker SD, Ponikowski P., J. Card. Fail. 17(11), 2011
PMID: 22041326
Iron deficiency in chronic heart failure: an international pooled analysis.
Klip IT, Comin-Colet J, Voors AA, Ponikowski P, Enjuanes C, Banasiak W, Lok DJ, Rosentryt P, Torrens A, Polonski L, van Veldhuisen DJ, van der Meer P, Jankowska EA., Am. Heart J. 165(4), 2013
PMID: 23537975
Ferric carboxymaltose in patients with heart failure and iron deficiency.
Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Luscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Ponikowski P; FAIR-HF Trial Investigators, Anker SD, Ponikowski P, Dickstein K, Filippatos GS, Luscher TF, Willenheimer R, Comin Colet J, Drexler H, Poole-Wilson PA, Wuthrich RP, Lubsen J, Altamirano JH, Taquini AC, Rodriguez SV, Spinar J, Povolny J, Belohlavek J, Paluch Z, Horak J, Anker S, Wolf D, Natour M, Durak M, Manolis A, Nanas J, Kremastinos DT, Alexopoulos D, Volterrani M, Vescovo G, Dickstein K, Mysliwiec M, Dluskiego K, Ogorek M, Kopernika M, Staneta P, Niegowska J, Dluzniewski M, Ponikowski P, Polonski L, Radoi M, Macarie CE, Iliescu CC, Dan GA, Kikeli PI, Pasechnik ES, Eremenko AA, Gorbachenkov AA, Bragina AE, Ivleva AY, Bart BY, Arutyunov GP, Khokhlov RA, Tereschenko SN, Lusov VA, Ardashev VN, Mareev VY, Kobalava ZD, Alexeeva OP, Oleynikov VE, Koziolova NA, Duplyakov DV, Petrov AA, Butko DU, Sitnikova MY, Berkovich OA, Boldueva SA, Minkin SR, Kostenko VA, Shvarts YG, Karpov YB, Nedogoda SV, Bruguera J, Gonzalez Costello J, Martinez Selles M, Quiles Granado J, Koval OA, Ignatenko GA, Kraiz IG, Prohorov OV, Tseluyko VI, Parkhomenko OM, Amosova KM, Rudenko LV, Gyrina OM, Lishnevska VY, Pavlyk SS, Kovalsky IP, Popik GS, Telyatnikova ZY, Chopey IV, Vizir VA., N. Engl. J. Med. 361(25), 2009
PMID: 19920054
Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency†.
Ponikowski P, van Veldhuisen DJ, Comin-Colet J, Ertl G, Komajda M, Mareev V, McDonagh T, Parkhomenko A, Tavazzi L, Levesque V, Mori C, Roubert B, Filippatos G, Ruschitzka F, Anker SD; CONFIRM-HF Investigators., Eur. Heart J. 36(11), 2014
PMID: 25176939
Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis.
Anker SD, Kirwan BA, van Veldhuisen DJ, Filippatos G, Comin-Colet J, Ruschitzka F, Luscher TF, Arutyunov GP, Motro M, Mori C, Roubert B, Pocock SJ, Ponikowski P., Eur. J. Heart Fail. 20(1), 2017
PMID: 28436136
Characteristics and external validity of the German Health Risk Institute (HRI) Database.
Andersohn F, Walker J., Pharmacoepidemiol Drug Saf 25(1), 2015
PMID: 26530279
Standard distance in univariate and multivariate analysis
AUTHOR UNKNOWN, 1986
Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores.
Normand ST, Landrum MB, Guadagnoli E, Ayanian JZ, Ryan TJ, Cleary PD, McNeil BJ., J Clin Epidemiol 54(4), 2001
PMID: 11297888
Gesetzliche Krankenversicherung, Kennzahlen und Faustformeln
AUTHOR UNKNOWN, 2018
Bevölkerung und Erwerbstätigkeit, Bevölkerungsfortschreibung auf Grundlage des Zensus 2011
AUTHOR UNKNOWN, 2016
Usefulness of Iron Deficiency Correction in Management of Patients With Heart Failure [from the Registry Analysis of Iron Deficiency-Heart Failure (RAID-HF) Registry].
Wienbergen H, Pfister O, Hochadel M, Michel S, Bruder O, Remppis BA, Maeder MT, Strasser R, von Scheidt W, Pauschinger M, Senges J, Hambrecht R; RAID-HF (Registry Analysis of Iron Deficiency–Heart Failure) REGISTRY Study Group., Am. J. Cardiol. 118(12), 2016
PMID: 27756479
Anemia and mortality in heart failure patients a systematic review and meta-analysis.
Groenveld HF, Januzzi JL, Damman K, van Wijngaarden J, Hillege HL, van Veldhuisen DJ, van der Meer P., J. Am. Coll. Cardiol. 52(10), 2008
PMID: 18755344
Cost-of-illness studies in heart failure: a systematic review 2004-2016.
Lesyuk W, Kriza C, Kolominsky-Rabas P., BMC Cardiovasc Disord 18(1), 2018
PMID: 29716540
[Health economic impact of heart failure: An analysis of the nationwide German database].
Zugck C, Muller A, Helms TM, Wildau HJ, Becks T, Hacker J, Haag S, Goldhagen K, Schwab JO., Dtsch. Med. Wochenschr. 135(13), 2010
PMID: 20333603
Heart failure: the commonest reason for hospital admission in Germany: medical and economic perspectives.
Neumann T, Biermann J, Erbel R, Neumann A, Wasem J, Ertl G, Dietz R., Dtsch Arztebl Int 106(16), 2009
PMID: 19547628
Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial.
Filippatos G, Farmakis D, Colet JC, Dickstein K, Luscher TF, Willenheimer R, Parissis J, Gaudesius G, Mori C, von Eisenhart Rothe B, Greenlaw N, Ford I, Ponikowski P, Anker SD., Eur. J. Heart Fail. 15(11), 2013
PMID: 23787722
Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial.
Okonko DO, Grzeslo A, Witkowski T, Mandal AK, Slater RM, Roughton M, Foldes G, Thum T, Majda J, Banasiak W, Missouris CG, Poole-Wilson PA, Anker SD, Ponikowski P., J. Am. Coll. Cardiol. 51(2), 2008
PMID: 18191732
Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial.
Lewis GD, Malhotra R, Hernandez AF, McNulty SE, Smith A, Felker GM, Tang WHW, LaRue SJ, Redfield MM, Semigran MJ, Givertz MM, Van Buren P, Whellan D, Anstrom KJ, Shah MR, Desvigne-Nickens P, Butler J, Braunwald E; NHLBI Heart Failure Clinical Research Network., JAMA 317(19), 2017
PMID: 28510680
Prevalence of anemia in patients admitted to hospital with a primary diagnosis of congestive heart failure.
Wexler D, Silverberg D, Sheps D, Blum M, Keren G, Iaina A, Schwartz D., Int. J. Cardiol. 96(1), 2004
PMID: 15203265
Prevalence and clinical impact of iron deficiency and anaemia among outpatients with chronic heart failure: The PrEP Registry.
von Haehling S, Gremmler U, Krumm M, Mibach F, Schon N, Taggeselle J, Dahm JB, Angermann CE., Clin Res Cardiol 106(6), 2017
PMID: 28229219
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