Modelling and simulating Lenski's long-term evolution experiment

Baake E, Gonzalez Casanova A, Probst S, Wakolbinger A (2019)
THEORETICAL POPULATION BIOLOGY 127: 58-74.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
We revisit the model by Wiser et al. (2013), which describes how the mean fitness increases over time due to beneficial mutations in Lenski's long-term evolution experiment. We develop the model further both conceptually and mathematically. Conceptually, we describe the experiment with the help of a Cannings model with mutation and selection, where the latter includes diminishing returns epistasis. The analysis sheds light on the growth dynamics within every single day and reveals a runtime effect, that is, the shortening of the daily growth period with increasing fitness; and it allows to clarify the contribution of epistasis to the mean fitness curve. Mathematically, we explain rigorous results in terms of a law of large numbers (in the limit of infinite population size and for a certain asymptotic parameter regime), and present approximations based on heuristics and supported by simulations for finite populations. (C) 2019 Elsevier Inc. All rights reserved.
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THEORETICAL POPULATION BIOLOGY
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127
Seite(n)
58-74
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Baake E, Gonzalez Casanova A, Probst S, Wakolbinger A. Modelling and simulating Lenski's long-term evolution experiment. THEORETICAL POPULATION BIOLOGY. 2019;127:58-74.
Baake, E., Gonzalez Casanova, A., Probst, S., & Wakolbinger, A. (2019). Modelling and simulating Lenski's long-term evolution experiment. THEORETICAL POPULATION BIOLOGY, 127, 58-74. doi:10.1016/j.tpb.2019.03.006
Baake, E., Gonzalez Casanova, A., Probst, S., and Wakolbinger, A. (2019). Modelling and simulating Lenski's long-term evolution experiment. THEORETICAL POPULATION BIOLOGY 127, 58-74.
Baake, E., et al., 2019. Modelling and simulating Lenski's long-term evolution experiment. THEORETICAL POPULATION BIOLOGY, 127, p 58-74.
E. Baake, et al., “Modelling and simulating Lenski's long-term evolution experiment”, THEORETICAL POPULATION BIOLOGY, vol. 127, 2019, pp. 58-74.
Baake, E., Gonzalez Casanova, A., Probst, S., Wakolbinger, A.: Modelling and simulating Lenski's long-term evolution experiment. THEORETICAL POPULATION BIOLOGY. 127, 58-74 (2019).
Baake, Ellen, Gonzalez Casanova, Adrian, Probst, Sebastian, and Wakolbinger, Anton. “Modelling and simulating Lenski's long-term evolution experiment”. THEORETICAL POPULATION BIOLOGY 127 (2019): 58-74.

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