Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination

Ismail M, Frese M, Patschkowski T, Ortseifen V, Niehaus K, Sewald N (2019)
ADVANCED SYNTHESIS & CATALYSIS 361(11): 2475-2486.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Flavin-dependent halogenases selectively introduce halogen substituents into (hetero-)aromatic substrates and require only molecular oxygen and halide salts for this regioselective oxidative CH-functionalization. Genomic analysis of Xanthomonas campestris pv. campestris B100 identified three novel putative members of this enzyme class. They were shown to introduce halogen substituents into, e. g., substituted indoles, while preferring bromide over chloride.
Stichworte
halogenases; bromination; regioselectivity; Xanthomonas
Erscheinungsjahr
2019
Zeitschriftentitel
ADVANCED SYNTHESIS & CATALYSIS
Band
361
Ausgabe
11
Seite(n)
2475-2486
ISSN
1615-4150
eISSN
1615-4169
Page URI
https://pub.uni-bielefeld.de/record/2936329

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Ismail M, Frese M, Patschkowski T, Ortseifen V, Niehaus K, Sewald N. Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination. ADVANCED SYNTHESIS & CATALYSIS. 2019;361(11):2475-2486.
Ismail, M., Frese, M., Patschkowski, T., Ortseifen, V., Niehaus, K., & Sewald, N. (2019). Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination. ADVANCED SYNTHESIS & CATALYSIS, 361(11), 2475-2486. doi:10.1002/adsc.201801591
Ismail, M., Frese, M., Patschkowski, T., Ortseifen, V., Niehaus, K., and Sewald, N. (2019). Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination. ADVANCED SYNTHESIS & CATALYSIS 361, 2475-2486.
Ismail, M., et al., 2019. Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination. ADVANCED SYNTHESIS & CATALYSIS, 361(11), p 2475-2486.
M. Ismail, et al., “Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination”, ADVANCED SYNTHESIS & CATALYSIS, vol. 361, 2019, pp. 2475-2486.
Ismail, M., Frese, M., Patschkowski, T., Ortseifen, V., Niehaus, K., Sewald, N.: Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination. ADVANCED SYNTHESIS & CATALYSIS. 361, 2475-2486 (2019).
Ismail, Mohamed, Frese, Marcel, Patschkowski, Thomas, Ortseifen, Vera, Niehaus, Karsten, and Sewald, Norbert. “Flavin-Dependent Halogenases from Xanthomonas campestris pv. campestris B100 Prefer Bromination over Chlorination”. ADVANCED SYNTHESIS & CATALYSIS 361.11 (2019): 2475-2486.