Alignment- and reference-free phylogenomics with colored de-Bruijn graphs

Wittler R (2019)
arXiv:1905.04165.

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We present a new whole-genome based approach to infer large-scale phylogenies that is alignment- and reference-free. In contrast to other methods, it does not rely on pairwise comparisons to determine distances to infer edges in a tree. Instead, a colored de-Bruijn graph is constructed, and information on common subsequences is extracted to infer phylogenetic splits. Application to different datasets confirms robustness of the approach. A comparison to other state-of-the-art whole-genome based methods indicates comparable or higher accuracy and efficiency.
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arXiv:1905.04165
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Wittler R. Alignment- and reference-free phylogenomics with colored de-Bruijn graphs. arXiv:1905.04165. 2019.
Wittler, R. (2019). Alignment- and reference-free phylogenomics with colored de-Bruijn graphs. arXiv:1905.04165
Wittler, R. (2019). Alignment- and reference-free phylogenomics with colored de-Bruijn graphs. arXiv:1905.04165.
Wittler, R., 2019. Alignment- and reference-free phylogenomics with colored de-Bruijn graphs. arXiv:1905.04165.
R. Wittler, “Alignment- and reference-free phylogenomics with colored de-Bruijn graphs”, arXiv:1905.04165, 2019.
Wittler, R.: Alignment- and reference-free phylogenomics with colored de-Bruijn graphs. arXiv:1905.04165. (2019).
Wittler, Roland. “Alignment- and reference-free phylogenomics with colored de-Bruijn graphs”. arXiv:1905.04165 (2019).
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2019-05-16T07:12:35Z

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