Blind source separation using latent Gaussian graphical models

Illner K, Fuchs C, Theis FJ (2012)
In: Ninth International Workshop on Computational Systems Biology, WCSB 2012. Larjo A, Schober S, Farhan M, Bossert M, Yli-Harja O, Tampere International Center for Signal Processing. (Eds); , TICSP series(61). Tampere, Finland: 43-50.

Konferenzbeitrag | Veröffentlicht | Englisch
 
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Autor*in
Illner, Katrin; Fuchs, ChristianeUniBi ; Theis, Fabian J.
Herausgeber*in
Larjo, Antti; Schober, Steffen; Farhan, Muhammad; Bossert, Martin; Yli-Harja, Olli
herausgebende Körperschaft
Tampere International Center for Signal Processing.
Abstract / Bemerkung
We want to identify independent projections of interest inmultivariate data in an unsupervised manner. Dealing withdata of a specific temporal or spatial structure is well es-tablished for this so-called blind source separation prob-lem. The recently published GraDe-algorithm addressesmore complex network structures often found in biology;it analytically separates sources with respect to a givennetwork. We translate these separation assumptions andpropose a flexible Bayesian model to include for instancemissing observations and parameter priors. Technically,we define a Gaussian graphical model with latent variablesand estimate the parameters using expectation maximiza-tion. As large-scale application we consider gene expres-sion data, where the dependence structure is given by aliterature-derived transcriptional regulation network. Wedemonstrate that the model identifies relevant biologicalprocesses.
Erscheinungsjahr
2012
Titel des Konferenzbandes
Ninth International Workshop on Computational Systems Biology, WCSB 2012
Band
TICSP series
Ausgabe
61
Seite(n)
43 - 50
Konferenz
Ninth International Workshop on Computational Systems Biology, WCSB 2012
Konferenzort
Ulm
Konferenzdatum
2012-06-04 – 2012-06-06
ISBN
978-952-15-2853-8
Page URI
https://pub.uni-bielefeld.de/record/2934073

Zitieren

Illner K, Fuchs C, Theis FJ. Blind source separation using latent Gaussian graphical models. In: Larjo A, Schober S, Farhan M, Bossert M, Yli-Harja O, Tampere International Center for Signal Processing., eds. Ninth International Workshop on Computational Systems Biology, WCSB 2012. Vol TICSP series. Tampere, Finland; 2012: 43-50.
Illner, K., Fuchs, C., & Theis, F. J. (2012). Blind source separation using latent Gaussian graphical models. In A. Larjo, S. Schober, M. Farhan, M. Bossert, O. Yli-Harja, & Tampere International Center for Signal Processing. (Eds.), Ninth International Workshop on Computational Systems Biology, WCSB 2012 (Vol. TICSP series, pp. 43-50). Tampere, Finland.
Illner, K., Fuchs, C., and Theis, F. J. (2012). “Blind source separation using latent Gaussian graphical models” in Ninth International Workshop on Computational Systems Biology, WCSB 2012, Larjo, A., Schober, S., Farhan, M., Bossert, M., Yli-Harja, O., and Tampere International Center for Signal Processing. eds., vol. TICSP series, (Tampere, Finland), 43-50.
Illner, K., Fuchs, C., & Theis, F.J., 2012. Blind source separation using latent Gaussian graphical models. In A. Larjo, et al., eds. Ninth International Workshop on Computational Systems Biology, WCSB 2012. no.TICSP series Tampere, Finland, pp. 43-50.
K. Illner, C. Fuchs, and F.J. Theis, “Blind source separation using latent Gaussian graphical models”, Ninth International Workshop on Computational Systems Biology, WCSB 2012, A. Larjo, et al., eds., vol. TICSP series, Tampere, Finland: 2012, pp.43-50.
Illner, K., Fuchs, C., Theis, F.J.: Blind source separation using latent Gaussian graphical models. In: Larjo, A., Schober, S., Farhan, M., Bossert, M., Yli-Harja, O., and Tampere International Center for Signal Processing. (eds.) Ninth International Workshop on Computational Systems Biology, WCSB 2012. TICSP series, p. 43-50. Tampere, Finland (2012).
Illner, Katrin, Fuchs, Christiane, and Theis, Fabian J. “Blind source separation using latent Gaussian graphical models”. Ninth International Workshop on Computational Systems Biology, WCSB 2012. Ed. Antti Larjo, Steffen Schober, Muhammad Farhan, Martin Bossert, Olli Yli-Harja, and Tampere International Center for Signal Processing. Tampere, Finland, 2012.Vol. TICSP series. 43-50.

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