Atrx promotes heterochromatin formation at retrotransposons

Sadic D, Schmidt K, Groh S, Kondofersky I, Ellwart J, Fuchs C, Theis FJ, Schotta G (2015)
EMBO reports 16(7): 836-850.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Sadic, Dennis; Schmidt, Katharina; Groh, Sophia; Kondofersky, Ivan; Ellwart, Joachim; Fuchs, ChristianeUniBi ; Theis, Fabian J.; Schotta, Gunnar
Einrichtung
Fakultät für Wirtschaftswissenschaften > Lehrstuhl für Data Science
Abstract / Bemerkung
More than 50% of mammalian genomes consist of retrotransposon sequences. Silencing of retrotransposons by heterochromatin is essential to ensure genomic stability and transcriptional integrity. Here, we identified a short sequence element in intracisternal A particle (IAP) retrotransposons that is sufficient to trigger heterochromatin formation. We used this sequence in a genome-wide shRNA screen and identified the chromatin remodeler Atrx as a novel regulator of IAP silencing. Atrx binds to IAP elements and is necessary for efficient heterochromatin formation. In addition, Atrx facilitates a robust and largely inaccessible heterochromatin structure as Atrx knockout cells display increased chromatin accessibility at retrotransposons and non-repetitive heterochromatic loci. In summary, we demonstrate a direct role of Atrx in the establishment and robust maintenance of heterochromatin.
Erscheinungsjahr
2015
Zeitschriftentitel
EMBO reports
Band
16
Ausgabe
7
Seite(n)
836-850
ISSN
1469-221X
eISSN
1469-3178
Page URI
https://pub.uni-bielefeld.de/record/2934023

Zitieren

Sadic D, Schmidt K, Groh S, et al. Atrx promotes heterochromatin formation at retrotransposons. EMBO reports. 2015;16(7):836-850.
Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F. J., et al. (2015). Atrx promotes heterochromatin formation at retrotransposons. EMBO reports, 16(7), 836-850. doi:10.15252/embr.201439937
Sadic, Dennis, Schmidt, Katharina, Groh, Sophia, Kondofersky, Ivan, Ellwart, Joachim, Fuchs, Christiane, Theis, Fabian J., and Schotta, Gunnar. 2015. “Atrx promotes heterochromatin formation at retrotransposons”. EMBO reports 16 (7): 836-850.
Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F. J., and Schotta, G. (2015). Atrx promotes heterochromatin formation at retrotransposons. EMBO reports 16, 836-850.
Sadic, D., et al., 2015. Atrx promotes heterochromatin formation at retrotransposons. EMBO reports, 16(7), p 836-850.
D. Sadic, et al., “Atrx promotes heterochromatin formation at retrotransposons”, EMBO reports, vol. 16, 2015, pp. 836-850.
Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F.J., Schotta, G.: Atrx promotes heterochromatin formation at retrotransposons. EMBO reports. 16, 836-850 (2015).
Sadic, Dennis, Schmidt, Katharina, Groh, Sophia, Kondofersky, Ivan, Ellwart, Joachim, Fuchs, Christiane, Theis, Fabian J., and Schotta, Gunnar. “Atrx promotes heterochromatin formation at retrotransposons”. EMBO reports 16.7 (2015): 836-850.

34 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells.
Reber S, Mechtersheimer J, Nasif S, Benitez JA, Colombo M, Domanski M, Jutzi D, Hedlund E, Ruepp MD., Mol Biol Cell 29(2), 2018
PMID: 29167381
Telomere chromatin establishment and its maintenance during mammalian development.
Tardat M, Déjardin J., Chromosoma 127(1), 2018
PMID: 29250704
A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.
Fukuda K, Okuda A, Yusa K, Shinkai Y., Genome Res 28(6), 2018
PMID: 29728365
The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.
Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ, Rowe HM., Genome Res 28(6), 2018
PMID: 29728366
Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine.
Rowland ME, Jiang Y, Beier F, Bérubé NG., Aging (Albany NY) 10(6), 2018
PMID: 29883366
Mutant ATRX: uncovering a new therapeutic target for glioma.
Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR, Castro MG., Expert Opin Ther Targets 22(7), 2018
PMID: 29889582
KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.
Tie CH, Fernandes L, Conde L, Robbez-Masson L, Sumner RP, Peacock T, Rodriguez-Plata MT, Mickute G, Gifford R, Towers GJ, Herrero J, Rowe HM., EMBO Rep 19(10), 2018
PMID: 30061100
Rainbow-Seq: Combining Cell Lineage Tracing with Single-Cell RNA Sequencing in Preimplantation Embryos.
Biase FH, Wu Q, Calandrelli R, Rivas-Astroza M, Zhou S, Chen Z, Zhong S., iScience 7(), 2018
PMID: 30267678
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.
Cabral JM, Oh HS, Knipe DM., Elife 7(), 2018
PMID: 30465651
The Histone Variant H3.3 in Transcriptional Regulation and Human Disease.
Shi L, Wen H, Shi X., J Mol Biol 429(13), 2017
PMID: 27894815
Histone variants on the move: substrates for chromatin dynamics.
Talbert PB, Henikoff S., Nat Rev Mol Cell Biol 18(2), 2017
PMID: 27924075
Variants of core histones and their roles in cell fate decisions, development and cancer.
Buschbeck M, Hake SB., Nat Rev Mol Cell Biol 18(5), 2017
PMID: 28144029
Silencing of endogenous retroviruses by heterochromatin.
Groh S, Schotta G., Cell Mol Life Sci 74(11), 2017
PMID: 28160052
Variable DAXX gene methylation is a common feature of placental trophoblast differentiation, preeclampsia, and response to hypoxia.
Novakovic B, Evain-Brion D, Murthi P, Fournier T, Saffery R., FASEB J 31(6), 2017
PMID: 28223336
ATRX and DAXX: Mechanisms and Mutations.
Dyer MA, Qadeer ZA, Valle-Garcia D, Bernstein E., Cold Spring Harb Perspect Med 7(3), 2017
PMID: 28062559
Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development.
Magaraki A, van der Heijden G, Sleddens-Linkels E, Magarakis L, van Cappellen WA, Peters AHFM, Gribnau J, Baarends WM, Eijpe M., Epigenetics Chromatin 10(), 2017
PMID: 28293300
PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX.
Delbarre E, Ivanauskiene K, Spirkoski J, Shah A, Vekterud K, Moskaug JØ, Bøe SO, Wong LH, Küntziger T, Collas P., Genome Res 27(6), 2017
PMID: 28341773
Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression.
Duc C, Benoit M, Détourné G, Simon L, Poulet A, Jung M, Veluchamy A, Latrasse D, Le Goff S, Cotterell S, Tatout C, Benhamed M, Probst AV., Plant Cell 29(7), 2017
PMID: 28684426
dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres.
Chavez J, Murillo-Maldonado JM, Bahena V, Cruz AK, Castañeda-Sortibrán A, Rodriguez-Arnaiz R, Zurita M, Valadez-Graham V., Chromosoma 126(6), 2017
PMID: 28688038
Elsässer et al. reply.
Elsässer SJ, Noh KM, Diaz N, Allis CD, Banaszynski LA., Nature 548(7665), 2017
PMID: 28770850
The Role of ATRX in Glioma Biology.
Nandakumar P, Mansouri A, Das S., Front Oncol 7(), 2017
PMID: 29034211
Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.
Hoelper D, Huang H, Jain AY, Patel DJ, Lewis PW., Nat Commun 8(1), 2017
PMID: 29084956
Mechanisms of epigenetic remodelling during preimplantation development.
Ross PJ, Canovas S., Reprod Fertil Dev 28(1-2), 2016
PMID: 27062872
New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone.
Voon HP, Wong LH., Nucleic Acids Res 44(4), 2016
PMID: 26773061
RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition.
Newhart A, Powers SL, Shastrula PK, Sierra I, Joo LM, Hayden JE, Cohen AR, Janicki SM., Mol Biol Cell 27(7), 2016
PMID: 26842893
Molecular features of cellular reprogramming and development.
Smith ZD, Sindhu C, Meissner A., Nat Rev Mol Cell Biol 17(3), 2016
PMID: 26883001
Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.
Pasquarella A, Ebert A, Pereira de Almeida G, Hinterberger M, Kazerani M, Nuber A, Ellwart J, Klein L, Busslinger M, Schotta G., Development 143(10), 2016
PMID: 27013243
ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.
Valle-García D, Qadeer ZA, McHugh DS, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E., Epigenetics 11(6), 2016
PMID: 27029610
Transposable elements in the mammalian embryo: pioneers surviving through stealth and service.
Gerdes P, Richardson SR, Mager DL, Faulkner GJ., Genome Biol 17(), 2016
PMID: 27161170
Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire.
Thompson PJ, Macfarlan TS, Lorincz MC., Mol Cell 62(5), 2016
PMID: 27259207
Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.
Ramesh V, Bayam E, Cernilogar FM, Bonapace IM, Schulze M, Riemenschneider MJ, Schotta G, Götz M., Genes Dev 30(19), 2016
PMID: 27798843
Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres.
Udugama M, M Chang FT, Chan FL, Tang MC, Pickett HA, R McGhie JD, Mayne L, Collas P, Mann JR, Wong LH., Nucleic Acids Res 43(21), 2015
PMID: 26304540
TERRA and the state of the telomere.
Rippe K, Luke B., Nat Struct Mol Biol 22(11), 2015
PMID: 26581519
Emerging roles of ATRX in cancer.
Watson LA, Goldberg H, Bérubé NG., Epigenomics 7(8), 2015
PMID: 26646632

60 References

Daten bereitgestellt von Europe PubMed Central.

Loss of ATRX leads to chromosome cohesion and congression defects.
Ritchie K, Seah C, Moulin J, Isaac C, Dick F, Berube NG., J. Cell Biol. 180(2), 2008
PMID: 18227278
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations.
Liu XY, Gerges N, Korshunov A, Sabha N, Khuong-Quang DA, Fontebasso AM, Fleming A, Hadjadj D, Schwartzentruber J, Majewski J, Dong Z, Siegel P, Albrecht S, Croul S, Jones DT, Kool M, Tonjes M, Reifenberger G, Faury D, Zadeh G, Pfister S, Jabado N., Acta Neuropathol. 124(5), 2012
PMID: 22886134
Embryonic stem cells use ZFP809 to silence retroviral DNAs.
Wolf D, Goff SP., Nature 458(7242), 2009
PMID: 19270682
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells.
Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, Yaw LP, Robson P, Lim B, Ng HH., Genes Dev. 23(21), 2009
PMID: 19884257
KAP1 controls endogenous retroviruses in embryonic stem cells.
Rowe HM, Jakobsson J, Mesnard D, Rougemont J, Reynard S, Aktas T, Maillard PV, Layard-Liesching H, Verp S, Marquis J, Spitz F, Constam DB, Trono D., Nature 463(7278), 2010
PMID: 20075919
ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.
Kernohan KD, Jiang Y, Tremblay DC, Bonvissuto AC, Eubanks JH, Mann MR, Berube NG., Dev. Cell 18(2), 2010
PMID: 20159591
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells.
Wong LH, McGhie JD, Sim M, Anderson MA, Ahn S, Hannan RD, George AJ, Morgan KA, Mann JR, Choo KH., Genome Res. 20(3), 2010
PMID: 20110566
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD., Cell 140(5), 2010
PMID: 20211137
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET.
Matsui T, Leung D, Miyashita H, Maksakova IA, Miyachi H, Kimura H, Tachibana M, Lorincz MC, Shinkai Y., Nature 464(7290), 2010
PMID: 20164836
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Drane P, Ouararhni K, Depaux A, Shuaib M, Hamiche A., Genes Dev. 24(12), 2010
PMID: 20504901
Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism.
Hutnick LK, Huang X, Loo TC, Ma Z, Fan G., J. Biol. Chem. 285(27), 2010
PMID: 20404320
De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET.
Rowe HM, Friedli M, Offner S, Verp S, Mesnard D, Marquis J, Aktas T, Trono D., Development 140(3), 2013
PMID: 23293284
SUMO: a multifaceted modifier of chromatin structure and function.
Cubenas-Potts C, Matunis MJ., Dev. Cell 24(1), 2013
PMID: 23328396
Retroviral DNA methylation and epigenetic repression are mediated by the antiviral host protein Daxx.
Shalginskikh N, Poleshko A, Skalka AM, Katz RA., J. Virol. 87(4), 2012
PMID: 23221555
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells.
Rowe HM, Kapopoulou A, Corsinotti A, Fasching L, Macfarlan TS, Tarabay Y, Viville S, Jakobsson J, Pfaff SL, Trono D., Genome Res. 23(3), 2012
PMID: 23233547
Methylation-dependent and -independent genomic targeting principles of the MBD protein family.
Baubec T, Ivanek R, Lienert F, Schubeler D., Cell 153(2), 2013
PMID: 23582333
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
Hahn M, Dambacher S, Dulev S, Kuznetsova AY, Eck S, Worz S, Sadic D, Schulte M, Mallm JP, Maiser A, Debs P, von Melchner H, Leonhardt H, Schermelleh L, Rohr K, Rippe K, Storchova Z, Schotta G., Genes Dev. 27(8), 2013
PMID: 23599346
Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1.
Leung D, Du T, Wagner U, Xie W, Lee AY, Goyal P, Li Y, Szulwach KE, Jin P, Lorincz MC, Ren B., Proc. Natl. Acad. Sci. U.S.A. 111(18), 2014
PMID: 24757056
Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.
Bierhoff H, Dammert MA, Brocks D, Dambacher S, Schotta G, Grummt I., Mol. Cell 54(4), 2014
PMID: 24768537
Somatic retrotransposition in human cancer revealed by whole-genome and exome sequencing.
Helman E, Lawrence MS, Stewart C, Sougnez C, Getz G, Meyerson M., Genome Res. 24(7), 2014
PMID: 24823667
Evolutionally dynamic L1 regulation in embryonic stem cells.
Castro-Diaz N, Ecco G, Coluccio A, Kapopoulou A, Yazdanpanah B, Friedli M, Duc J, Jang SM, Turelli P, Trono D., Genes Dev. 28(13), 2014
PMID: 24939876
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation.
Gibbons RJ, McDowell TL, Raman S, O'Rourke DM, Garrick D, Ayyub H, Higgs DR., Nat. Genet. 24(4), 2000
PMID: 10742099
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T., Cell 107(3), 2001
PMID: 11701123
Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse.
Lane N, Dean W, Erhardt S, Hajkova P, Surani A, Walter J, Reik W., Genesis 35(2), 2003
PMID: 12533790
ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.
De La Fuente R, Viveiros MM, Wigglesworth K, Eppig JJ., Dev. Biol. 272(1), 2004
PMID: 15242786
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L.
Bourc'his D, Bestor TH., Nature 431(7004), 2004
PMID: 15318244
Methylation levels of maternal and paternal genomes during preimplantation development.
Howlett SK, Reik W., Development 113(1), 1991
PMID: 1764989
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome).
Gibbons RJ, Picketts DJ, Villard L, Higgs DR., Cell 80(6), 1995
PMID: 7697714
KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, Neilson EG, Rauscher FJ 3rd., Genes Dev. 10(16), 1996
PMID: 8769649
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.
Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R, Chambon P., EMBO J. 15(23), 1996
PMID: 8978696
A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins.
Kim SS, Chen YM, O'Leary E, Witzgall R, Vidal M, Bonventre JV., Proc. Natl. Acad. Sci. U.S.A. 93(26), 1996
PMID: 8986806
Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W., Nucleic Acids Res. 24(24), 1996
PMID: 9016654
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila.
Ebert A, Schotta G, Lein S, Kubicek S, Krauss V, Jenuwein T, Reuter G., Genes Dev. 18(23), 2004
PMID: 15574598
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.
Bulut-Karslioglu A, De La Rosa-Velazquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galan C, Winter GE, Engist B, Gerle B, O'Sullivan RJ, Martens JH, Walter J, Manke T, Lachner M, Jenuwein T., Mol. Cell 55(2), 2014
PMID: 24981170
Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements.
Turelli P, Castro-Diaz N, Marzetta F, Kapopoulou A, Raclot C, Duc J, Tieng V, Quenneville S, Trono D., Genome Res. 24(8), 2014
PMID: 24879559
Specificity, propagation, and memory of pericentric heterochromatin.
Muller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G, Hofer T, Rippe K., Mol. Syst. Biol. 10(), 2014
PMID: 25134515
Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
Lin DY, Huang YS, Jeng JC, Kuo HY, Chang CC, Chao TT, Ho CC, Chen YC, Lin TP, Fang HI, Hung CC, Suen CS, Hwang MJ, Chang KS, Maul GG, Shih HM., Mol. Cell 24(3), 2006
PMID: 17081986
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.
Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, Wood WG, Higgs DR, Gibbons RJ., PLoS Genet. 2(4), 2006
PMID: 16628246
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.
Sarma K, Cifuentes-Rojas C, Ergun A, Del Rosario A, Jeon Y, White F, Sadreyev R, Lee JT., Cell 159(4), 2014
PMID: 25417162
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander ES, Bernstein BE., Nature 448(7153), 2007
PMID: 17603471
TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells.
Wolf D, Goff SP., Cell 131(1), 2007
PMID: 17923087
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
Ivanov AV, Peng H, Yurchenko V, Yap KL, Negorev DG, Schultz DC, Psulkowski E, Fredericks WJ, White DE, Maul GG, Sadofsky MJ, Zhou MM, Rauscher FJ 3rd., Mol. Cell 28(5), 2007
PMID: 18082607
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD., Proc. Natl. Acad. Sci. U.S.A. 107(32), 2010
PMID: 20651253
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.
Law MJ, Lower KM, Voon HP, Hughes JR, Garrick D, Viprakasit V, Mitson M, De Gobbi M, Marra M, Morris A, Abbott A, Wilder SP, Taylor S, Santos GM, Cross J, Ayyub H, Jones S, Ragoussis J, Rhodes D, Dunham I, Higgs DR, Gibbons RJ., Cell 143(3), 2010
PMID: 21029860
The enemy within: an epigenetic role of retrotransposons in cancer initiation.
Wilkins AS., Bioessays 32(10), 2010
PMID: 20715060
Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.
Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B., Mol. Cell 41(1), 2011
PMID: 21211724
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA Jr, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N., Science 331(6021), 2011
PMID: 21252315
DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs.
Karimi MM, Goyal P, Maksakova IA, Bilenky M, Leung D, Tang JX, Shinkai Y, Mager DL, Jones S, Hirst M, Lorincz MC., Cell Stem Cell 8(6), 2011
PMID: 21624812
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
Eustermann S, Yang JC, Law MJ, Amos R, Chapman LM, Jelinska C, Garrick D, Clynes D, Gibbons RJ, Rhodes D, Higgs DR, Neuhaus D., Nat. Struct. Mol. Biol. 18(7), 2011
PMID: 21666677
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y., Nat. Struct. Mol. Biol. 18(7), 2011
PMID: 21666679
Altered telomeres in tumors with ATRX and DAXX mutations.
Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK., Science 333(6041), 2011
PMID: 21719641
KAP1 protein: an enigmatic master regulator of the genome.
Iyengar S, Farnham PJ., J. Biol. Chem. 286(30), 2011
PMID: 21652716
Identification of genetic elements that autonomously determine DNA methylation states.
Lienert F, Wirbelauer C, Som I, Dean A, Mohn F, Schubeler D., Nat. Genet. 43(11), 2011
PMID: 21964573
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.
Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D., Mol. Cell 44(3), 2011
PMID: 22055183
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tonjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jager N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Fruhwald MC, Roggendorf W, Kramm C, Durken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N., Nature 482(7384), 2012
PMID: 22286061
Association of age at diagnosis and genetic mutations in patients with neuroblastoma.
Cheung NK, Zhang J, Lu C, Parker M, Bahrami A, Tickoo SK, Heguy A, Pappo AS, Federico S, Dalton J, Cheung IY, Ding L, Fulton R, Wang J, Chen X, Becksfort J, Wu J, Billups CA, Ellison D, Mardis ER, Wilson RK, Downing JR, Dyer MA; St Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project., JAMA 307(10), 2012
PMID: 22416102
Dynamics and memory of heterochromatin in living cells.
Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR., Cell 149(7), 2012
PMID: 22704655
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK; ALT Starr Cancer Consortium., PLoS Genet. 8(7), 2012
PMID: 22829774
A transcription factor-based mechanism for mouse heterochromatin formation.
Bulut-Karslioglu A, Perrera V, Scaranaro M, de la Rosa-Velazquez IA, van de Nobelen S, Shukeir N, Popow J, Gerle B, Opravil S, Pagani M, Meidhof S, Brabletz T, Manke T, Lachner M, Jenuwein T., Nat. Struct. Mol. Biol. 19(10), 2012
PMID: 22983563
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T., Genes Dev. 22(15), 2008
PMID: 18676810
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