Atrx promotes heterochromatin formation at retrotransposons

Sadic D, Schmidt K, Groh S, Kondofersky I, Ellwart J, Fuchs C, Theis FJ, Schotta G (2015)
EMBO reports 16(7): 836-850.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Sadic, Dennis; Schmidt, Katharina; Groh, Sophia; Kondofersky, Ivan; Ellwart, Joachim; Fuchs, ChristianeUniBi ; Theis, Fabian J.; Schotta, Gunnar
Abstract / Bemerkung
More than 50% of mammalian genomes consist of retrotransposon sequences. Silencing of retrotransposons by heterochromatin is essential to ensure genomic stability and transcriptional integrity. Here, we identified a short sequence element in intracisternal A particle (IAP) retrotransposons that is sufficient to trigger heterochromatin formation. We used this sequence in a genome-wide shRNA screen and identified the chromatin remodeler Atrx as a novel regulator of IAP silencing. Atrx binds to IAP elements and is necessary for efficient heterochromatin formation. In addition, Atrx facilitates a robust and largely inaccessible heterochromatin structure as Atrx knockout cells display increased chromatin accessibility at retrotransposons and non-repetitive heterochromatic loci. In summary, we demonstrate a direct role of Atrx in the establishment and robust maintenance of heterochromatin.
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Sadic D, Schmidt K, Groh S, et al. Atrx promotes heterochromatin formation at retrotransposons. EMBO reports. 2015;16(7):836-850.
Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F. J., et al. (2015). Atrx promotes heterochromatin formation at retrotransposons. EMBO reports, 16(7), 836-850. doi:10.15252/embr.201439937
Sadic, Dennis, Schmidt, Katharina, Groh, Sophia, Kondofersky, Ivan, Ellwart, Joachim, Fuchs, Christiane, Theis, Fabian J., and Schotta, Gunnar. 2015. “Atrx promotes heterochromatin formation at retrotransposons”. EMBO reports 16 (7): 836-850.
Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F. J., and Schotta, G. (2015). Atrx promotes heterochromatin formation at retrotransposons. EMBO reports 16, 836-850.
Sadic, D., et al., 2015. Atrx promotes heterochromatin formation at retrotransposons. EMBO reports, 16(7), p 836-850.
D. Sadic, et al., “Atrx promotes heterochromatin formation at retrotransposons”, EMBO reports, vol. 16, 2015, pp. 836-850.
Sadic, D., Schmidt, K., Groh, S., Kondofersky, I., Ellwart, J., Fuchs, C., Theis, F.J., Schotta, G.: Atrx promotes heterochromatin formation at retrotransposons. EMBO reports. 16, 836-850 (2015).
Sadic, Dennis, Schmidt, Katharina, Groh, Sophia, Kondofersky, Ivan, Ellwart, Joachim, Fuchs, Christiane, Theis, Fabian J., and Schotta, Gunnar. “Atrx promotes heterochromatin formation at retrotransposons”. EMBO reports 16.7 (2015): 836-850.

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