Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data
Guinney J, Wang T, Laajala TD, Winner KK, Bare JC, Neto EC, Khan SA, Peddinti G, Airola A, Pahikkala T, Mirtti T, et al. (2016)
The Lancet Oncology 18(1): 132-142.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Guinney, Justin;
Wang, Tao;
Laajala, Teemu D;
Winner, Kimberly Kanigel;
Bare, J Christopher;
Neto, Elias Chaibub;
Khan, Suleiman A;
Peddinti, Gopal;
Airola, Antti;
Pahikkala, Tapio;
Mirtti, Tuomas;
Yu, Thomas
Alle
Alle
Abstract / Bemerkung
Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model for prediction of survival in patients with metastatic castration-resistant prostate cancer but also engage a community of international data scientists to study this disease.
Erscheinungsjahr
2016
Zeitschriftentitel
The Lancet Oncology
Band
18
Ausgabe
1
Seite(n)
132-142
ISSN
1470-2045
Page URI
https://pub.uni-bielefeld.de/record/2934013
Zitieren
Guinney J, Wang T, Laajala TD, et al. Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data. The Lancet Oncology. 2016;18(1):132-142.
Guinney, J., Wang, T., Laajala, T. D., Winner, K. K., Bare, J. C., Neto, E. C., Khan, S. A., et al. (2016). Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data. The Lancet Oncology, 18(1), 132-142. doi:10.1016/s1470-2045(16)30560-5
Guinney, Justin, Wang, Tao, Laajala, Teemu D, Winner, Kimberly Kanigel, Bare, J Christopher, Neto, Elias Chaibub, Khan, Suleiman A, et al. 2016. “Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data”. The Lancet Oncology 18 (1): 132-142.
Guinney, J., Wang, T., Laajala, T. D., Winner, K. K., Bare, J. C., Neto, E. C., Khan, S. A., Peddinti, G., Airola, A., Pahikkala, T., et al. (2016). Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data. The Lancet Oncology 18, 132-142.
Guinney, J., et al., 2016. Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data. The Lancet Oncology, 18(1), p 132-142.
J. Guinney, et al., “Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data”, The Lancet Oncology, vol. 18, 2016, pp. 132-142.
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Guinney, Justin, Wang, Tao, Laajala, Teemu D, Winner, Kimberly Kanigel, Bare, J Christopher, Neto, Elias Chaibub, Khan, Suleiman A, Peddinti, Gopal, Airola, Antti, Pahikkala, Tapio, Mirtti, Tuomas, Yu, Thomas, Bot, Brian M, Shen, Liji, Abdallah, Kald, Norman, Thea, Friend, Stephen, Stolovitzky, Gustavo, Soule, Howard, Sweeney, Christopher J, Ryan, Charles J, Scher, Howard I, Sartor, Oliver, Xie, Yang, Aittokallio, Tero, Zhou, Fang Liz, Costello, James C, Abdallah, Kald, Aittokallio, Tero, Airola, Antti, Anghe, Catalina, Azima, Helia, Baertsch, Robert, Ballester, Pedro J, Bare, Chris, Bhandari, Vinayak, Bot, Brian M, Dang, Cuong C, Dunbar, Maria Bekker-Nielsen, Buchardt, Ann-Sophie, Buturovic, Ljubomir, Cao, Da, Chalise, Prabhakar, Cho, Junwoo, Chu, Tzu-Ming, Coley, R Yates, Conjeti, Sailesh, Correia, Sara, Costello, James C, Dai, Ziwei, Dai, Junqiang, Dargatz, Philip, Delavarkhan, Sam, Deng, Detian, Dhanik, Ankur, Du, Yu, Elangovan, Aparna, Ellis, Shellie, Elo, Laura L, Espiritu, Shadrielle M, Fan, Fan, Farshi, Ashkan B, Freitas, Ana, Fridley, Brooke, Friend, Stephen, Fuchs, Christiane, Gofer, Eyal, Peddinti, Gopalacharyulu, Graw, Stefan, Greiner, Russ, Guan, Yuanfang, Guinney, Justin, Guo, Jing, Gupta, Pankaj, Guyer, Anna I, Han, Jiawei, Hansen, Niels R, Chang, Billy HW, Hirvonen, Outi, Huang, Barbara, Huang, Chao, Hwang, Jinseub, Ibrahim, Joseph G, Jayaswa, Vivek, Jeon, Jouhyun, Ji, Zhicheng, Juvvadi, Deekshith, Jyrkkiö, Sirkku, Kanigel-Winner, Kimberly, Katouzian, Amin, Kazanov, Marat D, Khan, Suleiman A, Khayyer, Shahin, Kim, Dalho, Golinska, Agnieszka K, Koestler, Devin, Kokowicz, Fernanda, Kondofersky, Ivan, Krautenbacher, Norbert, Krstajic, Damjan, Kumar, Luke, Kurz, Christoph, Kyan, Matthew, Laajala, Teemu D, Laimighofer, Michael, Lee, Eunjee, Lesinski, Wojciech, Li, Miaozhu, Li, Ye, Lian, Qiuyu, Liang, Xiaotao, Lim, Minseong, Lin, Henry, Lin, Xihui, Lu, Jing, Mahmoudian, Mehrad, Manshaei, Roozbeh, Meier, Richard, Miljkovic, Dejan, Mirtti, Tuomas, Mnich, Krzysztof, Navab, Nassir, Neto, Elias C, Newton, Yulia, Norman, Thea, Pahikkala, Tapio, Pal, Subhabrata, Park, Byeongju, Patel, Jaykumar, Pathak, Swetabh, Pattin, Alejandrina, Ankerst, Donna P, Peng, Jian, Petersen, Anne H, Philip, Robin, Piccolo, Stephen R, Pölsterl, Sebastian, Polewko-Klim, Aneta, Rao, Karthik, Ren, Xiang, Rocha, Miguel, Rudnicki, Witold R., Ryan, Charles J, Ryu, Hyunnam, Sartor, Oliver, Scherb, Hagen, Sehgal, Raghav, Seyednasrollah, Fatemeh, Shang, Jingbo, Shao, Bin, Shen, Liji, Sher, Howard, Shiga, Motoki, Sokolov, Artem, Söllner, Julia F, Song, Lei, Soule, Howard, Stolovitzky, Gustavo, Stuart, Josh, Sun, Ren, Sweeney, Christopher J, Tahmasebi, Nazanin, Tan, Kar-Tong, Tomaziu, Lisbeth, Usset, Joseph, Vang, Yeeleng S, Vega, Roberto, Vieira, Vitor, Wang, David, Wang, Difei, Wang, Junmei, Wang, Lichao, Wang, Sheng, Wang, Tao, Wang, Yue, Wolfinger, Russ, Wong, Chris, Wu, Zhenke, Xiao, Jinfeng, Xie, Xiaohui, Xie, Yang, Xin, Doris, Yang, Hojin, Yu, Nancy, Yu, Thomas, Yu, Xiang, Zahedi, Sulmaz, Zanin, Massimiliano, Zhang, Chihao, Zhang, Jingwen, Zhang, Shihua, Zhang, Yanchun, Zhou, Fang Liz, Zhu, Hongtu, Zhu, Shanfeng, and Zhu, Yuxin. “Prediction of overall survival for patients with metastatic castration-resistant prostate cancer. Development of a prognostic model through a crowdsourced challenge with open clinical trial data”. The Lancet Oncology 18.1 (2016): 132-142.
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Halabi S, Lin CY, Kelly WK, Fizazi KS, Moul JW, Kaplan EB, Morris MJ, Small EJ., J. Clin. Oncol. 32(7), 2014
PMID: 24449231
Aflibercept versus placebo in combination with docetaxel and prednisone for treatment of men with metastatic castration-resistant prostate cancer (VENICE): a phase 3, double-blind randomised trial.
Tannock IF, Fizazi K, Ivanov S, Karlsson CT, Flechon A, Skoneczna I, Orlandi F, Gravis G, Matveev V, Bavbek S, Gil T, Viana L, Aren O, Karyakin O, Elliott T, Birtle A, Magherini E, Hatteville L, Petrylak D, Tombal B, Rosenthal M; VENICE investigators., Lancet Oncol. 14(8), 2013
PMID: 23742877
Tannock IF, Fizazi K, Ivanov S, Karlsson CT, Flechon A, Skoneczna I, Orlandi F, Gravis G, Matveev V, Bavbek S, Gil T, Viana L, Aren O, Karyakin O, Elliott T, Birtle A, Magherini E, Hatteville L, Petrylak D, Tombal B, Rosenthal M; VENICE investigators., Lancet Oncol. 14(8), 2013
PMID: 23742877
Abiraterone and increased survival in metastatic prostate cancer.
Berruti A, Pia A, Terzolo M., N. Engl. J. Med. 365(8), 2011
PMID: 21864182
Berruti A, Pia A, Terzolo M., N. Engl. J. Med. 365(8), 2011
PMID: 21864182
Increased survival with enzalutamide in prostate cancer after chemotherapy.
Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, Armstrong AJ, Flaig TW, Flechon A, Mainwaring P, Fleming M, Hainsworth JD, Hirmand M, Selby B, Seely L, de Bono JS; AFFIRM Investigators, Alasino C, Bella S, Carraro S, Geist M, Abdi E, Begbie S, Briscoe K, Davis I, Dowling A, Ganju V, Gurney H, Hovey E, Ng S, Nottage M, Rosenthal M, Stockler M, Tan T, Wong S, Young R, Krainer M, Loidl W, Machiels J, Mebis J, Renard V, Dumez H, Van Aelst F, Werbrouck P, Ellard S, Joshua A, Karakiewicz P, Lacombe L, Lattouf JB, Michels J, Mukherjee S, Ruether D, Venner P, Winquist E, Wood L, Aren O, Gonzalez P, Pastor P, Baumgaertner I, Beuzeboc P, Bompas E, Boyle H, Colombel M, Delva R, Eymard J, Gravis G, Guillot A, Houede N, Joly F, Kaphan R, Loriot Y, Oudard S, Priou F, Tartas S, Theodore C, Tourani JM, Voog E, Bogemann M, Hadaschik B, Hammerer P, Heidenreich A, Holzer W, Merseburger A, Stenzl A, Steuber T, Suttmann H, Trojan L, Wirth M, Cerbone L, Conte P, Passalacqua R, Tucci M, Gerritsen W, Jassem J, Kalinka-Warzocha E, Olubiec J, De Bruyne R, Malan J, Vorobiof D, Bellmunt J, Carles J, Duran I, Font A, Gil-Bazo I, Maroto J, Bahl A, Choudhury A, Hoskin P, James N, Jones R, Mazhar D, O'Sullivan J, Payne H, Pedley I, Protheroe A, Waxman J, Zivi A, Alexander B, Appleman L, Aragon-Ching J, Arrowsmith E, Assikis V, Beer T, Berry W, Bolger G, Bryce A, Bubley G, Chatta G, Denmeade S, Deshpande H, Dorff T, Galsky M, George D, Giudice R, Glode M, Golshayan AR, Goodman O, Graff J, Green L, Green R, Haas N, Higano C, Hutson T, Kohli M, Liu G, May J, Mendelson D, Picus J, Pili R, Posadas E, Redfern C, Rettig M, Ryan C, Scholz M, Sharifi N, Sosman J, Srinivas S, Tagawa S, Twardowski P, Vaishampayan U, Wong YN., N. Engl. J. Med. 367(13), 2012
PMID: 22894553
Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, Armstrong AJ, Flaig TW, Flechon A, Mainwaring P, Fleming M, Hainsworth JD, Hirmand M, Selby B, Seely L, de Bono JS; AFFIRM Investigators, Alasino C, Bella S, Carraro S, Geist M, Abdi E, Begbie S, Briscoe K, Davis I, Dowling A, Ganju V, Gurney H, Hovey E, Ng S, Nottage M, Rosenthal M, Stockler M, Tan T, Wong S, Young R, Krainer M, Loidl W, Machiels J, Mebis J, Renard V, Dumez H, Van Aelst F, Werbrouck P, Ellard S, Joshua A, Karakiewicz P, Lacombe L, Lattouf JB, Michels J, Mukherjee S, Ruether D, Venner P, Winquist E, Wood L, Aren O, Gonzalez P, Pastor P, Baumgaertner I, Beuzeboc P, Bompas E, Boyle H, Colombel M, Delva R, Eymard J, Gravis G, Guillot A, Houede N, Joly F, Kaphan R, Loriot Y, Oudard S, Priou F, Tartas S, Theodore C, Tourani JM, Voog E, Bogemann M, Hadaschik B, Hammerer P, Heidenreich A, Holzer W, Merseburger A, Stenzl A, Steuber T, Suttmann H, Trojan L, Wirth M, Cerbone L, Conte P, Passalacqua R, Tucci M, Gerritsen W, Jassem J, Kalinka-Warzocha E, Olubiec J, De Bruyne R, Malan J, Vorobiof D, Bellmunt J, Carles J, Duran I, Font A, Gil-Bazo I, Maroto J, Bahl A, Choudhury A, Hoskin P, James N, Jones R, Mazhar D, O'Sullivan J, Payne H, Pedley I, Protheroe A, Waxman J, Zivi A, Alexander B, Appleman L, Aragon-Ching J, Arrowsmith E, Assikis V, Beer T, Berry W, Bolger G, Bryce A, Bubley G, Chatta G, Denmeade S, Deshpande H, Dorff T, Galsky M, George D, Giudice R, Glode M, Golshayan AR, Goodman O, Graff J, Green L, Green R, Haas N, Higano C, Hutson T, Kohli M, Liu G, May J, Mendelson D, Picus J, Pili R, Posadas E, Redfern C, Rettig M, Ryan C, Scholz M, Sharifi N, Sosman J, Srinivas S, Tagawa S, Twardowski P, Vaishampayan U, Wong YN., N. Engl. J. Med. 367(13), 2012
PMID: 22894553
Crowdsourcing biomedical research: leveraging communities as innovation engines.
Saez-Rodriguez J, Costello JC, Friend SH, Kellen MR, Mangravite L, Meyer P, Norman T, Stolovitzky G., Nat. Rev. Genet. 17(8), 2016
PMID: 27418159
Saez-Rodriguez J, Costello JC, Friend SH, Kellen MR, Mangravite L, Meyer P, Norman T, Stolovitzky G., Nat. Rev. Genet. 17(8), 2016
PMID: 27418159
Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer.
Scher HI, Jia X, Chi K, de Wit R, Berry WR, Albers P, Henick B, Waterhouse D, Ruether DJ, Rosen PJ, Meluch AA, Nordquist LT, Venner PM, Heidenreich A, Chu L, Heller G., J. Clin. Oncol. 29(16), 2011
PMID: 21483004
Scher HI, Jia X, Chi K, de Wit R, Berry WR, Albers P, Henick B, Waterhouse D, Ruether DJ, Rosen PJ, Meluch AA, Nordquist LT, Venner PM, Heidenreich A, Chu L, Heller G., J. Clin. Oncol. 29(16), 2011
PMID: 21483004
A Global, Neutral Platform for Sharing Trial Data.
Bierer BE, Li R, Barnes M, Sim I., N. Engl. J. Med. 374(25), 2016
PMID: 27168194
Bierer BE, Li R, Barnes M, Sim I., N. Engl. J. Med. 374(25), 2016
PMID: 27168194
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.
Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, Sauerwine B, Kellen MR, Mangravite LM, Furia MD, Vollan HK, Rueda OM, Guinney J, Deflaux NA, Hoff B, Schildwachter X, Russnes HG, Park D, Vang VO, Pirtle T, Youseff L, Citro C, Curtis C, Kristensen VN, Hellerstein J, Friend SH, Stolovitzky G, Aparicio S, Caldas C, Borresen-Dale AL., Sci Transl Med 5(181), 2013
PMID: 23596205
Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, Sauerwine B, Kellen MR, Mangravite LM, Furia MD, Vollan HK, Rueda OM, Guinney J, Deflaux NA, Hoff B, Schildwachter X, Russnes HG, Park D, Vang VO, Pirtle T, Youseff L, Citro C, Curtis C, Kristensen VN, Hellerstein J, Friend SH, Stolovitzky G, Aparicio S, Caldas C, Borresen-Dale AL., Sci Transl Med 5(181), 2013
PMID: 23596205
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators., Lancet 376(9747), 2010
PMID: 20888992
de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators., Lancet 376(9747), 2010
PMID: 20888992
Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection.
Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY; ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC, Xi L, Dewal N, Fan Y, Wang W, Wheeler D, Wilm A, Ting GH, Li C, Bertrand D, Nagarajan N, Chen QR, Hsu CH, Hu Y, Yan C, Kibbe W, Meerzaman D, Cibulskis K, Rosenberg M, Bergelson L, Kiezun A, Radenbaugh A, Sertier AS, Ferrari A, Tonton L, Bhutani K, Hansen NF, Wang D, Song L, Lai Z, Liao Y, Shi W, Carbonell-Caballero J, Dopazo J, Lau CC, Guinney J., Nat. Methods 12(7), 2015
PMID: 25984700
Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY; ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC, Xi L, Dewal N, Fan Y, Wang W, Wheeler D, Wilm A, Ting GH, Li C, Bertrand D, Nagarajan N, Chen QR, Hsu CH, Hu Y, Yan C, Kibbe W, Meerzaman D, Cibulskis K, Rosenberg M, Bergelson L, Kiezun A, Radenbaugh A, Sertier AS, Ferrari A, Tonton L, Bhutani K, Hansen NF, Wang D, Song L, Lai Z, Liao Y, Shi W, Carbonell-Caballero J, Dopazo J, Lau CC, Guinney J., Nat. Methods 12(7), 2015
PMID: 25984700
Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer.
Fizazi K, Fizazi KS, Higano CS, Nelson JB, Gleave M, Miller K, Morris T, Nathan FE, McIntosh S, Pemberton K, Moul JW., J. Clin. Oncol. 31(14), 2013
PMID: 23569308
Fizazi K, Fizazi KS, Higano CS, Nelson JB, Gleave M, Miller K, Morris T, Nathan FE, McIntosh S, Pemberton K, Moul JW., J. Clin. Oncol. 31(14), 2013
PMID: 23569308
Avoiding Data Dumpsters--Toward Equitable and Useful Data Sharing.
Merson L, Gaye O, Guerin PJ., N. Engl. J. Med. 374(25), 2016
PMID: 27168351
Merson L, Gaye O, Guerin PJ., N. Engl. J. Med. 374(25), 2016
PMID: 27168351
Prognostic model for predicting survival in men with hormone-refractory metastatic prostate cancer.
Halabi S, Small EJ, Kantoff PW, Kattan MW, Kaplan EB, Dawson NA, Levine EG, Blumenstein BA, Vogelzang NJ., J. Clin. Oncol. 21(7), 2003
PMID: 12663709
Halabi S, Small EJ, Kantoff PW, Kattan MW, Kaplan EB, Dawson NA, Levine EG, Blumenstein BA, Vogelzang NJ., J. Clin. Oncol. 21(7), 2003
PMID: 12663709
A contemporary prognostic nomogram for men with hormone-refractory metastatic prostate cancer: a TAX327 study analysis.
Armstrong AJ, Garrett-Mayer ES, Yang YC, de Wit R, Tannock IF, Eisenberger M., Clin. Cancer Res. 13(21), 2007
PMID: 17975152
Armstrong AJ, Garrett-Mayer ES, Yang YC, de Wit R, Tannock IF, Eisenberger M., Clin. Cancer Res. 13(21), 2007
PMID: 17975152
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Tanimoto T, Hori A, Kami M., N. Engl. J. Med. 363(20), 2010
PMID: 21067392
Tanimoto T, Hori A, Kami M., N. Engl. J. Med. 363(20), 2010
PMID: 21067392
Enzalutamide in metastatic prostate cancer before chemotherapy.
Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya S, Carles J, Chowdhury S, Davis ID, de Bono JS, Evans CP, Fizazi K, Joshua AM, Kim CS, Kimura G, Mainwaring P, Mansbach H, Miller K, Noonberg SB, Perabo F, Phung D, Saad F, Scher HI, Taplin ME, Venner PM, Tombal B; PREVAIL Investigators, Begbie S, Bonaventura A, Boyce A, Chua W, de Souza P, Davis I, Gardiner F, Guminski A, Gurney H, Hovey E, Mainwaring P, Marx G, Mathlum M, Parente P, Parnis F, Pook D, Rosenthal M, Shapiro J, Toner G, Warren M, Wong S, Woo H, Janetschek G, Krainer M, Loidl W, Schmeller N, Mebis J, Renard V, Tombal B, Van Poppel H, Waltregny D, Werbrouck P, Attwell A, Canil C, Drachenberg D, Finch D, Gleave M, Joshua AM, Klotz L, Lacombe L, Mukherjee S, Ruether D, Saad F, Venner P, Winquist E, Wood L, Borre M, Holm-Nielsen A, Iversen P, Langkilde NC, Ostri P, Rathenborg P, Taari K, Tammela T, Vaarala M, Ala-Opas M, Beuzeboc P, Bompas E, Davin JL, Delva R, Ducos B, Flechon A, Gross-Goupil M, Guillot A, Houede N, Laguerre B, Latorzeff I, Lemoulec S, Loriot Y, Oudard S, Priou F, Vignot S, Voog E, Bogemann M, Bolenz C, Hadaschik B, Hammerer P, Klotz T, Merseburger A, Miller K, Ohlmann CH, Schrader M, Stenzl A, Strolin P, Suttmann H, Wirth M, Mermershtain W, Nativ O, Ramon J, Rosenbaum E, Sella A, Bracarda S, Cerbone L, De Giorgi U, Passalacqua R, Recine F, Scagliotti G, Sternberg C, Egawa S, Fukagai T, Fukumori T, Igawa T, Kamba T, Kimura G, Kosaka T, Matsuyama H, Nakatani T, Namiki S, Nishimura K, Nishiyama T, Nonomura N, Nozawa M, Numahata K, Okegawa T, Ueda T, Uemura H, Yamanaka Y, Yokomizo A, Yonese J, Jocys G, Ulys A, de Jong I, Mulders P, van den Eertwegh A, Vrijhof E, Dobrowolski A, Jassem J, Kalinka-Warzocha E, Kmieciak R, Milecki P, Al-Shukri S, Matveev V, Novikov A, Chiong E, Lau W, Balaz V, Brezovsky M, Goncalves F, Kliment J, Mincik I, Choi YD, Chung BH, Kim CS, Kwon DD, Lee HM, Lee KH, Lee SE, Alcaraz A, Bellmunt J, Burgos F, Carles J, Domenech M, Font A, Gallardo E, Garcia-Donas Jimenez J, Gil-Bazo I, Gomez Veiga F, Gonzalez A, Andren O, Bjartell A, Damber JE, Ljungberg B, Wiklund P, Bahl A, Chowdhury S, de Bono J, Gilbert D, Hoskin P, Malik Z, McLaren D, Payne H, Pedley I, Protheroe A, Tanguay J, Waxman J, Andriole G, Appleman L, Armstrong A, Beer T, Berry W, Bolger G, Courtney K, Dorff T, Evans C, Flaig T, Fleming M, Haas N, Hall S, Hauke S, Higano C, Keane T, Khan M, Kohli M, Koletsky A, Kuzel T, McNeel D, Nazemzadeh R, Rathkopf D, Redfern C, Rettig M, Singh P, Srinivas S, Taplin ME, Vaishampayan U, Armstrong AJ, Beer TM, Higano CS, Iversen P, Sternberg CN, Tombal B, Andresen C, Martinez H, McNees A, Parli T, Pham T, Tabora K, Thomrongsith L, Zhao S., N. Engl. J. Med. 371(5), 2014
PMID: 24881730
Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya S, Carles J, Chowdhury S, Davis ID, de Bono JS, Evans CP, Fizazi K, Joshua AM, Kim CS, Kimura G, Mainwaring P, Mansbach H, Miller K, Noonberg SB, Perabo F, Phung D, Saad F, Scher HI, Taplin ME, Venner PM, Tombal B; PREVAIL Investigators, Begbie S, Bonaventura A, Boyce A, Chua W, de Souza P, Davis I, Gardiner F, Guminski A, Gurney H, Hovey E, Mainwaring P, Marx G, Mathlum M, Parente P, Parnis F, Pook D, Rosenthal M, Shapiro J, Toner G, Warren M, Wong S, Woo H, Janetschek G, Krainer M, Loidl W, Schmeller N, Mebis J, Renard V, Tombal B, Van Poppel H, Waltregny D, Werbrouck P, Attwell A, Canil C, Drachenberg D, Finch D, Gleave M, Joshua AM, Klotz L, Lacombe L, Mukherjee S, Ruether D, Saad F, Venner P, Winquist E, Wood L, Borre M, Holm-Nielsen A, Iversen P, Langkilde NC, Ostri P, Rathenborg P, Taari K, Tammela T, Vaarala M, Ala-Opas M, Beuzeboc P, Bompas E, Davin JL, Delva R, Ducos B, Flechon A, Gross-Goupil M, Guillot A, Houede N, Laguerre B, Latorzeff I, Lemoulec S, Loriot Y, Oudard S, Priou F, Vignot S, Voog E, Bogemann M, Bolenz C, Hadaschik B, Hammerer P, Klotz T, Merseburger A, Miller K, Ohlmann CH, Schrader M, Stenzl A, Strolin P, Suttmann H, Wirth M, Mermershtain W, Nativ O, Ramon J, Rosenbaum E, Sella A, Bracarda S, Cerbone L, De Giorgi U, Passalacqua R, Recine F, Scagliotti G, Sternberg C, Egawa S, Fukagai T, Fukumori T, Igawa T, Kamba T, Kimura G, Kosaka T, Matsuyama H, Nakatani T, Namiki S, Nishimura K, Nishiyama T, Nonomura N, Nozawa M, Numahata K, Okegawa T, Ueda T, Uemura H, Yamanaka Y, Yokomizo A, Yonese J, Jocys G, Ulys A, de Jong I, Mulders P, van den Eertwegh A, Vrijhof E, Dobrowolski A, Jassem J, Kalinka-Warzocha E, Kmieciak R, Milecki P, Al-Shukri S, Matveev V, Novikov A, Chiong E, Lau W, Balaz V, Brezovsky M, Goncalves F, Kliment J, Mincik I, Choi YD, Chung BH, Kim CS, Kwon DD, Lee HM, Lee KH, Lee SE, Alcaraz A, Bellmunt J, Burgos F, Carles J, Domenech M, Font A, Gallardo E, Garcia-Donas Jimenez J, Gil-Bazo I, Gomez Veiga F, Gonzalez A, Andren O, Bjartell A, Damber JE, Ljungberg B, Wiklund P, Bahl A, Chowdhury S, de Bono J, Gilbert D, Hoskin P, Malik Z, McLaren D, Payne H, Pedley I, Protheroe A, Tanguay J, Waxman J, Andriole G, Appleman L, Armstrong A, Beer T, Berry W, Bolger G, Courtney K, Dorff T, Evans C, Flaig T, Fleming M, Haas N, Hall S, Hauke S, Higano C, Keane T, Khan M, Kohli M, Koletsky A, Kuzel T, McNeel D, Nazemzadeh R, Rathkopf D, Redfern C, Rettig M, Singh P, Srinivas S, Taplin ME, Vaishampayan U, Armstrong AJ, Beer TM, Higano CS, Iversen P, Sternberg CN, Tombal B, Andresen C, Martinez H, McNees A, Parli T, Pham T, Tabora K, Thomrongsith L, Zhao S., N. Engl. J. Med. 371(5), 2014
PMID: 24881730
A community effort to assess and improve drug sensitivity prediction algorithms.
Costello JC, Heiser LM, Georgii E, Gonen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K; NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G, Abbuehl JP, Aittokallio T, Allen J, Altman RB, Ammad-ud-din M, Balcome S, Bansal M, Battle A, Bender A, Berger B, Bernard J, Bhattacharjee M, Bhuvaneshwar K, Bieberich AA, Boehm F, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Cokelaer T, Collins JC, Costello JC, Creighton CJ, Cui J, Dampier W, Davisson VJ, De Baets B, Deshpande R, DiCamillo B, Dundar M, Duren Z, Ertel A, Fan H, Fang H, Gallahan D, Gauba R, Georgii E, Gonen M, Gottlieb A, Grau M, Gray JW, Gusev Y, Ha MJ, Han L, Harris M, Heiser LM, Henderson N, Hejase HA, Hintsanen P, Homicsko K, Honkela A, Hou JP, Hwang W, IJzerman AP, Kallioniemi O, Karacali B, Kaski S, Keles S, Kendziorski C, Khan SA, Kim J, Kim M, Kim Y, Knowles DA, Koller D, Lee J, Lee JK, Lenselink EB, Li B, Li B, Li J, Liang H, Ma J, Madhavan S, Menden MP, Mooney S, Mpindi JP, Myers CL, Newton MA, Overington JP, Pal R, Peng J, Pestell R, Prill RJ, Qiu P, Rajwa B, Sadanandam A, Saez-Rodriguez J, Sambo F, Shin H, Singer D, Song J, Song L, Sridhar A, Stock M, Stolovitzky G, Sun W, Ta T, Tadesse M, Tan M, Tang H, Theodorescu D, Toffolo GM, Tozeren A, Trepicchio W, Varoquaux N, Vert JP, Waegeman W, Walter T, Wan Q, Wang D, Wang NJ, Wang W, Wang Y, Wang Z, Wegner JK, Wennerberg K, Wu T, Xia T, Xiao G, Xie Y, Xu Y, Yang J, Yuan Y, Zhang S, Zhang XS, Zhao J, Zuo C, van Vlijmen HW, van Westen GJ., Nat. Biotechnol. 32(12), 2014
PMID: 24880487
Costello JC, Heiser LM, Georgii E, Gonen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K; NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G, Abbuehl JP, Aittokallio T, Allen J, Altman RB, Ammad-ud-din M, Balcome S, Bansal M, Battle A, Bender A, Berger B, Bernard J, Bhattacharjee M, Bhuvaneshwar K, Bieberich AA, Boehm F, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Cokelaer T, Collins JC, Costello JC, Creighton CJ, Cui J, Dampier W, Davisson VJ, De Baets B, Deshpande R, DiCamillo B, Dundar M, Duren Z, Ertel A, Fan H, Fang H, Gallahan D, Gauba R, Georgii E, Gonen M, Gottlieb A, Grau M, Gray JW, Gusev Y, Ha MJ, Han L, Harris M, Heiser LM, Henderson N, Hejase HA, Hintsanen P, Homicsko K, Honkela A, Hou JP, Hwang W, IJzerman AP, Kallioniemi O, Karacali B, Kaski S, Keles S, Kendziorski C, Khan SA, Kim J, Kim M, Kim Y, Knowles DA, Koller D, Lee J, Lee JK, Lenselink EB, Li B, Li B, Li J, Liang H, Ma J, Madhavan S, Menden MP, Mooney S, Mpindi JP, Myers CL, Newton MA, Overington JP, Pal R, Peng J, Pestell R, Prill RJ, Qiu P, Rajwa B, Sadanandam A, Saez-Rodriguez J, Sambo F, Shin H, Singer D, Song J, Song L, Sridhar A, Stock M, Stolovitzky G, Sun W, Ta T, Tadesse M, Tan M, Tang H, Theodorescu D, Toffolo GM, Tozeren A, Trepicchio W, Varoquaux N, Vert JP, Waegeman W, Walter T, Wan Q, Wang D, Wang NJ, Wang W, Wang Y, Wang Z, Wegner JK, Wennerberg K, Wu T, Xia T, Xiao G, Xie Y, Xu Y, Yang J, Yuan Y, Zhang S, Zhang XS, Zhao J, Zuo C, van Vlijmen HW, van Westen GJ., Nat. Biotechnol. 32(12), 2014
PMID: 24880487
Abiraterone in metastatic prostate cancer without previous chemotherapy.
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Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE; COU-AA-302 Investigators, Boyce A, Costello A, Davis I, Ganju V, Horvath L, Lynch R, Marx G, Parnis F, Shapiro J, Singhal N, Slancar M, Van Hazel G, Wong S, Yip D, Carpentier P, Luyten D, Rottey S, Van Aelst F, Cheng T, Chin J, Ellard S, Fradet Y, Gleave M, Joshua A, Klotz L, Martins H, North S, Abdel-Hamid S, Colombel M, Flechon A, Haillot O, Joly F, Oudard S, Priou F, Raymond E, Albers P, Boegemann M, Gleissner J, Gschwend J, Hammerer P, Heidenreich A, Kuczyk M, Miller K, Oetzel R, Roigas J, Steuber T, Stockle M, Wirth M, Papandreou C, Bracarda S, Marcello T, Sternberg C, Bangma C, de Reijke T, Arija J, Bellmunt J, Lopez R, Lopez-Brea M, Bjartell A, Damber J, Haggman M, Hellstrom M, Seke M, Brown J, Chowdhury S, Elliott T, Harland S, Innes H, James N, Jones R, Mazhar D, Paez E, Protheroe A, Staffurth J, Ahmann F, Andriole G, Arrowsmith E, Assikis V, Baron A, Berry W, Bubley G, Carney J, Chu L, Cosgriff T, Denmeade S, Deshpande H, Duchene D, Ferrari A, Frenkel E, Gabrail N, Garcia J, George D, Gomella L, Goodman O, Gore I, Gullo J, Hainsworth J, Hamid O, Hutson T, King D, Koh H, Koletsky A, Kudrik F, Lara P, Lyons R, Maranchie J, Modiano M, Nieva J, Nordquist L, Pinski J, Poiesz B, Polikoff J, Quinn D, Redfern C, Riggs S, Ryan C, Saleh M, Sartor A, Scholz M, Shore N, Srinivas S, Vaishampaya U, Vieweg J, Vira M, Vogelzang N, Wilding G, Wong Y, Belldegrun A, Kantoff PW, Carducci MA, Vogelzang NJ, Kelly WK, Auchus RJ, Meyers M, Rackoff W, Tran N, Yu M, Knoblauch R, Naini V, Matheny S, Maul S, Larsen J, Martin J, Wawda H, Goffredo D, Li J, Li S, Li B, Durve K, Morris MJ, Larson SM., N. Engl. J. Med. 368(2), 2012
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Regularized machine learning in the genetic prediction of complex traits.
Okser S, Pahikkala T, Airola A, Salakoski T, Ripatti S, Aittokallio T., PLoS Genet. 10(11), 2014
PMID: 25393026
Okser S, Pahikkala T, Airola A, Salakoski T, Ripatti S, Aittokallio T., PLoS Genet. 10(11), 2014
PMID: 25393026
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study.
Fizazi K, Carducci M, Smith M, Damiao R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, Jiang Q, Tadros S, Dansey R, Goessl C., Lancet 377(9768), 2011
PMID: 21353695
Fizazi K, Carducci M, Smith M, Damiao R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, Jiang Q, Tadros S, Dansey R, Goessl C., Lancet 377(9768), 2011
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Global cancer statistics.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D., CA Cancer J Clin 61(2), 2011
PMID: 21296855
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D., CA Cancer J Clin 61(2), 2011
PMID: 21296855
Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): a randomised, double-blind, placebo-controlled phase 3 trial.
Petrylak DP, Vogelzang NJ, Budnik N, Wiechno PJ, Sternberg CN, Doner K, Bellmunt J, Burke JM, de Olza MO, Choudhury A, Gschwend JE, Kopyltsov E, Flechon A, Van As N, Houede N, Barton D, Fandi A, Jungnelius U, Li S, de Wit R, Fizazi K., Lancet Oncol. 16(4), 2015
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Petrylak DP, Vogelzang NJ, Budnik N, Wiechno PJ, Sternberg CN, Doner K, Bellmunt J, Burke JM, de Olza MO, Choudhury A, Gschwend JE, Kopyltsov E, Flechon A, Van As N, Houede N, Barton D, Fandi A, Jungnelius U, Li S, de Wit R, Fizazi K., Lancet Oncol. 16(4), 2015
PMID: 25743937
Alpha emitter radium-223 and survival in metastatic prostate cancer.
Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fossa SD, Chodacki A, Wiechno P, Logue J, Seke M, Widmark A, Johannessen DC, Hoskin P, Bottomley D, James ND, Solberg A, Syndikus I, Kliment J, Wedel S, Boehmer S, Dall'Oglio M, Franzen L, Coleman R, Vogelzang NJ, O'Bryan-Tear CG, Staudacher K, Garcia-Vargas J, Shan M, Bruland OS, Sartor O; ALSYMPCA Investigators, Brown M, Dalley D, Dickie G, Dowling A, Elison B, Francis R, Harrup R, Jackson M, Jones E, Kirkwood I, Lin M, Macfarlane D, Martin J, Marx G, Miller A, Pittman K, Pocock N, Pointon O, Roach P, Rossleigh M, Sidhom M, Swift P, Taubman K, Unger S, Woo H, Billiet I, Deconnick H, Duck L, Dumont P, Arouca P, Cabral W, Horizonte B, Caspani A, Horizonte B, Coelho B, Damiao R, Kasai E, Koff W, Moraes AA, Murad A, Horizonte B, Oliveira F, Oliveria L, Sampaio C, Sapienza M, Serrano S, Vilela J, House L, Klotz L, Kuhl J, Leung E, Patel S, Reid R, Simone D, Vitols-McKay M, Bolcak K, Buncova M, Feltl D, Hora M, Kocak I, Kopacek R, Kraft O, Myslivecek M, Pernicka J, Schraml J, Zachoval R, Monnier A, Pecking A, Priou F, Quetu F, Rudenko B, Toubeau M, Wartski M, Zanetta G, Barsegian V, Brunkhorst T, Haese A, Hampel C, Kashammer S, Keil C, Klutmann S, Kranert T, Kuczyk M, Mommsen C, Pfestroff A, Reske S, Sahlmann CO, Schrader A, Strauss A, Truss MC, von Pokrzywnitzki W, Cheng H, Kwong P, Leung A, Leung S, Liu C, Tang F, Yau T, Yuen K, Agranovich S, Ben-Yosef R, Dror Y, Golan H, Levita M, Mechlis-Frish S, Mermershtain W, Sella A, Aglietta M, Amadori D, Ariano M, Asti M, Carrara F, Messina C, Poli G, Possa M, Rossetti C, Salvo D, de Jong A, Roeleveld T, van Riel M, van Tilburg E, Vergunst H, Verhagen P, Aurebekk A, Bjering K, Boe K, Fredenfeldt T, Grovnes T, Kasti U, Klepp DO, Larsen K, Nieder C, Pedersen L, Stokkan M, Tvedt B, Chlosta P, Demkow T, Glowa B, Jarzab B, Jarzemski P, Kasprzak K, Klijer R, Kolodziejczyk A, Landwojtowicz M, Mielczarek R, Ochman P, Poniatowicz-Frasunek E, Sowa A, Staszczak , Szczodry A, Zdrojowy R, Zebrowski J, Goh A, Ng C, Tay M, Arpasova M, Balaz V, Breza J, Cano M, Cuperkova J, Cvik M, Lesko J, Mincik I, Reznak I, Spisiakova D, Aranda E, Arbizu J, Banzo J, Bello P, Carles J, Castell J, Donas G, Estorch M, Fombellida J, Perez Gracia JL, Latre J, Llarena R, Lomena F, Lopez R, Maroto P, Mellado B, Mitjavila M, Reynes G, Ruibal A, Saenz-Cusi A, Axelsson B, Backlund M, Bergstrom P, Boling B, Falkmer U, Fransson A, Kindblom J, Lagerlund M, Larsson A, Lindgren U, Matscheko G, Starck SA, Anderson P, Bahl A, Bovill R, Chakraborti P, Cox R, Cripps H, Dixit S, Fletcher C, Foley M, Gannon K, Gibbs S, Gilmore B, Graham J, Heath C, Hooper S, Ibbett D, Jenkins C, Jones I, Lawrence G, Money-Kyrle J, Monk D, Mundy J, Murby B, Pascoe S, Przeslak A, Ramachandra P, Randerson S, Richardson A, Robinson A, Scrase C, Scuffham J, Staffurth J, Stockdale A, Sundar S, Vasanthan S, Waldock P, Walton S, Yarrow S, Arredondo S, Garcia-Ramirez J, Hudes G, Lamey R, Michalski J, Mosley D, Obranovich G, Sanders R, Sandler H, Sanford R, Tomblyn M, Vade Streek P., N. Engl. J. Med. 369(3), 2013
PMID: 23863050
Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fossa SD, Chodacki A, Wiechno P, Logue J, Seke M, Widmark A, Johannessen DC, Hoskin P, Bottomley D, James ND, Solberg A, Syndikus I, Kliment J, Wedel S, Boehmer S, Dall'Oglio M, Franzen L, Coleman R, Vogelzang NJ, O'Bryan-Tear CG, Staudacher K, Garcia-Vargas J, Shan M, Bruland OS, Sartor O; ALSYMPCA Investigators, Brown M, Dalley D, Dickie G, Dowling A, Elison B, Francis R, Harrup R, Jackson M, Jones E, Kirkwood I, Lin M, Macfarlane D, Martin J, Marx G, Miller A, Pittman K, Pocock N, Pointon O, Roach P, Rossleigh M, Sidhom M, Swift P, Taubman K, Unger S, Woo H, Billiet I, Deconnick H, Duck L, Dumont P, Arouca P, Cabral W, Horizonte B, Caspani A, Horizonte B, Coelho B, Damiao R, Kasai E, Koff W, Moraes AA, Murad A, Horizonte B, Oliveira F, Oliveria L, Sampaio C, Sapienza M, Serrano S, Vilela J, House L, Klotz L, Kuhl J, Leung E, Patel S, Reid R, Simone D, Vitols-McKay M, Bolcak K, Buncova M, Feltl D, Hora M, Kocak I, Kopacek R, Kraft O, Myslivecek M, Pernicka J, Schraml J, Zachoval R, Monnier A, Pecking A, Priou F, Quetu F, Rudenko B, Toubeau M, Wartski M, Zanetta G, Barsegian V, Brunkhorst T, Haese A, Hampel C, Kashammer S, Keil C, Klutmann S, Kranert T, Kuczyk M, Mommsen C, Pfestroff A, Reske S, Sahlmann CO, Schrader A, Strauss A, Truss MC, von Pokrzywnitzki W, Cheng H, Kwong P, Leung A, Leung S, Liu C, Tang F, Yau T, Yuen K, Agranovich S, Ben-Yosef R, Dror Y, Golan H, Levita M, Mechlis-Frish S, Mermershtain W, Sella A, Aglietta M, Amadori D, Ariano M, Asti M, Carrara F, Messina C, Poli G, Possa M, Rossetti C, Salvo D, de Jong A, Roeleveld T, van Riel M, van Tilburg E, Vergunst H, Verhagen P, Aurebekk A, Bjering K, Boe K, Fredenfeldt T, Grovnes T, Kasti U, Klepp DO, Larsen K, Nieder C, Pedersen L, Stokkan M, Tvedt B, Chlosta P, Demkow T, Glowa B, Jarzab B, Jarzemski P, Kasprzak K, Klijer R, Kolodziejczyk A, Landwojtowicz M, Mielczarek R, Ochman P, Poniatowicz-Frasunek E, Sowa A, Staszczak , Szczodry A, Zdrojowy R, Zebrowski J, Goh A, Ng C, Tay M, Arpasova M, Balaz V, Breza J, Cano M, Cuperkova J, Cvik M, Lesko J, Mincik I, Reznak I, Spisiakova D, Aranda E, Arbizu J, Banzo J, Bello P, Carles J, Castell J, Donas G, Estorch M, Fombellida J, Perez Gracia JL, Latre J, Llarena R, Lomena F, Lopez R, Maroto P, Mellado B, Mitjavila M, Reynes G, Ruibal A, Saenz-Cusi A, Axelsson B, Backlund M, Bergstrom P, Boling B, Falkmer U, Fransson A, Kindblom J, Lagerlund M, Larsson A, Lindgren U, Matscheko G, Starck SA, Anderson P, Bahl A, Bovill R, Chakraborti P, Cox R, Cripps H, Dixit S, Fletcher C, Foley M, Gannon K, Gibbs S, Gilmore B, Graham J, Heath C, Hooper S, Ibbett D, Jenkins C, Jones I, Lawrence G, Money-Kyrle J, Monk D, Mundy J, Murby B, Pascoe S, Przeslak A, Ramachandra P, Randerson S, Richardson A, Robinson A, Scrase C, Scuffham J, Staffurth J, Stockdale A, Sundar S, Vasanthan S, Waldock P, Walton S, Yarrow S, Arredondo S, Garcia-Ramirez J, Hudes G, Lamey R, Michalski J, Mosley D, Obranovich G, Sanders R, Sandler H, Sanford R, Tomblyn M, Vade Streek P., N. Engl. J. Med. 369(3), 2013
PMID: 23863050
A community computational challenge to predict the activity of pairs of compounds.
Bansal M, Yang J, Karan C, Menden MP, Costello JC, Tang H, Xiao G, Li Y, Allen J, Zhong R, Chen B, Kim M, Wang T, Heiser LM, Realubit R, Mattioli M, Alvarez MJ, Shen Y; NCI-DREAM Community, Gallahan D, Singer D, Saez-Rodriguez J, Xie Y, Stolovitzky G, Califano A; NCI-DREAM Community, Abbuehl JP, Allen J, Altman RB, Balcome S, Bansal M, Bell A, Bender A, Berger B, Bernard J, Bieberich AA, Borboudakis G, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Costello JC, Creighton CJ, Dampier W, Davisson VJ, Deshpande R, Diao L, Di Camillo B, Dundar M, Ertel A, Gallahan D, Goswami CP, Gottlieb A, Gould MN, Goya J, Grau M, Gray JW, Heiser LM, Hejase HA, Hoffmann MF, Homicsko K, Homilius M, Hwang W, Ijzerman AP, Kallioniemi O, Karacali B, Karan C, Kaski S, Kim J, Kim M, Krishnan A, Lee J, Lee YS, Lenselink EB, Lenz P, Li L, Li J, Li Y, Liang H, Mattioli M, Menden MP, Mpindi JP, Myers CL, Newton MA, Overington JP, Parkkinen J, Prill RJ, Peng J, Pestell R, Qiu P, Rajwa B, Realubit R, Sadanandam A, Saez-Rodriguez J, Sambo F, Singer D, Stolovitzky G, Sridhar A, Sun W, Tang H, Toffolo GM, Tozeren A, Troyanskaya OG, Tsamardinos I, van Vlijmen HW, Wang T, Wang W, Wegner JK, Wennerberg K, van Westen GJ, Xia T, Xiao G, Xie Y, Yang J, Yang Y, Yao V, Yuan Y, Zeng H, Zhang S, Zhao J, Zhou J, Zhong R., Nat. Biotechnol. 32(12), 2014
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Bansal M, Yang J, Karan C, Menden MP, Costello JC, Tang H, Xiao G, Li Y, Allen J, Zhong R, Chen B, Kim M, Wang T, Heiser LM, Realubit R, Mattioli M, Alvarez MJ, Shen Y; NCI-DREAM Community, Gallahan D, Singer D, Saez-Rodriguez J, Xie Y, Stolovitzky G, Califano A; NCI-DREAM Community, Abbuehl JP, Allen J, Altman RB, Balcome S, Bansal M, Bell A, Bender A, Berger B, Bernard J, Bieberich AA, Borboudakis G, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Costello JC, Creighton CJ, Dampier W, Davisson VJ, Deshpande R, Diao L, Di Camillo B, Dundar M, Ertel A, Gallahan D, Goswami CP, Gottlieb A, Gould MN, Goya J, Grau M, Gray JW, Heiser LM, Hejase HA, Hoffmann MF, Homicsko K, Homilius M, Hwang W, Ijzerman AP, Kallioniemi O, Karacali B, Karan C, Kaski S, Kim J, Kim M, Krishnan A, Lee J, Lee YS, Lenselink EB, Lenz P, Li L, Li J, Li Y, Liang H, Mattioli M, Menden MP, Mpindi JP, Myers CL, Newton MA, Overington JP, Parkkinen J, Prill RJ, Peng J, Pestell R, Qiu P, Rajwa B, Realubit R, Sadanandam A, Saez-Rodriguez J, Sambo F, Singer D, Stolovitzky G, Sridhar A, Sun W, Tang H, Toffolo GM, Tozeren A, Troyanskaya OG, Tsamardinos I, van Vlijmen HW, Wang T, Wang W, Wegner JK, Wennerberg K, van Westen GJ, Xia T, Xiao G, Xie Y, Yang J, Yang Y, Yao V, Yuan Y, Zeng H, Zhang S, Zhao J, Zhou J, Zhong R., Nat. Biotechnol. 32(12), 2014
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Nomogram for overall survival of patients with progressive metastatic prostate cancer after castration.
Smaletz O, Scher HI, Small EJ, Verbel DA, McMillan A, Regan K, Kelly WK, Kattan MW., J. Clin. Oncol. 20(19), 2002
PMID: 12351594
Smaletz O, Scher HI, Small EJ, Verbel DA, McMillan A, Regan K, Kelly WK, Kattan MW., J. Clin. Oncol. 20(19), 2002
PMID: 12351594
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, Xu Y, Frohlich MW, Schellhammer PF; IMPACT Study Investigators, Ahmed T, Amin A, Arseneau J, Barth N, Bernstein G, Bracken B, Burch P, Caggiano V, Chin J, Chodak G, Chu F, Corman J, Curti B, Dawson N, Deeken JF, Dubernet T, Fishman M, Flanigan R, Gailani F, Garbo L, Gardner T, Gelmann E, George D, Godfrey T, Gomella L, Guerra M, Hall S, Hanson J, Israeli R, Jancis E, Jewett MA, Kassabian V, Katz J, Klotz L, Koeneman K, Koh H, Kratzke R, Lance R, Lech J, Leichman L, Lemon R, Liang J, Libertino J, Lilly M, Malik I, Martin SE, McCaffrey J, McLeod D, McNeel D, Miles B, Murdock M, Nabhan C, Nemunaitis J, Notter D, Pantuck A, Perrotte P, Pessis D, Petrylak D, Polikoff J, Pommerville P, Ramanathan S, Rarick M, Richards J, Rifkin R, Rohatgi N, Rosenbluth R, Santucci R, Sayegh A, Seigne J, Shapira I, Shedhadeh N, Shepherd D, Sridhar S, Stephenson R, Teigland C, Thaker N, Vacirca J, Villa L Jr, Vogelzang N, Wertheim M, Wolff JH, Wurzel R, Yang C, Young J., N. Engl. J. Med. 363(5), 2010
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Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, Xu Y, Frohlich MW, Schellhammer PF; IMPACT Study Investigators, Ahmed T, Amin A, Arseneau J, Barth N, Bernstein G, Bracken B, Burch P, Caggiano V, Chin J, Chodak G, Chu F, Corman J, Curti B, Dawson N, Deeken JF, Dubernet T, Fishman M, Flanigan R, Gailani F, Garbo L, Gardner T, Gelmann E, George D, Godfrey T, Gomella L, Guerra M, Hall S, Hanson J, Israeli R, Jancis E, Jewett MA, Kassabian V, Katz J, Klotz L, Koeneman K, Koh H, Kratzke R, Lance R, Lech J, Leichman L, Lemon R, Liang J, Libertino J, Lilly M, Malik I, Martin SE, McCaffrey J, McLeod D, McNeel D, Miles B, Murdock M, Nabhan C, Nemunaitis J, Notter D, Pantuck A, Perrotte P, Pessis D, Petrylak D, Polikoff J, Pommerville P, Ramanathan S, Rarick M, Richards J, Rifkin R, Rohatgi N, Rosenbluth R, Santucci R, Sayegh A, Seigne J, Shapira I, Shedhadeh N, Shepherd D, Sridhar S, Stephenson R, Teigland C, Thaker N, Vacirca J, Villa L Jr, Vogelzang N, Wertheim M, Wolff JH, Wurzel R, Yang C, Young J., N. Engl. J. Med. 363(5), 2010
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Genomic Classification and Prognosis in Acute Myeloid Leukemia.
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Dohner K, Schlenk RF, Dohner H, Campbell PJ., N. Engl. J. Med. 374(23), 2016
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Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Dohner K, Schlenk RF, Dohner H, Campbell PJ., N. Engl. J. Med. 374(23), 2016
PMID: 27276561
Seeking the wisdom of crowds through challenge-based competitions in biomedical research.
Costello JC, Stolovitzky G., Clin. Pharmacol. Ther. 93(5), 2013
PMID: 23549146
Costello JC, Stolovitzky G., Clin. Pharmacol. Ther. 93(5), 2013
PMID: 23549146
Updated prognostic model for predicting overall survival in first-line chemotherapy for patients with metastatic castration-resistant prostate cancer.
Halabi S, Lin CY, Kelly WK, Fizazi KS, Moul JW, Kaplan EB, Morris MJ, Small EJ., J. Clin. Oncol. 32(7), 2014
PMID: 24449231
Halabi S, Lin CY, Kelly WK, Fizazi KS, Moul JW, Kaplan EB, Morris MJ, Small EJ., J. Clin. Oncol. 32(7), 2014
PMID: 24449231
Aflibercept versus placebo in combination with docetaxel and prednisone for treatment of men with metastatic castration-resistant prostate cancer (VENICE): a phase 3, double-blind randomised trial.
Tannock IF, Fizazi K, Ivanov S, Karlsson CT, Flechon A, Skoneczna I, Orlandi F, Gravis G, Matveev V, Bavbek S, Gil T, Viana L, Aren O, Karyakin O, Elliott T, Birtle A, Magherini E, Hatteville L, Petrylak D, Tombal B, Rosenthal M; VENICE investigators., Lancet Oncol. 14(8), 2013
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Tannock IF, Fizazi K, Ivanov S, Karlsson CT, Flechon A, Skoneczna I, Orlandi F, Gravis G, Matveev V, Bavbek S, Gil T, Viana L, Aren O, Karyakin O, Elliott T, Birtle A, Magherini E, Hatteville L, Petrylak D, Tombal B, Rosenthal M; VENICE investigators., Lancet Oncol. 14(8), 2013
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Abiraterone and increased survival in metastatic prostate cancer.
Berruti A, Pia A, Terzolo M., N. Engl. J. Med. 365(8), 2011
PMID: 21864182
Berruti A, Pia A, Terzolo M., N. Engl. J. Med. 365(8), 2011
PMID: 21864182
Increased survival with enzalutamide in prostate cancer after chemotherapy.
Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, Armstrong AJ, Flaig TW, Flechon A, Mainwaring P, Fleming M, Hainsworth JD, Hirmand M, Selby B, Seely L, de Bono JS; AFFIRM Investigators, Alasino C, Bella S, Carraro S, Geist M, Abdi E, Begbie S, Briscoe K, Davis I, Dowling A, Ganju V, Gurney H, Hovey E, Ng S, Nottage M, Rosenthal M, Stockler M, Tan T, Wong S, Young R, Krainer M, Loidl W, Machiels J, Mebis J, Renard V, Dumez H, Van Aelst F, Werbrouck P, Ellard S, Joshua A, Karakiewicz P, Lacombe L, Lattouf JB, Michels J, Mukherjee S, Ruether D, Venner P, Winquist E, Wood L, Aren O, Gonzalez P, Pastor P, Baumgaertner I, Beuzeboc P, Bompas E, Boyle H, Colombel M, Delva R, Eymard J, Gravis G, Guillot A, Houede N, Joly F, Kaphan R, Loriot Y, Oudard S, Priou F, Tartas S, Theodore C, Tourani JM, Voog E, Bogemann M, Hadaschik B, Hammerer P, Heidenreich A, Holzer W, Merseburger A, Stenzl A, Steuber T, Suttmann H, Trojan L, Wirth M, Cerbone L, Conte P, Passalacqua R, Tucci M, Gerritsen W, Jassem J, Kalinka-Warzocha E, Olubiec J, De Bruyne R, Malan J, Vorobiof D, Bellmunt J, Carles J, Duran I, Font A, Gil-Bazo I, Maroto J, Bahl A, Choudhury A, Hoskin P, James N, Jones R, Mazhar D, O'Sullivan J, Payne H, Pedley I, Protheroe A, Waxman J, Zivi A, Alexander B, Appleman L, Aragon-Ching J, Arrowsmith E, Assikis V, Beer T, Berry W, Bolger G, Bryce A, Bubley G, Chatta G, Denmeade S, Deshpande H, Dorff T, Galsky M, George D, Giudice R, Glode M, Golshayan AR, Goodman O, Graff J, Green L, Green R, Haas N, Higano C, Hutson T, Kohli M, Liu G, May J, Mendelson D, Picus J, Pili R, Posadas E, Redfern C, Rettig M, Ryan C, Scholz M, Sharifi N, Sosman J, Srinivas S, Tagawa S, Twardowski P, Vaishampayan U, Wong YN., N. Engl. J. Med. 367(13), 2012
PMID: 22894553
Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, Miller K, de Wit R, Mulders P, Chi KN, Shore ND, Armstrong AJ, Flaig TW, Flechon A, Mainwaring P, Fleming M, Hainsworth JD, Hirmand M, Selby B, Seely L, de Bono JS; AFFIRM Investigators, Alasino C, Bella S, Carraro S, Geist M, Abdi E, Begbie S, Briscoe K, Davis I, Dowling A, Ganju V, Gurney H, Hovey E, Ng S, Nottage M, Rosenthal M, Stockler M, Tan T, Wong S, Young R, Krainer M, Loidl W, Machiels J, Mebis J, Renard V, Dumez H, Van Aelst F, Werbrouck P, Ellard S, Joshua A, Karakiewicz P, Lacombe L, Lattouf JB, Michels J, Mukherjee S, Ruether D, Venner P, Winquist E, Wood L, Aren O, Gonzalez P, Pastor P, Baumgaertner I, Beuzeboc P, Bompas E, Boyle H, Colombel M, Delva R, Eymard J, Gravis G, Guillot A, Houede N, Joly F, Kaphan R, Loriot Y, Oudard S, Priou F, Tartas S, Theodore C, Tourani JM, Voog E, Bogemann M, Hadaschik B, Hammerer P, Heidenreich A, Holzer W, Merseburger A, Stenzl A, Steuber T, Suttmann H, Trojan L, Wirth M, Cerbone L, Conte P, Passalacqua R, Tucci M, Gerritsen W, Jassem J, Kalinka-Warzocha E, Olubiec J, De Bruyne R, Malan J, Vorobiof D, Bellmunt J, Carles J, Duran I, Font A, Gil-Bazo I, Maroto J, Bahl A, Choudhury A, Hoskin P, James N, Jones R, Mazhar D, O'Sullivan J, Payne H, Pedley I, Protheroe A, Waxman J, Zivi A, Alexander B, Appleman L, Aragon-Ching J, Arrowsmith E, Assikis V, Beer T, Berry W, Bolger G, Bryce A, Bubley G, Chatta G, Denmeade S, Deshpande H, Dorff T, Galsky M, George D, Giudice R, Glode M, Golshayan AR, Goodman O, Graff J, Green L, Green R, Haas N, Higano C, Hutson T, Kohli M, Liu G, May J, Mendelson D, Picus J, Pili R, Posadas E, Redfern C, Rettig M, Ryan C, Scholz M, Sharifi N, Sosman J, Srinivas S, Tagawa S, Twardowski P, Vaishampayan U, Wong YN., N. Engl. J. Med. 367(13), 2012
PMID: 22894553
Crowdsourcing biomedical research: leveraging communities as innovation engines.
Saez-Rodriguez J, Costello JC, Friend SH, Kellen MR, Mangravite L, Meyer P, Norman T, Stolovitzky G., Nat. Rev. Genet. 17(8), 2016
PMID: 27418159
Saez-Rodriguez J, Costello JC, Friend SH, Kellen MR, Mangravite L, Meyer P, Norman T, Stolovitzky G., Nat. Rev. Genet. 17(8), 2016
PMID: 27418159
Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer.
Scher HI, Jia X, Chi K, de Wit R, Berry WR, Albers P, Henick B, Waterhouse D, Ruether DJ, Rosen PJ, Meluch AA, Nordquist LT, Venner PM, Heidenreich A, Chu L, Heller G., J. Clin. Oncol. 29(16), 2011
PMID: 21483004
Scher HI, Jia X, Chi K, de Wit R, Berry WR, Albers P, Henick B, Waterhouse D, Ruether DJ, Rosen PJ, Meluch AA, Nordquist LT, Venner PM, Heidenreich A, Chu L, Heller G., J. Clin. Oncol. 29(16), 2011
PMID: 21483004
A Global, Neutral Platform for Sharing Trial Data.
Bierer BE, Li R, Barnes M, Sim I., N. Engl. J. Med. 374(25), 2016
PMID: 27168194
Bierer BE, Li R, Barnes M, Sim I., N. Engl. J. Med. 374(25), 2016
PMID: 27168194
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.
Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, Sauerwine B, Kellen MR, Mangravite LM, Furia MD, Vollan HK, Rueda OM, Guinney J, Deflaux NA, Hoff B, Schildwachter X, Russnes HG, Park D, Vang VO, Pirtle T, Youseff L, Citro C, Curtis C, Kristensen VN, Hellerstein J, Friend SH, Stolovitzky G, Aparicio S, Caldas C, Borresen-Dale AL., Sci Transl Med 5(181), 2013
PMID: 23596205
Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, Sauerwine B, Kellen MR, Mangravite LM, Furia MD, Vollan HK, Rueda OM, Guinney J, Deflaux NA, Hoff B, Schildwachter X, Russnes HG, Park D, Vang VO, Pirtle T, Youseff L, Citro C, Curtis C, Kristensen VN, Hellerstein J, Friend SH, Stolovitzky G, Aparicio S, Caldas C, Borresen-Dale AL., Sci Transl Med 5(181), 2013
PMID: 23596205
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial.
de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators., Lancet 376(9747), 2010
PMID: 20888992
de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators., Lancet 376(9747), 2010
PMID: 20888992
Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection.
Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY; ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC, Xi L, Dewal N, Fan Y, Wang W, Wheeler D, Wilm A, Ting GH, Li C, Bertrand D, Nagarajan N, Chen QR, Hsu CH, Hu Y, Yan C, Kibbe W, Meerzaman D, Cibulskis K, Rosenberg M, Bergelson L, Kiezun A, Radenbaugh A, Sertier AS, Ferrari A, Tonton L, Bhutani K, Hansen NF, Wang D, Song L, Lai Z, Liao Y, Shi W, Carbonell-Caballero J, Dopazo J, Lau CC, Guinney J., Nat. Methods 12(7), 2015
PMID: 25984700
Ewing AD, Houlahan KE, Hu Y, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P'ng C, Waggott D, Sabelnykova VY; ICGC-TCGA DREAM Somatic Mutation Calling Challenge participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin AA, Stuart JM, Boutros PC, Xi L, Dewal N, Fan Y, Wang W, Wheeler D, Wilm A, Ting GH, Li C, Bertrand D, Nagarajan N, Chen QR, Hsu CH, Hu Y, Yan C, Kibbe W, Meerzaman D, Cibulskis K, Rosenberg M, Bergelson L, Kiezun A, Radenbaugh A, Sertier AS, Ferrari A, Tonton L, Bhutani K, Hansen NF, Wang D, Song L, Lai Z, Liao Y, Shi W, Carbonell-Caballero J, Dopazo J, Lau CC, Guinney J., Nat. Methods 12(7), 2015
PMID: 25984700
Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer.
Fizazi K, Fizazi KS, Higano CS, Nelson JB, Gleave M, Miller K, Morris T, Nathan FE, McIntosh S, Pemberton K, Moul JW., J. Clin. Oncol. 31(14), 2013
PMID: 23569308
Fizazi K, Fizazi KS, Higano CS, Nelson JB, Gleave M, Miller K, Morris T, Nathan FE, McIntosh S, Pemberton K, Moul JW., J. Clin. Oncol. 31(14), 2013
PMID: 23569308
Avoiding Data Dumpsters--Toward Equitable and Useful Data Sharing.
Merson L, Gaye O, Guerin PJ., N. Engl. J. Med. 374(25), 2016
PMID: 27168351
Merson L, Gaye O, Guerin PJ., N. Engl. J. Med. 374(25), 2016
PMID: 27168351
Prognostic model for predicting survival in men with hormone-refractory metastatic prostate cancer.
Halabi S, Small EJ, Kantoff PW, Kattan MW, Kaplan EB, Dawson NA, Levine EG, Blumenstein BA, Vogelzang NJ., J. Clin. Oncol. 21(7), 2003
PMID: 12663709
Halabi S, Small EJ, Kantoff PW, Kattan MW, Kaplan EB, Dawson NA, Levine EG, Blumenstein BA, Vogelzang NJ., J. Clin. Oncol. 21(7), 2003
PMID: 12663709
A contemporary prognostic nomogram for men with hormone-refractory metastatic prostate cancer: a TAX327 study analysis.
Armstrong AJ, Garrett-Mayer ES, Yang YC, de Wit R, Tannock IF, Eisenberger M., Clin. Cancer Res. 13(21), 2007
PMID: 17975152
Armstrong AJ, Garrett-Mayer ES, Yang YC, de Wit R, Tannock IF, Eisenberger M., Clin. Cancer Res. 13(21), 2007
PMID: 17975152
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Tanimoto T, Hori A, Kami M., N. Engl. J. Med. 363(20), 2010
PMID: 21067392
Tanimoto T, Hori A, Kami M., N. Engl. J. Med. 363(20), 2010
PMID: 21067392
Enzalutamide in metastatic prostate cancer before chemotherapy.
Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya S, Carles J, Chowdhury S, Davis ID, de Bono JS, Evans CP, Fizazi K, Joshua AM, Kim CS, Kimura G, Mainwaring P, Mansbach H, Miller K, Noonberg SB, Perabo F, Phung D, Saad F, Scher HI, Taplin ME, Venner PM, Tombal B; PREVAIL Investigators, Begbie S, Bonaventura A, Boyce A, Chua W, de Souza P, Davis I, Gardiner F, Guminski A, Gurney H, Hovey E, Mainwaring P, Marx G, Mathlum M, Parente P, Parnis F, Pook D, Rosenthal M, Shapiro J, Toner G, Warren M, Wong S, Woo H, Janetschek G, Krainer M, Loidl W, Schmeller N, Mebis J, Renard V, Tombal B, Van Poppel H, Waltregny D, Werbrouck P, Attwell A, Canil C, Drachenberg D, Finch D, Gleave M, Joshua AM, Klotz L, Lacombe L, Mukherjee S, Ruether D, Saad F, Venner P, Winquist E, Wood L, Borre M, Holm-Nielsen A, Iversen P, Langkilde NC, Ostri P, Rathenborg P, Taari K, Tammela T, Vaarala M, Ala-Opas M, Beuzeboc P, Bompas E, Davin JL, Delva R, Ducos B, Flechon A, Gross-Goupil M, Guillot A, Houede N, Laguerre B, Latorzeff I, Lemoulec S, Loriot Y, Oudard S, Priou F, Vignot S, Voog E, Bogemann M, Bolenz C, Hadaschik B, Hammerer P, Klotz T, Merseburger A, Miller K, Ohlmann CH, Schrader M, Stenzl A, Strolin P, Suttmann H, Wirth M, Mermershtain W, Nativ O, Ramon J, Rosenbaum E, Sella A, Bracarda S, Cerbone L, De Giorgi U, Passalacqua R, Recine F, Scagliotti G, Sternberg C, Egawa S, Fukagai T, Fukumori T, Igawa T, Kamba T, Kimura G, Kosaka T, Matsuyama H, Nakatani T, Namiki S, Nishimura K, Nishiyama T, Nonomura N, Nozawa M, Numahata K, Okegawa T, Ueda T, Uemura H, Yamanaka Y, Yokomizo A, Yonese J, Jocys G, Ulys A, de Jong I, Mulders P, van den Eertwegh A, Vrijhof E, Dobrowolski A, Jassem J, Kalinka-Warzocha E, Kmieciak R, Milecki P, Al-Shukri S, Matveev V, Novikov A, Chiong E, Lau W, Balaz V, Brezovsky M, Goncalves F, Kliment J, Mincik I, Choi YD, Chung BH, Kim CS, Kwon DD, Lee HM, Lee KH, Lee SE, Alcaraz A, Bellmunt J, Burgos F, Carles J, Domenech M, Font A, Gallardo E, Garcia-Donas Jimenez J, Gil-Bazo I, Gomez Veiga F, Gonzalez A, Andren O, Bjartell A, Damber JE, Ljungberg B, Wiklund P, Bahl A, Chowdhury S, de Bono J, Gilbert D, Hoskin P, Malik Z, McLaren D, Payne H, Pedley I, Protheroe A, Tanguay J, Waxman J, Andriole G, Appleman L, Armstrong A, Beer T, Berry W, Bolger G, Courtney K, Dorff T, Evans C, Flaig T, Fleming M, Haas N, Hall S, Hauke S, Higano C, Keane T, Khan M, Kohli M, Koletsky A, Kuzel T, McNeel D, Nazemzadeh R, Rathkopf D, Redfern C, Rettig M, Singh P, Srinivas S, Taplin ME, Vaishampayan U, Armstrong AJ, Beer TM, Higano CS, Iversen P, Sternberg CN, Tombal B, Andresen C, Martinez H, McNees A, Parli T, Pham T, Tabora K, Thomrongsith L, Zhao S., N. Engl. J. Med. 371(5), 2014
PMID: 24881730
Beer TM, Armstrong AJ, Rathkopf DE, Loriot Y, Sternberg CN, Higano CS, Iversen P, Bhattacharya S, Carles J, Chowdhury S, Davis ID, de Bono JS, Evans CP, Fizazi K, Joshua AM, Kim CS, Kimura G, Mainwaring P, Mansbach H, Miller K, Noonberg SB, Perabo F, Phung D, Saad F, Scher HI, Taplin ME, Venner PM, Tombal B; PREVAIL Investigators, Begbie S, Bonaventura A, Boyce A, Chua W, de Souza P, Davis I, Gardiner F, Guminski A, Gurney H, Hovey E, Mainwaring P, Marx G, Mathlum M, Parente P, Parnis F, Pook D, Rosenthal M, Shapiro J, Toner G, Warren M, Wong S, Woo H, Janetschek G, Krainer M, Loidl W, Schmeller N, Mebis J, Renard V, Tombal B, Van Poppel H, Waltregny D, Werbrouck P, Attwell A, Canil C, Drachenberg D, Finch D, Gleave M, Joshua AM, Klotz L, Lacombe L, Mukherjee S, Ruether D, Saad F, Venner P, Winquist E, Wood L, Borre M, Holm-Nielsen A, Iversen P, Langkilde NC, Ostri P, Rathenborg P, Taari K, Tammela T, Vaarala M, Ala-Opas M, Beuzeboc P, Bompas E, Davin JL, Delva R, Ducos B, Flechon A, Gross-Goupil M, Guillot A, Houede N, Laguerre B, Latorzeff I, Lemoulec S, Loriot Y, Oudard S, Priou F, Vignot S, Voog E, Bogemann M, Bolenz C, Hadaschik B, Hammerer P, Klotz T, Merseburger A, Miller K, Ohlmann CH, Schrader M, Stenzl A, Strolin P, Suttmann H, Wirth M, Mermershtain W, Nativ O, Ramon J, Rosenbaum E, Sella A, Bracarda S, Cerbone L, De Giorgi U, Passalacqua R, Recine F, Scagliotti G, Sternberg C, Egawa S, Fukagai T, Fukumori T, Igawa T, Kamba T, Kimura G, Kosaka T, Matsuyama H, Nakatani T, Namiki S, Nishimura K, Nishiyama T, Nonomura N, Nozawa M, Numahata K, Okegawa T, Ueda T, Uemura H, Yamanaka Y, Yokomizo A, Yonese J, Jocys G, Ulys A, de Jong I, Mulders P, van den Eertwegh A, Vrijhof E, Dobrowolski A, Jassem J, Kalinka-Warzocha E, Kmieciak R, Milecki P, Al-Shukri S, Matveev V, Novikov A, Chiong E, Lau W, Balaz V, Brezovsky M, Goncalves F, Kliment J, Mincik I, Choi YD, Chung BH, Kim CS, Kwon DD, Lee HM, Lee KH, Lee SE, Alcaraz A, Bellmunt J, Burgos F, Carles J, Domenech M, Font A, Gallardo E, Garcia-Donas Jimenez J, Gil-Bazo I, Gomez Veiga F, Gonzalez A, Andren O, Bjartell A, Damber JE, Ljungberg B, Wiklund P, Bahl A, Chowdhury S, de Bono J, Gilbert D, Hoskin P, Malik Z, McLaren D, Payne H, Pedley I, Protheroe A, Tanguay J, Waxman J, Andriole G, Appleman L, Armstrong A, Beer T, Berry W, Bolger G, Courtney K, Dorff T, Evans C, Flaig T, Fleming M, Haas N, Hall S, Hauke S, Higano C, Keane T, Khan M, Kohli M, Koletsky A, Kuzel T, McNeel D, Nazemzadeh R, Rathkopf D, Redfern C, Rettig M, Singh P, Srinivas S, Taplin ME, Vaishampayan U, Armstrong AJ, Beer TM, Higano CS, Iversen P, Sternberg CN, Tombal B, Andresen C, Martinez H, McNees A, Parli T, Pham T, Tabora K, Thomrongsith L, Zhao S., N. Engl. J. Med. 371(5), 2014
PMID: 24881730
A community effort to assess and improve drug sensitivity prediction algorithms.
Costello JC, Heiser LM, Georgii E, Gonen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K; NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G, Abbuehl JP, Aittokallio T, Allen J, Altman RB, Ammad-ud-din M, Balcome S, Bansal M, Battle A, Bender A, Berger B, Bernard J, Bhattacharjee M, Bhuvaneshwar K, Bieberich AA, Boehm F, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Cokelaer T, Collins JC, Costello JC, Creighton CJ, Cui J, Dampier W, Davisson VJ, De Baets B, Deshpande R, DiCamillo B, Dundar M, Duren Z, Ertel A, Fan H, Fang H, Gallahan D, Gauba R, Georgii E, Gonen M, Gottlieb A, Grau M, Gray JW, Gusev Y, Ha MJ, Han L, Harris M, Heiser LM, Henderson N, Hejase HA, Hintsanen P, Homicsko K, Honkela A, Hou JP, Hwang W, IJzerman AP, Kallioniemi O, Karacali B, Kaski S, Keles S, Kendziorski C, Khan SA, Kim J, Kim M, Kim Y, Knowles DA, Koller D, Lee J, Lee JK, Lenselink EB, Li B, Li B, Li J, Liang H, Ma J, Madhavan S, Menden MP, Mooney S, Mpindi JP, Myers CL, Newton MA, Overington JP, Pal R, Peng J, Pestell R, Prill RJ, Qiu P, Rajwa B, Sadanandam A, Saez-Rodriguez J, Sambo F, Shin H, Singer D, Song J, Song L, Sridhar A, Stock M, Stolovitzky G, Sun W, Ta T, Tadesse M, Tan M, Tang H, Theodorescu D, Toffolo GM, Tozeren A, Trepicchio W, Varoquaux N, Vert JP, Waegeman W, Walter T, Wan Q, Wang D, Wang NJ, Wang W, Wang Y, Wang Z, Wegner JK, Wennerberg K, Wu T, Xia T, Xiao G, Xie Y, Xu Y, Yang J, Yuan Y, Zhang S, Zhang XS, Zhao J, Zuo C, van Vlijmen HW, van Westen GJ., Nat. Biotechnol. 32(12), 2014
PMID: 24880487
Costello JC, Heiser LM, Georgii E, Gonen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi JP, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K; NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW, Stolovitzky G, Abbuehl JP, Aittokallio T, Allen J, Altman RB, Ammad-ud-din M, Balcome S, Bansal M, Battle A, Bender A, Berger B, Bernard J, Bhattacharjee M, Bhuvaneshwar K, Bieberich AA, Boehm F, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Cokelaer T, Collins JC, Costello JC, Creighton CJ, Cui J, Dampier W, Davisson VJ, De Baets B, Deshpande R, DiCamillo B, Dundar M, Duren Z, Ertel A, Fan H, Fang H, Gallahan D, Gauba R, Georgii E, Gonen M, Gottlieb A, Grau M, Gray JW, Gusev Y, Ha MJ, Han L, Harris M, Heiser LM, Henderson N, Hejase HA, Hintsanen P, Homicsko K, Honkela A, Hou JP, Hwang W, IJzerman AP, Kallioniemi O, Karacali B, Kaski S, Keles S, Kendziorski C, Khan SA, Kim J, Kim M, Kim Y, Knowles DA, Koller D, Lee J, Lee JK, Lenselink EB, Li B, Li B, Li J, Liang H, Ma J, Madhavan S, Menden MP, Mooney S, Mpindi JP, Myers CL, Newton MA, Overington JP, Pal R, Peng J, Pestell R, Prill RJ, Qiu P, Rajwa B, Sadanandam A, Saez-Rodriguez J, Sambo F, Shin H, Singer D, Song J, Song L, Sridhar A, Stock M, Stolovitzky G, Sun W, Ta T, Tadesse M, Tan M, Tang H, Theodorescu D, Toffolo GM, Tozeren A, Trepicchio W, Varoquaux N, Vert JP, Waegeman W, Walter T, Wan Q, Wang D, Wang NJ, Wang W, Wang Y, Wang Z, Wegner JK, Wennerberg K, Wu T, Xia T, Xiao G, Xie Y, Xu Y, Yang J, Yuan Y, Zhang S, Zhang XS, Zhao J, Zuo C, van Vlijmen HW, van Westen GJ., Nat. Biotechnol. 32(12), 2014
PMID: 24880487
Abiraterone in metastatic prostate cancer without previous chemotherapy.
Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE; COU-AA-302 Investigators, Boyce A, Costello A, Davis I, Ganju V, Horvath L, Lynch R, Marx G, Parnis F, Shapiro J, Singhal N, Slancar M, Van Hazel G, Wong S, Yip D, Carpentier P, Luyten D, Rottey S, Van Aelst F, Cheng T, Chin J, Ellard S, Fradet Y, Gleave M, Joshua A, Klotz L, Martins H, North S, Abdel-Hamid S, Colombel M, Flechon A, Haillot O, Joly F, Oudard S, Priou F, Raymond E, Albers P, Boegemann M, Gleissner J, Gschwend J, Hammerer P, Heidenreich A, Kuczyk M, Miller K, Oetzel R, Roigas J, Steuber T, Stockle M, Wirth M, Papandreou C, Bracarda S, Marcello T, Sternberg C, Bangma C, de Reijke T, Arija J, Bellmunt J, Lopez R, Lopez-Brea M, Bjartell A, Damber J, Haggman M, Hellstrom M, Seke M, Brown J, Chowdhury S, Elliott T, Harland S, Innes H, James N, Jones R, Mazhar D, Paez E, Protheroe A, Staffurth J, Ahmann F, Andriole G, Arrowsmith E, Assikis V, Baron A, Berry W, Bubley G, Carney J, Chu L, Cosgriff T, Denmeade S, Deshpande H, Duchene D, Ferrari A, Frenkel E, Gabrail N, Garcia J, George D, Gomella L, Goodman O, Gore I, Gullo J, Hainsworth J, Hamid O, Hutson T, King D, Koh H, Koletsky A, Kudrik F, Lara P, Lyons R, Maranchie J, Modiano M, Nieva J, Nordquist L, Pinski J, Poiesz B, Polikoff J, Quinn D, Redfern C, Riggs S, Ryan C, Saleh M, Sartor A, Scholz M, Shore N, Srinivas S, Vaishampaya U, Vieweg J, Vira M, Vogelzang N, Wilding G, Wong Y, Belldegrun A, Kantoff PW, Carducci MA, Vogelzang NJ, Kelly WK, Auchus RJ, Meyers M, Rackoff W, Tran N, Yu M, Knoblauch R, Naini V, Matheny S, Maul S, Larsen J, Martin J, Wawda H, Goffredo D, Li J, Li S, Li B, Durve K, Morris MJ, Larson SM., N. Engl. J. Med. 368(2), 2012
PMID: 23228172
Ryan CJ, Smith MR, de Bono JS, Molina A, Logothetis CJ, de Souza P, Fizazi K, Mainwaring P, Piulats JM, Ng S, Carles J, Mulders PF, Basch E, Small EJ, Saad F, Schrijvers D, Van Poppel H, Mukherjee SD, Suttmann H, Gerritsen WR, Flaig TW, George DJ, Yu EY, Efstathiou E, Pantuck A, Winquist E, Higano CS, Taplin ME, Park Y, Kheoh T, Griffin T, Scher HI, Rathkopf DE; COU-AA-302 Investigators, Boyce A, Costello A, Davis I, Ganju V, Horvath L, Lynch R, Marx G, Parnis F, Shapiro J, Singhal N, Slancar M, Van Hazel G, Wong S, Yip D, Carpentier P, Luyten D, Rottey S, Van Aelst F, Cheng T, Chin J, Ellard S, Fradet Y, Gleave M, Joshua A, Klotz L, Martins H, North S, Abdel-Hamid S, Colombel M, Flechon A, Haillot O, Joly F, Oudard S, Priou F, Raymond E, Albers P, Boegemann M, Gleissner J, Gschwend J, Hammerer P, Heidenreich A, Kuczyk M, Miller K, Oetzel R, Roigas J, Steuber T, Stockle M, Wirth M, Papandreou C, Bracarda S, Marcello T, Sternberg C, Bangma C, de Reijke T, Arija J, Bellmunt J, Lopez R, Lopez-Brea M, Bjartell A, Damber J, Haggman M, Hellstrom M, Seke M, Brown J, Chowdhury S, Elliott T, Harland S, Innes H, James N, Jones R, Mazhar D, Paez E, Protheroe A, Staffurth J, Ahmann F, Andriole G, Arrowsmith E, Assikis V, Baron A, Berry W, Bubley G, Carney J, Chu L, Cosgriff T, Denmeade S, Deshpande H, Duchene D, Ferrari A, Frenkel E, Gabrail N, Garcia J, George D, Gomella L, Goodman O, Gore I, Gullo J, Hainsworth J, Hamid O, Hutson T, King D, Koh H, Koletsky A, Kudrik F, Lara P, Lyons R, Maranchie J, Modiano M, Nieva J, Nordquist L, Pinski J, Poiesz B, Polikoff J, Quinn D, Redfern C, Riggs S, Ryan C, Saleh M, Sartor A, Scholz M, Shore N, Srinivas S, Vaishampaya U, Vieweg J, Vira M, Vogelzang N, Wilding G, Wong Y, Belldegrun A, Kantoff PW, Carducci MA, Vogelzang NJ, Kelly WK, Auchus RJ, Meyers M, Rackoff W, Tran N, Yu M, Knoblauch R, Naini V, Matheny S, Maul S, Larsen J, Martin J, Wawda H, Goffredo D, Li J, Li S, Li B, Durve K, Morris MJ, Larson SM., N. Engl. J. Med. 368(2), 2012
PMID: 23228172
Regularized machine learning in the genetic prediction of complex traits.
Okser S, Pahikkala T, Airola A, Salakoski T, Ripatti S, Aittokallio T., PLoS Genet. 10(11), 2014
PMID: 25393026
Okser S, Pahikkala T, Airola A, Salakoski T, Ripatti S, Aittokallio T., PLoS Genet. 10(11), 2014
PMID: 25393026
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study.
Fizazi K, Carducci M, Smith M, Damiao R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, Jiang Q, Tadros S, Dansey R, Goessl C., Lancet 377(9768), 2011
PMID: 21353695
Fizazi K, Carducci M, Smith M, Damiao R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, Jiang Q, Tadros S, Dansey R, Goessl C., Lancet 377(9768), 2011
PMID: 21353695
Global cancer statistics.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D., CA Cancer J Clin 61(2), 2011
PMID: 21296855
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D., CA Cancer J Clin 61(2), 2011
PMID: 21296855
Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): a randomised, double-blind, placebo-controlled phase 3 trial.
Petrylak DP, Vogelzang NJ, Budnik N, Wiechno PJ, Sternberg CN, Doner K, Bellmunt J, Burke JM, de Olza MO, Choudhury A, Gschwend JE, Kopyltsov E, Flechon A, Van As N, Houede N, Barton D, Fandi A, Jungnelius U, Li S, de Wit R, Fizazi K., Lancet Oncol. 16(4), 2015
PMID: 25743937
Petrylak DP, Vogelzang NJ, Budnik N, Wiechno PJ, Sternberg CN, Doner K, Bellmunt J, Burke JM, de Olza MO, Choudhury A, Gschwend JE, Kopyltsov E, Flechon A, Van As N, Houede N, Barton D, Fandi A, Jungnelius U, Li S, de Wit R, Fizazi K., Lancet Oncol. 16(4), 2015
PMID: 25743937
Alpha emitter radium-223 and survival in metastatic prostate cancer.
Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fossa SD, Chodacki A, Wiechno P, Logue J, Seke M, Widmark A, Johannessen DC, Hoskin P, Bottomley D, James ND, Solberg A, Syndikus I, Kliment J, Wedel S, Boehmer S, Dall'Oglio M, Franzen L, Coleman R, Vogelzang NJ, O'Bryan-Tear CG, Staudacher K, Garcia-Vargas J, Shan M, Bruland OS, Sartor O; ALSYMPCA Investigators, Brown M, Dalley D, Dickie G, Dowling A, Elison B, Francis R, Harrup R, Jackson M, Jones E, Kirkwood I, Lin M, Macfarlane D, Martin J, Marx G, Miller A, Pittman K, Pocock N, Pointon O, Roach P, Rossleigh M, Sidhom M, Swift P, Taubman K, Unger S, Woo H, Billiet I, Deconnick H, Duck L, Dumont P, Arouca P, Cabral W, Horizonte B, Caspani A, Horizonte B, Coelho B, Damiao R, Kasai E, Koff W, Moraes AA, Murad A, Horizonte B, Oliveira F, Oliveria L, Sampaio C, Sapienza M, Serrano S, Vilela J, House L, Klotz L, Kuhl J, Leung E, Patel S, Reid R, Simone D, Vitols-McKay M, Bolcak K, Buncova M, Feltl D, Hora M, Kocak I, Kopacek R, Kraft O, Myslivecek M, Pernicka J, Schraml J, Zachoval R, Monnier A, Pecking A, Priou F, Quetu F, Rudenko B, Toubeau M, Wartski M, Zanetta G, Barsegian V, Brunkhorst T, Haese A, Hampel C, Kashammer S, Keil C, Klutmann S, Kranert T, Kuczyk M, Mommsen C, Pfestroff A, Reske S, Sahlmann CO, Schrader A, Strauss A, Truss MC, von Pokrzywnitzki W, Cheng H, Kwong P, Leung A, Leung S, Liu C, Tang F, Yau T, Yuen K, Agranovich S, Ben-Yosef R, Dror Y, Golan H, Levita M, Mechlis-Frish S, Mermershtain W, Sella A, Aglietta M, Amadori D, Ariano M, Asti M, Carrara F, Messina C, Poli G, Possa M, Rossetti C, Salvo D, de Jong A, Roeleveld T, van Riel M, van Tilburg E, Vergunst H, Verhagen P, Aurebekk A, Bjering K, Boe K, Fredenfeldt T, Grovnes T, Kasti U, Klepp DO, Larsen K, Nieder C, Pedersen L, Stokkan M, Tvedt B, Chlosta P, Demkow T, Glowa B, Jarzab B, Jarzemski P, Kasprzak K, Klijer R, Kolodziejczyk A, Landwojtowicz M, Mielczarek R, Ochman P, Poniatowicz-Frasunek E, Sowa A, Staszczak , Szczodry A, Zdrojowy R, Zebrowski J, Goh A, Ng C, Tay M, Arpasova M, Balaz V, Breza J, Cano M, Cuperkova J, Cvik M, Lesko J, Mincik I, Reznak I, Spisiakova D, Aranda E, Arbizu J, Banzo J, Bello P, Carles J, Castell J, Donas G, Estorch M, Fombellida J, Perez Gracia JL, Latre J, Llarena R, Lomena F, Lopez R, Maroto P, Mellado B, Mitjavila M, Reynes G, Ruibal A, Saenz-Cusi A, Axelsson B, Backlund M, Bergstrom P, Boling B, Falkmer U, Fransson A, Kindblom J, Lagerlund M, Larsson A, Lindgren U, Matscheko G, Starck SA, Anderson P, Bahl A, Bovill R, Chakraborti P, Cox R, Cripps H, Dixit S, Fletcher C, Foley M, Gannon K, Gibbs S, Gilmore B, Graham J, Heath C, Hooper S, Ibbett D, Jenkins C, Jones I, Lawrence G, Money-Kyrle J, Monk D, Mundy J, Murby B, Pascoe S, Przeslak A, Ramachandra P, Randerson S, Richardson A, Robinson A, Scrase C, Scuffham J, Staffurth J, Stockdale A, Sundar S, Vasanthan S, Waldock P, Walton S, Yarrow S, Arredondo S, Garcia-Ramirez J, Hudes G, Lamey R, Michalski J, Mosley D, Obranovich G, Sanders R, Sandler H, Sanford R, Tomblyn M, Vade Streek P., N. Engl. J. Med. 369(3), 2013
PMID: 23863050
Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fossa SD, Chodacki A, Wiechno P, Logue J, Seke M, Widmark A, Johannessen DC, Hoskin P, Bottomley D, James ND, Solberg A, Syndikus I, Kliment J, Wedel S, Boehmer S, Dall'Oglio M, Franzen L, Coleman R, Vogelzang NJ, O'Bryan-Tear CG, Staudacher K, Garcia-Vargas J, Shan M, Bruland OS, Sartor O; ALSYMPCA Investigators, Brown M, Dalley D, Dickie G, Dowling A, Elison B, Francis R, Harrup R, Jackson M, Jones E, Kirkwood I, Lin M, Macfarlane D, Martin J, Marx G, Miller A, Pittman K, Pocock N, Pointon O, Roach P, Rossleigh M, Sidhom M, Swift P, Taubman K, Unger S, Woo H, Billiet I, Deconnick H, Duck L, Dumont P, Arouca P, Cabral W, Horizonte B, Caspani A, Horizonte B, Coelho B, Damiao R, Kasai E, Koff W, Moraes AA, Murad A, Horizonte B, Oliveira F, Oliveria L, Sampaio C, Sapienza M, Serrano S, Vilela J, House L, Klotz L, Kuhl J, Leung E, Patel S, Reid R, Simone D, Vitols-McKay M, Bolcak K, Buncova M, Feltl D, Hora M, Kocak I, Kopacek R, Kraft O, Myslivecek M, Pernicka J, Schraml J, Zachoval R, Monnier A, Pecking A, Priou F, Quetu F, Rudenko B, Toubeau M, Wartski M, Zanetta G, Barsegian V, Brunkhorst T, Haese A, Hampel C, Kashammer S, Keil C, Klutmann S, Kranert T, Kuczyk M, Mommsen C, Pfestroff A, Reske S, Sahlmann CO, Schrader A, Strauss A, Truss MC, von Pokrzywnitzki W, Cheng H, Kwong P, Leung A, Leung S, Liu C, Tang F, Yau T, Yuen K, Agranovich S, Ben-Yosef R, Dror Y, Golan H, Levita M, Mechlis-Frish S, Mermershtain W, Sella A, Aglietta M, Amadori D, Ariano M, Asti M, Carrara F, Messina C, Poli G, Possa M, Rossetti C, Salvo D, de Jong A, Roeleveld T, van Riel M, van Tilburg E, Vergunst H, Verhagen P, Aurebekk A, Bjering K, Boe K, Fredenfeldt T, Grovnes T, Kasti U, Klepp DO, Larsen K, Nieder C, Pedersen L, Stokkan M, Tvedt B, Chlosta P, Demkow T, Glowa B, Jarzab B, Jarzemski P, Kasprzak K, Klijer R, Kolodziejczyk A, Landwojtowicz M, Mielczarek R, Ochman P, Poniatowicz-Frasunek E, Sowa A, Staszczak , Szczodry A, Zdrojowy R, Zebrowski J, Goh A, Ng C, Tay M, Arpasova M, Balaz V, Breza J, Cano M, Cuperkova J, Cvik M, Lesko J, Mincik I, Reznak I, Spisiakova D, Aranda E, Arbizu J, Banzo J, Bello P, Carles J, Castell J, Donas G, Estorch M, Fombellida J, Perez Gracia JL, Latre J, Llarena R, Lomena F, Lopez R, Maroto P, Mellado B, Mitjavila M, Reynes G, Ruibal A, Saenz-Cusi A, Axelsson B, Backlund M, Bergstrom P, Boling B, Falkmer U, Fransson A, Kindblom J, Lagerlund M, Larsson A, Lindgren U, Matscheko G, Starck SA, Anderson P, Bahl A, Bovill R, Chakraborti P, Cox R, Cripps H, Dixit S, Fletcher C, Foley M, Gannon K, Gibbs S, Gilmore B, Graham J, Heath C, Hooper S, Ibbett D, Jenkins C, Jones I, Lawrence G, Money-Kyrle J, Monk D, Mundy J, Murby B, Pascoe S, Przeslak A, Ramachandra P, Randerson S, Richardson A, Robinson A, Scrase C, Scuffham J, Staffurth J, Stockdale A, Sundar S, Vasanthan S, Waldock P, Walton S, Yarrow S, Arredondo S, Garcia-Ramirez J, Hudes G, Lamey R, Michalski J, Mosley D, Obranovich G, Sanders R, Sandler H, Sanford R, Tomblyn M, Vade Streek P., N. Engl. J. Med. 369(3), 2013
PMID: 23863050
A community computational challenge to predict the activity of pairs of compounds.
Bansal M, Yang J, Karan C, Menden MP, Costello JC, Tang H, Xiao G, Li Y, Allen J, Zhong R, Chen B, Kim M, Wang T, Heiser LM, Realubit R, Mattioli M, Alvarez MJ, Shen Y; NCI-DREAM Community, Gallahan D, Singer D, Saez-Rodriguez J, Xie Y, Stolovitzky G, Califano A; NCI-DREAM Community, Abbuehl JP, Allen J, Altman RB, Balcome S, Bansal M, Bell A, Bender A, Berger B, Bernard J, Bieberich AA, Borboudakis G, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Costello JC, Creighton CJ, Dampier W, Davisson VJ, Deshpande R, Diao L, Di Camillo B, Dundar M, Ertel A, Gallahan D, Goswami CP, Gottlieb A, Gould MN, Goya J, Grau M, Gray JW, Heiser LM, Hejase HA, Hoffmann MF, Homicsko K, Homilius M, Hwang W, Ijzerman AP, Kallioniemi O, Karacali B, Karan C, Kaski S, Kim J, Kim M, Krishnan A, Lee J, Lee YS, Lenselink EB, Lenz P, Li L, Li J, Li Y, Liang H, Mattioli M, Menden MP, Mpindi JP, Myers CL, Newton MA, Overington JP, Parkkinen J, Prill RJ, Peng J, Pestell R, Qiu P, Rajwa B, Realubit R, Sadanandam A, Saez-Rodriguez J, Sambo F, Singer D, Stolovitzky G, Sridhar A, Sun W, Tang H, Toffolo GM, Tozeren A, Troyanskaya OG, Tsamardinos I, van Vlijmen HW, Wang T, Wang W, Wegner JK, Wennerberg K, van Westen GJ, Xia T, Xiao G, Xie Y, Yang J, Yang Y, Yao V, Yuan Y, Zeng H, Zhang S, Zhao J, Zhou J, Zhong R., Nat. Biotechnol. 32(12), 2014
PMID: 25419740
Bansal M, Yang J, Karan C, Menden MP, Costello JC, Tang H, Xiao G, Li Y, Allen J, Zhong R, Chen B, Kim M, Wang T, Heiser LM, Realubit R, Mattioli M, Alvarez MJ, Shen Y; NCI-DREAM Community, Gallahan D, Singer D, Saez-Rodriguez J, Xie Y, Stolovitzky G, Califano A; NCI-DREAM Community, Abbuehl JP, Allen J, Altman RB, Balcome S, Bansal M, Bell A, Bender A, Berger B, Bernard J, Bieberich AA, Borboudakis G, Califano A, Chan C, Chen B, Chen TH, Choi J, Coelho LP, Costello JC, Creighton CJ, Dampier W, Davisson VJ, Deshpande R, Diao L, Di Camillo B, Dundar M, Ertel A, Gallahan D, Goswami CP, Gottlieb A, Gould MN, Goya J, Grau M, Gray JW, Heiser LM, Hejase HA, Hoffmann MF, Homicsko K, Homilius M, Hwang W, Ijzerman AP, Kallioniemi O, Karacali B, Karan C, Kaski S, Kim J, Kim M, Krishnan A, Lee J, Lee YS, Lenselink EB, Lenz P, Li L, Li J, Li Y, Liang H, Mattioli M, Menden MP, Mpindi JP, Myers CL, Newton MA, Overington JP, Parkkinen J, Prill RJ, Peng J, Pestell R, Qiu P, Rajwa B, Realubit R, Sadanandam A, Saez-Rodriguez J, Sambo F, Singer D, Stolovitzky G, Sridhar A, Sun W, Tang H, Toffolo GM, Tozeren A, Troyanskaya OG, Tsamardinos I, van Vlijmen HW, Wang T, Wang W, Wegner JK, Wennerberg K, van Westen GJ, Xia T, Xiao G, Xie Y, Yang J, Yang Y, Yao V, Yuan Y, Zeng H, Zhang S, Zhao J, Zhou J, Zhong R., Nat. Biotechnol. 32(12), 2014
PMID: 25419740
Nomogram for overall survival of patients with progressive metastatic prostate cancer after castration.
Smaletz O, Scher HI, Small EJ, Verbel DA, McMillan A, Regan K, Kelly WK, Kattan MW., J. Clin. Oncol. 20(19), 2002
PMID: 12351594
Smaletz O, Scher HI, Small EJ, Verbel DA, McMillan A, Regan K, Kelly WK, Kattan MW., J. Clin. Oncol. 20(19), 2002
PMID: 12351594
Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, Xu Y, Frohlich MW, Schellhammer PF; IMPACT Study Investigators, Ahmed T, Amin A, Arseneau J, Barth N, Bernstein G, Bracken B, Burch P, Caggiano V, Chin J, Chodak G, Chu F, Corman J, Curti B, Dawson N, Deeken JF, Dubernet T, Fishman M, Flanigan R, Gailani F, Garbo L, Gardner T, Gelmann E, George D, Godfrey T, Gomella L, Guerra M, Hall S, Hanson J, Israeli R, Jancis E, Jewett MA, Kassabian V, Katz J, Klotz L, Koeneman K, Koh H, Kratzke R, Lance R, Lech J, Leichman L, Lemon R, Liang J, Libertino J, Lilly M, Malik I, Martin SE, McCaffrey J, McLeod D, McNeel D, Miles B, Murdock M, Nabhan C, Nemunaitis J, Notter D, Pantuck A, Perrotte P, Pessis D, Petrylak D, Polikoff J, Pommerville P, Ramanathan S, Rarick M, Richards J, Rifkin R, Rohatgi N, Rosenbluth R, Santucci R, Sayegh A, Seigne J, Shapira I, Shedhadeh N, Shepherd D, Sridhar S, Stephenson R, Teigland C, Thaker N, Vacirca J, Villa L Jr, Vogelzang N, Wertheim M, Wolff JH, Wurzel R, Yang C, Young J., N. Engl. J. Med. 363(5), 2010
PMID: 20818862
Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, Xu Y, Frohlich MW, Schellhammer PF; IMPACT Study Investigators, Ahmed T, Amin A, Arseneau J, Barth N, Bernstein G, Bracken B, Burch P, Caggiano V, Chin J, Chodak G, Chu F, Corman J, Curti B, Dawson N, Deeken JF, Dubernet T, Fishman M, Flanigan R, Gailani F, Garbo L, Gardner T, Gelmann E, George D, Godfrey T, Gomella L, Guerra M, Hall S, Hanson J, Israeli R, Jancis E, Jewett MA, Kassabian V, Katz J, Klotz L, Koeneman K, Koh H, Kratzke R, Lance R, Lech J, Leichman L, Lemon R, Liang J, Libertino J, Lilly M, Malik I, Martin SE, McCaffrey J, McLeod D, McNeel D, Miles B, Murdock M, Nabhan C, Nemunaitis J, Notter D, Pantuck A, Perrotte P, Pessis D, Petrylak D, Polikoff J, Pommerville P, Ramanathan S, Rarick M, Richards J, Rifkin R, Rohatgi N, Rosenbluth R, Santucci R, Sayegh A, Seigne J, Shapira I, Shedhadeh N, Shepherd D, Sridhar S, Stephenson R, Teigland C, Thaker N, Vacirca J, Villa L Jr, Vogelzang N, Wertheim M, Wolff JH, Wurzel R, Yang C, Young J., N. Engl. J. Med. 363(5), 2010
PMID: 20818862
Genomic Classification and Prognosis in Acute Myeloid Leukemia.
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Dohner K, Schlenk RF, Dohner H, Campbell PJ., N. Engl. J. Med. 374(23), 2016
PMID: 27276561
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F, Bolli N, Gundem G, Van Loo P, Martincorena I, Ganly P, Mudie L, McLaren S, O'Meara S, Raine K, Jones DR, Teague JW, Butler AP, Greaves MF, Ganser A, Dohner K, Schlenk RF, Dohner H, Campbell PJ., N. Engl. J. Med. 374(23), 2016
PMID: 27276561
Seeking the wisdom of crowds through challenge-based competitions in biomedical research.
Costello JC, Stolovitzky G., Clin. Pharmacol. Ther. 93(5), 2013
PMID: 23549146
Costello JC, Stolovitzky G., Clin. Pharmacol. Ther. 93(5), 2013
PMID: 23549146
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