PUB - Publikationen an der Universität Bielefeld

Clinical review: nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications
Targher, J Clin Endocrinol Metab 98(), 2013

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes.
Birkenfeld AL, Shulman GI., Hepatology 59(2), 2014
PMID: 23929732

Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes
Ma, J Biol Chem 280(), 2005

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
Kim, J Clin Invest 101(), 1998

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
Li S, Brown MS, Goldstein JL., Proc. Natl. Acad. Sci. U.S.A. 107(8), 2010
PMID: 20133650

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD., Cell 156(4), 2014
PMID: 24529379

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance.
Tremblay F, Brule S, Hee Um S, Li Y, Masuda K, Roden M, Sun XJ, Krebs M, Polakiewicz RD, Thomas G, Marette A., Proc. Natl. Acad. Sci. U.S.A. 104(35), 2007
PMID: 17709744

High dietary protein intake, reducing or eliciting insulin resistance?
Rietman A, Schwarz J, Tome D, Kok FJ, Mensink M., Eur J Clin Nutr 68(9), 2014
PMID: 24986822

The metabolic response of subjects with type 2 diabetes to a high-protein, weight-maintenance diet
Nuttall, J Clin Endocrinol Metab 88(), 2003

Branched-chain amino acids in metabolic signalling and insulin resistance.
Lynch CJ, Adams SH., Nat Rev Endocrinol 10(12), 2014
PMID: 25287287

FGF21 is an endocrine signal of protein restriction
Laeger, J Clin Invest 124(), 2014

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR.
Gallinetti J, Harputlugil E, Mitchell JR., Biochem. J. 449(1), 2013
PMID: 23216249

Interplay between lipids and branched-chain amino acids in development of insulin resistance.
Newgard CB., Cell Metab. 15(5), 2012
PMID: 22560213

GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets.
McCarty MF., Med. Hypotheses 83(3), 2014
PMID: 25015767

High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China
Li, J Hepatol 58(), 2013

Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease.
Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, Badman MK, Martinez-Chantar ML, Maratos-Flier E., Gastroenterology 139(2), 2010
PMID: 20451522

The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy.
Liu J, Xu Y, Hu Y, Wang G., Metab. Clin. Exp. 64(3), 2014
PMID: 25516477

Fructose ingestion acutely stimulates circulating FGF21 levels in humans.
Dushay JR, Toschi E, Mitten EK, Fisher FM, Herman MA, Maratos-Flier E., Mol Metab 4(1), 2014
PMID: 25685689

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
von Holstein-Rathlou S, BonDurant LD, Peltekian L, Naber MC, Yin TC, Claflin KE, Urizar AI, Madsen AN, Ratner C, Holst B, Karstoft K, Vandenbeuch A, Anderson CB, Cassell MD, Thompson AP, Solomon TP, Rahmouni K, Kinnamon SC, Pieper AA, Gillum MP, Potthoff MJ., Cell Metab. 23(2), 2015
PMID: 26724858

Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin.
Mai K, Bobbert T, Groth C, Assmann A, Meinus S, Kraatz J, Andres J, Arafat AM, Pfeiffer AF, Mohlig M, Spranger J., Am. J. Physiol. Endocrinol. Metab. 299(1), 2010
PMID: 20424140

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans.
Theytaz F, Noguchi Y, Egli L, Campos V, Buehler T, Hodson L, Patterson BW, Nishikata N, Kreis R, Mittendorfer B, Fielding B, Boesch C, Tappy L., Am. J. Clin. Nutr. 96(5), 2012
PMID: 23034968

Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients.
Bortolotti M, Maiolo E, Corazza M, Van Dijke E, Schneiter P, Boss A, Carrel G, Giusti V, Le KA, Quo Chong DG, Buehler T, Kreis R, Boesch C, Tappy L., Clin Nutr 30(4), 2011
PMID: 21288612

High protein intake reduces intrahepatocellular lipid deposition in humans.
Bortolotti M, Kreis R, Debard C, Cariou B, Faeh D, Chetiveaux M, Ith M, Vermathen P, Stefanoni N, Le KA, Schneiter P, Krempf M, Vidal H, Boesch C, Tappy L., Am. J. Clin. Nutr. 90(4), 2009
PMID: 19710199

Increasing protein intake modulates lipid metabolism in healthy young men and women consuming a high-fat hypercaloric diet
Rietman, J Nutr 144(), 2014

Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes.
Machann J, Thamer C, Stefan N, Schwenzer NF, Kantartzis K, Haring HU, Claussen CD, Fritsche A, Schick F., Radiology 257(2), 2010
PMID: 20713612

Calculation of substrate oxidation rates in vivo from gaseous exchange
Frayn, J Appl Physiol Respir Environ Exerc Physiol 55(), 1983

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.
Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL., Am. J. Physiol. Endocrinol. Metab. 288(2), 2004
PMID: 15339742

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.
Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB., Hepatology 46(5), 2007
PMID: 17969036

The Enhanced Liver Fibrosis (ELF) score: normal values, influence factors and proposed cut-off values
Lichtinghagen, J Hepatol 59(), 2013

Splanchnic lipolysis in human obesity
Nielsen, J Clin Invest 113(), 2004

Serum n-6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study.
Yary T, Voutilainen S, Tuomainen TP, Ruusunen A, Nurmi T, Virtanen JK., Am. J. Clin. Nutr. 103(5), 2016
PMID: 27009754

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients.
Gallego-Escuredo JM, Gomez-Ambrosi J, Catalan V, Domingo P, Giralt M, Fruhbeck G, Villarroya F., Int J Obes (Lond) 39(1), 2014
PMID: 24813368

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice.
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE., Cell Metab. 17(5), 2013
PMID: 23663742

Hepatic Steatosis as a Marker of Metabolic Dysfunction.
Fabbrini E, Magkos F., Nutrients 7(6), 2015
PMID: 26102213

Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis.
Bradbury MW., Am. J. Physiol. Gastrointest. Liver Physiol. 290(2), 2006
PMID: 16407588

Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms.
Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S, Ponti V, Pagano G, Ferrannini E, Rizzetto M., Diabetologia 48(4), 2005
PMID: 15747110

Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content.
Fabbrini E, deHaseth D, Deivanayagam S, Mohammed BS, Vitola BE, Klein S., Obesity (Silver Spring) 17(1), 2008
PMID: 18948971

Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.
Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S., Gastroenterology 134(2), 2007
PMID: 18242210

Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver.
Iozzo P, Lautamaki R, Geisler F, Virtanen KA, Oikonen V, Haaparanta M, Yki-Jarvinen H, Ferrannini E, Knuuti J, Nuutila P., Diabetologia 47(7), 2004
PMID: 15243703

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.
Vatner DF, Majumdar SK, Kumashiro N, Petersen MC, Rahimi Y, Gattu AK, Bears M, Camporez JP, Cline GW, Jurczak MJ, Samuel VT, Shulman GI., Proc. Natl. Acad. Sci. U.S.A. 112(4), 2015
PMID: 25564660

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.
Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI., Cell 160(4), 2015
PMID: 25662011

The plasma lipidomic signature of nonalcoholic steatohepatitis.
Puri P, Wiest MM, Cheung O, Mirshahi F, Sargeant C, Min HK, Contos MJ, Sterling RK, Fuchs M, Zhou H, Watkins SM, Sanyal AJ., Hepatology 50(6), 2009
PMID: 19937697

Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial.
Bjermo H, Iggman D, Kullberg J, Dahlman I, Johansson L, Persson L, Berglund J, Pulkki K, Basu S, Uusitupa M, Rudling M, Arner P, Cederholm T, Ahlstrom H, Riserus U., Am. J. Clin. Nutr. 95(5), 2012
PMID: 22492369

Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis
Loomba, J Lipid Res 56(), 2015

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.
Sevastianova K, Santos A, Kotronen A, Hakkarainen A, Makkonen J, Silander K, Peltonen M, Romeo S, Lundbom J, Lundbom N, Olkkonen VM, Gylling H, Fielding BA, Rissanen A, Yki-Jarvinen H., Am. J. Clin. Nutr. 96(4), 2012
PMID: 22952180

A molecular model of human branched-chain amino acid metabolism.
Suryawan A, Hawes JW, Harris RA, Shimomura Y, Jenkins AE, Hutson SM., Am. J. Clin. Nutr. 68(1), 1998
PMID: 9665099

Muscle p70S6K phosphorylation in response to soy and dairy rich meals in middle aged men with metabolic syndrome: a randomised crossover trial.
Gran P, Larsen AE, Bonham M, Dordevic AL, Rupasinghe T, Silva C, Nahid A, Tull D, Sinclair AJ, Mitchell CJ, Cameron-Smith D., Nutr Metab (Lond) 11(1), 2014
PMID: 25302072

Feasibility and efficacy of an isocaloric high-protein vs. standard diet on insulin requirement, body weight and metabolic parameters in patients with type 2 diabetes on insulin therapy.
Luger M, Holstein B, Schindler K, Kruschitz R, Ludvik B., Exp. Clin. Endocrinol. Diabetes 121(5), 2013
PMID: 23674159

Fibroblast growth factor 21 is regulated by the IRE1alpha-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
Jiang, J Biol Chem 289(), 2014

Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.
Hale C, Chen MM, Stanislaus S, Chinookoswong N, Hager T, Wang M, Veniant MM, Xu J., Endocrinology 153(1), 2011
PMID: 22067317

FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho
Kharitonenkov, J Cell Physiol 215(), 2008

Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
Jobgen, J Nutr Biochem 17(), 2006

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.
Li H, Xu M, Lee J, He C, Xie Z., Am. J. Physiol. Endocrinol. Metab. 303(10), 2012
PMID: 22967499

Novel locus including FGF21 is associated with dietary macronutrient intake.
Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T, Ngwa JS; CHARGE Nutrition Working Group, Qi Q, Curhan GC, Rimm EB, Hunter DJ, Pasquale LR, Ridker PM, Hu FB, Chasman DI, Qi L; DietGen Consortium., Hum. Mol. Genet. 22(9), 2013
PMID: 23372041

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkila V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, McKeown NM, Mozaffarian D, Singleton A, Stirrups K, Viikari J, Ye Z, Bandinelli S, Barroso I, Deloukas P, Forouhi NG, Hofman A, Liu Y, Lyytikainen LP, North KE, Dimitriou M, Hallmans G, Kahonen M, Langenberg C, Ordovas JM, Uitterlinden AG, Hu FB, Kalafati IP, Raitakari O, Franco OH, Johnson A, Emilsson V, Schrack JA, Semba RD, Siscovick DS, Arnett DK, Borecki IB, Franks PW, Kritchevsky SB, Lehtimaki T, Loos RJ, Orho-Melander M, Rotter JI, Wareham NJ, Witteman JC, Ferrucci L, Dedoussis G, Cupples LA, Nettleton JA., Am. J. Clin. Nutr. 97(6), 2013
PMID: 23636237

FGF21 Regulates Sweet and Alcohol Preference.
Talukdar S, Owen BM, Song P, Hernandez G, Zhang Y, Zhou Y, Scott WT, Paratala B, Turner T, Smith A, Bernardo B, Muller CP, Tang H, Mangelsdorf DJ, Goodwin B, Kliewer SA., Cell Metab. 23(2), 2015
PMID: 26724861

Relationship between changes in serum levels of keratin 18 and changes in liver histology in children and adults with nonalcoholic fatty liver disease
Vuppalanchi, Clin Gastroenterol Hepatol 12(), 2014

Follow-up whole-body assessment of adipose tissue compartments during a lifestyle intervention in a large cohort at increased risk for type 2 diabetes.
Machann J, Thamer C, Stefan N, Schwenzer NF, Kantartzis K, Haring HU, Claussen CD, Fritsche A, Schick F., Radiology 257(2), 2010
PMID: 20713612

Topography mapping of whole body adipose tissue using A fully automated and standardized procedure
Wurslin, J Magn Reson Imaging 31(), 2010

Quantitative analysis of adipose tissue in single transverse slices for estimation of volumes of relevant fat tissue compartments: a study in a large cohort of subjects at risk for type 2 diabetes by MRI with comparison to anthropometric data.
Schwenzer NF, Machann J, Schraml C, Springer F, Ludescher B, Stefan N, Haring H, Fritsche A, Claussen CD, Schick F., Invest Radiol 45(12), 2010
PMID: 20829704

Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy.
Machann J, Thamer C, Schnoedt B, Stefan N, Haring HU, Claussen CD, Fritsche A, Schick F., Magn Reson Med 55(4), 2006
PMID: 16506186

Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: comparison with adipose tissue and plasma.
Baylin A, Kim MK, Donovan-Palmer A, Siles X, Dougherty L, Tocco P, Campos H., Am. J. Epidemiol. 162(4), 2005
PMID: 16014782

Free fatty acid metabolic profile and biomarkers of isolated post-challenge diabetes and type 2 diabetes mellitus based on GC-MS and multivariate statistical analysis
Liu, J Chromatogr B Analyt Technol Biomed Life Sci 878(), 2010