Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story

Obed A, Bashir A, Stern S, Jarrad A (2018)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Obed, Aiman; Bashir, Abdalla; Stern, SteffenUniBi; Jarrad, Anwar
Abstract / Bemerkung
Severe acute alcoholic liver disease (SAAH) unresponsive to medical therapy shows one-year-mortality rates of up to 90%. Most transplant centers request six months of alcohol abstinence prior to transplantation, the so-called "6-month rule." This regulation is not based on strong evidence, repeatedly making it a topic of controversial debates. The majority of patients with SAAH will die before fulfilling the 6-month rule. Therefore, liver transplantation (LT) protocols are becoming more flexible towards the rigid abstinence regulation, especially concerning SAAH patients. We conducted a literature review regarding LT in SAAH and its outcomes, including post-transplant mortality and recidivism. We studied available data on PubMed from 2011 and onwards whilst including articles dealing with genetic components, medical therapy and historic snapshots of alcoholism. Emerging studies recommend LT in SAAH not responding to medical therapies even without realizing the required abstinence period, since the majority of these patients would die within 6 months. SAAH without response to medical therapy has one-year-mortality rates of up to 90%. The 6-month rule is not based on strong evidence and is repeatedly a topic of controversial debates. There is genetic linkage to alcoholism and medical therapy is not as effective as estimated, yet. The 6-months-regulation has not shown to evidently decrease the risk of recidivism post-LT, which is a lifesaving treatment in SAAH patients. Insisting on rigid sobriety rules results in excluding patients with a low risk of recidivism from being transplanted. Moreover, the genetic linkage of alcoholism must be recognized.
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Obed A, Bashir A, Stern S, Jarrad A. Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. CLINICAL AND MOLECULAR HEPATOLOGY. 2018;24(4):358-366.
Obed, A., Bashir, A., Stern, S., & Jarrad, A. (2018). Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. CLINICAL AND MOLECULAR HEPATOLOGY, 24(4), 358-366. doi:10.3350/cmh.2018.0044
Obed, Aiman, Bashir, Abdalla, Stern, Steffen, and Jarrad, Anwar. 2018. “Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story”. CLINICAL AND MOLECULAR HEPATOLOGY 24 (4): 358-366.
Obed, A., Bashir, A., Stern, S., and Jarrad, A. (2018). Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. CLINICAL AND MOLECULAR HEPATOLOGY 24, 358-366.
Obed, A., et al., 2018. Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. CLINICAL AND MOLECULAR HEPATOLOGY, 24(4), p 358-366.
A. Obed, et al., “Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story”, CLINICAL AND MOLECULAR HEPATOLOGY, vol. 24, 2018, pp. 358-366.
Obed, A., Bashir, A., Stern, S., Jarrad, A.: Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. CLINICAL AND MOLECULAR HEPATOLOGY. 24, 358-366 (2018).
Obed, Aiman, Bashir, Abdalla, Stern, Steffen, and Jarrad, Anwar. “Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story”. CLINICAL AND MOLECULAR HEPATOLOGY 24.4 (2018): 358-366.

85 References

Daten bereitgestellt von Europe PubMed Central.

Alcoholic diseases in hepato-gastroenterology: a point of view.
Testino G., Hepatogastroenterology 55(82-83), 2008
PMID: 18613369
Vascular disorders of the liver.
Crawford JM., Clin Liver Dis 14(4), 2010
PMID: 21055687
EASL clinical practical guidelines: management of alcoholic liver disease.
European Association for the Study of Liver, Mathurin P, Hadengue A, Bataller R, Addolorato G, Burra P, Burt A, Caballeria J, Cortez-Pinto H, Day CP, Forrest EH, Gual A, Leon DA, Lligona A, Jepsen P, Mueller S, Pageaux GP, Roskams T, Seitz HK, Stickel F, Thursz M., J. Hepatol. 57(2), 2012
PMID: 22633836
Diagnosis and management of alcoholic hepatitis.
Sohail U, Satapathy SK., Clin Liver Dis 16(4), 2012
PMID: 23101979
Early liver transplantation for severe alcoholic hepatitis.
Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, Castel H, Duhamel A, Pageaux GP, Leroy V, Dharancy S, Louvet A, Boleslawski E, Lucidi V, Gustot T, Francoz C, Letoublon C, Castaing D, Belghiti J, Donckier V, Pruvot FR, Duclos-Vallee JC., N. Engl. J. Med. 365(19), 2011
PMID: 22070476
A shorter duration of pre-transplant abstinence predicts problem drinking after liver transplantation.
Tandon P, Goodman KJ, Ma MM, Wong WW, Mason AL, Meeberg G, Bergsten D, Carbonneau M, Bain VG., Am. J. Gastroenterol. 104(7), 2009
PMID: 19471253
Predictive factors of alcohol relapse after orthotopic liver transplantation for alcoholic liver disease.
Miguet M, Monnet E, Vanlemmens C, Gache P, Messner M, Hruskovsky S, Perarnau JM, Pageaux GP, Duvoux C, Minello A, Hillon P, Bresson-Hadni S, Mantion G, Miguet JP., Gastroenterol. Clin. Biol. 28(10 Pt 1), 2004
PMID: 15523219
Assessing priorities for allocation of donor liver grafts: survey of public and clinicians.
Neuberger J, Adams D, MacMaster P, Maidment A, Speed M., BMJ 317(7152), 1998
PMID: 9665895
Alcoholic liver disease.
O'Shea RS, Dasarathy S, McCullough AJ., Am. J. Gastroenterol. 105(1), 2009
PMID: 19904248
Alcoholic liver disease.
O'Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology., Hepatology 51(1), 2010
PMID: 20034030
Corticosteroid therapy of alcoholic hepatitis.
Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr., Gastroenterology 75(2), 1978
PMID: 352788
Prednisolone or pentoxifylline for alcoholic hepatitis.
Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH; STOPAH Trial, Thursz MR, Richardson P, Allison M, Austin A, Day CP, Gleeson D, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Roderick P, Stanton L, Wright M, Ryder S, Forrest EH, Bowers M, Downs JC, Ratcliffe I, Silk J, Hawkey C, Newsome P, Hepworth D, Falk S, Protheroe A, Stenning S, Standfield C, Abouda G, Agrawal A, Ala A, Aldersley M, Aspinall R, Bharathi S, Bramley P, Brind A, Christie J, Ch'ng CL, Cramp M, Collins C, Davis A, Dalziel H, Dear K, Dillon J, Fraser A, Forton D, Foster G, Foxton M, George K, Greenaway J, De Las Heras D, Heydtmann M, Holt A, Hood S, Hussaini H, James G, Jayaprakash A, Karmo M, Maltby J, Matull R, Mills P, Misra S, Mitchison H, Mitchell J, Moreea S, Morris J, Parker D, Perry M, Phillips M, Priest M, Saha S, Sen S, Sharer N, Singhal S, Sreedharan A, Saksena S, Shaw I, Singh G, Stewart S, Shorrock C, Smith A, Thompson S, Topping J, Vergis N, Vijayan B, Welfare M, Williams E, Wright G, Yeoman A., N. Engl. J. Med. 372(17), 2015
PMID: 25901427
The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids.
Louvet A, Naveau S, Abdelnour M, Ramond MJ, Diaz E, Fartoux L, Dharancy S, Texier F, Hollebecque A, Serfaty L, Boleslawski E, Deltenre P, Canva V, Pruvot FR, Mathurin P., Hepatology 45(6), 2007
PMID: 17518367
Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids.
Louvet A, Diaz E, Dharancy S, Coevoet H, Texier F, Thevenot T, Deltenre P, Canva V, Plane C, Mathurin P., J. Hepatol. 48(3), 2007
PMID: 18164508
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline.
Strieter RM, Remick DG, Ward PA, Spengler RN, Lynch JP 3rd, Larrick J, Kunkel SL., Biochem. Biophys. Res. Commun. 155(3), 1988
PMID: 2460096
Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial.
Akriviadis E, Botla R, Briggs W, Han S, Reynolds T, Shakil O., Gastroenterology 119(6), 2000
PMID: 11113085
Pentoxifylline vs. corticosteroid to treat severe alcoholic hepatitis: a randomised, non-inferiority, open trial.
Park SH, Kim DJ, Kim YS, Yim HJ, Tak WY, Lee HJ, Sohn JH, Yoon KT, Kim IH, Kim HS, Um SH, Baik SK, Lee JS, Suk KT, Kim SG, Suh SJ, Park SY, Kim TY, Jang JY; Korean Association for the Study of the Liver (KASL)-Alcohol Related Problems Study Group., J. Hepatol. 61(4), 2014
PMID: 24845609
Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis.
Nguyen-Khac E, Thevenot T, Piquet MA, Benferhat S, Goria O, Chatelain D, Tramier B, Dewaele F, Ghrib S, Rudler M, Carbonell N, Tossou H, Bental A, Bernard-Chabert B, Dupas JL; AAH-NAC Study Group, Decrombecque C, Brazier F, Bulant M, Bartoli E, Fahem R, Joly JP, Geslin G, Grigy C, Robert B, Coevoet H, Dahache K, Delcencerie R, Sevestre H, Beaumont C, Betsou F, Chaigneau C, Vastel E, Ollivier-Hourmand I, Dao T, Delaval G, Riachi G, di Martino V, Hammi R, Hezam H, Damaschin O., N. Engl. J. Med. 365(19), 2011
PMID: 22070475
A sober Reich? Alcohol and tobacco use in Nazi Germany.
Lewy J., Subst Use Misuse 41(8), 2006
PMID: 16798684

Götz A, Peter C, Pross C., 1994
[Liver graft].
WELCH CS., Maroc Med 34(359), 1955
PMID: 13296493
One-stage homotransplantation of the liver following total hepatectomy in dogs.
PMID: 13635834
PMID: 14100514
Current policies in hepatic transplantation: candidacy of patients with alcoholic liver disease or preformed antidonor antibodies and a reappraisal of biliary duct reconstruction.
Starzl TE, Putnam CW, Ishikawa M, Picache R, Husberg B, Halgrimson CG, Schroter G, Porter KA., Ann. N. Y. Acad. Sci. 252(), 1975
PMID: 1096710
Liver transplantation in the treatment of bleeding esophageal varices.
Iwatsuki S, Starzl TE, Todo S, Gordon RD, Tzakis AG, Marsh JW, Makowka L, Koneru B, Stieber A, Klintmalm G., Surgery 104(4), 1988
PMID: 3051474
Overview of the Genetics of Alcohol Use Disorder.
Tawa EA, Hall SD, Lohoff FW., Alcohol Alcohol. 51(5), 2016
PMID: 27445363
Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men.
Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG., Psychol Med 27(6), 1997
PMID: 9403910
The role of early life stress as a predictor for alcohol and drug dependence.
Enoch MA., Psychopharmacology (Berl.) 214(1), 2010
PMID: 20596857
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
Frank J, Cichon S, Treutlein J, Ridinger M, Mattheisen M, Hoffmann P, Herms S, Wodarz N, Soyka M, Zill P, Maier W, Mossner R, Gaebel W, Dahmen N, Scherbaum N, Schmal C, Steffens M, Lucae S, Ising M, Muller-Myhsok B, Nothen MM, Mann K, Kiefer F, Rietschel M., Addict Biol 17(1), 2011
PMID: 22004471
Diagnosis of alcoholic liver disease.
Torruellas C, French SW, Medici V., World J. Gastroenterol. 20(33), 2014
PMID: 25206273
Liver transplantation in patients with alcoholic cirrhosis: selection criteria and rates of survival and relapse.
Bird GL, O'Grady JG, Harvey FA, Calne RY, Williams R., BMJ 301(6742), 1990
PMID: 2383700
Orthotopic liver transplantation for alcoholic liver disease.
Kumar S, Stauber RE, Gavaler JS, Basista MH, Dindzans VJ, Schade RR, Rabinovitz M, Tarter RE, Gordon R, Starzl TE., Hepatology 11(2), 1990
PMID: 2307394
Predicting recidivism after orthotopic liver transplantation for alcoholic liver disease.
Osorio RW, Ascher NL, Avery M, Bacchetti P, Roberts JP, Lake JR., Hepatology 20(1 Pt 1), 1994
PMID: 8020879
Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients.
Obed A, Stern S, Jarrad A, Lorf T., World J. Gastroenterol. 21(14), 2015
PMID: 25892898

Caplan AL, Coelho DH., 1998
Responsibility, alcoholism, and liver transplantation.
Glannon W., J Med Philos 23(1), 1998
PMID: 9555633
Selection for and outcome of liver transplantation in alcoholic liver disease.
Lucey MR, Merion RM, Henley KS, Campbell DA Jr, Turcotte JG, Nostrant TT, Blow FC, Beresford TP., Gastroenterology 102(5), 1992
PMID: 1568583
Effects of alcohol abstinence on survival in cirrhotic portal hypertension: report from the Boston Inter-Hospital Liver Group
Soterakis J, Resnick R, Iber F., 1973
Cirrhotic portal hypertension: morbidity of continued alcoholism.
Pande NV, Resnick RH, Yee W, Eckardt VF, Shurberg JL., Gastroenterology 74(1), 1978
PMID: 618432
Priority setting: lessons from Oregon.
Dixon J, Welch HG., Lancet 337(8746), 1991
PMID: 1672977
Public and professional attitudes to transplanting alcoholic patients.
Neuberger J., Liver Transpl. 13(11 Suppl 2), 2007
PMID: 17969090
Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center.
Addolorato G, Mirijello A, Leggio L, Ferrulli A, D'Angelo C, Vassallo G, Cossari A, Gasbarrini G, Landolfi R, Agnes S, Gasbarrini A; Gemelli OLT Group, Abbate V, Abenavoli L, Antonelli M, Annicchiarico E, Avolio AW, Biolato M, Campanale C, Capristo E, Caputo F, Cesario V, Castagneto M, de Matthaeis N, Favale C, Ferrarese D, Garcovich M, Frongillo F, Grieco A, Malandrino N, Miele L, Milani A, Nesci A, Nure E, Pelecca G, Pepe G, Pietrogiacomi P, Pizzolante F, Pompili M, Ponziani FR, Rapaccini G, Riccardi L, Rinninella E, Santoro MC, Sganga G, Siciliano M, Vero V, Vonghia L., Alcohol. Clin. Exp. Res. 37(9), 2013
PMID: 23578009
Alcoholic hepatitis: current challenges and future directions.
Singal AK, Kamath PS, Gores GJ, Shah VH., Clin. Gastroenterol. Hepatol. 12(4), 2013
PMID: 23811249
Human carcinogenesis and alcohol in hepato-gastroenterology.
Testino G, Borro P, Ancarani O, Sumberaz A., Eur Rev Med Pharmacol Sci 16(4), 2012
PMID: 22696879
Should length of sobriety be a major determinant in liver transplant selection?
Rice JP, Lucey MR., Curr Opin Organ Transplant 18(3), 2013
PMID: 23492643
Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: an Italian position statement.
Testino G, Burra P, Bonino F, Piani F, Sumberaz A, Peressutti R, Giannelli Castiglione A, Patussi V, Fanucchi T, Ancarani O, De Cerce G, Iannini AT, Greco G, Mosti A, Durante M, Babocci P, Quartini M, Mioni D, Arico S, Baselice A, Leone S, Lozer F, Scafato E, Borro P; Group of Italian Regions., World J. Gastroenterol. 20(40), 2014
PMID: 25356027
Early Liver Transplantation for Severe Alcoholic Hepatitis in the United States--A Single-Center Experience.
Im GY, Kim-Schluger L, Shenoy A, Schubert E, Goel A, Friedman SL, Florman S, Schiano TD., Am. J. Transplant. 16(3), 2015
PMID: 26710309
Liver Transplantation for Alcoholic Liver Disease.
Addolorato G, Bataller R, Burra P, DiMartini A, Graziadei I, Lucey MR, Mathurin P, OʼGrady J, Pageaux G, Berenguer M., Transplantation 100(5), 2016
PMID: 26985744
Acute alcoholic hepatitis: a literature review and proposal of treatment.
Testino G, Leone S., Minerva Med. 109(4), 2017
PMID: 29115798
[Acute alcoholic hepatitis.]
Testino G, Scafato E, Patussi V., Recenti Prog Med 108(9), 2017
PMID: 28901345
Contemporary Policies Regarding Alcohol and Marijuana Use Among Liver Transplant Programs in the United States.
Zhu J, Chen PY, Frankel M, Selby RR, Fong TL., Transplantation 102(3), 2018
PMID: 29019813
Acute alcoholic hepatitis as indication for liver transplantation.
Jesudian AB, Brown RS Jr., Curr Opin Organ Transplant 21(2), 2016
PMID: 26867048
Orthotopic Liver Transplantation in Alcoholic Liver Disease Patients.
Germani G, Zanetto A, Ferrarese A, Russo FP, Senzolo M, Burra P., Rev Recent Clin Trials 11(3), 2016
PMID: 27527895
Three-year results of a pilot program in early liver transplantation for severe alcoholic hepatitis
Lee BP, Chen PH, Haugen C, Hernaez R, Gurakar A, Philosophe B., 2016
Role of liver transplantation in severe alcoholic hepatitis.
Daswani R, Kumar A, Sharma P, Singla V, Bansal N, Arora A., Clin Mol Hepatol 24(1), 2018
PMID: 29316778

Gutmann T, Schneewind KA, Schroth U, Schmidt VH, Elsässer A, Land W., 2003
Quality of life after liver transplantation for alcoholic liver disease.
Pereira SP, Howard LM, Muiesan P, Rela M, Heaton N, Williams R., Liver Transpl. 6(6), 2000
PMID: 11084065
Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking.
Kranzler HR, Armeli S, Wetherill R, Feinn R, Tennen H, Gelernter J, Covault J, Pond T., Addict Biol 21(2), 2014
PMID: 25496338
Alcohol addiction: a molecular biology perspective.
Ferraguti G, Pascale E, Lucarelli M., Curr. Med. Chem. 22(6), 2015
PMID: 25544474
Association of GABRG3 with alcohol dependence.
Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T., Alcohol. Clin. Exp. Res. 28(1), 2004
PMID: 14745296
The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages.
Dick DM, Bierut L, Hinrichs A, Fox L, Bucholz KK, Kramer J, Kuperman S, Hesselbrock V, Schuckit M, Almasy L, Tischfield J, Porjesz B, Begleiter H, Nurnberger J Jr, Xuei X, Edenberg HJ, Foroud T., Behav. Genet. 36(4), 2006
PMID: 16557364
Association between GABRA1 and drinking behaviors in the collaborative study on the genetics of alcoholism sample.
Dick DM, Plunkett J, Wetherill LF, Xuei X, Goate A, Hesselbrock V, Schuckit M, Crowe R, Edenberg HJ, Foroud T., Alcohol. Clin. Exp. Res. 30(7), 2006
PMID: 16792556
Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk.
Dick DM, Agrawal A, Wang JC, Hinrichs A, Bertelsen S, Bucholz KK, Schuckit M, Kramer J, Nurnberger J Jr, Tischfield J, Edenberg HJ, Goate A, Bierut LJ., Addiction 102(7), 2007
PMID: 17567401
Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.
Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, Budde JP, Goldstein EL, Kaplan D, Edenberg HJ, Nurnberger J Jr, Hesselbrock V, Schuckit M, Kuperman S, Tischfield J, Porjesz B, Begleiter H, Bierut LJ, Goate A., Alcohol. Clin. Exp. Res. 31(10), 2007
PMID: 17850642
Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition.
Jones KA, Porjesz B, Almasy L, Bierut L, Goate A, Wang JC, Dick DM, Hinrichs A, Kwon J, Rice JP, Rohrbaugh J, Stock H, Wu W, Bauer LO, Chorlian DB, Crowe RR, Edenberg HJ, Foroud T, Hesselbrock V, Kuperman S, Nurnberger J Jr, O'Connor SJ, Schuckit MA, Stimus AT, Tischfield JA, Reich T, Begleiter H., Int J Psychophysiol 53(2), 2004
PMID: 15210286
Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.
Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, Kwon JM, Wu W, Dick DM, Rice J, Jones K, Nurnberger JI Jr, Tischfield J, Porjesz B, Edenberg HJ, Hesselbrock V, Crowe R, Schuckit M, Begleiter H, Reich T, Goate AM, Bierut LJ., Hum. Mol. Genet. 13(17), 2004
PMID: 15229186
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM., Alcohol. Clin. Exp. Res. 31(2), 2007
PMID: 17250611
The Universal Declaration of Human Rights
Liver transplantation for alcoholic hepatitis: A survey of liver transplant centers.
Hasanin M, Dubay DA, McGuire BM, Schiano T, Singal AK., Liver Transpl. 21(11), 2015
PMID: 26136401
Liver transplantation for alcoholic hepatitis: A systematic review with meta-analysis.
Marot A, Dubois M, Trepo E, Moreno C, Deltenre P., PLoS ONE 13(1), 2018
PMID: 29324766
Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis.
Lee BP, Mehta N, Platt L, Gurakar A, Rice JP, Lucey MR, Im GY, Therapondos G, Han H, Victor DW, Fix OK, Dinges L, Dronamraju D, Hsu C, Voigt MD, Rinella ME, Maddur H, Eswaran S, Hause J, Foley D, Ghobrial RM, Dodge JL, Li Z, Terrault NA., Gastroenterology 155(2), 2018
PMID: 29655837
Early liver transplantation for severe alcoholic hepatitis: moving from controversy to consensus.
Lee BP, Terrault NA., Curr Opin Organ Transplant 23(2), 2018
PMID: 29389821
Impact of a first study of early transplantation in acute alcoholic hepatitis: Results of a nationwide survey in french liver transplantation programs.
Antonini TM, Guillaud O, Dumortier J, Dharancy S, Saliba F, Mathurin P, Duclos-Vallee JC, Duvoux C; for Groupe de Recherche Francais en Greffe de Foie (GReF2)., Liver Transpl. 24(6), 2018
PMID: 29476690

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