GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks

Shoshi A, Hofestädt R, Zolotareva O, Friedrichs M, Maier A, Ivanisenko VA, Dosenko VE, Bragina EY (2018)
JOURNAL OF INTEGRATIVE BIOINFORMATICS 15(4): 20180049.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The prevalence of comorbid diseases poses a major health issue for millions of people worldwide and an enormous socio-economic burden for society. The molecular mechanisms for the development of comorbidities need to be investigated. For this purpose, a workflow system was developed to aggregate data on biomedical entities from heterogeneous data sources. The process of integrating and merging all data sources of the workflow system was implemented as a semi-automatic pipeline that provides the import, fusion, and analysis of the highly connected biomedical data in a Neo4j database GenCoNet. As a starting point, data on the common comorbid diseases essential hypertension and bronchial asthma was integrated. GenCoNet (https: / /genconet.kalis-amts.de) is a curated database that provides a better understanding of hereditary bases of comorbidities.
Erscheinungsjahr
Zeitschriftentitel
JOURNAL OF INTEGRATIVE BIOINFORMATICS
Band
15
Ausgabe
4
Art.-Nr.
20180049
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Shoshi A, Hofestädt R, Zolotareva O, et al. GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks. JOURNAL OF INTEGRATIVE BIOINFORMATICS. 2018;15(4): 20180049.
Shoshi, A., Hofestädt, R., Zolotareva, O., Friedrichs, M., Maier, A., Ivanisenko, V. A., Dosenko, V. E., et al. (2018). GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks. JOURNAL OF INTEGRATIVE BIOINFORMATICS, 15(4), 20180049. doi:10.1515/jib-2018-0049
Shoshi, A., Hofestädt, R., Zolotareva, O., Friedrichs, M., Maier, A., Ivanisenko, V. A., Dosenko, V. E., and Bragina, E. Y. (2018). GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks. JOURNAL OF INTEGRATIVE BIOINFORMATICS 15:20180049.
Shoshi, A., et al., 2018. GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks. JOURNAL OF INTEGRATIVE BIOINFORMATICS, 15(4): 20180049.
A. Shoshi, et al., “GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks”, JOURNAL OF INTEGRATIVE BIOINFORMATICS, vol. 15, 2018, : 20180049.
Shoshi, A., Hofestädt, R., Zolotareva, O., Friedrichs, M., Maier, A., Ivanisenko, V.A., Dosenko, V.E., Bragina, E.Y.: GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks. JOURNAL OF INTEGRATIVE BIOINFORMATICS. 15, : 20180049 (2018).
Shoshi, Alban, Hofestädt, Ralf, Zolotareva, Olga, Friedrichs, Marcel, Maier, Alex, Ivanisenko, Vladimir A., Dosenko, Victor E., and Bragina, Elena Yu. “GenCoNet - A Graph Database for the Analysis of Comorbidities by Gene Networks”. JOURNAL OF INTEGRATIVE BIOINFORMATICS 15.4 (2018): 20180049.

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