Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases

Bragina EY, Goncharova IA, Garaeva AF, Nemerov, Evgeniy V, Babovskaya AA, Karpov AB, Semenova, Yulia V, Zhalsanova IZ, Gomboeva DE, Saik, Olga V, Zolotareva O, et al. (2018)
JOURNAL OF INTEGRATIVE BIOINFORMATICS 15(4): 20180052.

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Abstract / Bemerkung
Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand. A total of 96 eQTL SNPs were genotyped in 587 Russian individuals. Bronchial asthma alone was found to be associated with rs1927914 (TLR4), rs1928298 (intergenic variant), and rs1980616 (SERPINA1); hypertension alone was found to be associated with rs11065987 (intergenic variant); rs2284033 (IL2RB), rs11191582 (NT5C2), and rs11669386 (CARDS); comorbidity between asthma and hypertension was found to be associated with o rs1010461 (ANG/RNASE4), rs7038716, rs7026297 (LOC105376244), rs7025144 (intergenic variant), and rs2022318 (intergenic variant). The results suggest that genetic background of comorbidity of asthma and hypertension is En different from genetic backgrounds of both diseases manifesting isolated.
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JOURNAL OF INTEGRATIVE BIOINFORMATICS
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15
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4
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20180052
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Bragina EY, Goncharova IA, Garaeva AF, et al. Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. JOURNAL OF INTEGRATIVE BIOINFORMATICS. 2018;15(4): 20180052.
Bragina, E. Y., Goncharova, I. A., Garaeva, A. F., Nemerov, Evgeniy, V., Babovskaya, A. A., Karpov, A. B., Semenova, Yulia, V., et al. (2018). Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. JOURNAL OF INTEGRATIVE BIOINFORMATICS, 15(4), 20180052. doi:10.1515/jib-2018-0052
Bragina, E. Y., Goncharova, I. A., Garaeva, A. F., Nemerov, Evgeniy, V., Babovskaya, A. A., Karpov, A. B., Semenova, Yulia, V., Zhalsanova, I. Z., Gomboeva, D. E., Saik, Olga, V., et al. (2018). Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. JOURNAL OF INTEGRATIVE BIOINFORMATICS 15:20180052.
Bragina, E.Y., et al., 2018. Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. JOURNAL OF INTEGRATIVE BIOINFORMATICS, 15(4): 20180052.
E.Y. Bragina, et al., “Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases”, JOURNAL OF INTEGRATIVE BIOINFORMATICS, vol. 15, 2018, : 20180052.
Bragina, E.Y., Goncharova, I.A., Garaeva, A.F., Nemerov, Evgeniy, V., Babovskaya, A.A., Karpov, A.B., Semenova, Yulia, V., Zhalsanova, I.Z., Gomboeva, D.E., Saik, Olga, V., Zolotareva, O., Ivanisenko, V.A., Dosenko, V.E., Hofestädt, R., Freidin, M.B.: Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases. JOURNAL OF INTEGRATIVE BIOINFORMATICS. 15, : 20180052 (2018).
Bragina, Elena Yu, Goncharova, Irina A., Garaeva, Anna F., Nemerov, Evgeniy, V, Babovskaya, Anastasija A., Karpov, Andrey B., Semenova, Yulia, V, Zhalsanova, Irina Z., Gomboeva, Densema E., Saik, Olga, V, Zolotareva, Olga, Ivanisenko, Vladimir A., Dosenko, Victor E., Hofestädt, Ralf, and Freidin, Maxim B. “Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases”. JOURNAL OF INTEGRATIVE BIOINFORMATICS 15.4 (2018): 20180052.

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