In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas
Cazzamalli S, Figueras Agustí E, Petho L, Borbély AN, Steinkuhler C, Neri D, Sewald N (2018)
ACS Omega 3(11): 14726-14731.
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Autor*in
Cazzamalli, Samuele;
Figueras Agustí, EduardUniBi;
Petho, Lilla;
Borbély, Adina NoémiUniBi;
Steinkuhler, Christian;
Neri, Dario;
Sewald, NorbertUniBi 
Einrichtung
Abstract / Bemerkung
Traditional chemotherapeutics used in cancer therapy do not preferentially accumulate in tumor tissues. The conjugation to delivery vehicles like antibodies or small molecules has been proposed as a strategy to increase the tumor uptake and improve the therapeutic window of these drugs. Here, we report the synthesis and the biological evaluation of a novel small molecule-drug conjugate (SMDC) comprising a high-affinity bidentate acetazolamide derivative, targeting carbonic anhydrase IX (CAIX), and cryptophycin, a potent microtubule destabilizer. The biological activity of the novel SMDC was evaluated in vitro, measuring binding to the CAIX antigen by surface plasmon resonance and cytotoxicity against SKRC-52 cells. In vivo studies showed a delayed growth of tumors in nude mice bearing SKRC-52 renal cell carcinomas.
Erscheinungsjahr
2018
Zeitschriftentitel
ACS Omega
Band
3
Ausgabe
11
Seite(n)
14726-14731
Urheberrecht / Lizenzen
ISSN
2470-1343
Page URI
https://pub.uni-bielefeld.de/record/2932984
Zitieren
Cazzamalli S, Figueras Agustí E, Petho L, et al. In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas. ACS Omega. 2018;3(11):14726-14731.
Cazzamalli, S., Figueras Agustí, E., Petho, L., Borbély, A. N., Steinkuhler, C., Neri, D., & Sewald, N. (2018). In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas. ACS Omega, 3(11), 14726-14731. https://doi.org/10.1021/acsomega.8b02350
Cazzamalli, Samuele, Figueras Agustí, Eduard, Petho, Lilla, Borbély, Adina Noémi, Steinkuhler, Christian, Neri, Dario, and Sewald, Norbert. 2018. “In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas”. ACS Omega 3 (11): 14726-14731.
Cazzamalli, S., Figueras Agustí, E., Petho, L., Borbély, A. N., Steinkuhler, C., Neri, D., and Sewald, N. (2018). In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas. ACS Omega 3, 14726-14731.
Cazzamalli, S., et al., 2018. In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas. ACS Omega, 3(11), p 14726-14731.
S. Cazzamalli, et al., “In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas”, ACS Omega, vol. 3, 2018, pp. 14726-14731.
Cazzamalli, S., Figueras Agustí, E., Petho, L., Borbély, A.N., Steinkuhler, C., Neri, D., Sewald, N.: In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas. ACS Omega. 3, 14726-14731 (2018).
Cazzamalli, Samuele, Figueras Agustí, Eduard, Petho, Lilla, Borbély, Adina Noémi, Steinkuhler, Christian, Neri, Dario, and Sewald, Norbert. “In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas”. ACS Omega 3.11 (2018): 14726-14731.
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3 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Synthesis and Biological Evaluation of RGD⁻Cryptophycin Conjugates for Targeted Drug Delivery.
Borbély A, Figueras E, Martins A, Esposito S, Auciello G, Monteagudo E, Di Marco A, Summa V, Cordella P, Perego R, Kemker I, Frese M, Gallinari P, Steinkühler C, Sewald N., Pharmaceutics 11(4), 2019
PMID: 30939768
Borbély A, Figueras E, Martins A, Esposito S, Auciello G, Monteagudo E, Di Marco A, Summa V, Cordella P, Perego R, Kemker I, Frese M, Gallinari P, Steinkühler C, Sewald N., Pharmaceutics 11(4), 2019
PMID: 30939768
Octreotide Conjugates for Tumor Targeting and Imaging.
Figueras E, Martins A, Borbély A, Le Joncour V, Cordella P, Perego R, Modena D, Pagani P, Esposito S, Auciello G, Frese M, Gallinari P, Laakkonen P, Steinkühler C, Sewald N., Pharmaceutics 11(5), 2019
PMID: 31067748
Figueras E, Martins A, Borbély A, Le Joncour V, Cordella P, Perego R, Modena D, Pagani P, Esposito S, Auciello G, Frese M, Gallinari P, Laakkonen P, Steinkühler C, Sewald N., Pharmaceutics 11(5), 2019
PMID: 31067748
Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery.
Borbély A, Figueras E, Martins A, Bodero L, Raposo Moreira Dias A, López Rivas P, Pina A, Arosio D, Gallinari P, Frese M, Steinkühler C, Gennari C, Piarulli U, Sewald N., ChemistryOpen 8(6), 2019
PMID: 31275795
Borbély A, Figueras E, Martins A, Bodero L, Raposo Moreira Dias A, López Rivas P, Pina A, Arosio D, Gallinari P, Frese M, Steinkühler C, Gennari C, Piarulli U, Sewald N., ChemistryOpen 8(6), 2019
PMID: 31275795
68 References
Daten bereitgestellt von Europe PubMed Central.
Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.
Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS., Mol. Pharm. 15(6), 2018
PMID: 29715036
Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS., Mol. Pharm. 15(6), 2018
PMID: 29715036
Posttranslational Modifications and the Immunogenicity of Biotherapeutics.
Jefferis R., J Immunol Res 2016(), 2016
PMID: 27191002
Jefferis R., J Immunol Res 2016(), 2016
PMID: 27191002
Recent approaches for the synthesis of modified cryptophycins.
Weiss C, Sammet B, Sewald N., Nat Prod Rep 30(7), 2013
PMID: 23732943
Weiss C, Sammet B, Sewald N., Nat Prod Rep 30(7), 2013
PMID: 23732943
Approaches for the synthesis of functionalized cryptophycins.
Sammet B, Bogner T, Nahrwold M, Weiss C, Sewald N., J. Org. Chem. 75(20), 2010
PMID: 20857920
Sammet B, Bogner T, Nahrwold M, Weiss C, Sewald N., J. Org. Chem. 75(20), 2010
PMID: 20857920
Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C]docetaxel and positron emission tomography.
van der Veldt AA, Lubberink M, Mathijssen RH, Loos WJ, Herder GJ, Greuter HN, Comans EF, Rutten HB, Eriksson J, Windhorst AD, Hendrikse NH, Postmus PE, Smit EF, Lammertsma AA., Clin. Cancer Res. 19(15), 2013
PMID: 23620410
van der Veldt AA, Lubberink M, Mathijssen RH, Loos WJ, Herder GJ, Greuter HN, Comans EF, Rutten HB, Eriksson J, Windhorst AD, Hendrikse NH, Postmus PE, Smit EF, Lammertsma AA., Clin. Cancer Res. 19(15), 2013
PMID: 23620410
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
Wichert M, Krall N, Decurtins W, Franzini RM, Pretto F, Schneider P, Neri D, Scheuermann J., Nat Chem 7(3), 2015
PMID: 25698334
Wichert M, Krall N, Decurtins W, Franzini RM, Pretto F, Schneider P, Neri D, Scheuermann J., Nat Chem 7(3), 2015
PMID: 25698334
A multicenter phase II study of the cryptophycin analog LY355703 in patients with platinum-resistant ovarian cancer.
D'Agostino G, del Campo J, Mellado B, Izquierdo MA, Minarik T, Cirri L, Marini L, Perez-Gracia JL, Scambia G., Int. J. Gynecol. Cancer 16(1), 2006
PMID: 16445613
D'Agostino G, del Campo J, Mellado B, Izquierdo MA, Minarik T, Cirri L, Marini L, Perez-Gracia JL, Scambia G., Int. J. Gynecol. Cancer 16(1), 2006
PMID: 16445613
Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical.
Leamon CP, Parker MA, Vlahov IR, Xu LC, Reddy JA, Vetzel M, Douglas N., Bioconjug. Chem. 13(6), 2002
PMID: 12440854
Leamon CP, Parker MA, Vlahov IR, Xu LC, Reddy JA, Vetzel M, Douglas N., Bioconjug. Chem. 13(6), 2002
PMID: 12440854
Targeted drug delivery for cancer therapy: the other side of antibodies.
Firer MA, Gellerman G., J Hematol Oncol 5(), 2012
PMID: 23140144
Firer MA, Gellerman G., J Hematol Oncol 5(), 2012
PMID: 23140144
Novel unit B cryptophycin analogues as payloads for targeted therapy.
Figueras E, Borbely A, Ismail M, Frese M, Sewald N., Beilstein J Org Chem 14(), 2018
PMID: 29977395
Figueras E, Borbely A, Ismail M, Frese M, Sewald N., Beilstein J Org Chem 14(), 2018
PMID: 29977395
A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors.
Krall N, Pretto F, Decurtins W, Bernardes GJ, Supuran CT, Neri D., Angew. Chem. Int. Ed. Engl. 53(16), 2014
PMID: 24623670
Krall N, Pretto F, Decurtins W, Bernardes GJ, Supuran CT, Neri D., Angew. Chem. Int. Ed. Engl. 53(16), 2014
PMID: 24623670
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.
Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G., Med Res Rev 38(6), 2018
PMID: 29635752
Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G., Med Res Rev 38(6), 2018
PMID: 29635752
Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody-Drug Conjugates.
Dal Corso A, Cazzamalli S, Gebleux R, Mattarella M, Neri D., Bioconjug. Chem. 28(7), 2017
PMID: 28662334
Dal Corso A, Cazzamalli S, Gebleux R, Mattarella M, Neri D., Bioconjug. Chem. 28(7), 2017
PMID: 28662334
99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer.
Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW., J. Nucl. Med. 54(8), 2013
PMID: 23733925
Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW., J. Nucl. Med. 54(8), 2013
PMID: 23733925
A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo.
Dal Corso A, Gebleux R, Murer P, Soltermann A, Neri D., J Control Release 264(), 2017
PMID: 28867376
Dal Corso A, Gebleux R, Murer P, Soltermann A, Neri D., J Control Release 264(), 2017
PMID: 28867376
Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis.
Cazzamalli S, Dal Corso A, Widmayer F, Neri D., J. Am. Chem. Soc. 140(5), 2018
PMID: 29342352
Cazzamalli S, Dal Corso A, Widmayer F, Neri D., J. Am. Chem. Soc. 140(5), 2018
PMID: 29342352
The cryptophycins as potent payloads for antibody drug conjugates.
Verma VA, Pillow TH, DePalatis L, Li G, Phillips GL, Polson AG, Raab HE, Spencer S, Zheng B., Bioorg. Med. Chem. Lett. 25(4), 2015
PMID: 25613677
Verma VA, Pillow TH, DePalatis L, Li G, Phillips GL, Polson AG, Raab HE, Spencer S, Zheng B., Bioorg. Med. Chem. Lett. 25(4), 2015
PMID: 25613677
Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma.
Cazzamalli S, Corso AD, Neri D., J Control Release 246(), 2016
PMID: 27890855
Cazzamalli S, Corso AD, Neri D., J Control Release 246(), 2016
PMID: 27890855
Curative properties of noninternalizing antibody-drug conjugates based on maytansinoids.
Perrino E, Steiner M, Krall N, Bernardes GJ, Pretto F, Casi G, Neri D., Cancer Res. 74(9), 2014
PMID: 24520075
Perrino E, Steiner M, Krall N, Bernardes GJ, Pretto F, Casi G, Neri D., Cancer Res. 74(9), 2014
PMID: 24520075
Next generation antibody drugs: pursuit of the 'high-hanging fruit'.
Carter PJ, Lazar GA., Nat Rev Drug Discov 17(3), 2017
PMID: 29192287
Carter PJ, Lazar GA., Nat Rev Drug Discov 17(3), 2017
PMID: 29192287
Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors.
Ginj M, Zhang H, Waser B, Cescato R, Wild D, Wang X, Erchegyi J, Rivier J, Macke HR, Reubi JC., Proc. Natl. Acad. Sci. U.S.A. 103(44), 2006
PMID: 17056720
Ginj M, Zhang H, Waser B, Cescato R, Wild D, Wang X, Erchegyi J, Rivier J, Macke HR, Reubi JC., Proc. Natl. Acad. Sci. U.S.A. 103(44), 2006
PMID: 17056720
Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients.
van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, van der Hoeven JJ, Windhorst AD, Lammertsma AA, Lubberink M., Eur. J. Nucl. Med. Mol. Imaging 37(10), 2010
PMID: 20508935
van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, van der Hoeven JJ, Windhorst AD, Lammertsma AA, Lubberink M., Eur. J. Nucl. Med. Mol. Imaging 37(10), 2010
PMID: 20508935
Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors.
Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH., Invest New Drugs 23(3), 2005
PMID: 15868377
Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH., Invest New Drugs 23(3), 2005
PMID: 15868377
Targeting carbonic anhydrase IX with small organic ligands.
Wichert M, Krall N., Curr Opin Chem Biol 26(), 2015
PMID: 25721398
Wichert M, Krall N., Curr Opin Chem Biol 26(), 2015
PMID: 25721398
Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy.
Chen H, Lin Z, Arnst KE, Miller DD, Li W., Molecules 22(8), 2017
PMID: 28763044
Chen H, Lin Z, Arnst KE, Miller DD, Li W., Molecules 22(8), 2017
PMID: 28763044
Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2.
Cazzamalli S, Ziffels B, Widmayer F, Murer P, Pellegrini G, Pretto F, Wulhfard S, Neri D., Clin. Cancer Res. 24(15), 2018
PMID: 29691298
Cazzamalli S, Ziffels B, Widmayer F, Murer P, Pellegrini G, Pretto F, Wulhfard S, Neri D., Clin. Cancer Res. 24(15), 2018
PMID: 29691298
Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma.
Cazzamalli S, Dal Corso A, Neri D., Mol. Cancer Ther. 15(12), 2016
PMID: 27609641
Cazzamalli S, Dal Corso A, Neri D., Mol. Cancer Ther. 15(12), 2016
PMID: 27609641
Strategies and challenges for the next generation of antibody-drug conjugates.
Beck A, Goetsch L, Dumontet C, Corvaia N., Nat Rev Drug Discov 16(5), 2017
PMID: 28303026
Beck A, Goetsch L, Dumontet C, Corvaia N., Nat Rev Drug Discov 16(5), 2017
PMID: 28303026
Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis.
Nahrwold M, Weiß C, Bogner T, Mertink F, Conradi J, Sammet B, Palmisano R, Royo Gracia S, Preuße T, Sewald N., J. Med. Chem. 56(5), 2013
PMID: 23387527
Nahrwold M, Weiß C, Bogner T, Mertink F, Conradi J, Sammet B, Palmisano R, Royo Gracia S, Preuße T, Sewald N., J. Med. Chem. 56(5), 2013
PMID: 23387527
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK., Cancer Res. 55(17), 1995
PMID: 7641188
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK., Cancer Res. 55(17), 1995
PMID: 7641188
Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting.
Weiss C, Figueras E, Borbely AN, Sewald N., J. Pept. Sci. 23(7-8), 2017
PMID: 28661555
Weiss C, Figueras E, Borbely AN, Sewald N., J. Pept. Sci. 23(7-8), 2017
PMID: 28661555
Efficient synthesis of cryptophycin-52 and novel para-alkoxymethyl unit A analogues.
Eissler S, Bogner T, Nahrwold M, Sewald N., Chemistry 15(42), 2009
PMID: 19760734
Eissler S, Bogner T, Nahrwold M, Sewald N., Chemistry 15(42), 2009
PMID: 19760734
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Dorywalska M, Dushin R, Moine L, Farias SE, Zhou D, Navaratnam T, Lui V, Hasa-Moreno A, Casas MG, Tran TT, Delaria K, Liu SH, Foletti D, O'Donnell CJ, Pons J, Shelton DL, Rajpal A, Strop P., Mol. Cancer Ther. 15(5), 2016
PMID: 26944918
Dorywalska M, Dushin R, Moine L, Farias SE, Zhou D, Navaratnam T, Lui V, Hasa-Moreno A, Casas MG, Tran TT, Delaria K, Liu SH, Foletti D, O'Donnell CJ, Pons J, Shelton DL, Rajpal A, Strop P., Mol. Cancer Ther. 15(5), 2016
PMID: 26944918
Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.
Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS., Mol. Pharm. 15(6), 2018
PMID: 29715036
Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS., Mol. Pharm. 15(6), 2018
PMID: 29715036
Posttranslational Modifications and the Immunogenicity of Biotherapeutics.
Jefferis R., J Immunol Res 2016(), 2016
PMID: 27191002
Jefferis R., J Immunol Res 2016(), 2016
PMID: 27191002
Recent approaches for the synthesis of modified cryptophycins.
Weiss C, Sammet B, Sewald N., Nat Prod Rep 30(7), 2013
PMID: 23732943
Weiss C, Sammet B, Sewald N., Nat Prod Rep 30(7), 2013
PMID: 23732943
Approaches for the synthesis of functionalized cryptophycins.
Sammet B, Bogner T, Nahrwold M, Weiss C, Sewald N., J. Org. Chem. 75(20), 2010
PMID: 20857920
Sammet B, Bogner T, Nahrwold M, Weiss C, Sewald N., J. Org. Chem. 75(20), 2010
PMID: 20857920
Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C]docetaxel and positron emission tomography.
van der Veldt AA, Lubberink M, Mathijssen RH, Loos WJ, Herder GJ, Greuter HN, Comans EF, Rutten HB, Eriksson J, Windhorst AD, Hendrikse NH, Postmus PE, Smit EF, Lammertsma AA., Clin. Cancer Res. 19(15), 2013
PMID: 23620410
van der Veldt AA, Lubberink M, Mathijssen RH, Loos WJ, Herder GJ, Greuter HN, Comans EF, Rutten HB, Eriksson J, Windhorst AD, Hendrikse NH, Postmus PE, Smit EF, Lammertsma AA., Clin. Cancer Res. 19(15), 2013
PMID: 23620410
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
Wichert M, Krall N, Decurtins W, Franzini RM, Pretto F, Schneider P, Neri D, Scheuermann J., Nat Chem 7(3), 2015
PMID: 25698334
Wichert M, Krall N, Decurtins W, Franzini RM, Pretto F, Schneider P, Neri D, Scheuermann J., Nat Chem 7(3), 2015
PMID: 25698334
A multicenter phase II study of the cryptophycin analog LY355703 in patients with platinum-resistant ovarian cancer.
D'Agostino G, del Campo J, Mellado B, Izquierdo MA, Minarik T, Cirri L, Marini L, Perez-Gracia JL, Scambia G., Int. J. Gynecol. Cancer 16(1), 2006
PMID: 16445613
D'Agostino G, del Campo J, Mellado B, Izquierdo MA, Minarik T, Cirri L, Marini L, Perez-Gracia JL, Scambia G., Int. J. Gynecol. Cancer 16(1), 2006
PMID: 16445613
Synthesis and biological evaluation of EC20: a new folate-derived, (99m)Tc-based radiopharmaceutical.
Leamon CP, Parker MA, Vlahov IR, Xu LC, Reddy JA, Vetzel M, Douglas N., Bioconjug. Chem. 13(6), 2002
PMID: 12440854
Leamon CP, Parker MA, Vlahov IR, Xu LC, Reddy JA, Vetzel M, Douglas N., Bioconjug. Chem. 13(6), 2002
PMID: 12440854
Targeted drug delivery for cancer therapy: the other side of antibodies.
Firer MA, Gellerman G., J Hematol Oncol 5(), 2012
PMID: 23140144
Firer MA, Gellerman G., J Hematol Oncol 5(), 2012
PMID: 23140144
Novel unit B cryptophycin analogues as payloads for targeted therapy.
Figueras E, Borbely A, Ismail M, Frese M, Sewald N., Beilstein J Org Chem 14(), 2018
PMID: 29977395
Figueras E, Borbely A, Ismail M, Frese M, Sewald N., Beilstein J Org Chem 14(), 2018
PMID: 29977395
A small-molecule drug conjugate for the treatment of carbonic anhydrase IX expressing tumors.
Krall N, Pretto F, Decurtins W, Bernardes GJ, Supuran CT, Neri D., Angew. Chem. Int. Ed. Engl. 53(16), 2014
PMID: 24623670
Krall N, Pretto F, Decurtins W, Bernardes GJ, Supuran CT, Neri D., Angew. Chem. Int. Ed. Engl. 53(16), 2014
PMID: 24623670
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.
Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G., Med Res Rev 38(6), 2018
PMID: 29635752
Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G., Med Res Rev 38(6), 2018
PMID: 29635752
Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody-Drug Conjugates.
Dal Corso A, Cazzamalli S, Gebleux R, Mattarella M, Neri D., Bioconjug. Chem. 28(7), 2017
PMID: 28662334
Dal Corso A, Cazzamalli S, Gebleux R, Mattarella M, Neri D., Bioconjug. Chem. 28(7), 2017
PMID: 28662334
99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer.
Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW., J. Nucl. Med. 54(8), 2013
PMID: 23733925
Hillier SM, Maresca KP, Lu G, Merkin RD, Marquis JC, Zimmerman CN, Eckelman WC, Joyal JL, Babich JW., J. Nucl. Med. 54(8), 2013
PMID: 23733925
A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo.
Dal Corso A, Gebleux R, Murer P, Soltermann A, Neri D., J Control Release 264(), 2017
PMID: 28867376
Dal Corso A, Gebleux R, Murer P, Soltermann A, Neri D., J Control Release 264(), 2017
PMID: 28867376
Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis.
Cazzamalli S, Dal Corso A, Widmayer F, Neri D., J. Am. Chem. Soc. 140(5), 2018
PMID: 29342352
Cazzamalli S, Dal Corso A, Widmayer F, Neri D., J. Am. Chem. Soc. 140(5), 2018
PMID: 29342352
The cryptophycins as potent payloads for antibody drug conjugates.
Verma VA, Pillow TH, DePalatis L, Li G, Phillips GL, Polson AG, Raab HE, Spencer S, Zheng B., Bioorg. Med. Chem. Lett. 25(4), 2015
PMID: 25613677
Verma VA, Pillow TH, DePalatis L, Li G, Phillips GL, Polson AG, Raab HE, Spencer S, Zheng B., Bioorg. Med. Chem. Lett. 25(4), 2015
PMID: 25613677
Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma.
Cazzamalli S, Corso AD, Neri D., J Control Release 246(), 2016
PMID: 27890855
Cazzamalli S, Corso AD, Neri D., J Control Release 246(), 2016
PMID: 27890855
Curative properties of noninternalizing antibody-drug conjugates based on maytansinoids.
Perrino E, Steiner M, Krall N, Bernardes GJ, Pretto F, Casi G, Neri D., Cancer Res. 74(9), 2014
PMID: 24520075
Perrino E, Steiner M, Krall N, Bernardes GJ, Pretto F, Casi G, Neri D., Cancer Res. 74(9), 2014
PMID: 24520075
Next generation antibody drugs: pursuit of the 'high-hanging fruit'.
Carter PJ, Lazar GA., Nat Rev Drug Discov 17(3), 2017
PMID: 29192287
Carter PJ, Lazar GA., Nat Rev Drug Discov 17(3), 2017
PMID: 29192287
Radiolabeled somatostatin receptor antagonists are preferable to agonists for in vivo peptide receptor targeting of tumors.
Ginj M, Zhang H, Waser B, Cescato R, Wild D, Wang X, Erchegyi J, Rivier J, Macke HR, Reubi JC., Proc. Natl. Acad. Sci. U.S.A. 103(44), 2006
PMID: 17056720
Ginj M, Zhang H, Waser B, Cescato R, Wild D, Wang X, Erchegyi J, Rivier J, Macke HR, Reubi JC., Proc. Natl. Acad. Sci. U.S.A. 103(44), 2006
PMID: 17056720
Biodistribution and radiation dosimetry of 11C-labelled docetaxel in cancer patients.
van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, van der Hoeven JJ, Windhorst AD, Lammertsma AA, Lubberink M., Eur. J. Nucl. Med. Mol. Imaging 37(10), 2010
PMID: 20508935
van der Veldt AA, Hendrikse NH, Smit EF, Mooijer MP, Rijnders AY, Gerritsen WR, van der Hoeven JJ, Windhorst AD, Lammertsma AA, Lubberink M., Eur. J. Nucl. Med. Mol. Imaging 37(10), 2010
PMID: 20508935
Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors.
Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH., Invest New Drugs 23(3), 2005
PMID: 15868377
Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH., Invest New Drugs 23(3), 2005
PMID: 15868377
Targeting carbonic anhydrase IX with small organic ligands.
Wichert M, Krall N., Curr Opin Chem Biol 26(), 2015
PMID: 25721398
Wichert M, Krall N., Curr Opin Chem Biol 26(), 2015
PMID: 25721398
Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy.
Chen H, Lin Z, Arnst KE, Miller DD, Li W., Molecules 22(8), 2017
PMID: 28763044
Chen H, Lin Z, Arnst KE, Miller DD, Li W., Molecules 22(8), 2017
PMID: 28763044
Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2.
Cazzamalli S, Ziffels B, Widmayer F, Murer P, Pellegrini G, Pretto F, Wulhfard S, Neri D., Clin. Cancer Res. 24(15), 2018
PMID: 29691298
Cazzamalli S, Ziffels B, Widmayer F, Murer P, Pellegrini G, Pretto F, Wulhfard S, Neri D., Clin. Cancer Res. 24(15), 2018
PMID: 29691298
Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma.
Cazzamalli S, Dal Corso A, Neri D., Mol. Cancer Ther. 15(12), 2016
PMID: 27609641
Cazzamalli S, Dal Corso A, Neri D., Mol. Cancer Ther. 15(12), 2016
PMID: 27609641
Strategies and challenges for the next generation of antibody-drug conjugates.
Beck A, Goetsch L, Dumontet C, Corvaia N., Nat Rev Drug Discov 16(5), 2017
PMID: 28303026
Beck A, Goetsch L, Dumontet C, Corvaia N., Nat Rev Drug Discov 16(5), 2017
PMID: 28303026
Conjugates of modified cryptophycins and RGD-peptides enter target cells by endocytosis.
Nahrwold M, Weiß C, Bogner T, Mertink F, Conradi J, Sammet B, Palmisano R, Royo Gracia S, Preuße T, Sewald N., J. Med. Chem. 56(5), 2013
PMID: 23387527
Nahrwold M, Weiß C, Bogner T, Mertink F, Conradi J, Sammet B, Palmisano R, Royo Gracia S, Preuße T, Sewald N., J. Med. Chem. 56(5), 2013
PMID: 23387527
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK., Cancer Res. 55(17), 1995
PMID: 7641188
Yuan F, Dellian M, Fukumura D, Leunig M, Berk DA, Torchilin VP, Jain RK., Cancer Res. 55(17), 1995
PMID: 7641188
Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting.
Weiss C, Figueras E, Borbely AN, Sewald N., J. Pept. Sci. 23(7-8), 2017
PMID: 28661555
Weiss C, Figueras E, Borbely AN, Sewald N., J. Pept. Sci. 23(7-8), 2017
PMID: 28661555
Efficient synthesis of cryptophycin-52 and novel para-alkoxymethyl unit A analogues.
Eissler S, Bogner T, Nahrwold M, Sewald N., Chemistry 15(42), 2009
PMID: 19760734
Eissler S, Bogner T, Nahrwold M, Sewald N., Chemistry 15(42), 2009
PMID: 19760734
Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Dorywalska M, Dushin R, Moine L, Farias SE, Zhou D, Navaratnam T, Lui V, Hasa-Moreno A, Casas MG, Tran TT, Delaria K, Liu SH, Foletti D, O'Donnell CJ, Pons J, Shelton DL, Rajpal A, Strop P., Mol. Cancer Ther. 15(5), 2016
PMID: 26944918
Dorywalska M, Dushin R, Moine L, Farias SE, Zhou D, Navaratnam T, Lui V, Hasa-Moreno A, Casas MG, Tran TT, Delaria K, Liu SH, Foletti D, O'Donnell CJ, Pons J, Shelton DL, Rajpal A, Strop P., Mol. Cancer Ther. 15(5), 2016
PMID: 26944918
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