Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398

Busche T, Hillion M, Loi VV, Berg D, Walther B, Semmler T, Strommenger B, Witte W, Cuny C, Mellmann A, Holmes MA, et al. (2018)
MOLECULAR & CELLULAR PROTEOMICS 17(12): 2412-2433.

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Autor*in
Busche, TobiasUniBi; Hillion, Melanie; Loi, Vu Van; Berg, David; Walther, Birgit; Semmler, Torsten; Strommenger, Birgit; Witte, Wolfgang; Cuny, Christiane; Mellmann, Alexander; Holmes, Mark A.; Kalinowski, Joern
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Abstract / Bemerkung
The spread of methicillin-resistant Staphylococcus aureus (MRSA) in the community, hospitals and in livestock is mediated by highly diverse virulence factors that include secreted toxins, superantigens, enzymes and surface-associated adhesins allowing host adaptation and colonization. Here, we combined proteogenomics, secretome and phenotype analyses to compare the secreted virulence factors in selected S. aureus isolates of the dominant human- and livestock-associated genetic lineages CC8, CC22, and CC398. The proteogenomic comparison revealed 2181 core genes and 1306 accessory genes in 18 S. aureus isolates reflecting the high genome diversity. Using secretome analysis, we identified 869 secreted proteins with 538 commons in eight isolates of CC8, CC22, and CC398. These include 64 predicted extracellular and 37 cell surface proteins that account for 82.4% of total secretome abundance. Among the top 10 most abundantly secreted virulence factors are the major autolysins (Ati, IsaA, Sle1, SAUPAN006375000), lipases and lipoteichoic acid hydrolases (Lip, Geh, LtaS), cytolytic toxins (Hla, Hlb, Psmpi) and proteases (SspB). The CC398 isolates showed lower secretion of cell wall proteins, but higher secretion of alpha- and beta-hemolysins (Hla, Nib) which correlated with an increased Agr activity and strong hemolysis. CC398 strains were further characterized by lower biofilm formation and staphyloxanthin levels because of decreased SigB activity. Overall, comparative secretome analyses revealed CC8- or CC22-specific enterotoxin and Spl protease secretion as well as Agr- and SigB-controlled differences in exotoxin and surface protein secretion between human-specific and zoonotic lineages of S. aureus.
Erscheinungsjahr
2018
Zeitschriftentitel
MOLECULAR & CELLULAR PROTEOMICS
Band
17
Ausgabe
12
Seite(n)
2412-2433
ISSN
1535-9476
eISSN
1535-9484
Page URI
https://pub.uni-bielefeld.de/record/2932978

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Busche T, Hillion M, Loi VV, et al. Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. MOLECULAR & CELLULAR PROTEOMICS. 2018;17(12):2412-2433.
Busche, T., Hillion, M., Loi, V. V., Berg, D., Walther, B., Semmler, T., Strommenger, B., et al. (2018). Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. MOLECULAR & CELLULAR PROTEOMICS, 17(12), 2412-2433. doi:10.1074/mcp.RA118.001036
Busche, T., Hillion, M., Loi, V. V., Berg, D., Walther, B., Semmler, T., Strommenger, B., Witte, W., Cuny, C., Mellmann, A., et al. (2018). Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. MOLECULAR & CELLULAR PROTEOMICS 17, 2412-2433.
Busche, T., et al., 2018. Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. MOLECULAR & CELLULAR PROTEOMICS, 17(12), p 2412-2433.
T. Busche, et al., “Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398”, MOLECULAR & CELLULAR PROTEOMICS, vol. 17, 2018, pp. 2412-2433.
Busche, T., Hillion, M., Loi, V.V., Berg, D., Walther, B., Semmler, T., Strommenger, B., Witte, W., Cuny, C., Mellmann, A., Holmes, M.A., Kalinowski, J., Adrian, L., Bernhardt, J., Antelmann, H.: Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. MOLECULAR & CELLULAR PROTEOMICS. 17, 2412-2433 (2018).
Busche, Tobias, Hillion, Melanie, Loi, Vu Van, Berg, David, Walther, Birgit, Semmler, Torsten, Strommenger, Birgit, Witte, Wolfgang, Cuny, Christiane, Mellmann, Alexander, Holmes, Mark A., Kalinowski, Joern, Adrian, Lorenz, Bernhardt, Joerg, and Antelmann, Haike. “Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398”. MOLECULAR & CELLULAR PROTEOMICS 17.12 (2018): 2412-2433.

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Exoproteome Heterogeneity among Closely Related Staphylococcus aureus t437 Isolates and Possible Implications for Virulence.
Zhao X, Palma Medina LM, Stobernack T, Glasner C, de Jong A, Utari P, Setroikromo R, Quax WJ, Otto A, Becher D, Buist G, van Dijl JM., J Proteome Res 18(7), 2019
PMID: 31119940

226 References

Daten bereitgestellt von Europe PubMed Central.

Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.
Novick RP, Ross HF, Projan SJ, Kornblum J, Kreiswirth B, Moghazeh S., EMBO J. 12(10), 1993
PMID: 7691599
Genomic variation and evolution of Staphylococcus aureus.
Lindsay JA., Int. J. Med. Microbiol. 300(2-3), 2009
PMID: 19811948
Identification of Staphylococcus aureus genes involved in the formation of structured macrocolonies.
Wermser C, Lopez D., Microbiology (Reading, Engl.) 164(5), 2018
PMID: 29638209
Roary: rapid large-scale prokaryote pan genome analysis.
Page AJ, Cummins CA, Hunt M, Wong VK, Reuter S, Holden MT, Fookes M, Falush D, Keane JA, Parkhill J., Bioinformatics 31(22), 2015
PMID: 26198102
Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.
Kuhn ML, Prachi P, Minasov G, Shuvalova L, Ruan J, Dubrovska I, Winsor J, Giraldi M, Biagini M, Liberatori S, Savino S, Bagnoli F, Anderson WF, Grandi G., FASEB J. 28(4), 2014
PMID: 24421400
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.
Foster TJ, Geoghegan JA, Ganesh VK, Hook M., Nat. Rev. Microbiol. 12(1), 2014
PMID: 24336184
Diversity of prophages in dominant Staphylococcus aureus clonal lineages.
Goerke C, Pantucek R, Holtfreter S, Schulte B, Zink M, Grumann D, Broker BM, Doskar J, Wolz C., J. Bacteriol. 191(11), 2009
PMID: 19329640
Biofilm formation as microbial development.
O'Toole G, Kaplan HB, Kolter R., Annu. Rev. Microbiol. 54(), 2000
PMID: 11018124
Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases.
Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis JS, Sim RB, van Wamel WJ, van Kessel KP, van Strijp JA., Nat. Immunol. 6(9), 2005
PMID: 16086019
Two-dimensional analysis of exoproteins of methicillin-resistant Staphylococcus aureus (MRSA) for possible epidemiological applications.
Nakano M, Kawano Y, Kawagish M, Hasegawa T, Iinuma Y, Oht M., Microbiol. Immunol. 46(1), 2002
PMID: 11911184
Excretion of cytoplasmic proteins (ECP) in Staphylococcus aureus.
Ebner P, Prax M, Nega M, Koch I, Dube L, Yu W, Rinker J, Popella P, Flotenmeyer M, Gotz F., Mol. Microbiol. 97(4), 2015
PMID: 26009926
Staphylococcal innate immune evasion.
Rooijakkers SH, van Kessel KP, van Strijp JA., Trends Microbiol. 13(12), 2005
PMID: 16242332
Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398.
Jung P, Abdelbary MM, Kraushaar B, Fetsch A, Geisel J, Herrmann M, Witte W, Cuny C, Bischoff M., Vet. Microbiol. 200(), 2016
PMID: 26923248
MLST revisited: the gene-by-gene approach to bacterial genomics.
Maiden MC, Jansen van Rensburg MJ, Bray JE, Earle SG, Ford SA, Jolley KA, McCarthy ND., Nat. Rev. Microbiol. 11(10), 2013
PMID: 23979428
Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.
Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH., J. Immunol. 186(11), 2011
PMID: 21502375
Prokka: rapid prokaryotic genome annotation.
Seemann T., Bioinformatics 30(14), 2014
PMID: 24642063
The role of nasal carriage in Staphylococcus aureus infections.
Wertheim HF, Melles DC, Vos MC, van Leeuwen W, van Belkum A, Verbrugh HA, Nouwen JL., Lancet Infect Dis 5(12), 2005
PMID: 16310147
Staphylococcus aureus determinants for nasal colonization.
Weidenmaier C, Goerke C, Wolz C., Trends Microbiol. 20(5), 2012
PMID: 22494802
Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation.
Ziebandt AK, Kusch H, Degner M, Jaglitz S, Sibbald MJ, Arends JP, Chlebowicz MA, Albrecht D, Pantucek R, Doskar J, Ziebuhr W, Broker BM, Hecker M, van Dijl JM, Engelmann S., Proteomics 10(8), 2010
PMID: 20186749
Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis.
Schlievert PM, Strandberg KL, Lin YC, Peterson ML, Leung DY., J. Allergy Clin. Immunol. 125(1), 2010
PMID: 20109735
Methicillin-susceptible ST398 Staphylococcus aureus responsible for bloodstream infections: an emerging human-adapted subclone?
Valentin-Domelier AS, Girard M, Bertrand X, Violette J, Francois P, Donnio PY, Talon D, Quentin R, Schrenzel J, van der Mee-Marquet N; Bloodstream Infection Study Group of the Reseau des Hygienistes du Centre (RHC), Amirault P, Archambault M, Bachelier MN, Bloc D, Boucher M, Cattier B, Chandesris C, Chevereau V, Courouble G, Courtin MC, Decreux C, De Gialluly C, Denis C, Deperrois F, Fievre C, Foloppe P, Fongauffier F, Fournier-Hoock R, Girard N, Gourdet T, Graveron JL, Grobost F, Guillon MF, Guinard F, Harriau P, Hombrouck-Alet C, Imbault D, Jehanno D, Kourta MJ, Laurent O, Lehiani O, Lepineux Da Rocha A, Lesimple AL, Louvier X, Michel V, Morange V, Morel-Desjardins E, Morin E, Naudion C, Narbey D, Neveu C, Paba O, Perigois F, Petit Le Gouas G, Poitvin D, Prevost-Oussar M, Ratovohery D, Rousseau B, Roussin A, Secher A, Watt S., PLoS ONE 6(12), 2011
PMID: 22163008
The Staphylococcus aureus Two-Component System AgrAC Displays Four Distinct Genomic Arrangements That Delineate Genomic Virulence Factor Signatures.
Choudhary KS, Mih N, Monk J, Kavvas E, Yurkovich JT, Sakoulas G, Palsson BO., Front Microbiol 9(), 2018
PMID: 29887846
Excretion of cytosolic proteins (ECP) in bacteria.
Gotz F, Yu W, Dube L, Prax M, Ebner P., Int. J. Med. Microbiol. 305(2), 2014
PMID: 25596889
Staphylococcus aureus: a well-armed pathogen.
Archer GL., Clin. Infect. Dis. 26(5), 1998
PMID: 9597249
Biogeography and virulence of Staphylococcus aureus.
Fan J, Shu M, Zhang G, Zhou W, Jiang Y, Zhu Y, Chen G, Peacock SJ, Wan C, Pan W, Feil EJ., PLoS ONE 4(7), 2009
PMID: 19593449
Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus.
Peng HL, Novick RP, Kreiswirth B, Kornblum J, Schlievert P., J. Bacteriol. 170(9), 1988
PMID: 2457579
Tools for label-free peptide quantification.
Nahnsen S, Bielow C, Reinert K, Kohlbacher O., Mol. Cell Proteomics 12(3), 2012
PMID: 23250051
The impact of zoonotic MRSA colonization and infection in Germany.
Kock R, Ballhausen B, Bischoff M, Cuny C, Eckmanns T, Fetsch A, Harmsen D, Goerge T, Oberheitmann B, Schwarz S, Selhorst T, Tenhagen BA, Walther B, Witte W, Ziebuhr W, Becker K., Berl. Munch. Tierarztl. Wochenschr. 127(9-10), 2014
PMID: 25868166
Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.
Cox J, Hein MY, Luber CA, Paron I, Nagaraj N, Mann M., Mol. Cell Proteomics 13(9), 2014
PMID: 24942700
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
Holden MT, Hsu LY, Kurt K, Weinert LA, Mather AE, Harris SR, Strommenger B, Layer F, Witte W, de Lencastre H, Skov R, Westh H, Zemlickova H, Coombs G, Kearns AM, Hill RL, Edgeworth J, Gould I, Gant V, Cooke J, Edwards GF, McAdam PR, Templeton KE, McCann A, Zhou Z, Castillo-Ramirez S, Feil EJ, Hudson LO, Enright MC, Balloux F, Aanensen DM, Spratt BG, Fitzgerald JR, Parkhill J, Achtman M, Bentley SD, Nubel U., Genome Res. 23(4), 2013
PMID: 23299977
Evolution of methicillin-resistant Staphylococcus aureus towards increasing resistance.
Strommenger B, Bartels MD, Kurt K, Layer F, Rohde SM, Boye K, Westh H, Witte W, De Lencastre H, Nubel U., J. Antimicrob. Chemother. 69(3), 2013
PMID: 24150844
Regulation of exoprotein gene expression in Staphylococcus aureus by agar.
Recsei P, Kreiswirth B, O'Reilly M, Schlievert P, Gruss A, Novick RP., Mol. Gen. Genet. 202(1), 1986
PMID: 3007938
Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus.
Walther B, Monecke S, Ruscher C, Friedrich AW, Ehricht R, Slickers P, Soba A, Wleklinski CG, Wieler LH, Lubke-Becker A., J. Clin. Microbiol. 47(3), 2008
PMID: 19109463
Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
Bischoff M, Dunman P, Kormanec J, Macapagal D, Murphy E, Mounts W, Berger-Bachi B, Projan S., J. Bacteriol. 186(13), 2004
PMID: 15205410
What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?
Painter KL, Krishna A, Wigneshweraraj S, Edwards AM., Trends Microbiol. 22(12), 2014
PMID: 25300477
PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes.
Yu NY, Wagner JR, Laird MR, Melli G, Rey S, Lo R, Dao P, Sahinalp SC, Ester M, Foster LJ, Brinkman FS., Bioinformatics 26(13), 2010
PMID: 20472543
LA-MRSA CC398 differ from classical community acquired-MRSA and hospital acquired-MRSA lineages: functional analysis of infection and colonization processes.
Ballhausen B, Jung P, Kriegeskorte A, Makgotlho PE, Ruffing U, von Muller L, Kock R, Peters G, Herrmann M, Ziebuhr W, Becker K, Bischoff M., Int. J. Med. Microbiol. 304(7), 2014
PMID: 25034858
Recent emergence of Staphylococcus aureus clonal complex 398 in human blood cultures.
Verkade E, Bergmans AM, Budding AE, van Belkum A, Savelkoul P, Buiting AG, Kluytmans J., PLoS ONE 7(10), 2012
PMID: 23094014
Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8.
Strauß L, Stegger M, Akpaka PE, Alabi A, Breurec S, Coombs G, Egyir B, Larsen AR, Laurent F, Monecke S, Peters G, Skov R, Strommenger B, Vandenesch F, Schaumburg F, Mellmann A., Proc. Natl. Acad. Sci. U.S.A. 114(49), 2017
PMID: 29158405
Visualization of LC-MS/MS proteomics data in MaxQuant.
Tyanova S, Temu T, Carlson A, Sinitcyn P, Mann M, Cox J., Proteomics 15(8), 2015
PMID: 25644178
AureoWiki The repository of the Staphylococcus aureus research and annotation community.
Fuchs S, Mehlan H, Bernhardt J, Hennig A, Michalik S, Surmann K, Pane-Farre J, Giese A, Weiss S, Backert L, Herbig A, Nieselt K, Hecker M, Volker U, Mader U., Int. J. Med. Microbiol. 308(6), 2017
PMID: 29198880
Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition.
Koch G, Yepes A, Forstner KU, Wermser C, Stengel ST, Modamio J, Ohlsen K, Foster KR, Lopez D., Cell 158(5), 2014
PMID: 25171407
The pathogenicity and host adaptation of livestock-associated MRSA CC398.
Ballhausen B, Kriegeskorte A, van Alen S, Jung P, Kock R, Peters G, Bischoff M, Becker K., Vet. Microbiol. 200(), 2016
PMID: 27236228
Architecture of a Species: Phylogenomics of Staphylococcus aureus.
Planet PJ, Narechania A, Chen L, Mathema B, Boundy S, Archer G, Kreiswirth B., Trends Microbiol. 25(2), 2016
PMID: 27751626
Mass spectrometry-based proteomics turns quantitative.
Ong SE, Mann M., Nat. Chem. Biol. 1(5), 2005
PMID: 16408053
Commercial Biocides Induce Transfer of Prophage Φ13 from Human Strains of Staphylococcus aureus to Livestock CC398.
Tang Y, Nielsen LN, Hvitved A, Haaber JK, Wirtz C, Andersen PS, Larsen J, Wolz C, Ingmer H., Front Microbiol 8(), 2017
PMID: 29270158
Non-classical Protein Excretion Is Boosted by PSMα-Induced Cell Leakage.
Ebner P, Luqman A, Reichert S, Hauf K, Popella P, Forchhammer K, Otto M, Gotz F., Cell Rep 20(6), 2017
PMID: 28793253
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, Welty D, Long RD, Dorward DW, Gardner DJ, Lina G, Kreiswirth BN, DeLeo FR., J. Infect. Dis. 194(12), 2006
PMID: 17109350
Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis.
Wetzstein M, Volker U, Dedio J, Lobau S, Zuber U, Schiesswohl M, Herget C, Hecker M, Schumann W., J. Bacteriol. 174(10), 1992
PMID: 1339421
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
Stentzel S, Teufelberger A, Nordengrun M, Kolata J, Schmidt F, van Crombruggen K, Michalik S, Kumpfmuller J, Tischer S, Schweder T, Hecker M, Engelmann S, Volker U, Krysko O, Bachert C, Broker BM., J. Allergy Clin. Immunol. 139(2), 2016
PMID: 27315768
Proteomic characterization of the human centrosome by protein correlation profiling.
Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M., Nature 426(6966), 2003
PMID: 14654843
A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes.
Smagur J, Guzik K, Magiera L, Bzowska M, Gruca M, Thogersen IB, Enghild JJ, Potempa J., J Innate Immun 1(2), 2008
PMID: 20375568
Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present.
Bantscheff M, Lemeer S, Savitski MM, Kuster B., Anal Bioanal Chem 404(4), 2012
PMID: 22772140
The hyaluronate lyase of Staphylococcus aureus - a virulence factor?
Makris G, Wright JD, Ingham E, Holland KT., Microbiology (Reading, Engl.) 150(Pt 6), 2004
PMID: 15184586
Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria.
Novick RP, Muir TW., Curr. Opin. Microbiol. 2(1), 1999
PMID: 10047551
Andromeda: a peptide search engine integrated into the MaxQuant environment.
Cox J, Neuhauser N, Michalski A, Scheltema RA, Olsen JV, Mann M., J. Proteome Res. 10(4), 2011
PMID: 21254760
Differential gene expression in response to phenol and catechol reveals different metabolic activities for the degradation of aromatic compounds in Bacillus subtilis.
Tam le T, Eymann C, Albrecht D, Sietmann R, Schauer F, Hecker M, Antelmann H., Environ. Microbiol. 8(8), 2006
PMID: 16872404
2016 update of the PRIDE database and its related tools.
Vizcaino JA, Csordas A, Del-Toro N, Dianes JA, Griss J, Lavidas I, Mayer G, Perez-Riverol Y, Reisinger F, Ternent T, Xu QW, Wang R, Hermjakob H., Nucleic Acids Res. 44(22), 2016
PMID: 27683222
Complete Genome Sequence of the MRSA Isolate HC1335 from ST239 Lineage Displaying a Truncated AgrC Histidine Kinase Receptor.
Botelho AM, Costa MO, Beltrame CO, Ferreira FA, Lima NC, Costa BS, de Morais GL, Souza RC, Almeida LG, Vasconcelos AT, Nicolas MF, Figueiredo AM., Genome Biol Evol 8(10), 2016
PMID: 27635055
agr function in clinical Staphylococcus aureus isolates.
Traber KE, Lee E, Benson S, Corrigan R, Cantera M, Shopsin B, Novick RP., Microbiology (Reading, Engl.) 154(Pt 8), 2008
PMID: 18667559
What is MRSA?
Pantosti A, Venditti M., Eur. Respir. J. 34(5), 2009
PMID: 19880619
Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation.
Lauderdale KJ, Boles BR, Cheung AL, Horswill AR., Infect. Immun. 77(4), 2009
PMID: 19188357
Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage.
Schmidt T, Zundorf J, Gruger T, Brandenburg K, Reiners AL, Zinserling J, Witte W, Schnitzler N., Clin. Microbiol. Infect. 19(3), 2012
PMID: 22360315
A comparative analysis of computational approaches to relative protein quantification using peptide peak intensities in label-free LC-MS proteomics experiments.
Matzke MM, Brown JN, Gritsenko MA, Metz TO, Pounds JG, Rodland KD, Shukla AK, Smith RD, Waters KM, McDermott JE, Webb-Robertson BJ., Proteomics 13(3-4), 2012
PMID: 23019139
Pathogenesis of methicillin-resistant Staphylococcus aureus infection.
Gordon RJ, Lowy FD., Clin. Infect. Dis. 46 Suppl 5(), 2008
PMID: 18462090
Distribution of enterotoxin genes among carriage- and infection-associated isolates of Staphylococcus aureus.
Nashev D, Toshkova K, Bizeva L, Akineden O, Lammler C, Zschock M., Lett. Appl. Microbiol. 45(6), 2007
PMID: 17944839
An assessment of software solutions for the analysis of mass spectrometry based quantitative proteomics data.
Mueller LN, Brusniak MY, Mani DR, Aebersold R., J. Proteome Res. 7(1), 2008
PMID: 18173218
Mass spectrometry and protein analysis.
Domon B, Aebersold R., Science 312(5771), 2006
PMID: 16614208
The bacterial superantigen and superantigen-like proteins.
Fraser JD, Proft T., Immunol. Rev. 225(), 2008
PMID: 18837785
Secrets of the secretome in Staphylococcus aureus.
Kusch H, Engelmann S., Int. J. Med. Microbiol. 304(2), 2013
PMID: 24424242
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.
Spaan AN, van Strijp JAG, Torres VJ., Nat. Rev. Microbiol. 15(7), 2017
PMID: 28420883
Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus.
Bischoff M, Entenza JM, Giachino P., J. Bacteriol. 183(17), 2001
PMID: 11489871
Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages.
Smagur J, Guzik K, Bzowska M, Kuzak M, Zarebski M, Kantyka T, Walski M, Gajkowska B, Potempa J., Biol. Chem. 390(4), 2009
PMID: 19284294
Epidemiology of methicillin-resistant Staphylococcus aureus.
Boucher HW, Corey GR., Clin. Infect. Dis. 46 Suppl 5(), 2008
PMID: 18462089
S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics.
Chi BK, Gronau K, Mader U, Hessling B, Becher D, Antelmann H., Mol. Cell Proteomics 10(11), 2011
PMID: 21749987
Human antibody responses against non-covalently cell wall-bound Staphylococcus aureus proteins.
Romero Pastrana F, Neef J, Koedijk DGAM, de Graaf D, Duipmans J, Jonkman MF, Engelmann S, van Dijl JM, Buist G., Sci Rep 8(1), 2018
PMID: 29459694
Structure and biological activities of beta toxin from Staphylococcus aureus.
Huseby M, Shi K, Brown CK, Digre J, Mengistu F, Seo KS, Bohach GA, Schlievert PM, Ohlendorf DH, Earhart CA., J. Bacteriol. 189(23), 2007
PMID: 17873030
Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis.
Cheung GY, Wang R, Khan BA, Sturdevant DE, Otto M., Infect. Immun. 79(5), 2011
PMID: 21402769
SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.
Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, Lesin VM, Nikolenko SI, Pham S, Prjibelski AD, Pyshkin AV, Sirotkin AV, Vyahhi N, Tesler G, Alekseyev MA, Pevzner PA., J. Comput. Biol. 19(5), 2012
PMID: 22506599
Community-associated MRSA: what makes them special?
Otto M., Int. J. Med. Microbiol. 303(6-7), 2013
PMID: 23517691
Staphylococcus aureus genomics and the impact of horizontal gene transfer.
Lindsay JA., Int. J. Med. Microbiol. 304(2), 2013
PMID: 24439196
Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States.
Tenover FC, McDougal LK, Goering RV, Killgore G, Projan SJ, Patel JB, Dunman PM., J. Clin. Microbiol. 44(1), 2006
PMID: 16390957
Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus.
Loi VV, Busche T, Tedin K, Bernhardt J, Wollenhaupt J, Huyen NTT, Weise C, Kalinowski J, Wahl MC, Fulde M, Antelmann H., Antioxid. Redox Signal. 29(7), 2018
PMID: 29237286
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M., Mol. Cell 32(1), 2008
PMID: 18851841
Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock.
Price LB, Stegger M, Hasman H, Aziz M, Larsen J, Andersen PS, Pearson T, Waters AE, Foster JT, Schupp J, Gillece J, Driebe E, Liu CM, Springer B, Zdovc I, Battisti A, Franco A, Zmudzki J, Schwarz S, Butaye P, Jouy E, Pomba C, Porrero MC, Ruimy R, Smith TC, Robinson DA, Weese JS, Arriola CS, Yu F, Laurent F, Keim P, Skov R, Aarestrup FM., MBio 3(1), 2012
PMID: 22354957
Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions.
Geoghegan JA, Foster TJ., Curr. Top. Microbiol. Immunol. 409(), 2017
PMID: 26667044
The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia.
Paharik AE, Salgado-Pabon W, Meyerholz DK, White MJ, Schlievert PM, Horswill AR., mSphere 1(5), 2016
PMID: 27747296
Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus.
Ebner P, Rinker J, Nguyen MT, Popella P, Nega M, Luqman A, Schittek B, Di Marco M, Stevanovic S, Gotz F., Infect. Immun. 84(6), 2016
PMID: 27001537
Genomic and proteomic characterization of Staphylococcus aureus mastitis isolates of bovine origin.
Wolf C, Kusch H, Monecke S, Albrecht D, Holtfreter S, von Eiff C, Petzl W, Rainard P, Broker BM, Engelmann S., Proteomics 11(12), 2011
PMID: 21595036
Utilization of glycerophosphodiesters by Staphylococcus aureus.
Jorge AM, Schneider J, Unsleber S, Gohring N, Mayer C, Peschel A., Mol. Microbiol. 103(2), 2016
PMID: 27726204
Pore-forming toxins: ancient, but never really out of fashion.
Dal Peraro M, van der Goot FG., Nat. Rev. Microbiol. 14(2), 2015
PMID: 26639780
Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases.
Pietrocola G, Nobile G, Rindi S, Speziale P., Front Cell Infect Microbiol 7(), 2017
PMID: 28529927
Staphylococcus aureus infections.
Lowy FD., N. Engl. J. Med. 339(8), 1998
PMID: 9709046
Quantitative mass spectrometry in proteomics: a critical review.
Bantscheff M, Schirle M, Sweetman G, Rick J, Kuster B., Anal Bioanal Chem 389(4), 2007
PMID: 17668192
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.
Novick RP, Ross HF, Projan SJ, Kornblum J, Kreiswirth B, Moghazeh S., EMBO J. 12(10), 1993
PMID: 7691599
Genomic variation and evolution of Staphylococcus aureus.
Lindsay JA., Int. J. Med. Microbiol. 300(2-3), 2009
PMID: 19811948
Identification of Staphylococcus aureus genes involved in the formation of structured macrocolonies.
Wermser C, Lopez D., Microbiology (Reading, Engl.) 164(5), 2018
PMID: 29638209
Roary: rapid large-scale prokaryote pan genome analysis.
Page AJ, Cummins CA, Hunt M, Wong VK, Reuter S, Holden MT, Fookes M, Falush D, Keane JA, Parkhill J., Bioinformatics 31(22), 2015
PMID: 26198102
Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.
Kuhn ML, Prachi P, Minasov G, Shuvalova L, Ruan J, Dubrovska I, Winsor J, Giraldi M, Biagini M, Liberatori S, Savino S, Bagnoli F, Anderson WF, Grandi G., FASEB J. 28(4), 2014
PMID: 24421400
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.
Foster TJ, Geoghegan JA, Ganesh VK, Hook M., Nat. Rev. Microbiol. 12(1), 2014
PMID: 24336184
Diversity of prophages in dominant Staphylococcus aureus clonal lineages.
Goerke C, Pantucek R, Holtfreter S, Schulte B, Zink M, Grumann D, Broker BM, Doskar J, Wolz C., J. Bacteriol. 191(11), 2009
PMID: 19329640
Biofilm formation as microbial development.
O'Toole G, Kaplan HB, Kolter R., Annu. Rev. Microbiol. 54(), 2000
PMID: 11018124
Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases.
Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis JS, Sim RB, van Wamel WJ, van Kessel KP, van Strijp JA., Nat. Immunol. 6(9), 2005
PMID: 16086019
Two-dimensional analysis of exoproteins of methicillin-resistant Staphylococcus aureus (MRSA) for possible epidemiological applications.
Nakano M, Kawano Y, Kawagish M, Hasegawa T, Iinuma Y, Oht M., Microbiol. Immunol. 46(1), 2002
PMID: 11911184
Excretion of cytoplasmic proteins (ECP) in Staphylococcus aureus.
Ebner P, Prax M, Nega M, Koch I, Dube L, Yu W, Rinker J, Popella P, Flotenmeyer M, Gotz F., Mol. Microbiol. 97(4), 2015
PMID: 26009926
Staphylococcal innate immune evasion.
Rooijakkers SH, van Kessel KP, van Strijp JA., Trends Microbiol. 13(12), 2005
PMID: 16242332
Impact of bacteriophage Saint3 carriage on the immune evasion capacity and hemolytic potential of Staphylococcus aureus CC398.
Jung P, Abdelbary MM, Kraushaar B, Fetsch A, Geisel J, Herrmann M, Witte W, Cuny C, Bischoff M., Vet. Microbiol. 200(), 2016
PMID: 26923248
MLST revisited: the gene-by-gene approach to bacterial genomics.
Maiden MC, Jansen van Rensburg MJ, Bray JE, Earle SG, Ford SA, Jolley KA, McCarthy ND., Nat. Rev. Microbiol. 11(10), 2013
PMID: 23979428
Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.
Laarman AJ, Ruyken M, Malone CL, van Strijp JA, Horswill AR, Rooijakkers SH., J. Immunol. 186(11), 2011
PMID: 21502375
Prokka: rapid prokaryotic genome annotation.
Seemann T., Bioinformatics 30(14), 2014
PMID: 24642063
The role of nasal carriage in Staphylococcus aureus infections.
Wertheim HF, Melles DC, Vos MC, van Leeuwen W, van Belkum A, Verbrugh HA, Nouwen JL., Lancet Infect Dis 5(12), 2005
PMID: 16310147
Staphylococcus aureus determinants for nasal colonization.
Weidenmaier C, Goerke C, Wolz C., Trends Microbiol. 20(5), 2012
PMID: 22494802
Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation.
Ziebandt AK, Kusch H, Degner M, Jaglitz S, Sibbald MJ, Arends JP, Chlebowicz MA, Albrecht D, Pantucek R, Doskar J, Ziebuhr W, Broker BM, Hecker M, van Dijl JM, Engelmann S., Proteomics 10(8), 2010
PMID: 20186749
Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis.
Schlievert PM, Strandberg KL, Lin YC, Peterson ML, Leung DY., J. Allergy Clin. Immunol. 125(1), 2010
PMID: 20109735
Methicillin-susceptible ST398 Staphylococcus aureus responsible for bloodstream infections: an emerging human-adapted subclone?
Valentin-Domelier AS, Girard M, Bertrand X, Violette J, Francois P, Donnio PY, Talon D, Quentin R, Schrenzel J, van der Mee-Marquet N; Bloodstream Infection Study Group of the Reseau des Hygienistes du Centre (RHC), Amirault P, Archambault M, Bachelier MN, Bloc D, Boucher M, Cattier B, Chandesris C, Chevereau V, Courouble G, Courtin MC, Decreux C, De Gialluly C, Denis C, Deperrois F, Fievre C, Foloppe P, Fongauffier F, Fournier-Hoock R, Girard N, Gourdet T, Graveron JL, Grobost F, Guillon MF, Guinard F, Harriau P, Hombrouck-Alet C, Imbault D, Jehanno D, Kourta MJ, Laurent O, Lehiani O, Lepineux Da Rocha A, Lesimple AL, Louvier X, Michel V, Morange V, Morel-Desjardins E, Morin E, Naudion C, Narbey D, Neveu C, Paba O, Perigois F, Petit Le Gouas G, Poitvin D, Prevost-Oussar M, Ratovohery D, Rousseau B, Roussin A, Secher A, Watt S., PLoS ONE 6(12), 2011
PMID: 22163008
The Staphylococcus aureus Two-Component System AgrAC Displays Four Distinct Genomic Arrangements That Delineate Genomic Virulence Factor Signatures.
Choudhary KS, Mih N, Monk J, Kavvas E, Yurkovich JT, Sakoulas G, Palsson BO., Front Microbiol 9(), 2018
PMID: 29887846
Excretion of cytosolic proteins (ECP) in bacteria.
Gotz F, Yu W, Dube L, Prax M, Ebner P., Int. J. Med. Microbiol. 305(2), 2014
PMID: 25596889
Staphylococcus aureus: a well-armed pathogen.
Archer GL., Clin. Infect. Dis. 26(5), 1998
PMID: 9597249
Biogeography and virulence of Staphylococcus aureus.
Fan J, Shu M, Zhang G, Zhou W, Jiang Y, Zhu Y, Chen G, Peacock SJ, Wan C, Pan W, Feil EJ., PLoS ONE 4(7), 2009
PMID: 19593449
Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus.
Peng HL, Novick RP, Kreiswirth B, Kornblum J, Schlievert P., J. Bacteriol. 170(9), 1988
PMID: 2457579
Tools for label-free peptide quantification.
Nahnsen S, Bielow C, Reinert K, Kohlbacher O., Mol. Cell Proteomics 12(3), 2012
PMID: 23250051
The impact of zoonotic MRSA colonization and infection in Germany.
Kock R, Ballhausen B, Bischoff M, Cuny C, Eckmanns T, Fetsch A, Harmsen D, Goerge T, Oberheitmann B, Schwarz S, Selhorst T, Tenhagen BA, Walther B, Witte W, Ziebuhr W, Becker K., Berl. Munch. Tierarztl. Wochenschr. 127(9-10), 2014
PMID: 25868166
Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.
Cox J, Hein MY, Luber CA, Paron I, Nagaraj N, Mann M., Mol. Cell Proteomics 13(9), 2014
PMID: 24942700
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
Holden MT, Hsu LY, Kurt K, Weinert LA, Mather AE, Harris SR, Strommenger B, Layer F, Witte W, de Lencastre H, Skov R, Westh H, Zemlickova H, Coombs G, Kearns AM, Hill RL, Edgeworth J, Gould I, Gant V, Cooke J, Edwards GF, McAdam PR, Templeton KE, McCann A, Zhou Z, Castillo-Ramirez S, Feil EJ, Hudson LO, Enright MC, Balloux F, Aanensen DM, Spratt BG, Fitzgerald JR, Parkhill J, Achtman M, Bentley SD, Nubel U., Genome Res. 23(4), 2013
PMID: 23299977
Evolution of methicillin-resistant Staphylococcus aureus towards increasing resistance.
Strommenger B, Bartels MD, Kurt K, Layer F, Rohde SM, Boye K, Westh H, Witte W, De Lencastre H, Nubel U., J. Antimicrob. Chemother. 69(3), 2013
PMID: 24150844
Regulation of exoprotein gene expression in Staphylococcus aureus by agar.
Recsei P, Kreiswirth B, O'Reilly M, Schlievert P, Gruss A, Novick RP., Mol. Gen. Genet. 202(1), 1986
PMID: 3007938
Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus.
Walther B, Monecke S, Ruscher C, Friedrich AW, Ehricht R, Slickers P, Soba A, Wleklinski CG, Wieler LH, Lubke-Becker A., J. Clin. Microbiol. 47(3), 2008
PMID: 19109463
Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.
Bischoff M, Dunman P, Kormanec J, Macapagal D, Murphy E, Mounts W, Berger-Bachi B, Projan S., J. Bacteriol. 186(13), 2004
PMID: 15205410
What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?
Painter KL, Krishna A, Wigneshweraraj S, Edwards AM., Trends Microbiol. 22(12), 2014
PMID: 25300477
PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes.
Yu NY, Wagner JR, Laird MR, Melli G, Rey S, Lo R, Dao P, Sahinalp SC, Ester M, Foster LJ, Brinkman FS., Bioinformatics 26(13), 2010
PMID: 20472543
LA-MRSA CC398 differ from classical community acquired-MRSA and hospital acquired-MRSA lineages: functional analysis of infection and colonization processes.
Ballhausen B, Jung P, Kriegeskorte A, Makgotlho PE, Ruffing U, von Muller L, Kock R, Peters G, Herrmann M, Ziebuhr W, Becker K, Bischoff M., Int. J. Med. Microbiol. 304(7), 2014
PMID: 25034858
Recent emergence of Staphylococcus aureus clonal complex 398 in human blood cultures.
Verkade E, Bergmans AM, Budding AE, van Belkum A, Savelkoul P, Buiting AG, Kluytmans J., PLoS ONE 7(10), 2012
PMID: 23094014
Origin, evolution, and global transmission of community-acquired Staphylococcus aureus ST8.
Strauß L, Stegger M, Akpaka PE, Alabi A, Breurec S, Coombs G, Egyir B, Larsen AR, Laurent F, Monecke S, Peters G, Skov R, Strommenger B, Vandenesch F, Schaumburg F, Mellmann A., Proc. Natl. Acad. Sci. U.S.A. 114(49), 2017
PMID: 29158405
Visualization of LC-MS/MS proteomics data in MaxQuant.
Tyanova S, Temu T, Carlson A, Sinitcyn P, Mann M, Cox J., Proteomics 15(8), 2015
PMID: 25644178
AureoWiki The repository of the Staphylococcus aureus research and annotation community.
Fuchs S, Mehlan H, Bernhardt J, Hennig A, Michalik S, Surmann K, Pane-Farre J, Giese A, Weiss S, Backert L, Herbig A, Nieselt K, Hecker M, Volker U, Mader U., Int. J. Med. Microbiol. 308(6), 2017
PMID: 29198880
Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition.
Koch G, Yepes A, Forstner KU, Wermser C, Stengel ST, Modamio J, Ohlsen K, Foster KR, Lopez D., Cell 158(5), 2014
PMID: 25171407
The pathogenicity and host adaptation of livestock-associated MRSA CC398.
Ballhausen B, Kriegeskorte A, van Alen S, Jung P, Kock R, Peters G, Bischoff M, Becker K., Vet. Microbiol. 200(), 2016
PMID: 27236228
Architecture of a Species: Phylogenomics of Staphylococcus aureus.
Planet PJ, Narechania A, Chen L, Mathema B, Boundy S, Archer G, Kreiswirth B., Trends Microbiol. 25(2), 2016
PMID: 27751626
Mass spectrometry-based proteomics turns quantitative.
Ong SE, Mann M., Nat. Chem. Biol. 1(5), 2005
PMID: 16408053
Commercial Biocides Induce Transfer of Prophage Φ13 from Human Strains of Staphylococcus aureus to Livestock CC398.
Tang Y, Nielsen LN, Hvitved A, Haaber JK, Wirtz C, Andersen PS, Larsen J, Wolz C, Ingmer H., Front Microbiol 8(), 2017
PMID: 29270158
Non-classical Protein Excretion Is Boosted by PSMα-Induced Cell Leakage.
Ebner P, Luqman A, Reichert S, Hauf K, Popella P, Forchhammer K, Otto M, Gotz F., Cell Rep 20(6), 2017
PMID: 28793253
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?
Voyich JM, Otto M, Mathema B, Braughton KR, Whitney AR, Welty D, Long RD, Dorward DW, Gardner DJ, Lina G, Kreiswirth BN, DeLeo FR., J. Infect. Dis. 194(12), 2006
PMID: 17109350
Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis.
Wetzstein M, Volker U, Dedio J, Lobau S, Zuber U, Schiesswohl M, Herget C, Hecker M, Schumann W., J. Bacteriol. 174(10), 1992
PMID: 1339421
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
Stentzel S, Teufelberger A, Nordengrun M, Kolata J, Schmidt F, van Crombruggen K, Michalik S, Kumpfmuller J, Tischer S, Schweder T, Hecker M, Engelmann S, Volker U, Krysko O, Bachert C, Broker BM., J. Allergy Clin. Immunol. 139(2), 2016
PMID: 27315768
Proteomic characterization of the human centrosome by protein correlation profiling.
Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M., Nature 426(6966), 2003
PMID: 14654843
A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes.
Smagur J, Guzik K, Magiera L, Bzowska M, Gruca M, Thogersen IB, Enghild JJ, Potempa J., J Innate Immun 1(2), 2008
PMID: 20375568
Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present.
Bantscheff M, Lemeer S, Savitski MM, Kuster B., Anal Bioanal Chem 404(4), 2012
PMID: 22772140
The hyaluronate lyase of Staphylococcus aureus - a virulence factor?
Makris G, Wright JD, Ingham E, Holland KT., Microbiology (Reading, Engl.) 150(Pt 6), 2004
PMID: 15184586
Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria.
Novick RP, Muir TW., Curr. Opin. Microbiol. 2(1), 1999
PMID: 10047551
Andromeda: a peptide search engine integrated into the MaxQuant environment.
Cox J, Neuhauser N, Michalski A, Scheltema RA, Olsen JV, Mann M., J. Proteome Res. 10(4), 2011
PMID: 21254760
Differential gene expression in response to phenol and catechol reveals different metabolic activities for the degradation of aromatic compounds in Bacillus subtilis.
Tam le T, Eymann C, Albrecht D, Sietmann R, Schauer F, Hecker M, Antelmann H., Environ. Microbiol. 8(8), 2006
PMID: 16872404
2016 update of the PRIDE database and its related tools.
Vizcaino JA, Csordas A, Del-Toro N, Dianes JA, Griss J, Lavidas I, Mayer G, Perez-Riverol Y, Reisinger F, Ternent T, Xu QW, Wang R, Hermjakob H., Nucleic Acids Res. 44(22), 2016
PMID: 27683222
Complete Genome Sequence of the MRSA Isolate HC1335 from ST239 Lineage Displaying a Truncated AgrC Histidine Kinase Receptor.
Botelho AM, Costa MO, Beltrame CO, Ferreira FA, Lima NC, Costa BS, de Morais GL, Souza RC, Almeida LG, Vasconcelos AT, Nicolas MF, Figueiredo AM., Genome Biol Evol 8(10), 2016
PMID: 27635055
agr function in clinical Staphylococcus aureus isolates.
Traber KE, Lee E, Benson S, Corrigan R, Cantera M, Shopsin B, Novick RP., Microbiology (Reading, Engl.) 154(Pt 8), 2008
PMID: 18667559
What is MRSA?
Pantosti A, Venditti M., Eur. Respir. J. 34(5), 2009
PMID: 19880619
Interconnections between Sigma B, agr, and proteolytic activity in Staphylococcus aureus biofilm maturation.
Lauderdale KJ, Boles BR, Cheung AL, Horswill AR., Infect. Immun. 77(4), 2009
PMID: 19188357
Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage.
Schmidt T, Zundorf J, Gruger T, Brandenburg K, Reiners AL, Zinserling J, Witte W, Schnitzler N., Clin. Microbiol. Infect. 19(3), 2012
PMID: 22360315
A comparative analysis of computational approaches to relative protein quantification using peptide peak intensities in label-free LC-MS proteomics experiments.
Matzke MM, Brown JN, Gritsenko MA, Metz TO, Pounds JG, Rodland KD, Shukla AK, Smith RD, Waters KM, McDermott JE, Webb-Robertson BJ., Proteomics 13(3-4), 2012
PMID: 23019139
Pathogenesis of methicillin-resistant Staphylococcus aureus infection.
Gordon RJ, Lowy FD., Clin. Infect. Dis. 46 Suppl 5(), 2008
PMID: 18462090
Distribution of enterotoxin genes among carriage- and infection-associated isolates of Staphylococcus aureus.
Nashev D, Toshkova K, Bizeva L, Akineden O, Lammler C, Zschock M., Lett. Appl. Microbiol. 45(6), 2007
PMID: 17944839
An assessment of software solutions for the analysis of mass spectrometry based quantitative proteomics data.
Mueller LN, Brusniak MY, Mani DR, Aebersold R., J. Proteome Res. 7(1), 2008
PMID: 18173218
Mass spectrometry and protein analysis.
Domon B, Aebersold R., Science 312(5771), 2006
PMID: 16614208
The bacterial superantigen and superantigen-like proteins.
Fraser JD, Proft T., Immunol. Rev. 225(), 2008
PMID: 18837785
Secrets of the secretome in Staphylococcus aureus.
Kusch H, Engelmann S., Int. J. Med. Microbiol. 304(2), 2013
PMID: 24424242
Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.
Spaan AN, van Strijp JAG, Torres VJ., Nat. Rev. Microbiol. 15(7), 2017
PMID: 28420883
Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus.
Bischoff M, Entenza JM, Giachino P., J. Bacteriol. 183(17), 2001
PMID: 11489871
Staphylococcal cysteine protease staphopain B (SspB) induces rapid engulfment of human neutrophils and monocytes by macrophages.
Smagur J, Guzik K, Bzowska M, Kuzak M, Zarebski M, Kantyka T, Walski M, Gajkowska B, Potempa J., Biol. Chem. 390(4), 2009
PMID: 19284294
Epidemiology of methicillin-resistant Staphylococcus aureus.
Boucher HW, Corey GR., Clin. Infect. Dis. 46 Suppl 5(), 2008
PMID: 18462089
S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics.
Chi BK, Gronau K, Mader U, Hessling B, Becher D, Antelmann H., Mol. Cell Proteomics 10(11), 2011
PMID: 21749987
Human antibody responses against non-covalently cell wall-bound Staphylococcus aureus proteins.
Romero Pastrana F, Neef J, Koedijk DGAM, de Graaf D, Duipmans J, Jonkman MF, Engelmann S, van Dijl JM, Buist G., Sci Rep 8(1), 2018
PMID: 29459694
Structure and biological activities of beta toxin from Staphylococcus aureus.
Huseby M, Shi K, Brown CK, Digre J, Mengistu F, Seo KS, Bohach GA, Schlievert PM, Ohlendorf DH, Earhart CA., J. Bacteriol. 189(23), 2007
PMID: 17873030
Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis.
Cheung GY, Wang R, Khan BA, Sturdevant DE, Otto M., Infect. Immun. 79(5), 2011
PMID: 21402769
SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.
Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, Lesin VM, Nikolenko SI, Pham S, Prjibelski AD, Pyshkin AV, Sirotkin AV, Vyahhi N, Tesler G, Alekseyev MA, Pevzner PA., J. Comput. Biol. 19(5), 2012
PMID: 22506599
Community-associated MRSA: what makes them special?
Otto M., Int. J. Med. Microbiol. 303(6-7), 2013
PMID: 23517691
Staphylococcus aureus genomics and the impact of horizontal gene transfer.
Lindsay JA., Int. J. Med. Microbiol. 304(2), 2013
PMID: 24439196
Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States.
Tenover FC, McDougal LK, Goering RV, Killgore G, Projan SJ, Patel JB, Dunman PM., J. Clin. Microbiol. 44(1), 2006
PMID: 16390957
Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus.
Loi VV, Busche T, Tedin K, Bernhardt J, Wollenhaupt J, Huyen NTT, Weise C, Kalinowski J, Wahl MC, Fulde M, Antelmann H., Antioxid. Redox Signal. 29(7), 2018
PMID: 29237286
RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus.
Queck SY, Jameson-Lee M, Villaruz AE, Bach TH, Khan BA, Sturdevant DE, Ricklefs SM, Li M, Otto M., Mol. Cell 32(1), 2008
PMID: 18851841
Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock.
Price LB, Stegger M, Hasman H, Aziz M, Larsen J, Andersen PS, Pearson T, Waters AE, Foster JT, Schupp J, Gillece J, Driebe E, Liu CM, Springer B, Zdovc I, Battisti A, Franco A, Zmudzki J, Schwarz S, Butaye P, Jouy E, Pomba C, Porrero MC, Ruimy R, Smith TC, Robinson DA, Weese JS, Arriola CS, Yu F, Laurent F, Keim P, Skov R, Aarestrup FM., MBio 3(1), 2012
PMID: 22354957
Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions.
Geoghegan JA, Foster TJ., Curr. Top. Microbiol. Immunol. 409(), 2017
PMID: 26667044
The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia.
Paharik AE, Salgado-Pabon W, Meyerholz DK, White MJ, Schlievert PM, Horswill AR., mSphere 1(5), 2016
PMID: 27747296
Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus.
Ebner P, Rinker J, Nguyen MT, Popella P, Nega M, Luqman A, Schittek B, Di Marco M, Stevanovic S, Gotz F., Infect. Immun. 84(6), 2016
PMID: 27001537
Genomic and proteomic characterization of Staphylococcus aureus mastitis isolates of bovine origin.
Wolf C, Kusch H, Monecke S, Albrecht D, Holtfreter S, von Eiff C, Petzl W, Rainard P, Broker BM, Engelmann S., Proteomics 11(12), 2011
PMID: 21595036
Utilization of glycerophosphodiesters by Staphylococcus aureus.
Jorge AM, Schneider J, Unsleber S, Gohring N, Mayer C, Peschel A., Mol. Microbiol. 103(2), 2016
PMID: 27726204
Pore-forming toxins: ancient, but never really out of fashion.
Dal Peraro M, van der Goot FG., Nat. Rev. Microbiol. 14(2), 2015
PMID: 26639780
Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases.
Pietrocola G, Nobile G, Rindi S, Speziale P., Front Cell Infect Microbiol 7(), 2017
PMID: 28529927
Staphylococcus aureus infections.
Lowy FD., N. Engl. J. Med. 339(8), 1998
PMID: 9709046
Quantitative mass spectrometry in proteomics: a critical review.
Bantscheff M, Schirle M, Sweetman G, Rick J, Kuster B., Anal Bioanal Chem 389(4), 2007
PMID: 17668192

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