ENCODE and the parts of the human genome

Kaiser MI (2018)
Studies in history and philosophy of biological and biomedical sciences 72: 28-37.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Abstract / Bemerkung
This paper examines a specific kind of part-whole relations that exist in the molecular genetic domain. The central question is under which conditions a particular molecule, such as a DNA sequence, is a biological part of the human genome. I address this question by analyzing how biologists in fact partition the human genome into parts. This paper thus presents a case study in the metaphysics of biological practice. I develop a metaphysical account of genomic parthood by analyzing the investigative and reasoning practices in the ENCODE (ENCyclopedia Of DNA Elements) project. My account reveals two conditions that determine whether a molecule is a part of the human genome (i.e., a genomic part). First, genomic parts must possess a causal role function in the genome as a whole, that is, their functions must contribute to the genome directing the overall functioning of the cell. Second, genomic parts must have a specific chemical structure and be actual segments of the DNA sequence of the genome.
Stichworte
Part-whole relation; ENCODE; Genome; Causal role function; Structure
Erscheinungsjahr
2018
Zeitschriftentitel
Studies in history and philosophy of biological and biomedical sciences
Band
72
Seite(n)
28-37
ISSN
1369-8486
eISSN
1879-2499
Page URI
https://pub.uni-bielefeld.de/record/2932745

Zitieren

Kaiser MI. ENCODE and the parts of the human genome. Studies in history and philosophy of biological and biomedical sciences. 2018;72:28-37.
Kaiser, M. I. (2018). ENCODE and the parts of the human genome. Studies in history and philosophy of biological and biomedical sciences, 72, 28-37. doi:10.1016/j.shpsc.2018.10.008
Kaiser, M. I. (2018). ENCODE and the parts of the human genome. Studies in history and philosophy of biological and biomedical sciences 72, 28-37.
Kaiser, M.I., 2018. ENCODE and the parts of the human genome. Studies in history and philosophy of biological and biomedical sciences, 72, p 28-37.
M.I. Kaiser, “ENCODE and the parts of the human genome”, Studies in history and philosophy of biological and biomedical sciences, vol. 72, 2018, pp. 28-37.
Kaiser, M.I.: ENCODE and the parts of the human genome. Studies in history and philosophy of biological and biomedical sciences. 72, 28-37 (2018).
Kaiser, Marie I. “ENCODE and the parts of the human genome”. Studies in history and philosophy of biological and biomedical sciences 72 (2018): 28-37.

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 30385203
PubMed | Europe PMC

Suchen in

Google Scholar