ENCODE and the parts of the human genome

Kaiser MI (2018)
STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES 72: 28-37.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
This paper examines a specific kind of part-whole relations that exist in the molecular genetic domain. The central question is under which conditions a particular molecule, such as a DNA sequence, is a biological part of the human genome. I address this question by analyzing how biologists in fact partition the human genome into parts. This paper thus presents a case study in the metaphysics of biological practice. I develop a metaphysical account of genomic parthood by analyzing the investigative and reasoning practices in the ENCODE (ENCyclopedia Of DNA Elements) project. My account reveals two conditions that determine whether a molecule is a part of the human genome (i.e., a genomic part). First, genomic parts must possess a causal role function in the genome as a whole, that is, their functions must contribute to the genome directing the overall functioning of the cell. Second, genomic parts must have a specific chemical structure and be actual segments of the DNA sequence of the genome.
Erscheinungsjahr
Zeitschriftentitel
STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES
Band
72
Seite(n)
28-37
ISSN
eISSN
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Kaiser MI. ENCODE and the parts of the human genome. STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES. 2018;72:28-37.
Kaiser, M. I. (2018). ENCODE and the parts of the human genome. STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES, 72, 28-37. doi:10.1016/j.shpsc.2018.10.008
Kaiser, M. I. (2018). ENCODE and the parts of the human genome. STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES 72, 28-37.
Kaiser, M.I., 2018. ENCODE and the parts of the human genome. STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES, 72, p 28-37.
M.I. Kaiser, “ENCODE and the parts of the human genome”, STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES, vol. 72, 2018, pp. 28-37.
Kaiser, M.I.: ENCODE and the parts of the human genome. STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES. 72, 28-37 (2018).
Kaiser, Marie I. “ENCODE and the parts of the human genome”. STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE PART C. STUDIES IN HISTORY AND PHILOSOPHY OF BIOLOGICAL AND BIOMEDIAL SCIENCES 72 (2018): 28-37.

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PMID: 30385203
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