New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd

Sema DK, Lannang AM, Tatsimo SJN, Mujeeb-ur-Rehman M-ur-R, Yousuf S, Zoufou D, Iqbal U, Wansi JD, Sewald N, Choudhary MI (2018)
Phytochemistry Letters 26: 78-82.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Sema, Denis Kehdinga; Lannang, Alain Meli; Tatsimo, Simplice J. N.; Mujeeb-ur-Rehman, Mujeeb-ur-Rehman; Yousuf, Sammer; Zoufou, Denis; Iqbal, Urooj; Wansi, Jean Duplex; Sewald, NorbertUniBi ; Choudhary, M. Iqbal
Abstract / Bemerkung
Two new (1-2) and eight known (3-10) secondary metabolites were isolated from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Among them, an indane derivative kniphofiarindane (1), and naphthalene derivative kniphofiarexine (2), were identified as new natural products. 1D- and 2D-NMR spectroscopic studies together with single-crystal X-ray diffraction techniques were employed in the structural elucidation of the new compounds, 1 and 2. These compounds were evaluated for their cytotoxic effect against kidney epithelial cell line (LLC-MK2). Compound 3 was found to be highly cytotoxic, while compounds 1, and 10 showed moderate cytotoxicity with CC50 values of 4.44 +/- 0.79, 16.35 +/- 1.54, and 11.24 +/- 1.22 mu g/mL, respectively against the tested standard Gleevec (Imatinib), (CC (50) = 18.50 +/- 1.21 mu g/mL). Compounds 8, and 9 also showed moderate anti-inflammatory activity (CC (50 )= 38.7 +/- 4.90, and 20.00 +/- 4.40 mu g/mL, respectively) against ROS production.
Stichworte
Kniphofia reflexa; Indane; Cytotoxicity; LLC-MK2; Naphthalene; Anti-inflammatory
Erscheinungsjahr
2018
Zeitschriftentitel
Phytochemistry Letters
Band
26
Seite(n)
78-82
ISSN
1874-3900
eISSN
1876-7486
Page URI
https://pub.uni-bielefeld.de/record/2930512

Zitieren

Sema DK, Lannang AM, Tatsimo SJN, et al. New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Phytochemistry Letters. 2018;26:78-82.
Sema, D. K., Lannang, A. M., Tatsimo, S. J. N., Mujeeb-ur-Rehman, M. -ur- R., Yousuf, S., Zoufou, D., Iqbal, U., et al. (2018). New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Phytochemistry Letters, 26, 78-82. doi:10.1016/j.phytol.2018.05.025
Sema, D. K., Lannang, A. M., Tatsimo, S. J. N., Mujeeb-ur-Rehman, M. -ur- R., Yousuf, S., Zoufou, D., Iqbal, U., Wansi, J. D., Sewald, N., and Choudhary, M. I. (2018). New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Phytochemistry Letters 26, 78-82.
Sema, D.K., et al., 2018. New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Phytochemistry Letters, 26, p 78-82.
D.K. Sema, et al., “New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd”, Phytochemistry Letters, vol. 26, 2018, pp. 78-82.
Sema, D.K., Lannang, A.M., Tatsimo, S.J.N., Mujeeb-ur-Rehman, M.-ur-R., Yousuf, S., Zoufou, D., Iqbal, U., Wansi, J.D., Sewald, N., Choudhary, M.I.: New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd. Phytochemistry Letters. 26, 78-82 (2018).
Sema, Denis Kehdinga, Lannang, Alain Meli, Tatsimo, Simplice J. N., Mujeeb-ur-Rehman, Mujeeb-ur-Rehman, Yousuf, Sammer, Zoufou, Denis, Iqbal, Urooj, Wansi, Jean Duplex, Sewald, Norbert, and Choudhary, M. Iqbal. “New indane and naphthalene derivatives from the rhizomes of Kniphofia reflexa Hutchinson ex Codd”. Phytochemistry Letters 26 (2018): 78-82.

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