Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages

Herrera MG, Pizzuto M, Lonez C, Rott K, Hütten A, Sewald N, Ruysschaert J-M, Dodero VI (2018)
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14(4): 1417-1427.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Gliadin, an immunogenic protein present in wheat, is not fully degraded by humans and after the normal gastric and pancreatic digestion, the immunodominant 33-mer gliadin peptide remains unprocessed. The 33-mer gliadin peptide is found in human faeces and urine, proving not only its proteolytic resistance in vivo but more importantly its transport through the entire human body. Here, we demonstrate that 33-mer supramolecular structures larger than 220 nm induce the overexpression of nuclear factor kappa B (NF-kappa B) via a specific Toll-like Receptor (TLR) 2 and ( TLR) 4 dependent pathway and the secretion of pro-inflammatory cytokines such as IP-10/CXCL10 and TNF-alpha. Using helium ion microscopy, we elucidated the initial stages of oligomerisation of 33-mer gliadin peptide, showing that rod-like oligomers are nucleation sites for protofilament formation. The relevance of the 33-mer supramolecular structures in the early stages of the disease is paving new perspectives in the understanding of gluten-related disorders. (C) 2018 Elsevier Inc. All rights reserved.
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Zeitschriftentitel
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Band
14
Ausgabe
4
Seite(n)
1417-1427
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Herrera MG, Pizzuto M, Lonez C, et al. Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2018;14(4):1417-1427.
Herrera, M. G., Pizzuto, M., Lonez, C., Rott, K., Hütten, A., Sewald, N., Ruysschaert, J. - M., et al. (2018). Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 14(4), 1417-1427. doi:10.1016/j.nano.2018.04.014
Herrera, M. G., Pizzuto, M., Lonez, C., Rott, K., Hütten, A., Sewald, N., Ruysschaert, J. - M., and Dodero, V. I. (2018). Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14, 1417-1427.
Herrera, M.G., et al., 2018. Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 14(4), p 1417-1427.
M.G. Herrera, et al., “Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages”, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, vol. 14, 2018, pp. 1417-1427.
Herrera, M.G., Pizzuto, M., Lonez, C., Rott, K., Hütten, A., Sewald, N., Ruysschaert, J.-M., Dodero, V.I.: Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 14, 1417-1427 (2018).
Herrera, Maria Georgina, Pizzuto, Malvina, Lonez, Caroline, Rott, Karsten, Hütten, Andreas, Sewald, Norbert, Ruysschaert, Jean-Marie, and Dodero, Veronica Isabel. “Large supramolecular structures of 33-mer gliadin peptide activate toll-like receptors in macrophages”. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14.4 (2018): 1417-1427.

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Trehalose Modulates Autophagy Process to Counteract Gliadin Cytotoxicity in an In Vitro Celiac Disease Model.
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PMID: 31013754

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