3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21

Mahmoud MM, Abdel-Razek AS, Frese M, Soliman HSM, Sewald N, Shaaban M (2018)
MEDICINAL CHEMISTRY RESEARCH 27(7): 1834-1842.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Three new naturally-occurring 3,4-dihydroquinoline-2-one derivatives: 8-Hydroxy-3,4-dihydro-1H-quinolin-2-one (1), 3,4-dihydro-1H-quinolin-2-one (2) and 8-methoxy-3,4-dihydro-1H-quinolin-2-one (3), together with linoleic acid, glycerol monolinoleate and phenyl acetic acid were isolated from the Streptomyces sp. LGE21, derived from Lemna gibba. Structures of the new alkaloids (1-3) were determined by extensive 1D and 2D NMR, and MS measurements. In vitro cytotoxic studies of 1-3 and linoleic acid, in comparison with the original extract were assayed against liver cancer HEPG2 cell line and the human cervix carcinoma cell line (KB-3-1). The antimicrobial activity of the strain extract and compounds 1-3 were achieved as well. The new metabolites exhibited weak cytotoxic activities against cancer cell lines and growth inhibitory activity against a panel of tested bacterial strains.
Stichworte
New dihydroquinolin-2-ones; Extremophilic Streptomyces sp.; Taxonomy; Biological activity
Erscheinungsjahr
2018
Zeitschriftentitel
MEDICINAL CHEMISTRY RESEARCH
Band
27
Ausgabe
7
Seite(n)
1834-1842
ISSN
1054-2523
eISSN
1554-8120
Page URI
https://pub.uni-bielefeld.de/record/2921219

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Mahmoud MM, Abdel-Razek AS, Frese M, Soliman HSM, Sewald N, Shaaban M. 3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21. MEDICINAL CHEMISTRY RESEARCH. 2018;27(7):1834-1842.
Mahmoud, M. M., Abdel-Razek, A. S., Frese, M., Soliman, H. S. M., Sewald, N., & Shaaban, M. (2018). 3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21. MEDICINAL CHEMISTRY RESEARCH, 27(7), 1834-1842. doi:10.1007/s00044-018-2195-8
Mahmoud, M. M., Abdel-Razek, A. S., Frese, M., Soliman, H. S. M., Sewald, N., and Shaaban, M. (2018). 3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21. MEDICINAL CHEMISTRY RESEARCH 27, 1834-1842.
Mahmoud, M.M., et al., 2018. 3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21. MEDICINAL CHEMISTRY RESEARCH, 27(7), p 1834-1842.
M.M. Mahmoud, et al., “3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21”, MEDICINAL CHEMISTRY RESEARCH, vol. 27, 2018, pp. 1834-1842.
Mahmoud, M.M., Abdel-Razek, A.S., Frese, M., Soliman, H.S.M., Sewald, N., Shaaban, M.: 3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21. MEDICINAL CHEMISTRY RESEARCH. 27, 1834-1842 (2018).
Mahmoud, Manar M., Abdel-Razek, Ahmed S., Frese, Marcel, Soliman, Hesham S. M., Sewald, Norbert, and Shaaban, Mohamed. “3,4-Dihydro-quinolin-2-one derivatives from extremophilic Streptomyces sp LGE21”. MEDICINAL CHEMISTRY RESEARCH 27.7 (2018): 1834-1842.