Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes
Krüger T, Weiland S, Falck G, Gerlach M, Boschanski M, Alam S, Müller K, Dierks T, Sewald N (2018)
Angewandte Chemie International Edition 57(24): 7245-7249.
Zeitschriftenaufsatz
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Einrichtung
Abstract / Bemerkung
Formylglycine-generating enzymes are of increasing interest in the field of bioconjugation chemistry. They catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid C-formylglycine (FGly). This non-canonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions. The prototypic formylglycine-generating enzyme (FGE) and the iron-sulfur protein AtsB display slight variations in their recognition sequences. We designed specific tags in peptides and proteins that were selectively converted by the different enzymes. Combination of the different tag motifs within a single peptide or recombinant protein enabled the independent and consecutive introduction of two formylglycine residues and the generation of heterobifunctionalized protein conjugates.
Stichworte
bioconjugation;
enzyme catalysis;
formylglycine;
peptides;
radical-SAM;
enzymes
Erscheinungsjahr
2018
Zeitschriftentitel
Angewandte Chemie International Edition
Band
57
Ausgabe
24
Seite(n)
7245-7249
ISSN
1433-7851
eISSN
1521-3773
Page URI
https://pub.uni-bielefeld.de/record/2920942
Zitieren
Krüger T, Weiland S, Falck G, et al. Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes. Angewandte Chemie International Edition. 2018;57(24):7245-7249.
Krüger, T., Weiland, S., Falck, G., Gerlach, M., Boschanski, M., Alam, S., Müller, K., et al. (2018). Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes. Angewandte Chemie International Edition, 57(24), 7245-7249. https://doi.org/10.1002/anie.201803183
Krüger, Tobias, Weiland, Stefanie, Falck, Georg, Gerlach, Marcus, Boschanski, Mareile, Alam, Sarfaraz, Müller, Kristian, Dierks, Thomas, and Sewald, Norbert. 2018. “Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes”. Angewandte Chemie International Edition 57 (24): 7245-7249.
Krüger, T., Weiland, S., Falck, G., Gerlach, M., Boschanski, M., Alam, S., Müller, K., Dierks, T., and Sewald, N. (2018). Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes. Angewandte Chemie International Edition 57, 7245-7249.
Krüger, T., et al., 2018. Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes. Angewandte Chemie International Edition, 57(24), p 7245-7249.
T. Krüger, et al., “Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes”, Angewandte Chemie International Edition, vol. 57, 2018, pp. 7245-7249.
Krüger, T., Weiland, S., Falck, G., Gerlach, M., Boschanski, M., Alam, S., Müller, K., Dierks, T., Sewald, N.: Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes. Angewandte Chemie International Edition. 57, 7245-7249 (2018).
Krüger, Tobias, Weiland, Stefanie, Falck, Georg, Gerlach, Marcus, Boschanski, Mareile, Alam, Sarfaraz, Müller, Kristian, Dierks, Thomas, and Sewald, Norbert. “Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes”. Angewandte Chemie International Edition 57.24 (2018): 7245-7249.
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Two-Fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes
Krüger T (2019)
Bielefeld: Universität Bielefeld.
Krüger T (2019)
Bielefeld: Universität Bielefeld.
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