Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined

Neumann E, Kakorin S (2018)
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 47(4): 373-387.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
The chemical thermodynamic concept for membrane electroporation is critically revisited. The hysteresis in the electric field dependence of the rapid in-field electroporation events (on the in-field hysteresis branch) and the slower post-field pore resealing process (zero-field hysteresis branch) is a typical ensemble property involving rapid single-pore opening-closing events that are temporally and spatially distributed. In the case of spherical membrane shells in homogeneous external fields, the acting local field is dependent on the polar-angular position. Hence, the experimental state distribution constant and the ensemble rate coefficients are statistical position averages; they are cosine square averages of the polar angle. Advanced flux analysis uses the concept of time-dependent flux coefficients reflecting the kinetics of the rate-limiting structural processes of electroporation and membrane resealing. The explicit integral flux equations rationalize the sigmoid onset of the in-field kinetics and quantify the post-field-stretched exponentials as exponentials of exponentials. Finally, the new analytical proposal for the evaluation of the electric field strength dependence of global cell electroporation data starts with the low-field range and continues with iterative parameter optimisation over the entire field strength range.
Stichworte
Electroporation hysteresis; Electrothermodynamical analysis; Pore state; ensemble; Time-dependent flux coefficient; Single-pore state statistics
Erscheinungsjahr
2018
Zeitschriftentitel
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Band
47
Ausgabe
4
Seite(n)
373-387
ISSN
0175-7571
eISSN
1432-1017
Page URI
https://pub.uni-bielefeld.de/record/2920687

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Neumann E, Kakorin S. Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2018;47(4):373-387.
Neumann, E., & Kakorin, S. (2018). Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 47(4), 373-387. doi:10.1007/s00249-018-1305-3
Neumann, E., and Kakorin, S. (2018). Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 47, 373-387.
Neumann, E., & Kakorin, S., 2018. Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 47(4), p 373-387.
E. Neumann and S. Kakorin, “Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined”, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, vol. 47, 2018, pp. 373-387.
Neumann, E., Kakorin, S.: Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 47, 373-387 (2018).
Neumann, Eberhard, and Kakorin, Sergej. “Membrane electroporation: chemical thermodynamics and flux kinetics revisited and refined”. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 47.4 (2018): 373-387.

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