Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi

Mambou CS, Nono RN, Chouna JR, Tamokou J-de-D, Nkeng-Efouet-Alango P, Sewald N (2018)
ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C 73(5-6): 241-246.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
The antibacterial-guided investigation of the stem bark extract of Pseudocedrela kotschyi led to the isolation of a new secotirucallane triterpene derivative: 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid (1), together with the known one: 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (2) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic (3). The structures of the isolated compounds were elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy. Extracts, fractions and compounds (1-3) were tested in vitro for antibacterial activity against two Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus ATCC 25923), and two Gram negative bacteria (Escherichia coli S2(1) and Pseudomonas aeruginosa). The MeOH extract and the Hex/CH2Cl2 (70:30) fraction showed significant levels of activity (MIC = 64-256 mu g/mL) compared with the two reference drugs [ciprofloxacin: MIC (0.5-1 mu g/mL) and amoxicillin: MIC (1-128 mu g/mL)]. Moreover, the compound 2 isolated from this Hex/CH2Cl2 (70:30) fraction had the greatest potential value against S. aureus, E. coli and P. aeruginosa, with minimum inhibitory concentrations (MIC) ranging from 4-16 mu g/mL.
Stichworte
antibacterial; Meliaceae; Pseudocedrela kotschyi; secotirucallane; triterpenes
Erscheinungsjahr
2018
Zeitschriftentitel
ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C
Band
73
Ausgabe
5-6
Seite(n)
241-246
ISSN
0939-5075
eISSN
1865-7125
Page URI
https://pub.uni-bielefeld.de/record/2920325

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Mambou CS, Nono RN, Chouna JR, Tamokou J-de-D, Nkeng-Efouet-Alango P, Sewald N. Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C. 2018;73(5-6):241-246.
Mambou, C. S., Nono, R. N., Chouna, J. R., Tamokou, J. -de- D., Nkeng-Efouet-Alango, P., & Sewald, N. (2018). Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C, 73(5-6), 241-246. doi:10.1515/znc-2017-0207
Mambou, C. S., Nono, R. N., Chouna, J. R., Tamokou, J. -de- D., Nkeng-Efouet-Alango, P., and Sewald, N. (2018). Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C 73, 241-246.
Mambou, C.S., et al., 2018. Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C, 73(5-6), p 241-246.
C.S. Mambou, et al., “Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi”, ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C, vol. 73, 2018, pp. 241-246.
Mambou, C.S., Nono, R.N., Chouna, J.R., Tamokou, J.-de-D., Nkeng-Efouet-Alango, P., Sewald, N.: Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C. 73, 241-246 (2018).
Mambou, Christele Sorele, Nono, Raymond Ngansop, Chouna, Jean Rodolphe, Tamokou, Jean-de-Dieu, Nkeng-Efouet-Alango, Pepin, and Sewald, Norbert. “Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi”. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C 73.5-6 (2018): 241-246.

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