Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi

Mambou CS, Nono RN, Chouna JR, Tamokou J-de-D, Nkeng-Efouet-Alango P, Sewald N (2018)
ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C 73(5-6): 241-246.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The antibacterial-guided investigation of the stem bark extract of Pseudocedrela kotschyi led to the isolation of a new secotirucallane triterpene derivative: 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid (1), together with the known one: 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (2) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic (3). The structures of the isolated compounds were elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy. Extracts, fractions and compounds (1-3) were tested in vitro for antibacterial activity against two Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus ATCC 25923), and two Gram negative bacteria (Escherichia coli S2(1) and Pseudomonas aeruginosa). The MeOH extract and the Hex/CH2Cl2 (70:30) fraction showed significant levels of activity (MIC = 64-256 mu g/mL) compared with the two reference drugs [ciprofloxacin: MIC (0.5-1 mu g/mL) and amoxicillin: MIC (1-128 mu g/mL)]. Moreover, the compound 2 isolated from this Hex/CH2Cl2 (70:30) fraction had the greatest potential value against S. aureus, E. coli and P. aeruginosa, with minimum inhibitory concentrations (MIC) ranging from 4-16 mu g/mL.
Erscheinungsjahr
Zeitschriftentitel
ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C
Band
73
Ausgabe
5-6
Seite(n)
241-246
ISSN
eISSN
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Mambou CS, Nono RN, Chouna JR, Tamokou J-de-D, Nkeng-Efouet-Alango P, Sewald N. Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C. 2018;73(5-6):241-246.
Mambou, C. S., Nono, R. N., Chouna, J. R., Tamokou, J. -de- D., Nkeng-Efouet-Alango, P., & Sewald, N. (2018). Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C, 73(5-6), 241-246. doi:10.1515/znc-2017-0207
Mambou, C. S., Nono, R. N., Chouna, J. R., Tamokou, J. -de- D., Nkeng-Efouet-Alango, P., and Sewald, N. (2018). Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C 73, 241-246.
Mambou, C.S., et al., 2018. Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C, 73(5-6), p 241-246.
C.S. Mambou, et al., “Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi”, ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C, vol. 73, 2018, pp. 241-246.
Mambou, C.S., Nono, R.N., Chouna, J.R., Tamokou, J.-de-D., Nkeng-Efouet-Alango, P., Sewald, N.: Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C. 73, 241-246 (2018).
Mambou, Christele Sorele, Nono, Raymond Ngansop, Chouna, Jean Rodolphe, Tamokou, Jean-de-Dieu, Nkeng-Efouet-Alango, Pepin, and Sewald, Norbert. “Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi”. ZEITSCHRIFT FUER NATURFORSCHUNG SECTION C 73.5-6 (2018): 241-246.

25 References

Daten bereitgestellt von Europe PubMed Central.

Hepatoprotective and antioxidant effect of stem barks extracts: methanolic and aqueous of Pseudocedrela kotschyi (Meliaceae) on paracetamol-induced hepatic damage in rats
AUTHOR UNKNOWN, Asian J Biomed Pharm Sci 7(), 2017
Phytochemical, analgesic and anti-inflammatory effects of the ethylacetate extract of the leaves of Pseudocedrella kotschyii
AUTHOR UNKNOWN, Afr J Tradit Complement Altern Med 5(), 2008
Revision of the structure of limonoid pseudrelone B from Pseudocedrela kotschyii
AUTHOR UNKNOWN, Phytochemistry 27(), 1988
Structural characterization of tetranortriterpenes from Pseudrocedrela kotschyi and Trichilia emetica and study of their activity towards the chaperone Hsp90.
Piaz FD, Malafronte N, Romano A, Gallotta D, Belisario MA, Bifulco G, Gualtieri MJ, Sanogo R, Tommasi ND, Pisano C., Phytochemistry 75(), 2012
PMID: 22226245
Evaluation of the antiulcer properties of Pseudocedrela kotschyi stem bark extract
AUTHOR UNKNOWN, Disc Innov 13(), 2001
Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens.
Tamokou Jde D, Tala MF, Wabo HK, Kuiate JR, Tane P., J Ethnopharmacol 124(3), 2009
PMID: 19464353
Toxicological evaluation of the aqueous extract of Pseudocedrela kotschyi (Meliaceae) stem bark in albino rats
AUTHOR UNKNOWN, J Pharm Biol Sci 5(), 2017
Antimicrobial activity of extracts of leaves of Pseudocedrela kotschyi (Schweinf) Harms
AUTHOR UNKNOWN, Afr J Biotechnol 9(), 2010
A limonoid, pseudrelone B, from Pseudocedrela kotschyii
AUTHOR UNKNOWN, Phytochemistry 18(), 1979
Inhibition of in-vitro growth of Plasmodium falciparum by Pseudocedrela kotschyi extract alone and in combination with Fagara zanthoxyloides extract.
Kassim OO, Loyevsky M, Amonoo H, Lashley L, Ako-Nai KA, Gordeuk VR., Trans. R. Soc. Trop. Med. Hyg. 103(7), 2009
PMID: 19328510
Complex secondary metabolites from Ludwigia leptocarpa with potent antibacterial and antioxidant activities.
Mabou FD, Tamokou JD, Ngnokam D, Voutquenne-Nazabadioko L, Kuiate JR, Bag PK., Drug Discov Ther 10(3), 2016
PMID: 27431270
B, C and 7-deacetoxy-7-oxogedunin from the trunk wood of Pseudocedrela kotschyii
AUTHOR UNKNOWN, Tetrahedron Lett 36(), 1967
Nephroprotective activities of ethanolic roots extract of Pseudocedrela kotschyi against oxidative stress and nephrotoxicity in alloxan induced diabetic albino rats
AUTHOR UNKNOWN, Br J Pharmacol Toxicol 5(), 2014
Antileishmanial activities associated with plants used in the Malian traditional medicine.
Ahua KM, Ioset JR, Ioset KN, Diallo D, Mauel J, Hostettmann K., J Ethnopharmacol 110(1), 2006
PMID: 17097842
Kostchyienones A and B, new antiplasmodial and cytotoxicity of limonoids from the roots of Pseudocedrela kotschyi (Schweinf.) Harms.
Sidjui LS, Nganso YOD, Toghueo RMK, Wakeu BNK, Dameue JT, Mkounga P, Adhikari A, Lateef M, Folefoc GN, Ali MS., Z. Naturforsch., C, J. Biosci. 73(3-4), 2018
PMID: 28917086
Effect of extract of Pseudocedrela kotscyi on blood glucose concentration of alloxan induced diabetic albino rats
AUTHOR UNKNOWN, East J Med 14(), 2009
In-vitro antimicrobial activities of methanol extracts of Zanthoxylum xanthoxyloides and Pseudocedrela kotschyi
AUTHOR UNKNOWN, Afr J Biomed Res 13(), 2010
Natural resins and bioactive natural products thereof as potential antimicrobial agents.
Termentzi A, Fokialakis N, Skaltsounis AL., Curr. Pharm. Des. 17(13), 2011
PMID: 21470116
Antinociceptive activity of the crude methanolic extract of Pseudocedrela kotschyi and its chloroform and n-butanol fractions in mice
AUTHOR UNKNOWN, J Pharmacol Biomed Sci 6(), 2016
Recent advances in antitubercular natural products.
Garcia A, Bocanegra-Garcia V, Palma-Nicolas JP, Rivera G., Eur J Med Chem 49(), 2012
PMID: 22280816

AUTHOR UNKNOWN, 1958
Traditional medicine in north Cote-d'Ivoire: screening of 50 medicinal plants for antibacterial activity.
Kone WM, Atindehou KK, Terreaux C, Hostettmann K, Traore D, Dosso M., J Ethnopharmacol 93(1), 2004
PMID: 15182903
Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.
Hay AE, Ioset JR, Ahua KM, Diallo D, Brun R, Hostettmann K., J. Nat. Prod. 70(1), 2007
PMID: 17253841
Tetranortriterpenoids and related compounds. Part 25. Two 3,4-secotirucallane derivatives and 2′-hydroxyrohitukin from the bark of Guarea cedrata (Meliaceae)
AUTHOR UNKNOWN, Can J Chem 58(), 1980

AUTHOR UNKNOWN, 1986

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