Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity

Hartmann M, Zeier T, Bernsdorff F, Reichel-Deland V, Kim D, Hohmann M, Scholten N, Schuck S, Bräutigam A, Hoelzel T, Ganter C, et al. (2018)
Cell 173(2): 456-469.e16.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 4.59 MB
Autor*in
Hartmann, Michael; Zeier, Tatyana; Bernsdorff, Friederike; Reichel-Deland, Vanessa; Kim, Denis; Hohmann, Michele; Scholten, Nicola; Schuck, Stefan; Bräutigam, AndreaUniBi ; Hoelzel, Torsten; Ganter, Christian; Zeier, Juergen
Alle
Abstract / Bemerkung
Following a previous microbial inoculation, plants can induce broad-spectrum immunity to pathogen infection, a phenomenon known as systemic acquired resistance (SAR). SAR establishment in Arabidopsis thaliana is regulated by the Lys catabolite pipecolic acid (Pip) and flavin-dependent-monooxygenase1 (FMO1). Here, we show that elevated Pip is sufficient to induce an FMO1-dependent transcriptional reprogramming of leaves that is reminiscent of SAR. In planta and in vitro analyses demonstrate that FMO1 functions as a pipecolate N-hydroxylase, catalyzing the biochemical conversion of Pip to N-hydroxypipecolic acid (NHP). NHP-systemically accumulates in plants after microbial attack. When exogenously applied, it overrides the defect of NHP-deficient fmo1 in acquired resistance and acts as a potent inducer of plant immunity to bacterial and oomycete infection. Our work has identified a pathogen-inducible L-Lys catabolic pathway in plants that generates the N-hydroxylated amino acid NHP as a critical regulator of systemic acquired resistance to pathogen infection.
Erscheinungsjahr
2018
Zeitschriftentitel
Cell
Band
173
Ausgabe
2
Seite(n)
456-469.e16
ISSN
0092-8674
eISSN
1097-4172
Page URI
https://pub.uni-bielefeld.de/record/2919293

Zitieren

Hartmann M, Zeier T, Bernsdorff F, et al. Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell. 2018;173(2):456-469.e16.
Hartmann, M., Zeier, T., Bernsdorff, F., Reichel-Deland, V., Kim, D., Hohmann, M., Scholten, N., et al. (2018). Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell, 173(2), 456-469.e16. doi:10.1016/j.cell.2018.02.049
Hartmann, M., Zeier, T., Bernsdorff, F., Reichel-Deland, V., Kim, D., Hohmann, M., Scholten, N., Schuck, S., Bräutigam, A., Hoelzel, T., et al. (2018). Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell 173, 456-469.e16.
Hartmann, M., et al., 2018. Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell, 173(2), p 456-469.e16.
M. Hartmann, et al., “Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity”, Cell, vol. 173, 2018, pp. 456-469.e16.
Hartmann, M., Zeier, T., Bernsdorff, F., Reichel-Deland, V., Kim, D., Hohmann, M., Scholten, N., Schuck, S., Bräutigam, A., Hoelzel, T., Ganter, C., Zeier, J.: Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell. 173, 456-469.e16 (2018).
Hartmann, Michael, Zeier, Tatyana, Bernsdorff, Friederike, Reichel-Deland, Vanessa, Kim, Denis, Hohmann, Michele, Scholten, Nicola, Schuck, Stefan, Bräutigam, Andrea, Hoelzel, Torsten, Ganter, Christian, and Zeier, Juergen. “Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity”. Cell 173.2 (2018): 456-469.e16.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
This Item is protected by copyright and/or related rights. [...]
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2019-09-06T09:18:58Z
MD5 Prüfsumme
70f29fb0d08721b3b379f6acb140e0a7

15 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

The NAC family transcription factor GmNAC42-1 regulates biosynthesis of the anticancer and neuroprotective glyceollins in soybean.
Jahan MA, Harris B, Lowery M, Coburn K, Infante AM, Percifield RJ, Ammer AG, Kovinich N., BMC Genomics 20(1), 2019
PMID: 30786857
A gossypol biosynthetic intermediate disturbs plant defence response.
Tian X, Fang X, Huang JQ, Wang LJ, Mao YB, Chen XY., Philos Trans R Soc Lond B Biol Sci 374(1767), 2019
PMID: 30967019
Involvement of Salicylic Acid in Anthracnose Infection in Tea Plants Revealed by Transcriptome Profiling.
Shi YL, Sheng YY, Cai ZY, Yang R, Li QS, Li XM, Li D, Guo XY, Lu JL, Ye JH, Wang KR, Zhang LJ, Liang YR, Zheng XQ., Int J Mol Sci 20(10), 2019
PMID: 31108845
Root-specific camalexin biosynthesis controls the plant growth-promoting effects of multiple bacterial strains.
Koprivova A, Schuck S, Jacoby RP, Klinkhammer I, Welter B, Leson L, Martyn A, Nauen J, Grabenhorst N, Mandelkow JF, Zuccaro A, Zeier J, Kopriva S., Proc Natl Acad Sci U S A 116(31), 2019
PMID: 31311863
Signals of Systemic Immunity in Plants: Progress and Open Questions.
Ádám AL, Nagy ZÁ, Kátay G, Mergenthaler E, Viczián O., Int J Mol Sci 19(4), 2018
PMID: 29642641
N-hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis.
Chen YC, Holmes EC, Rajniak J, Kim JG, Tang S, Fischer CR, Mudgett MB, Sattely ES., Proc Natl Acad Sci U S A 115(21), 2018
PMID: 29735713
A critical role for Arabidopsis MILDEW RESISTANCE LOCUS O2 in systemic acquired resistance.
Gruner K, Zeier T, Aretz C, Zeier J., Plant J 94(6), 2018
PMID: 29660188
Systemic Acquired Resistance and Salicylic Acid: Past, Present, and Future.
Klessig DF, Choi HW, Dempsey DA., Mol Plant Microbe Interact 31(9), 2018
PMID: 29781762
Chemical Activation of EDS1/PAD4 Signaling Leading to Pathogen Resistance in Arabidopsis.
Joglekar S, Suliman M, Bartsch M, Halder V, Maintz J, Bautor J, Zeier J, Parker JE, Kombrink E., Plant Cell Physiol 59(8), 2018
PMID: 29931201
A MPK3/6-WRKY33-ALD1-Pipecolic Acid Regulatory Loop Contributes to Systemic Acquired Resistance.
Wang Y, Schuck S, Wu J, Yang P, Döring AC, Zeier J, Tsuda K., Plant Cell 30(10), 2018
PMID: 30228125
Recent Advances in Synthetic Chemical Inducers of Plant Immunity.
Zhou M, Wang W., Front Plant Sci 9(), 2018
PMID: 30459795
Different Pathogen Defense Strategies in Arabidopsis: More than Pathogen Recognition.
Zhang W, Zhao F, Jiang L, Chen C, Wu L, Liu Z., Cells 7(12), 2018
PMID: 30544557

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 29576453
PubMed | Europe PMC

Suchen in

Google Scholar