Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity
Hartmann M, Zeier T, Bernsdorff F, Reichel-Deland V, Kim D, Hohmann M, Scholten N, Schuck S, Bräutigam A, Hoelzel T, Ganter C, et al. (2018)
Cell 173(2): 456-469.e16.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Hartmann, Michael;
Zeier, Tatyana;
Bernsdorff, Friederike;
Reichel-Deland, Vanessa;
Kim, Denis;
Hohmann, Michele;
Scholten, Nicola;
Schuck, Stefan;
Bräutigam, AndreaUniBi ;
Hoelzel, Torsten;
Ganter, Christian;
Zeier, Juergen
Einrichtung
Abstract / Bemerkung
Following a previous microbial inoculation, plants can induce broad-spectrum immunity to pathogen infection, a phenomenon known as systemic acquired resistance (SAR). SAR establishment in Arabidopsis thaliana is regulated by the Lys catabolite pipecolic acid (Pip) and flavin-dependent-monooxygenase1 (FMO1). Here, we show that elevated Pip is sufficient to induce an FMO1-dependent transcriptional reprogramming of leaves that is reminiscent of SAR. In planta and in vitro analyses demonstrate that FMO1 functions as a pipecolate N-hydroxylase, catalyzing the biochemical conversion of Pip to N-hydroxypipecolic acid (NHP). NHP-systemically accumulates in plants after microbial attack. When exogenously applied, it overrides the defect of NHP-deficient fmo1 in acquired resistance and acts as a potent inducer of plant immunity to bacterial and oomycete infection. Our work has identified a pathogen-inducible L-Lys catabolic pathway in plants that generates the N-hydroxylated amino acid NHP as a critical regulator of systemic acquired resistance to pathogen infection.
Erscheinungsjahr
2018
Zeitschriftentitel
Cell
Band
173
Ausgabe
2
Seite(n)
456-469.e16
ISSN
0092-8674
eISSN
1097-4172
Page URI
https://pub.uni-bielefeld.de/record/2919293
Zitieren
Hartmann M, Zeier T, Bernsdorff F, et al. Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell. 2018;173(2):456-469.e16.
Hartmann, M., Zeier, T., Bernsdorff, F., Reichel-Deland, V., Kim, D., Hohmann, M., Scholten, N., et al. (2018). Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell, 173(2), 456-469.e16. doi:10.1016/j.cell.2018.02.049
Hartmann, Michael, Zeier, Tatyana, Bernsdorff, Friederike, Reichel-Deland, Vanessa, Kim, Denis, Hohmann, Michele, Scholten, Nicola, et al. 2018. “Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity”. Cell 173 (2): 456-469.e16.
Hartmann, M., Zeier, T., Bernsdorff, F., Reichel-Deland, V., Kim, D., Hohmann, M., Scholten, N., Schuck, S., Bräutigam, A., Hoelzel, T., et al. (2018). Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell 173, 456-469.e16.
Hartmann, M., et al., 2018. Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell, 173(2), p 456-469.e16.
M. Hartmann, et al., “Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity”, Cell, vol. 173, 2018, pp. 456-469.e16.
Hartmann, M., Zeier, T., Bernsdorff, F., Reichel-Deland, V., Kim, D., Hohmann, M., Scholten, N., Schuck, S., Bräutigam, A., Hoelzel, T., Ganter, C., Zeier, J.: Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity. Cell. 173, 456-469.e16 (2018).
Hartmann, Michael, Zeier, Tatyana, Bernsdorff, Friederike, Reichel-Deland, Vanessa, Kim, Denis, Hohmann, Michele, Scholten, Nicola, Schuck, Stefan, Bräutigam, Andrea, Hoelzel, Torsten, Ganter, Christian, and Zeier, Juergen. “Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity”. Cell 173.2 (2018): 456-469.e16.
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2019-09-06T09:18:58Z
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