Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells
Schürmann M, Brotzmann V, Bütow M, Greiner J, Höving A, Kaltschmidt C, Kaltschmidt B, Sudhoff H (2018)
Stem Cell Reviews and Reports 14(2): 277–285.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Schürmann, Matthias;
Brotzmann, Viktoria;
Bütow, Marlena;
Greiner, JohannesUniBi 
;
Höving, Anna;
Kaltschmidt, ChristianUniBi;
Kaltschmidt, BarbaraUniBi;
Sudhoff, HolgerUniBi
;
Höving, Anna;
Kaltschmidt, ChristianUniBi;
Kaltschmidt, BarbaraUniBi;
Sudhoff, HolgerUniBi Einrichtung
Abstract / Bemerkung
Due to their extraordinarily broad differentiation potential and persistence during adulthood, adult neural crest-derived stem cells (NCSCs) are highly promising candidates for clinical applications, particularly when facing the challenging treatment of neurodegenerative diseases or complex craniofacial injuries. Successful application of human NCSCs in regenerative medicine and pharmaceutical research mainly relies on the availability of sufficient amounts of tissue for cell isolation procedures. Facing this challenge, we here describe for the first time a novel population of NCSCs within the middle turbinate of the human nasal cavity. From a surgical point of view, high amounts of tissue are routinely and easily removed during nasal biopsies. Investigating the presence of putative stem cells in obtained middle turbinate tissue by immunohistochemistry, we observed Nestin+/p75NTR+/S100+/α smooth muscle actin (αSMA)− cells, which we successfully isolated and cultivated in vitro. Cultivated middle turbinate stem cells (MTSCs) kept their expression of neural crest and stemness markers Nestin, p75 and S100 and showed the capability of sphere formation and clonal growth, indicating their stem cell character. Application of directed in vitro differentiation assays resulted in successful differentiation of MTSCs into osteogenic and neuronal cell types. Regarding the high amount of tissue obtained during surgery as well as their broad differentiation capability, MTSCs seem to be a highly promising novel neural crest stem cell population for applications in cell replacement therapy and pharmacological research.
Stichworte
NCSCs;
Human;
Nasal cavity;
Middle turbinate;
Neural crest;
Adult stem cells
Erscheinungsjahr
2018
Zeitschriftentitel
Stem Cell Reviews and Reports
Band
14
Ausgabe
2
Seite(n)
277–285
ISSN
1550-8943
Page URI
https://pub.uni-bielefeld.de/record/2919161
Zitieren
Schürmann M, Brotzmann V, Bütow M, et al. Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports. 2018;14(2):277–285.
Schürmann, M., Brotzmann, V., Bütow, M., Greiner, J., Höving, A., Kaltschmidt, C., Kaltschmidt, B., et al. (2018). Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports, 14(2), 277–285. https://doi.org/10.1007/s12015-017-9797-2
Schürmann, Matthias, Brotzmann, Viktoria, Bütow, Marlena, Greiner, Johannes, Höving, Anna, Kaltschmidt, Christian, Kaltschmidt, Barbara, and Sudhoff, Holger. 2018. “Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells”. Stem Cell Reviews and Reports 14 (2): 277–285.
Schürmann, M., Brotzmann, V., Bütow, M., Greiner, J., Höving, A., Kaltschmidt, C., Kaltschmidt, B., and Sudhoff, H. (2018). Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports 14, 277–285.
Schürmann, M., et al., 2018. Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports, 14(2), p 277–285.
M. Schürmann, et al., “Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells”, Stem Cell Reviews and Reports, vol. 14, 2018, pp. 277–285.
Schürmann, M., Brotzmann, V., Bütow, M., Greiner, J., Höving, A., Kaltschmidt, C., Kaltschmidt, B., Sudhoff, H.: Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports. 14, 277–285 (2018).
Schürmann, Matthias, Brotzmann, Viktoria, Bütow, Marlena, Greiner, Johannes, Höving, Anna, Kaltschmidt, Christian, Kaltschmidt, Barbara, and Sudhoff, Holger. “Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells”. Stem Cell Reviews and Reports 14.2 (2018): 277–285.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
68 References
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PMID: 1561270
Surgery of the turbinates and "empty nose" syndrome.
Scheithauer MO., GMS Curr Top Otorhinolaryngol Head Neck Surg 9(), 2010
PMID: 22073107
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PMID: 22073107
Culture bag systems for clinical applications of adult human neural crest-derived stem cells.
Greiner JF, Grunwald LM, Muller J, Sudhoff H, Widera D, Kaltschmidt C, Kaltschmidt B., Stem Cell Res Ther 5(2), 2014
PMID: 24629140
Greiner JF, Grunwald LM, Muller J, Sudhoff H, Widera D, Kaltschmidt C, Kaltschmidt B., Stem Cell Res Ther 5(2), 2014
PMID: 24629140
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Muller J, Ossig C, Greiner JF, Hauser S, Fauser M, Widera D, Kaltschmidt C, Storch A, Kaltschmidt B., Stem Cells Transl Med 4(1), 2014
PMID: 25479965
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Toma JG, Akhavan M, Fernandes KJ, Barnabe-Heider F, Sadikot A, Kaplan DR, Miller FD., Nat. Cell Biol. 3(9), 2001
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Delorme B, Nivet E, Gaillard J, Haupl T, Ringe J, Deveze A, Magnan J, Sohier J, Khrestchatisky M, Roman FS, Charbord P, Sensebe L, Layrolle P, Feron F., Stem Cells Dev. 19(6), 2010
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Greiner JF, Hauser S, Widera D, Muller J, Qunneis F, Zander C, Martin I, Mallah J, Schuetzmann D, Prante C, Schwarze H, Prohaska W, Beyer A, Rott K, Hutten A, Golzhauser A, Sudhoff H, Kaltschmidt C, Kaltschmidt B., Eur Cell Mater 22(), 2011
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PMID: 22179938
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Viktorov IV, Savchenko EA, Chekhonin VP., Bull. Exp. Biol. Med. 144(4), 2007
PMID: 18642721
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PMID: 18642721
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Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ, Baker CV., Proc. Natl. Acad. Sci. U.S.A. 107(49), 2010
PMID: 21078992
Barraud P, Seferiadis AA, Tyson LD, Zwart MF, Szabo-Rogers HL, Ruhrberg C, Liu KJ, Baker CV., Proc. Natl. Acad. Sci. U.S.A. 107(49), 2010
PMID: 21078992
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Nakashima T, Kimmelman CP, Snow JB Jr., Arch Otolaryngol 110(10), 1984
PMID: 6477257
Nakashima T, Kimmelman CP, Snow JB Jr., Arch Otolaryngol 110(10), 1984
PMID: 6477257
Label-free nonlinear optical microscopy detects early markers for osteogenic differentiation of human stem cells.
Hofemeier AD, Hachmeister H, Pilger C, Schurmann M, Greiner JF, Nolte L, Sudhoff H, Kaltschmidt C, Huser T, Kaltschmidt B., Sci Rep 6(), 2016
PMID: 27225821
Hofemeier AD, Hachmeister H, Pilger C, Schurmann M, Greiner JF, Nolte L, Sudhoff H, Kaltschmidt C, Huser T, Kaltschmidt B., Sci Rep 6(), 2016
PMID: 27225821
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
Schofield R., Blood Cells 4(1-2), 1978
PMID: 747780
Schofield R., Blood Cells 4(1-2), 1978
PMID: 747780
Isolation of novel multipotent neural crest-derived stem cells from adult human inferior turbinate.
Hauser S, Widera D, Qunneis F, Muller J, Zander C, Greiner J, Strauss C, Luningschror P, Heimann P, Schwarze H, Ebmeyer J, Sudhoff H, Arauzo-Bravo MJ, Greber B, Zaehres H, Scholer H, Kaltschmidt C, Kaltschmidt B., Stem Cells Dev. 21(5), 2012
PMID: 22128806
Hauser S, Widera D, Qunneis F, Muller J, Zander C, Greiner J, Strauss C, Luningschror P, Heimann P, Schwarze H, Ebmeyer J, Sudhoff H, Arauzo-Bravo MJ, Greber B, Zaehres H, Scholer H, Kaltschmidt C, Kaltschmidt B., Stem Cells Dev. 21(5), 2012
PMID: 22128806
Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche.
Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, Morgan JE., Cell 122(2), 2005
PMID: 16051152
Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, Morgan JE., Cell 122(2), 2005
PMID: 16051152
Adult craniofacial stem cells: sources and relation to the neural crest.
Kaltschmidt B, Kaltschmidt C, Widera D., Stem Cell Rev Rep 8(3), 2012
PMID: 22170630
Kaltschmidt B, Kaltschmidt C, Widera D., Stem Cell Rev Rep 8(3), 2012
PMID: 22170630
Fibrin gel improves the survival of transplanted myoblasts.
Gerard C, Forest MA, Beauregard G, Skuk D, Tremblay JP., Cell Transplant 21(1), 2011
PMID: 21535909
Gerard C, Forest MA, Beauregard G, Skuk D, Tremblay JP., Cell Transplant 21(1), 2011
PMID: 21535909
Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons.
Barnett SC, Alexander CL, Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn LT, Papanastassiou V, Kennedy PG, Franklin RJ., Brain 123 ( Pt 8)(), 2000
PMID: 10908188
Barnett SC, Alexander CL, Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn LT, Papanastassiou V, Kennedy PG, Franklin RJ., Brain 123 ( Pt 8)(), 2000
PMID: 10908188
Fibrin sealant treatment of splenic injuries during oesophagectomy.
Modi P, Rahamim J., Eur J Cardiothorac Surg 28(1), 2005
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Material in PUB:
Teil dieser Dissertation
Blood plasma-mediated effects on regenerative features of a novel adult human cardiac stem cell population
Höving A (2021)
Bielefeld: Universität Bielefeld.
Höving A (2021)
Bielefeld: Universität Bielefeld.
Teil von PUB Eintrag
Heterogeneity of adult human stem cells in physiology and pathogenesis
Greiner J (2021)
Bielefeld: Universität Bielefeld.
Greiner J (2021)
Bielefeld: Universität Bielefeld.
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