Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells
Schürmann M, Brotzmann V, Bütow M, Greiner J, Höving A, Kaltschmidt C, Kaltschmidt B, Sudhoff H (2018)
Stem Cell Reviews and Reports 14(2): 277–285.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Schürmann, Matthias;
Brotzmann, Viktoria;
Bütow, Marlena;
Greiner, JohannesUniBi 
;
Höving, Anna;
Kaltschmidt, ChristianUniBi;
Kaltschmidt, BarbaraUniBi;
Sudhoff, HolgerUniBi
;
Höving, Anna;
Kaltschmidt, ChristianUniBi;
Kaltschmidt, BarbaraUniBi;
Sudhoff, HolgerUniBi Einrichtung
Abstract / Bemerkung
Due to their extraordinarily broad differentiation potential and persistence during adulthood, adult neural crest-derived stem cells (NCSCs) are highly promising candidates for clinical applications, particularly when facing the challenging treatment of neurodegenerative diseases or complex craniofacial injuries. Successful application of human NCSCs in regenerative medicine and pharmaceutical research mainly relies on the availability of sufficient amounts of tissue for cell isolation procedures. Facing this challenge, we here describe for the first time a novel population of NCSCs within the middle turbinate of the human nasal cavity. From a surgical point of view, high amounts of tissue are routinely and easily removed during nasal biopsies. Investigating the presence of putative stem cells in obtained middle turbinate tissue by immunohistochemistry, we observed Nestin+/p75NTR+/S100+/α smooth muscle actin (αSMA)− cells, which we successfully isolated and cultivated in vitro. Cultivated middle turbinate stem cells (MTSCs) kept their expression of neural crest and stemness markers Nestin, p75 and S100 and showed the capability of sphere formation and clonal growth, indicating their stem cell character. Application of directed in vitro differentiation assays resulted in successful differentiation of MTSCs into osteogenic and neuronal cell types. Regarding the high amount of tissue obtained during surgery as well as their broad differentiation capability, MTSCs seem to be a highly promising novel neural crest stem cell population for applications in cell replacement therapy and pharmacological research.
Stichworte
NCSCs;
Human;
Nasal cavity;
Middle turbinate;
Neural crest;
Adult stem cells
Erscheinungsjahr
2018
Zeitschriftentitel
Stem Cell Reviews and Reports
Band
14
Ausgabe
2
Seite(n)
277–285
ISSN
1550-8943
Page URI
https://pub.uni-bielefeld.de/record/2919161
Zitieren
Schürmann M, Brotzmann V, Bütow M, et al. Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports. 2018;14(2):277–285.
Schürmann, M., Brotzmann, V., Bütow, M., Greiner, J., Höving, A., Kaltschmidt, C., Kaltschmidt, B., et al. (2018). Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports, 14(2), 277–285. https://doi.org/10.1007/s12015-017-9797-2
Schürmann, Matthias, Brotzmann, Viktoria, Bütow, Marlena, Greiner, Johannes, Höving, Anna, Kaltschmidt, Christian, Kaltschmidt, Barbara, and Sudhoff, Holger. 2018. “Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells”. Stem Cell Reviews and Reports 14 (2): 277–285.
Schürmann, M., Brotzmann, V., Bütow, M., Greiner, J., Höving, A., Kaltschmidt, C., Kaltschmidt, B., and Sudhoff, H. (2018). Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports 14, 277–285.
Schürmann, M., et al., 2018. Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports, 14(2), p 277–285.
M. Schürmann, et al., “Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells”, Stem Cell Reviews and Reports, vol. 14, 2018, pp. 277–285.
Schürmann, M., Brotzmann, V., Bütow, M., Greiner, J., Höving, A., Kaltschmidt, C., Kaltschmidt, B., Sudhoff, H.: Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells. Stem Cell Reviews and Reports. 14, 277–285 (2018).
Schürmann, Matthias, Brotzmann, Viktoria, Bütow, Marlena, Greiner, Johannes, Höving, Anna, Kaltschmidt, Christian, Kaltschmidt, Barbara, and Sudhoff, Holger. “Identification of a Novel High Yielding Source of Multipotent Adult Human Neural Crest-Derived Stem Cells”. Stem Cell Reviews and Reports 14.2 (2018): 277–285.
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PMID: 18642721
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PMID: 6477257
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The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
Schofield R., Blood Cells 4(1-2), 1978
PMID: 747780
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Hauser S, Widera D, Qunneis F, Muller J, Zander C, Greiner J, Strauss C, Luningschror P, Heimann P, Schwarze H, Ebmeyer J, Sudhoff H, Arauzo-Bravo MJ, Greber B, Zaehres H, Scholer H, Kaltschmidt C, Kaltschmidt B., Stem Cells Dev. 21(5), 2012
PMID: 22128806
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PMID: 22128806
Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche.
Collins CA, Olsen I, Zammit PS, Heslop L, Petrie A, Partridge TA, Morgan JE., Cell 122(2), 2005
PMID: 16051152
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PMID: 16051152
Adult craniofacial stem cells: sources and relation to the neural crest.
Kaltschmidt B, Kaltschmidt C, Widera D., Stem Cell Rev Rep 8(3), 2012
PMID: 22170630
Kaltschmidt B, Kaltschmidt C, Widera D., Stem Cell Rev Rep 8(3), 2012
PMID: 22170630
Fibrin gel improves the survival of transplanted myoblasts.
Gerard C, Forest MA, Beauregard G, Skuk D, Tremblay JP., Cell Transplant 21(1), 2011
PMID: 21535909
Gerard C, Forest MA, Beauregard G, Skuk D, Tremblay JP., Cell Transplant 21(1), 2011
PMID: 21535909
Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons.
Barnett SC, Alexander CL, Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn LT, Papanastassiou V, Kennedy PG, Franklin RJ., Brain 123 ( Pt 8)(), 2000
PMID: 10908188
Barnett SC, Alexander CL, Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn LT, Papanastassiou V, Kennedy PG, Franklin RJ., Brain 123 ( Pt 8)(), 2000
PMID: 10908188
Fibrin sealant treatment of splenic injuries during oesophagectomy.
Modi P, Rahamim J., Eur J Cardiothorac Surg 28(1), 2005
PMID: 15876541
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Material in PUB:
Teil von PUB Eintrag
Heterogeneity of adult human stem cells in physiology and pathogenesis
Greiner J (2021)
Bielefeld: Universität Bielefeld.
Greiner J (2021)
Bielefeld: Universität Bielefeld.
Teil dieser Dissertation
Blood plasma-mediated effects on regenerative features of a novel adult human cardiac stem cell population
Höving A (2021)
Bielefeld: Universität Bielefeld.
Höving A (2021)
Bielefeld: Universität Bielefeld.
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