Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics

Müller K, Falck G (2018)
Antibodies 7(1): 4.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 1.44 MB
Abstract / Bemerkung
Strategies for site-specific modification of proteins have increased in number, complexity, and specificity over the last years. Such modifications hold the promise to broaden the use of existing biopharmaceuticals or to tailor novel proteins for therapeutic or diagnostic applications. The recent quest for next-generation antibody–drug conjugates (ADCs) sparked research into techniques with site selectivity. While purely chemical approaches often impede control of dosage or locus of derivatization, naturally occurring enzymes and proteins bear the ability of co- or post-translational protein modifications at particular residues, thus enabling unique coupling reactions or protein fusions. This review provides a general overview and focuses on chemo-enzymatic methods including enzymes such as formylglycine-generating enzyme, sortase, and transglutaminase. Applications for the conjugation of antibodies and antibody mimetics are reported. View Full-Text
Stichworte
chemo-enzymatic labeling; armed antibody; antibody coupling; antibody conjugation
Erscheinungsjahr
2018
Zeitschriftentitel
Antibodies
Band
7
Ausgabe
1
Art.-Nr.
4
ISSN
2073-4468
Page URI
https://pub.uni-bielefeld.de/record/2917494

Zitieren

Müller K, Falck G. Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies. 2018;7(1): 4.
Müller, K., & Falck, G. (2018). Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies, 7(1), 4. doi:10.3390/antib7010004
Müller, K., and Falck, G. (2018). Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies 7:4.
Müller, K., & Falck, G., 2018. Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies, 7(1): 4.
K. Müller and G. Falck, “Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics”, Antibodies, vol. 7, 2018, : 4.
Müller, K., Falck, G.: Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics. Antibodies. 7, : 4 (2018).
Müller, Kristian, and Falck, Georg. “Enzyme-Based labeling strategies for antibody–drug conjugates and antibody mimetics”. Antibodies 7.1 (2018): 4.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung 4.0 International Public License (CC-BY 4.0):
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2019-09-06T09:18:56Z
MD5 Prüfsumme
173fcb905872acb2966b97efc3d68f94

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 31544857
PubMed | Europe PMC

Suchen in

Google Scholar