Genetic variants linked to education predict longevity

Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G, Nagy R, Amador C, et al. (2016)
Proceedings of the National Academy of Sciences 113(47): 13366-13371.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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This article contains supporting information online at [http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1605334113/-/DCSupplemental](http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1605334113/-/DCSupplemental).
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
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Proceedings of the National Academy of Sciences
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113
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47
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13366-13371
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Marioni RE, Ritchie SJ, Joshi PK, et al. Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences. 2016;113(47):13366-13371.
Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., et al. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113(47), 13366-13371. doi:10.1073/pnas.1605334113
Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Nagy, R., et al. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences 113, 13366-13371.
Marioni, R.E., et al., 2016. Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113(47), p 13366-13371.
R.E. Marioni, et al., “Genetic variants linked to education predict longevity”, Proceedings of the National Academy of Sciences, vol. 113, 2016, pp. 13366-13371.
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Marioni, Riccardo E., Ritchie, Stuart J., Joshi, Peter K., Hagenaars, Saskia P., Okbay, Aysu, Fischer, Krista, Adams, Mark J., Hill, W. David, Davies, Gail, Nagy, Reka, Amador, Carmen, Läll, Kristi, Metspalu, Andres, Liewald, David C., Campbell, Archie, Wilson, James F., Hayward, Caroline, Esko, Tõnu, Porteous, David J., Gale, Catharine R., Deary, Ian J., Beauchamp, Jonathan P., Fontana, Mark A., Lee, James J., Pers, Tune H., Rietveld, Cornelius A., Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S. 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Roy, Timpson, Nicholas J, Tiemeier, Henning, Tung, Joyce Y., Uitterlinden, André G., Vitart, Veronique, Vollenweider, Peter, Weir, David R., Wright, Alan F., Conley, Dalton C., Krueger, Robert F., Smith, George Davey, Hofman, Albert, Laibson, David I., Medland, Sarah E., Meyer, Michelle N., Yang, Jian, Johannesson, Magnus, Visscher, Peter M., Koellinger, Philipp D., Cesarini, David, and Benjamin, Daniel J. “Genetic variants linked to education predict longevity”. Proceedings of the National Academy of Sciences 113.47 (2016): 13366-13371.
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