Genetic variants linked to education predict longevity

Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G, Nagy R, Amador C, et al. (2016)
Proceedings of the National Academy of Sciences 113(47): 13366-13371.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Marioni, Riccardo E.; Ritchie, Stuart J.; Joshi, Peter K.; Hagenaars, Saskia P.; Okbay, Aysu; Fischer, Krista; Adams, Mark J.; Hill, W. David; Davies, Gail; Nagy, Reka; Amador, Carmen; Läll, Kristi
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Abstract / Bemerkung
This article contains supporting information online at [http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1605334113/-/DCSupplemental](http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1605334113/-/DCSupplemental).
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
Stichworte
Soziales und Gesundheit; Bildung; Kultursektor; Non-Profit-Sektor; Lebenserwartung; Lernen; Bildung; Genetische Forschung; Prognose; Gesundheitszustand; Gesundheitsstatistik
Erscheinungsjahr
2016
Zeitschriftentitel
Proceedings of the National Academy of Sciences
Band
113
Ausgabe
47
Seite(n)
13366-13371
ISSN
0027-8424, 1091-6490
Page URI
https://pub.uni-bielefeld.de/record/2917257

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Marioni RE, Ritchie SJ, Joshi PK, et al. Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences. 2016;113(47):13366-13371.
Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., et al. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113(47), 13366-13371. https://doi.org/10.1073/pnas.1605334113
Marioni, Riccardo E., Ritchie, Stuart J., Joshi, Peter K., Hagenaars, Saskia P., Okbay, Aysu, Fischer, Krista, Adams, Mark J., et al. 2016. “Genetic variants linked to education predict longevity”. Proceedings of the National Academy of Sciences 113 (47): 13366-13371.
Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Nagy, R., et al. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences 113, 13366-13371.
Marioni, R.E., et al., 2016. Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113(47), p 13366-13371.
R.E. Marioni, et al., “Genetic variants linked to education predict longevity”, Proceedings of the National Academy of Sciences, vol. 113, 2016, pp. 13366-13371.
Marioni, R.E., Ritchie, S.J., Joshi, P.K., Hagenaars, S.P., Okbay, A., Fischer, K., Adams, M.J., Hill, W.D., Davies, G., Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D.C., Campbell, A., Wilson, J.F., Hayward, C., Esko, T., Porteous, D.J., Gale, C.R., Deary, I.J., Beauchamp, J.P., Fontana, M.A., Lee, J.J., Pers, T.H., Rietveld, C.A., Turley, P., Chen, G.-B., Emilsson, V., Meddens, S.F.W., Oskarsson, S., Pickrell, J.K., Thom, K., Timshel, P., Vlaming, R., Abdellaoui, A., Ahluwalia, T.S., Bacelis, J., Baumbach, C., Bjornsdottir, G., Brandsma, J.H., Concas, M.P., Derringer, J., Furlotte, N.A., Galesloot, T.E., Girotto, G., Gupta, R., Hall, L.M., Harris, S.E., Hofer, E., Horikoshi, M., Huffman, J.E., Kaasik, K., Kalafati, I.P., Karlsson, R., Kong, A., Lahti, J., van der Lee, S.J., Leeuw, C., Lind, P.A., Lindgren, K.-O., Liu, T., Mangino, M., Marten, J., Mihailov, E., Miller, M.B., van der Most, P.J., Oldmeadow, C., Payton, A., Pervjakova, N., Peyrot, W.J., Qian, Y., Raitakari, O., Rueedi, R., Salvi, E., Schmidt, B., Schraut, K.E., Shi, J., Smith, A.V., Poot, R.A., St. Pourcain, B., Teumer, A., Thorleifsson, G., Verweij, N., Vuckovic, D., Wellmann, J., Westra, H.-J., Yang, J., Zhao, W., Zhu, Z., Alizadeh, B.Z., Amin, N., Bakshi, A., Baumeister, S.E., Ginevra, G., Bønnelykke, K., Boyle, P.A., Campbell, H., Cappuccio, F.P., De Neve, J.-E., Deloukas, P., Demuth, I., Ding, J., Eibich, P., Eisele, L., Eklund, N., Evans, D.M., Faul, J.D., Feitosa, M.F., Forstner, A.J., Gandin, I., Gunnarsson, B., Halldórsson, B.V., Harris, T.B., Heath, A.C., Hocking, L.J., Holliday, E.G., Homuth, G., Horan, M.A., Hottenga, J.-J., de Jager, P.L., Jugessur, A., Kaakinen, M.A., Kähönen, M., Kanoni, S., Keltigangas-Järvinen, L., Kiemeney, L.A.L.M., Kolcic, I., Koskinen, S., Kraja, A.T., Kroh, M., Kutalik, Z., Latvala, A., Launer, L.J., Lebreton, M.P., Levinson, D.F., Lichtenstein, P., Lichtner, P., Loukola, A., Madden, P.A., Mägi, R., Mäki-Opas, T., Marques-Vidal, P., Meddens, G.A., McMahon, G., Meisinger, C., Meitinger, T., Milaneschi, Y., Milani, L., Montgomery, G.W., Myhre, R., Nelson, C.P., Nyholt, D.R., Ollier, W.E.R., Palotie, A., Paternoster, L., Pedersen, N.L., Petrovic, K.E., Räikkönen, K., Ring, S.M., Robino, A., Rostapshova, O., Rudan, I., Rustichini, A., Salomaa, V., Sanders, A.R., Sarin, A.-P., Schmidt, H., Scott, R.J., Smith, B.H., Smith, J.A., Staessen, J.A., Steinhagen-Thiessen, E., Strauch, K., Terracciano, A., Tobin, M.D., Ulivi, S., Vaccargiu, S., Quaye, L., van Rooij, F.J.A., Venturini, C., Vinkhuyzen, A.A.E., Völker, U., Völzke, H., Vonk, J.M., Vozzi, D., Waage, J., Ware, E.B., Willemsen, G., Attia, J.R., Bennett, D.A., Berger, K., Bertram, L., Bisgaard, H., Boomsma, D.I., Borecki, I.B., Bultmann, U., Chabris, C.F., Cucca, F., Cusi, D., Dedoussis, G.V., van Duijn, C.M., Eriksson, J.G., Franke, B., Franke, L., Gasparini, P., Gejman, P.V., Gieger, C., Grabe, H.-J., Gratten, J., Groenen, P.J.F., Gudnason, V., van der Harst, P., Hinds, D.A., Hoffmann, W., Hypponen, E., Iacono, W.G., Jacobsson, B., Järvelin, M.-R., Jöckel, K.-H., Kaprio, J., Kardia, S.L.R., Lehtimäki, T., Lehrer, S.F., Magnusson, P.K.E., Martin, N.G., McGue, M., Pendleton, N., Penninx, B.W.J.H., Perola, M., Pirastu, N., Pirastu, M., Polasek, O., Posthuma, D., Power, C., Province, M.A., Samani, N.J., Schlessinger, D., Schmidt, R., Sørensen, T.I.A., Spector, T.D., Stefansson, K., Thorsteinsdottir, U., Thurik, A.R., Timpson, N.J., Tiemeier, H., Tung, J.Y., Uitterlinden, A.G., Vitart, V., Vollenweider, P., Weir, D.R., Wright, A.F., Conley, D.C., Krueger, R.F., Smith, G.D., Hofman, A., Laibson, D.I., Medland, S.E., Meyer, M.N., Yang, J., Johannesson, M., Visscher, P.M., Koellinger, P.D., Cesarini, D., Benjamin, D.J.: Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences. 113, 13366-13371 (2016).
Marioni, Riccardo E., Ritchie, Stuart J., Joshi, Peter K., Hagenaars, Saskia P., Okbay, Aysu, Fischer, Krista, Adams, Mark J., Hill, W. David, Davies, Gail, Nagy, Reka, Amador, Carmen, Läll, Kristi, Metspalu, Andres, Liewald, David C., Campbell, Archie, Wilson, James F., Hayward, Caroline, Esko, Tõnu, Porteous, David J., Gale, Catharine R., Deary, Ian J., Beauchamp, Jonathan P., Fontana, Mark A., Lee, James J., Pers, Tune H., Rietveld, Cornelius A., Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S. 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Second-generation PLINK: rising to the challenge of larger and richer datasets.
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