VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release
Dingjan I, Paardekooper LM, Verboogen DRJ, Fischer von Mollard G, ter Beest M, van den Bogaart G (2017)
European Journal of Cell Biology 96(7): 705-714.
Zeitschriftenaufsatz
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Autor*in
Dingjan, Ilse;
Paardekooper, Laurent M.;
Verboogen, Danielle R. J.;
Fischer von Mollard, GabrieleUniBi
;
ter Beest, Martin;
van den Bogaart, Geert
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Einrichtung
Abstract / Bemerkung
Cross-presentation of foreign antigen in major histocompatibility complex (MHC) class I by dendritic cells (DCs) requires activation of the NADPH-oxidase NOX2 complex. We recently showed that NOX2 is recruited to phagosomes by the SNARE protein VAMP8 where NOX2-produced reactive oxygen species (ROS) cause lipid oxidation and membrane disruption, promoting antigen translocation into the cytosol for cross-presentation. In this study, we extend these findings by showing that VAMP8 is also involved in NOX2 trafficking to endosomes. Moreover, we demonstrate in both human and mouse DCs that absence of VAMP8 leads to decreased ROS production, lipid peroxidation and antigen translocation, and that this impairs cross-presentation. In contrast, knockdown of VAMP8 did not affect recruitment of MHC class I and the transporter associated with antigen processing 1 (TAP1) to phagosomes, although surface levels of MHC class I were reduced. Thus, in addition to a secretory role, VAMP8-mediates trafficking of NOX2 to endosomes and phagosomes and this promotes induction of cytolytic T cell immune responses. (C) 2017 The Authors. Published by Elsevier GmbH.
Stichworte
Dendritic cells;
VAMPS;
NOX2;
Cross-presentation;
Lipid peroxidation
Erscheinungsjahr
2017
Zeitschriftentitel
European Journal of Cell Biology
Band
96
Ausgabe
7
Seite(n)
705-714
Urheberrecht / Lizenzen
ISSN
0171-9335
eISSN
1618-1298
Page URI
https://pub.uni-bielefeld.de/record/2916455
Zitieren
Dingjan I, Paardekooper LM, Verboogen DRJ, Fischer von Mollard G, ter Beest M, van den Bogaart G. VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release. European Journal of Cell Biology. 2017;96(7):705-714.
Dingjan, I., Paardekooper, L. M., Verboogen, D. R. J., Fischer von Mollard, G., ter Beest, M., & van den Bogaart, G. (2017). VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release. European Journal of Cell Biology, 96(7), 705-714. doi:10.1016/j.ejcb.2017.06.007
Dingjan, Ilse, Paardekooper, Laurent M., Verboogen, Danielle R. J., Fischer von Mollard, Gabriele, ter Beest, Martin, and van den Bogaart, Geert. 2017. “VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release”. European Journal of Cell Biology 96 (7): 705-714.
Dingjan, I., Paardekooper, L. M., Verboogen, D. R. J., Fischer von Mollard, G., ter Beest, M., and van den Bogaart, G. (2017). VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release. European Journal of Cell Biology 96, 705-714.
Dingjan, I., et al., 2017. VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release. European Journal of Cell Biology, 96(7), p 705-714.
I. Dingjan, et al., “VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release”, European Journal of Cell Biology, vol. 96, 2017, pp. 705-714.
Dingjan, I., Paardekooper, L.M., Verboogen, D.R.J., Fischer von Mollard, G., ter Beest, M., van den Bogaart, G.: VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release. European Journal of Cell Biology. 96, 705-714 (2017).
Dingjan, Ilse, Paardekooper, Laurent M., Verboogen, Danielle R. J., Fischer von Mollard, Gabriele, ter Beest, Martin, and van den Bogaart, Geert. “VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release”. European Journal of Cell Biology 96.7 (2017): 705-714.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
6 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
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