Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review

Koeckerling E, Karrasch L, Schweitzer A, Razum O, Krause G (2017)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Koeckerling, Elena; Karrasch, Laura; Schweitzer, Aparna; Razum, OliverUniBi; Krause, Gerard
Abstract / Bemerkung
In 2011, Germany experienced one of the largest outbreaks of entero-hemorrhagic Escherichia coli (EHEC) ever reported. Four years thereafter, we systematically searched for scientific publications in PubMed and MEDPILOT relating to this outbreak in order to assess the pattern of respective research activities and to assess the main findings and recommendations in the field of public health. Following PRISMA guidelines, we selected 133 publications, half of which were published within 17 months after outbreak onset. Clinical medicine was covered by 71, microbiology by 60, epidemiology by 46, outbreak reporting by 11, and food safety by 9 papers. Those on the last three topics drew conclusions on methods in surveillance, diagnosis, and outbreak investigation, on resources in public health, as well as on inter-agency collaboration, and public communication. Although the outbreak primarily affected Germany, most publications were conducted by multinational cooperations. Our findings document how soon and in which fields research was conducted with respect to this outbreak.
disease outbreaks; Shiga-toxigenic/entero-hemorrhagic Escherichia coli; hemolytic uremic syndrome; Germany; research
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Koeckerling E, Karrasch L, Schweitzer A, Razum O, Krause G. Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. FRONTIERS IN PUBLIC HEALTH. 2017;5: 332.
Koeckerling, E., Karrasch, L., Schweitzer, A., Razum, O., & Krause, G. (2017). Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. FRONTIERS IN PUBLIC HEALTH, 5, 332. doi:10.3389/fpubh.2017.00332
Koeckerling, Elena, Karrasch, Laura, Schweitzer, Aparna, Razum, Oliver, and Krause, Gerard. 2017. “Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review”. FRONTIERS IN PUBLIC HEALTH 5: 332.
Koeckerling, E., Karrasch, L., Schweitzer, A., Razum, O., and Krause, G. (2017). Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. FRONTIERS IN PUBLIC HEALTH 5:332.
Koeckerling, E., et al., 2017. Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. FRONTIERS IN PUBLIC HEALTH, 5: 332.
E. Koeckerling, et al., “Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review”, FRONTIERS IN PUBLIC HEALTH, vol. 5, 2017, : 332.
Koeckerling, E., Karrasch, L., Schweitzer, A., Razum, O., Krause, G.: Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review. FRONTIERS IN PUBLIC HEALTH. 5, : 332 (2017).
Koeckerling, Elena, Karrasch, Laura, Schweitzer, Aparna, Razum, Oliver, and Krause, Gerard. “Public Health Research Resulting from One of the world's Largest Outbreaks Caused by Entero-Hemorrhagic Escherichia coli in Germany 2011: A Review”. FRONTIERS IN PUBLIC HEALTH 5 (2017): 332.

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Fruit Decay to Diseases: Can Induced Resistance and Priming Help?
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Selection and characterization of a candidate therapeutic bacteriophage that lyses the Escherichia coli O104:H4 strain from the 2011 outbreak in Germany.
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Enterohemorrhagic Escherichia coli Infections and the Hemolytic-Uremic Syndrome.
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New insights into Shiga toxin-mediated endothelial dysfunction in hemolytic uremic syndrome.
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Alignment-free design of highly discriminatory diagnostic primer sets for Escherichia coli O104:H4 outbreak strains.
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Identification of the Shiga toxin-producing Escherichia coli O104:H4 strain responsible for a food poisoning outbreak in Germany by PCR.
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Escherichia coli O104:H4 outbreak in Germany--clarification of the origin of the epidemic.
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Comparative study on the high pressure inactivation behavior of the Shiga toxin-producing Escherichia coli O104:H4 and O157:H7 outbreak strains and a non-pathogenic surrogate.
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Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4.
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[Managing EHEC in hospital routine].
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Epidemiological analysis of a cluster within the outbreak of Shiga toxin-producing Escherichia coli serotype O104:H4 in Northern Germany, 2011.
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[Segmental necrotizing colitis in a patient with E. coli O104:H4 infection].
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TV news and concerns about - the EHEC-outbreak 2011 in Germany.
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Carrier prevalence, secondary household transmission, and long-term shedding in 2 districts during the Escherichia coli O104:H4 outbreak in Germany, 2011.
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[Patient with haemolytic uremic syndrome and Escherichia coli (EHEC) infection].
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Escherichia coli O104:H4 outbreak from sprouted seeds.
Soon JM, Seaman P, Baines RN., Int J Hyg Environ Health 216(3), 2012
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Trachtman H, Austin C, Lewinski M, Stahl RA., Nat Rev Nephrol 8(11), 2012
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Should health organizations use web 2.0 media in times of an infectious disease crisis? An in-depth qualitative study of citizens' information behavior during an EHEC outbreak.
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Enhanced surveillance during a large outbreak of bloody diarrhoea and haemolytic uraemic syndrome caused by Shiga toxin/verotoxin-producing Escherichia coli in Germany, May to June 2011.
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Trace-back and trace-forward tools developed ad hoc and used during the STEC O104:H4 outbreak 2011 in Germany and generic concepts for future outbreak situations.
Weiser AA, Gross S, Schielke A, Wigger JF, Ernert A, Adolphs J, Fetsch A, Muller-Graf C, Kasbohrer A, Mosbach-Schulz O, Appel B, Greiner M., Foodborne Pathog. Dis. 10(3), 2012
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Neurologic manifestations of E coli infection-induced hemolytic-uremic syndrome in adults.
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Central nervous system involvement in adults with epidemic hemolytic uremic syndrome.
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Associations of age and sex with the clinical outcome and incubation period of Shiga toxin-producing Escherichia coli O104:H4 infections, 2011.
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A new health threat in Europe: Shiga toxin-producing Escherichia coli O104:H4 infections.
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Treatment of enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome (eHUS).
Wurzner R, Riedl M, Rosales A, Orth-Holler D., Semin. Thromb. Hemost. 40(4), 2014
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Real-time multiplex PCR for detecting Shiga toxin 2-producing Escherichia coli O104:H4 in human stools.
Zhang W, Bielaszewska M, Bauwens A, Fruth A, Mellmann A, Karch H., J. Clin. Microbiol. 50(5), 2012
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Lability of the pAA Virulence Plasmid in Escherichia coli O104:H4: Implications for Virulence in Humans.
Zhang W, Bielaszewska M, Kunsmann L, Mellmann A, Bauwens A, Kock R, Kossow A, Anders A, Gatermann S, Karch H., PLoS ONE 8(6), 2013
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The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation.
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Risk factors for development of hemolytic uremic syndrome in a cohort of adult patients with STEC 0104:H4 infection.
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