Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks
Saik OV, Demenkov PS, Ivanisenko TV, Bragina EY, Freidin MB, Goncharova IA, Dosenko VE, Zolotareva O, Hofestädt R, Lavrik IN, Rogaev EI, et al. (2018)
BMC Medical Genomics 11(1): 15.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Saik, Olga V.;
Demenkov, Pavel S.;
Ivanisenko, Timofey V.;
Bragina, Elena Y.;
Freidin, Maxim B.;
Goncharova, Irirna A.;
Dosenko, Victor E.;
Zolotareva, OlgaUniBi;
Hofestädt, RalfUniBi;
Lavrik, Inna N.;
Rogaev, Evgeny I.;
Ivanisenko, Vladimir A.
Einrichtung
Abstract / Bemerkung
Background: Hypertension and bronchial asthma are a major issue for people's health. As of 2014, approximately one billion adults, or similar to 22% of the world population, have had hypertension. As of 2011, 235-330 million people globally have been affected by asthma and approximately 250,000-345,000 people have died each year from the disease. The development of the effective treatment therapies against these diseases is complicated by their comorbidity features. This is often a major problem in diagnosis and their treatment. Hence, in this study the bioinformatical methodology for the analysis of the comorbidity of these two diseases have been developed. As such, the search for candidate genes related to the comorbid conditions of asthma and hypertension can help in elucidating the molecular mechanisms underlying the comorbid condition of these two diseases, and can also be useful for genotyping and identifying new drug targets. Results: Using ANDSystem, the reconstruction and analysis of gene networks associated with asthma and hypertension was carried out. The gene network of asthma included 755 genes/proteins and 62,603 interactions, while the gene network of hypertension - 713 genes/proteins and 45,479 interactions. Two hundred and five genes/proteins and 9638 interactions were shared between asthma and hypertension. An approach for ranking genes implicated in the comorbid condition of two diseases was proposed. The approach is based on nine criteria for ranking genes by their importance, including standard methods of gene prioritization (Endeavor, ToppGene) as well as original criteria that take into account the characteristics of an associative gene network and the presence of known polymorphisms in the analysed genes. According to the proposed approach, the genes IL10, TLR4, and CAT had the highest priority in the development of comorbidity of these two diseases. Additionally, it was revealed that the list of top genes is enriched with apoptotic genes and genes involved in biological processes related to the functioning of central nervous system. Conclusions: The application of methods of reconstruction and analysis of gene networks is a productive tool for studying the molecular mechanisms of comorbid conditions. The method put forth to rank genes by their importance to the comorbid condition of asthma and hypertension was employed that resulted in prediction of 10 genes, playing the key role in the development of the comorbid condition. The results can be utilised to plan experiments for identification of novel candidate genes along with searching for novel pharmacological targets.
Erscheinungsjahr
2018
Zeitschriftentitel
BMC Medical Genomics
Band
11
Ausgabe
1
Art.-Nr.
15
ISSN
1755-8794
Page URI
https://pub.uni-bielefeld.de/record/2915515
Zitieren
Saik OV, Demenkov PS, Ivanisenko TV, et al. Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Medical Genomics. 2018;11(1): 15.
Saik, O. V., Demenkov, P. S., Ivanisenko, T. V., Bragina, E. Y., Freidin, M. B., Goncharova, I. A., Dosenko, V. E., et al. (2018). Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Medical Genomics, 11(1), 15. doi:10.1186/s12920-018-0331-4
Saik, Olga V., Demenkov, Pavel S., Ivanisenko, Timofey V., Bragina, Elena Y., Freidin, Maxim B., Goncharova, Irirna A., Dosenko, Victor E., et al. 2018. “Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks”. BMC Medical Genomics 11 (1): 15.
Saik, O. V., Demenkov, P. S., Ivanisenko, T. V., Bragina, E. Y., Freidin, M. B., Goncharova, I. A., Dosenko, V. E., Zolotareva, O., Hofestädt, R., Lavrik, I. N., et al. (2018). Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Medical Genomics 11:15.
Saik, O.V., et al., 2018. Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Medical Genomics, 11(1): 15.
O.V. Saik, et al., “Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks”, BMC Medical Genomics, vol. 11, 2018, : 15.
Saik, O.V., Demenkov, P.S., Ivanisenko, T.V., Bragina, E.Y., Freidin, M.B., Goncharova, I.A., Dosenko, V.E., Zolotareva, O., Hofestädt, R., Lavrik, I.N., Rogaev, E.I., Ivanisenko, V.A.: Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Medical Genomics. 11, : 15 (2018).
Saik, Olga V., Demenkov, Pavel S., Ivanisenko, Timofey V., Bragina, Elena Y., Freidin, Maxim B., Goncharova, Irirna A., Dosenko, Victor E., Zolotareva, Olga, Hofestädt, Ralf, Lavrik, Inna N., Rogaev, Evgeny I., and Ivanisenko, Vladimir A. “Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks”. BMC Medical Genomics 11.1 (2018): 15.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
4 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Conserved MicroRNA Act Boldly During Sprout Development and Quality Formation in Pingyang Tezaocha (Camellia sinensis).
Zhao L, Chen C, Wang Y, Shen J, Ding Z., Front Genet 10(), 2019
PMID: 31001312
Zhao L, Chen C, Wang Y, Shen J, Ding Z., Front Genet 10(), 2019
PMID: 31001312
shRNA-Induced Knockdown of a Bioinformatically Predicted Target IL10 Influences Functional Parameters in Spontaneously Hypertensive Rats with Asthma.
Drevytska T, Morhachov R, Tumanovska L, Portnichenko G, Nagibin V, Boldyriev O, Lapikova-Bryhinska T, Gurianova V, Dons'koi B, Freidin M, Ivanisenko V, Bragina EY, Hofestädt R, Dosenko V., J Integr Bioinform 15(4), 2018
PMID: 30530891
Drevytska T, Morhachov R, Tumanovska L, Portnichenko G, Nagibin V, Boldyriev O, Lapikova-Bryhinska T, Gurianova V, Dons'koi B, Freidin M, Ivanisenko V, Bragina EY, Hofestädt R, Dosenko V., J Integr Bioinform 15(4), 2018
PMID: 30530891
Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases.
Bragina EY, Goncharova IA, Garaeva AF, Nemerov EV, Babovskaya AA, Karpov AB, Semenova YV, Zhalsanova IZ, Gomboeva DE, Saik OV, Zolotareva OI, Ivanisenko VA, Dosenko VE, Hofestaedt R, Freidin MB., J Integr Bioinform 15(4), 2018
PMID: 30530896
Bragina EY, Goncharova IA, Garaeva AF, Nemerov EV, Babovskaya AA, Karpov AB, Semenova YV, Zhalsanova IZ, Gomboeva DE, Saik OV, Zolotareva OI, Ivanisenko VA, Dosenko VE, Hofestaedt R, Freidin MB., J Integr Bioinform 15(4), 2018
PMID: 30530896
Search for New Candidate Genes Involved in the Comorbidity of Asthma and Hypertension Based on Automatic Analysis of Scientific Literature.
Saik OV, Demenkov PS, Ivanisenko TV, Bragina EY, Freidin MB, Dosenko VE, Zolotareva OI, Choynzonov EL, Hofestaedt R, Ivanisenko VA., J Integr Bioinform 15(4), 2018
PMID: 30864351
Saik OV, Demenkov PS, Ivanisenko TV, Bragina EY, Freidin MB, Dosenko VE, Zolotareva OI, Choynzonov EL, Hofestaedt R, Ivanisenko VA., J Integr Bioinform 15(4), 2018
PMID: 30864351
167 References
Daten bereitgestellt von Europe PubMed Central.
Fatty acids and chronic low grade inflammation associated with obesity and the metabolic syndrome.
Cooke AA, Connaughton RM, Lyons CL, McMorrow AM, Roche HM., Eur. J. Pharmacol. 785(), 2016
PMID: 27083551
Cooke AA, Connaughton RM, Lyons CL, McMorrow AM, Roche HM., Eur. J. Pharmacol. 785(), 2016
PMID: 27083551
Inflammation in the pathophysiology of essential hypertension.
Montecucco F, Pende A, Quercioli A, Mach F., J. Nephrol. 24(1), 2011
PMID: 20437401
Montecucco F, Pende A, Quercioli A, Mach F., J. Nephrol. 24(1), 2011
PMID: 20437401
Inflammation and Arterial Hypertension: From Pathophysiological Links to Risk Prediction.
Pietri P, Vlachopoulos C, Tousoulis D., Curr. Med. Chem. 22(23), 2015
PMID: 25891108
Pietri P, Vlachopoulos C, Tousoulis D., Curr. Med. Chem. 22(23), 2015
PMID: 25891108
Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases.
Chehimi M, Vidal H, Eljaafari A., J Clin Med 6(7), 2017
PMID: 28708082
Chehimi M, Vidal H, Eljaafari A., J Clin Med 6(7), 2017
PMID: 28708082
Role of immune cells in obesity induced low grade inflammation and insulin resistance.
Asghar A, Sheikh N., Cell. Immunol. 315(), 2017
PMID: 28285710
Asghar A, Sheikh N., Cell. Immunol. 315(), 2017
PMID: 28285710
Asthma and risk of cardiovascular disease or all-cause mortality: a meta-analysis.
Xu M, Xu J, Yang X., Ann Saudi Med 37(2), 2017
PMID: 28377538
Xu M, Xu J, Yang X., Ann Saudi Med 37(2), 2017
PMID: 28377538
de JD, Majoor CJ, van’t C, Bel EH, van T., 2012
The comorbidity burden of the treated asthma patient population in British Columbia
Prosser R, Carleton B, Smith A., 2010
Prosser R, Carleton B, Smith A., 2010
Asthma predicts cardiovascular disease events: the multi-ethnic study of atherosclerosis.
Tattersall MC, Guo M, Korcarz CE, Gepner AD, Kaufman JD, Liu KJ, Barr RG, Donohue KM, McClelland RL, Delaney JA, Stein JH., Arterioscler. Thromb. Vasc. Biol. 35(6), 2015
PMID: 25908767
Tattersall MC, Guo M, Korcarz CE, Gepner AD, Kaufman JD, Liu KJ, Barr RG, Donohue KM, McClelland RL, Delaney JA, Stein JH., Arterioscler. Thromb. Vasc. Biol. 35(6), 2015
PMID: 25908767
Prevalence of Comorbidities in Asthma and Nonasthma Patients: A Meta-analysis.
Su X, Ren Y, Li M, Zhao X, Kong L, Kang J., Medicine (Baltimore) 95(22), 2016
PMID: 27258489
Su X, Ren Y, Li M, Zhao X, Kong L, Kang J., Medicine (Baltimore) 95(22), 2016
PMID: 27258489
AUTHOR UNKNOWN, 0
Hypertension as an autoimmune and inflammatory disease.
Solak Y, Afsar B, Vaziri ND, Aslan G, Yalcin CE, Covic A, Kanbay M., Hypertens. Res. 39(8), 2016
PMID: 27053010
Solak Y, Afsar B, Vaziri ND, Aslan G, Yalcin CE, Covic A, Kanbay M., Hypertens. Res. 39(8), 2016
PMID: 27053010
Treatment of allergic rhinitis can improve blood pressure control.
Magen E, Yosefy C, Viskoper RJ, Mishal J., J Hum Hypertens 20(11), 2006
PMID: 16967045
Magen E, Yosefy C, Viskoper RJ, Mishal J., J Hum Hypertens 20(11), 2006
PMID: 16967045
Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma.
Litonjua AA, Tantisira KG, Lake S, Lazarus R, Richter BG, Gabriel S, Silverman ES, Weiss ST., Respir. Res. 6(), 2005
PMID: 15935090
Litonjua AA, Tantisira KG, Lake S, Lazarus R, Richter BG, Gabriel S, Silverman ES, Weiss ST., Respir. Res. 6(), 2005
PMID: 15935090
Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.
Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR., J. Immunol. 178(10), 2007
PMID: 17475846
Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR., J. Immunol. 178(10), 2007
PMID: 17475846
Coronary artery abnormalities in Hyper-IgE syndrome.
Freeman AF, Avila EM, Shaw PA, Davis J, Hsu AP, Welch P, Matta JR, Hadigan C, Pettigrew RI, Holland SM, Gharib AM., J. Clin. Immunol. 31(3), 2011
PMID: 21494893
Freeman AF, Avila EM, Shaw PA, Davis J, Hsu AP, Welch P, Matta JR, Hadigan C, Pettigrew RI, Holland SM, Gharib AM., J. Clin. Immunol. 31(3), 2011
PMID: 21494893
Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study.
Morales DR, Lipworth BJ, Donnan PT, Jackson C, Guthrie B., BMC Med 15(1), 2017
PMID: 28126029
Morales DR, Lipworth BJ, Donnan PT, Jackson C, Guthrie B., BMC Med 15(1), 2017
PMID: 28126029
AUTHOR UNKNOWN, 0
ISH NIA OS-03 genetic determinants of essential hypertension in the population of Tatars from Russia
Timasheva Y, Nasibullin T, Imaeva E, Mirsaeva G, Mustafina O., 2016
Timasheva Y, Nasibullin T, Imaeva E, Mirsaeva G, Mustafina O., 2016
Association between β2-adrenoceptor gene polymorphisms and asthma risk: an updated meta-analysis.
Xie H, Cheng Y, Huo Y, Huang G, Su J., PLoS ONE 9(7), 2014
PMID: 24992184
Xie H, Cheng Y, Huo Y, Huang G, Su J., PLoS ONE 9(7), 2014
PMID: 24992184
STAT6 links IL-4/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease.
Nofziger C, Vezzoli V, Dossena S, Schonherr T, Studnicka J, Nofziger J, Vanoni S, Stephan S, Silva ME, Meyer G, Paulmichl M., Clin. Pharmacol. Ther. 90(3), 2011
PMID: 21814192
Nofziger C, Vezzoli V, Dossena S, Schonherr T, Studnicka J, Nofziger J, Vanoni S, Stephan S, Silva ME, Meyer G, Paulmichl M., Clin. Pharmacol. Ther. 90(3), 2011
PMID: 21814192
Resistance to hypertension and high Cl- excretion in humans with SLC26A4 mutations.
Kim BG, Yoo TH, Yoo JE, Seo YJ, Jung J, Choi JY., Clin. Genet. 91(3), 2016
PMID: 27090054
Kim BG, Yoo TH, Yoo JE, Seo YJ, Jung J, Choi JY., Clin. Genet. 91(3), 2016
PMID: 27090054
Identification of allelic variants of pendrin (SLC26A4) with loss and gain of function.
Dossena S, Bizhanova A, Nofziger C, Bernardinelli E, Ramsauer J, Kopp P, Paulmichl M., Cell. Physiol. Biochem. 28(3), 2011
PMID: 22116359
Dossena S, Bizhanova A, Nofziger C, Bernardinelli E, Ramsauer J, Kopp P, Paulmichl M., Cell. Physiol. Biochem. 28(3), 2011
PMID: 22116359
Do mutations of the Pendred syndrome gene, SLC26A4, confer resistance to asthma and hypertension?
Madeo AC, Manichaikul A, Pryor SP, Griffith AJ., J. Med. Genet. 46(6), 2009
PMID: 19289392
Madeo AC, Manichaikul A, Pryor SP, Griffith AJ., J. Med. Genet. 46(6), 2009
PMID: 19289392
Plasma membrane Cl⁻/HCO₃⁻ exchangers: structure, mechanism and physiology.
Bonar PT, Casey JR., Channels (Austin) 2(5), 2008
PMID: 19066446
Bonar PT, Casey JR., Channels (Austin) 2(5), 2008
PMID: 19066446
Hypertension and Asthma: A Comorbid Relationship.
Christiansen SC, Schatz M, Yang SJ, Ngor E, Chen W, Zuraw BL., J Allergy Clin Immunol Pract 4(1), 2015
PMID: 26342745
Christiansen SC, Schatz M, Yang SJ, Ngor E, Chen W, Zuraw BL., J Allergy Clin Immunol Pract 4(1), 2015
PMID: 26342745
Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms.
Ekins S, Bugrim A, Brovold L, Kirillov E, Nikolsky Y, Rakhmatulin E, Sorokina S, Ryabov A, Serebryiskaya T, Melnikov A, Metz J, Nikolskaya T., Xenobiotica 36(10-11), 2006
PMID: 17118913
Ekins S, Bugrim A, Brovold L, Kirillov E, Nikolsky Y, Rakhmatulin E, Sorokina S, Ryabov A, Serebryiskaya T, Melnikov A, Metz J, Nikolskaya T., Xenobiotica 36(10-11), 2006
PMID: 17118913
Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886.
Mayburd AL, Martlinez A, Sackett D, Liu H, Shih J, Tauler J, Avis I, Mulshine JL., Clin. Cancer Res. 12(6), 2006
PMID: 16551867
Mayburd AL, Martlinez A, Sackett D, Liu H, Shih J, Tauler J, Avis I, Mulshine JL., Clin. Cancer Res. 12(6), 2006
PMID: 16551867
ANDVisio: a new tool for graphic visualization and analysis of literature mined associative gene networks in the ANDSystem
Demenkov PS, Ivanisenko TV, Kolchanov NA, Ivanisenko VA., 2012
Demenkov PS, Ivanisenko TV, Kolchanov NA, Ivanisenko VA., 2012
ANDSystem: an Associative Network Discovery System for automated literature mining in the field of biology.
Ivanisenko VA, Saik OV, Ivanisenko NV, Tiys ES, Ivanisenko TV, Demenkov PS, Kolchanov NA., BMC Syst Biol 9 Suppl 2(), 2015
PMID: 25881313
Ivanisenko VA, Saik OV, Ivanisenko NV, Tiys ES, Ivanisenko TV, Demenkov PS, Kolchanov NA., BMC Syst Biol 9 Suppl 2(), 2015
PMID: 25881313
Functional divergence of Helicobacter pylori related to early gastric cancer.
Momynaliev KT, Kashin SV, Chelysheva VV, Selezneva OV, Demina IA, Serebryakova MV, Alexeev D, Ivanisenko VA, Aman E, Govorun VM., J. Proteome Res. 9(1), 2010
PMID: 19886703
Momynaliev KT, Kashin SV, Chelysheva VV, Selezneva OV, Demina IA, Serebryakova MV, Alexeev D, Ivanisenko VA, Aman E, Govorun VM., J. Proteome Res. 9(1), 2010
PMID: 19886703
Permanent proteins in the urine of healthy humans during the Mars-500 experiment.
Larina IM, Pastushkova LKh, Tiys ES, Kireev KS, Kononikhin AS, Starodubtseva NL, Popov IA, Custaud MA, Dobrokhotov IV, Nikolaev EN, Kolchanov NA, Ivanisenko VA., J Bioinform Comput Biol 13(1), 2015
PMID: 25572715
Larina IM, Pastushkova LKh, Tiys ES, Kireev KS, Kononikhin AS, Starodubtseva NL, Popov IA, Custaud MA, Dobrokhotov IV, Nikolaev EN, Kolchanov NA, Ivanisenko VA., J Bioinform Comput Biol 13(1), 2015
PMID: 25572715
Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain.
Petrovskiy ED, Saik OV, Tiys ES, Lavrik IN, Kolchanov NA, Ivanisenko VA., BMC Genomics 16 Suppl 13(), 2015
PMID: 26693857
Petrovskiy ED, Saik OV, Tiys ES, Lavrik IN, Kolchanov NA, Ivanisenko VA., BMC Genomics 16 Suppl 13(), 2015
PMID: 26693857
Mosaic gene network modelling identified new regulatory mechanisms in HCV infection.
Popik OV, Petrovskiy ED, Mishchenko EL, Lavrik IN, Ivanisenko VA., Virus Res. 218(), 2015
PMID: 26481968
Popik OV, Petrovskiy ED, Mishchenko EL, Lavrik IN, Ivanisenko VA., Virus Res. 218(), 2015
PMID: 26481968
Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis.
Bragina EY, Tiys ES, Freidin MB, Koneva LA, Demenkov PS, Ivanisenko VA, Kolchanov NA, Puzyrev VP., Immunogenetics 66(7-8), 2014
PMID: 24954693
Bragina EY, Tiys ES, Freidin MB, Koneva LA, Demenkov PS, Ivanisenko VA, Kolchanov NA, Puzyrev VP., Immunogenetics 66(7-8), 2014
PMID: 24954693
Molecular association of pathogenetic contributors to pre-eclampsia (pre-eclampsia associome).
Glotov AS, Tiys ES, Vashukova ES, Pakin VS, Demenkov PS, Saik OV, Ivanisenko TV, Arzhanova ON, Mozgovaya EV, Zainulina MS, Kolchanov NA, Baranov VS, Ivanisenko VA., BMC Syst Biol 9 Suppl 2(), 2015
PMID: 25879409
Glotov AS, Tiys ES, Vashukova ES, Pakin VS, Demenkov PS, Saik OV, Ivanisenko TV, Arzhanova ON, Mozgovaya EV, Zainulina MS, Kolchanov NA, Baranov VS, Ivanisenko VA., BMC Syst Biol 9 Suppl 2(), 2015
PMID: 25879409
Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma
Saik OV, Konovalova NA, Demenkov PS, Ivanisenko NV, Ivanisenko TV, Ivanoshchuk DE, Konovalova OS, Podkolodnaya OA, Lavrik IN, Kolchanov NA, Ivanisenko VA., 2017
Saik OV, Konovalova NA, Demenkov PS, Ivanisenko NV, Ivanisenko TV, Ivanoshchuk DE, Konovalova OS, Podkolodnaya OA, Lavrik IN, Kolchanov NA, Ivanisenko VA., 2017
Novel tuberculosis susceptibility candidate genes revealed by the reconstruction and analysis of associative networks.
Bragina EY, Tiys ES, Rudko AA, Ivanisenko VA, Freidin MB., Infect. Genet. Evol. 46(), 2016
PMID: 27810501
Bragina EY, Tiys ES, Rudko AA, Ivanisenko VA, Freidin MB., Infect. Genet. Evol. 46(), 2016
PMID: 27810501
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
Huang da W, Sherman BT, Lempicki RA., Nat Protoc 4(1), 2009
PMID: 19131956
Huang da W, Sherman BT, Lempicki RA., Nat Protoc 4(1), 2009
PMID: 19131956
Hagberg A, Swart P, Chult D., 2008
Candidate gene prioritization with Endeavour.
Tranchevent LC, Ardeshirdavani A, ElShal S, Alcaide D, Aerts J, Auboeuf D, Moreau Y., Nucleic Acids Res. 44(W1), 2016
PMID: 27131783
Tranchevent LC, Ardeshirdavani A, ElShal S, Alcaide D, Aerts J, Auboeuf D, Moreau Y., Nucleic Acids Res. 44(W1), 2016
PMID: 27131783
Gene prioritization through genomic data fusion.
Aerts S, Lambrechts D, Maity S, Van Loo P, Coessens B, De Smet F, Tranchevent LC, De Moor B, Marynen P, Hassan B, Carmeliet P, Moreau Y., Nat. Biotechnol. 24(5), 2006
PMID: 16680138
Aerts S, Lambrechts D, Maity S, Van Loo P, Coessens B, De Smet F, Tranchevent LC, De Moor B, Marynen P, Hassan B, Carmeliet P, Moreau Y., Nat. Biotechnol. 24(5), 2006
PMID: 16680138
Improved human disease candidate gene prioritization using mouse phenotype.
Chen J, Xu H, Aronow BJ, Jegga AG., BMC Bioinformatics 8(), 2007
PMID: 17939863
Chen J, Xu H, Aronow BJ, Jegga AG., BMC Bioinformatics 8(), 2007
PMID: 17939863
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization.
Chen J, Bardes EE, Aronow BJ, Jegga AG., Nucleic Acids Res. 37(Web Server issue), 2009
PMID: 19465376
Chen J, Bardes EE, Aronow BJ, Jegga AG., Nucleic Acids Res. 37(Web Server issue), 2009
PMID: 19465376
AUTHOR UNKNOWN, 0
Python for scientists and engineers
Millman KJ, Aivazis M., 2011
Millman KJ, Aivazis M., 2011
Multiple hypothesis testing
Shaffer JP., 1995
Shaffer JP., 1995
Population genomics of human gene expression.
Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S, Tavare S, Deloukas P, Dermitzakis ET., Nat. Genet. 39(10), 2007
PMID: 17873874
Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, Montgomery S, Tavare S, Deloukas P, Dermitzakis ET., Nat. Genet. 39(10), 2007
PMID: 17873874
Finding the missing heritability of complex diseases.
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM., Nature 461(7265), 2009
PMID: 19812666
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM., Nature 461(7265), 2009
PMID: 19812666
Integrating common and rare genetic variation in diverse human populations.
International HapMap 3 Consortium, Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, Yu F, Peltonen L, Dermitzakis E, Bonnen PE, Altshuler DM, Gibbs RA, de Bakker PI, Deloukas P, Gabriel SB, Gwilliam R, Hunt S, Inouye M, Jia X, Palotie A, Parkin M, Whittaker P, Yu F, Chang K, Hawes A, Lewis LR, Ren Y, Wheeler D, Gibbs RA, Muzny DM, Barnes C, Darvishi K, Hurles M, Korn JM, Kristiansson K, Lee C, McCarrol SA, Nemesh J, Dermitzakis E, Keinan A, Montgomery SB, Pollack S, Price AL, Soranzo N, Bonnen PE, Gibbs RA, Gonzaga-Jauregui C, Keinan A, Price AL, Yu F, Anttila V, Brodeur W, Daly MJ, Leslie S, McVean G, Moutsianas L, Nguyen H, Schaffner SF, Zhang Q, Ghori MJ, McGinnis R, McLaren W, Pollack S, Price AL, Schaffner SF, Takeuchi F, Grossman SR, Shlyakhter I, Hostetter EB, Sabeti PC, Adebamowo CA, Foster MW, Gordon DR, Licinio J, Manca MC, Marshall PA, Matsuda I, Ngare D, Wang VO, Reddy D, Rotimi CN, Royal CD, Sharp RR, Zeng C, Brooks LD, McEwen JE., Nature 467(7311), 2010
PMID: 20811451
International HapMap 3 Consortium, Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM, Gibbs RA, Peltonen L, Dermitzakis E, Schaffner SF, Yu F, Peltonen L, Dermitzakis E, Bonnen PE, Altshuler DM, Gibbs RA, de Bakker PI, Deloukas P, Gabriel SB, Gwilliam R, Hunt S, Inouye M, Jia X, Palotie A, Parkin M, Whittaker P, Yu F, Chang K, Hawes A, Lewis LR, Ren Y, Wheeler D, Gibbs RA, Muzny DM, Barnes C, Darvishi K, Hurles M, Korn JM, Kristiansson K, Lee C, McCarrol SA, Nemesh J, Dermitzakis E, Keinan A, Montgomery SB, Pollack S, Price AL, Soranzo N, Bonnen PE, Gibbs RA, Gonzaga-Jauregui C, Keinan A, Price AL, Yu F, Anttila V, Brodeur W, Daly MJ, Leslie S, McVean G, Moutsianas L, Nguyen H, Schaffner SF, Zhang Q, Ghori MJ, McGinnis R, McLaren W, Pollack S, Price AL, Schaffner SF, Takeuchi F, Grossman SR, Shlyakhter I, Hostetter EB, Sabeti PC, Adebamowo CA, Foster MW, Gordon DR, Licinio J, Manca MC, Marshall PA, Matsuda I, Ngare D, Wang VO, Reddy D, Rotimi CN, Royal CD, Sharp RR, Zeng C, Brooks LD, McEwen JE., Nature 467(7311), 2010
PMID: 20811451
The Genotype-Tissue Expression (GTEx) project.
GTEx Consortium, Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, DeLuca D, MacArthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Kyung H, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis T, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel A, Wright F, Shabalin A, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little AR, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, Moore HF., Nat. Genet. 45(6), 2013
PMID: 23715323
GTEx Consortium, Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, DeLuca D, MacArthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Kyung H, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis T, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel A, Wright F, Shabalin A, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little AR, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, Moore HF., Nat. Genet. 45(6), 2013
PMID: 23715323
AUTHOR UNKNOWN, 0
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL., Science 344(6183), 2014
PMID: 24786080
Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL., Science 344(6183), 2014
PMID: 24786080
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS.
Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ., PLoS Genet. 6(4), 2010
PMID: 20369019
Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ., PLoS Genet. 6(4), 2010
PMID: 20369019
The Ensembl genome database project.
Hubbard T, Barker D, Birney E, Cameron G, Chen Y, Clark L, Cox T, Cuff J, Curwen V, Down T, Durbin R, Eyras E, Gilbert J, Hammond M, Huminiecki L, Kasprzyk A, Lehvaslaiho H, Lijnzaad P, Melsopp C, Mongin E, Pettett R, Pocock M, Potter S, Rust A, Schmidt E, Searle S, Slater G, Smith J, Spooner W, Stabenau A, Stalker J, Stupka E, Ureta-Vidal A, Vastrik I, Clamp M., Nucleic Acids Res. 30(1), 2002
PMID: 11752248
Hubbard T, Barker D, Birney E, Cameron G, Chen Y, Clark L, Cox T, Cuff J, Curwen V, Down T, Durbin R, Eyras E, Gilbert J, Hammond M, Huminiecki L, Kasprzyk A, Lehvaslaiho H, Lijnzaad P, Melsopp C, Mongin E, Pettett R, Pocock M, Potter S, Rust A, Schmidt E, Searle S, Slater G, Smith J, Spooner W, Stabenau A, Stalker J, Stupka E, Ureta-Vidal A, Vastrik I, Clamp M., Nucleic Acids Res. 30(1), 2002
PMID: 11752248
SNPedia: a wiki supporting personal genome annotation, interpretation and analysis.
Cariaso M, Lennon G., Nucleic Acids Res. 40(Database issue), 2011
PMID: 22140107
Cariaso M, Lennon G., Nucleic Acids Res. 40(Database issue), 2011
PMID: 22140107
miRdSNP: a database of disease-associated SNPs and microRNA target sites on 3'UTRs of human genes.
Bruno AE, Li L, Kalabus JL, Pan Y, Yu A, Hu Z., BMC Genomics 13(), 2012
PMID: 22276777
Bruno AE, Li L, Kalabus JL, Pan Y, Yu A, Hu Z., BMC Genomics 13(), 2012
PMID: 22276777
The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog).
MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, Junkins H, McMahon A, Milano A, Morales J, Pendlington ZM, Welter D, Burdett T, Hindorff L, Flicek P, Cunningham F, Parkinson H., Nucleic Acids Res. 45(D1), 2016
PMID: 27899670
MacArthur J, Bowler E, Cerezo M, Gil L, Hall P, Hastings E, Junkins H, McMahon A, Milano A, Morales J, Pendlington ZM, Welter D, Burdett T, Hindorff L, Flicek P, Cunningham F, Parkinson H., Nucleic Acids Res. 45(D1), 2016
PMID: 27899670
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants.
Pinero J, Bravo A, Queralt-Rosinach N, Gutierrez-Sacristan A, Deu-Pons J, Centeno E, Garcia-Garcia J, Sanz F, Furlong LI., Nucleic Acids Res. 45(D1), 2016
PMID: 27924018
Pinero J, Bravo A, Queralt-Rosinach N, Gutierrez-Sacristan A, Deu-Pons J, Centeno E, Garcia-Garcia J, Sanz F, Furlong LI., Nucleic Acids Res. 45(D1), 2016
PMID: 27924018
AUTHOR UNKNOWN, 0
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G., Nat. Genet. 25(1), 2000
PMID: 10802651
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G., Nat. Genet. 25(1), 2000
PMID: 10802651
AmiGO: online access to ontology and annotation data.
Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S; AmiGO Hub; Web Presence Working Group, Ireland A, Lomax J, Carbon S, Mungall C, Hitz B, Balakrishnan R, Dolan M, Wood V, Hong E, Gaudet P., Bioinformatics 25(2), 2008
PMID: 19033274
Carbon S, Ireland A, Mungall CJ, Shu S, Marshall B, Lewis S; AmiGO Hub; Web Presence Working Group, Ireland A, Lomax J, Carbon S, Mungall C, Hitz B, Balakrishnan R, Dolan M, Wood V, Hong E, Gaudet P., Bioinformatics 25(2), 2008
PMID: 19033274
Genetic overlap between measures of hyperactivity/inattention and mood in children and adolescents.
Cole J, Ball HA, Martin NC, Scourfield J, McGuffin P., J Am Acad Child Adolesc Psychiatry 48(11), 2009
PMID: 19797986
Cole J, Ball HA, Martin NC, Scourfield J, McGuffin P., J Am Acad Child Adolesc Psychiatry 48(11), 2009
PMID: 19797986
Genetic bases of human comorbidity
Puzyrev VP., 2015
Puzyrev VP., 2015
Comorbidities of Psoriasis - Exploring the Links by Network Approach.
Sundarrajan S, Arumugam M., PLoS ONE 11(3), 2016
PMID: 26966903
Sundarrajan S, Arumugam M., PLoS ONE 11(3), 2016
PMID: 26966903
Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE.
Hong X, Tsai HJ, Liu X, Arguelles L, Kumar R, Wang G, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang X., J. Allergy Clin. Immunol. 126(5), 2010
PMID: 21050946
Hong X, Tsai HJ, Liu X, Arguelles L, Kumar R, Wang G, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang X., J. Allergy Clin. Immunol. 126(5), 2010
PMID: 21050946
AUTHOR UNKNOWN, 0
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Turpeinen H, Seppala I, Lyytikainen LP, Raitoharju E, Hutri-Kahonen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kahonen M, Lehtimaki T, Pesu M., Hum. Genet. 134(6), 2015
PMID: 25813623
Turpeinen H, Seppala I, Lyytikainen LP, Raitoharju E, Hutri-Kahonen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kahonen M, Lehtimaki T, Pesu M., Hum. Genet. 134(6), 2015
PMID: 25813623
TNF-alpha inhibitors in asthma and COPD: we must not throw the baby out with the bath water.
Matera MG, Calzetta L, Cazzola M., Pulm Pharmacol Ther 23(2), 2009
PMID: 19853667
Matera MG, Calzetta L, Cazzola M., Pulm Pharmacol Ther 23(2), 2009
PMID: 19853667
Tumor necrosis factor alpha-mediated asthma?.
Nabe T., Int. Arch. Allergy Immunol. 160(2), 2012
PMID: 23018199
Nabe T., Int. Arch. Allergy Immunol. 160(2), 2012
PMID: 23018199
Tumor necrosis factor-α: regulation of renal function and blood pressure.
Ramseyer VD, Garvin JL., Am. J. Physiol. Renal Physiol. 304(10), 2013
PMID: 23515717
Ramseyer VD, Garvin JL., Am. J. Physiol. Renal Physiol. 304(10), 2013
PMID: 23515717
Network biology: understanding the cell's functional organization.
Barabasi AL, Oltvai ZN., Nat. Rev. Genet. 5(2), 2004
PMID: 14735121
Barabasi AL, Oltvai ZN., Nat. Rev. Genet. 5(2), 2004
PMID: 14735121
Maintenance of NF-kappa B activity is dependent on protein synthesis and the continuous presence of external stimuli.
Hohmann HP, Remy R, Scheidereit C, van Loon AP., Mol. Cell. Biol. 11(1), 1991
PMID: 1986224
Hohmann HP, Remy R, Scheidereit C, van Loon AP., Mol. Cell. Biol. 11(1), 1991
PMID: 1986224
Peripheral blood mononuclear cell NF-kappaB p105 mRNA decreases during asthmatic attacks.
Matsumura Y., Biomed. Pharmacother. 62(3), 2007
PMID: 17913447
Matsumura Y., Biomed. Pharmacother. 62(3), 2007
PMID: 17913447
NF-kappaB signaling in chronic inflammatory airway disease
Schuliga M., 2015
Schuliga M., 2015
Blood oxygen transport and endothelial dysfunction in patients with arterial hypertension.
Zinchuk VV, Pronko TP, Lis MA., Clin Physiol Funct Imaging 24(4), 2004
PMID: 15233834
Zinchuk VV, Pronko TP, Lis MA., Clin Physiol Funct Imaging 24(4), 2004
PMID: 15233834
A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats.
Magyar K, Deres L, Eros K, Bruszt K, Seress L, Hamar J, Hideg K, Balogh A, Gallyas F Jr, Sumegi B, Toth K, Halmosi R., Biochim. Biophys. Acta 1842(7), 2014
PMID: 24657811
Magyar K, Deres L, Eros K, Bruszt K, Seress L, Hamar J, Hideg K, Balogh A, Gallyas F Jr, Sumegi B, Toth K, Halmosi R., Biochim. Biophys. Acta 1842(7), 2014
PMID: 24657811
NFkappaB regulates plasma apolipoprotein A-I and high density lipoprotein cholesterol through inhibition of peroxisome proliferator-activated receptor alpha.
Morishima A, Ohkubo N, Maeda N, Miki T, Mitsuda N., J. Biol. Chem. 278(40), 2003
PMID: 12882972
Morishima A, Ohkubo N, Maeda N, Miki T, Mitsuda N., J. Biol. Chem. 278(40), 2003
PMID: 12882972
[Dyslipoproteinemia in primary hypertension].
Chotkowska EW, Sznajderman M, Szczesniewska D, Niegowska J, Rywik S., Pol. Arch. Med. Wewn. 97(2), 1997
PMID: 9312761
Chotkowska EW, Sznajderman M, Szczesniewska D, Niegowska J, Rywik S., Pol. Arch. Med. Wewn. 97(2), 1997
PMID: 9312761
Correlation between serum cystatin C level and elderly hypertensive patients combined coronary heart disease.
Wang Y, Su X, Zhang W, Yang W, Wang Y, He Y., Int J Clin Exp Med 8(4), 2015
PMID: 26131241
Wang Y, Su X, Zhang W, Yang W, Wang Y, He Y., Int J Clin Exp Med 8(4), 2015
PMID: 26131241
Apolipoprotein mimetic peptides: a new approach for the treatment of asthma.
Yao X, Vitek MP, Remaley AT, Levine SJ., Front Pharmacol 3(), 2012
PMID: 22408624
Yao X, Vitek MP, Remaley AT, Levine SJ., Front Pharmacol 3(), 2012
PMID: 22408624
Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.
Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS., Clin. Exp. Allergy 43(8), 2013
PMID: 23889245
Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS., Clin. Exp. Allergy 43(8), 2013
PMID: 23889245
Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall.
Getz GS, Reardon CA., J. Lipid Res. 50 Suppl(), 2008
PMID: 19018038
Getz GS, Reardon CA., J. Lipid Res. 50 Suppl(), 2008
PMID: 19018038
In silico gene prioritization by integrating multiple data sources.
Chen Y, Wang W, Zhou Y, Shields R, Chanda SK, Elston RC, Li J., PLoS ONE 6(6), 2011
PMID: 21731658
Chen Y, Wang W, Zhou Y, Shields R, Chanda SK, Elston RC, Li J., PLoS ONE 6(6), 2011
PMID: 21731658
AUTHOR UNKNOWN, 0
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search.
Rappaport N, Twik M, Plaschkes I, Nudel R, Iny Stein T, Levitt J, Gershoni M, Morrey CP, Safran M, Lancet D., Nucleic Acids Res. 45(D1), 2016
PMID: 27899610
Rappaport N, Twik M, Plaschkes I, Nudel R, Iny Stein T, Levitt J, Gershoni M, Morrey CP, Safran M, Lancet D., Nucleic Acids Res. 45(D1), 2016
PMID: 27899610
Differences in kidney function and incident hypertension: the multi-ethnic study of atherosclerosis.
Kestenbaum B, Rudser KD, de Boer IH, Peralta CA, Fried LF, Shlipak MG, Palmas W, Stehman-Breen C, Siscovick DS., Ann. Intern. Med. 148(7), 2008
PMID: 18378946
Kestenbaum B, Rudser KD, de Boer IH, Peralta CA, Fried LF, Shlipak MG, Palmas W, Stehman-Breen C, Siscovick DS., Ann. Intern. Med. 148(7), 2008
PMID: 18378946
Impact of asthmatic control status on serum cystatin C concentrations.
Shigemura M, Konno S, Nasuhara Y, Shimizu C, Matsuno K, Nishimura M., Clin. Chem. Lab. Med. 50(8), 2012
PMID: 23035264
Shigemura M, Konno S, Nasuhara Y, Shimizu C, Matsuno K, Nishimura M., Clin. Chem. Lab. Med. 50(8), 2012
PMID: 23035264
Genetic predisposition to left ventricular hypertrophy and the potential involvement of cystatin-C in untreated hypertension.
Tousoulis D, Androulakis E, Papageorgiou N, Miliou A, Chatzistamatiou E, Oikonomou E, Moustakas G, Kallikazaros I, Stefanadis C., Am. J. Hypertens. 26(5), 2013
PMID: 23479071
Tousoulis D, Androulakis E, Papageorgiou N, Miliou A, Chatzistamatiou E, Oikonomou E, Moustakas G, Kallikazaros I, Stefanadis C., Am. J. Hypertens. 26(5), 2013
PMID: 23479071
Effect of different 1, 25-(OH)2D3 doses on high mobility group box1 and toll-like receptors 4 expression in lung tissue of asthmatic mice.
Qiao J, Luan B, Gu H, Zhang Y., Int J Clin Exp Med 8(3), 2015
PMID: 26064304
Qiao J, Luan B, Gu H, Zhang Y., Int J Clin Exp Med 8(3), 2015
PMID: 26064304
Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats.
Bomfim GF, Dos Santos RA, Oliveira MA, Giachini FR, Akamine EH, Tostes RC, Fortes ZB, Webb RC, Carvalho MH., Clin. Sci. 122(11), 2012
PMID: 22233532
Bomfim GF, Dos Santos RA, Oliveira MA, Giachini FR, Akamine EH, Tostes RC, Fortes ZB, Webb RC, Carvalho MH., Clin. Sci. 122(11), 2012
PMID: 22233532
Inhibition by fenoterol of human eosinophil functions including beta2-adrenoceptor-independent actions.
Tachibana A, Kato M, Kimura H, Fujiu T, Suzuki M, Morikawa A., Clin. Exp. Immunol. 130(3), 2002
PMID: 12452831
Tachibana A, Kato M, Kimura H, Fujiu T, Suzuki M, Morikawa A., Clin. Exp. Immunol. 130(3), 2002
PMID: 12452831
Characterization of a panel of six beta2-adrenergic receptor antibodies by indirect immunofluorescence microscopy.
Koryakina YA, Fowler TW, Jones SM, Schnackenberg BJ, Cornett LE, Kurten RC., Respir. Res. 9(), 2008
PMID: 18423037
Koryakina YA, Fowler TW, Jones SM, Schnackenberg BJ, Cornett LE, Kurten RC., Respir. Res. 9(), 2008
PMID: 18423037
Association of beta2-adrenergic receptor polymorphisms with severe asthma.
Holloway JW, Dunbar PR, Riley GA, Sawyer GM, Fitzharris PF, Pearce N, Le Gros GS, Beasley R., Clin. Exp. Allergy 30(8), 2000
PMID: 10931116
Holloway JW, Dunbar PR, Riley GA, Sawyer GM, Fitzharris PF, Pearce N, Le Gros GS, Beasley R., Clin. Exp. Allergy 30(8), 2000
PMID: 10931116
Beta2-adrenergic receptor gene polymorphism in Chinese Northern asthmatics.
Gao JM, Lin YG, Qiu CC, Liu YW, Ma Y, Liu Y., Chin. Med. Sci. J. 19(3), 2004
PMID: 15506640
Gao JM, Lin YG, Qiu CC, Liu YW, Ma Y, Liu Y., Chin. Med. Sci. J. 19(3), 2004
PMID: 15506640
Positional genomic analysis identifies the beta(2)-adrenergic receptor gene as a susceptibility locus for human hypertension.
Bray MS, Krushkal J, Li L, Ferrell R, Kardia S, Sing CF, Turner ST, Boerwinkle E., Circulation 101(25), 2000
PMID: 10869257
Bray MS, Krushkal J, Li L, Ferrell R, Kardia S, Sing CF, Turner ST, Boerwinkle E., Circulation 101(25), 2000
PMID: 10869257
Polymorphisms of the beta2 -adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies.
Herrmann SM, Nicaud V, Tiret L, Evans A, Kee F, Ruidavets JB, Arveiler D, Luc G, Morrison C, Hoehe MR, Paul M, Cambien F., J. Hypertens. 20(2), 2002
PMID: 11821707
Herrmann SM, Nicaud V, Tiret L, Evans A, Kee F, Ruidavets JB, Arveiler D, Luc G, Morrison C, Hoehe MR, Paul M, Cambien F., J. Hypertens. 20(2), 2002
PMID: 11821707
Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.
Chung F., Mediators Inflamm. 10(2), 2001
PMID: 11405550
Chung F., Mediators Inflamm. 10(2), 2001
PMID: 11405550
Role of IL-10 in the resolution of airway inflammation.
Ogawa Y, Duru EA, Ameredes BT., Curr. Mol. Med. 8(5), 2008
PMID: 18691071
Ogawa Y, Duru EA, Ameredes BT., Curr. Mol. Med. 8(5), 2008
PMID: 18691071
Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats
Tinsley JH, South S, Chiasson VL, Mitchell BM., 2010
Tinsley JH, South S, Chiasson VL, Mitchell BM., 2010
IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.
Harmon A, Cornelius D, Amaral L, Paige A, Herse F, Ibrahim T, Wallukat G, Faulkner J, Moseley J, Dechend R, LaMarca B., Hypertens Pregnancy 34(3), 2015
PMID: 25996051
Harmon A, Cornelius D, Amaral L, Paige A, Herse F, Ibrahim T, Wallukat G, Faulkner J, Moseley J, Dechend R, LaMarca B., Hypertens Pregnancy 34(3), 2015
PMID: 25996051
Reduced superoxide dismutase in lung cells of patients with asthma.
Smith LJ, Shamsuddin M, Sporn PH, Denenberg M, Anderson J., Free Radic. Biol. Med. 22(7), 1997
PMID: 9098106
Smith LJ, Shamsuddin M, Sporn PH, Denenberg M, Anderson J., Free Radic. Biol. Med. 22(7), 1997
PMID: 9098106
Are free radicals involved in the pathobiology of human essential hypertension?
Kumar KV, Das UN., Free Radic. Res. Commun. 19(1), 1993
PMID: 8225035
Kumar KV, Das UN., Free Radic. Res. Commun. 19(1), 1993
PMID: 8225035
Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice.
Godin N, Liu F, Lau GJ, Brezniceanu ML, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS., Kidney Int. 77(12), 2010
PMID: 20237455
Godin N, Liu F, Lau GJ, Brezniceanu ML, Chenier I, Filep JG, Ingelfinger JR, Zhang SL, Chan JS., Kidney Int. 77(12), 2010
PMID: 20237455
Changes in levels of catalase and glutathione in erythrocytes of patients with stable asthma, treated with beclomethasone dipropionate.
Pennings HJ, Borm PJ, Evelo CT, Wouters EF., Eur. Respir. J. 13(6), 1999
PMID: 10445599
Pennings HJ, Borm PJ, Evelo CT, Wouters EF., Eur. Respir. J. 13(6), 1999
PMID: 10445599
Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma.
Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki Y., J. Radiat. Res. 44(2), 2003
PMID: 13678337
Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki Y., J. Radiat. Res. 44(2), 2003
PMID: 13678337
Apoptosis occurs in endothelial cells during hypertension-induced microvascular rarefaction.
Gobe G, Browning J, Howard T, Hogg N, Winterford C, Cross R., J. Struct. Biol. 118(1), 1997
PMID: 9087915
Gobe G, Browning J, Howard T, Hogg N, Winterford C, Cross R., J. Struct. Biol. 118(1), 1997
PMID: 9087915
AUTHOR UNKNOWN, 0
[Eosinophil apoptosis in asthma].
Druilhe A, Letuve S, Pretolani M., Pathol. Biol. 48(6), 2000
PMID: 10965536
Druilhe A, Letuve S, Pretolani M., Pathol. Biol. 48(6), 2000
PMID: 10965536
Resistance to Fas-mediated T cell apoptosis in asthma.
Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ., J. Immunol. 162(3), 1999
PMID: 9973434
Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ., J. Immunol. 162(3), 1999
PMID: 9973434
Apoptosis in target organs of hypertension.
Hamet P, Richard L, Dam TV, Teiger E, Orlov SN, Gaboury L, Gossard F, Tremblay J., Hypertension 26(4), 1995
PMID: 7558225
Hamet P, Richard L, Dam TV, Teiger E, Orlov SN, Gaboury L, Gossard F, Tremblay J., Hypertension 26(4), 1995
PMID: 7558225
Inflammation and apoptosis in hypertension. Relevance of the extent of target organ damage
Morillas P, de H, Castillo J, Quiles J, Bertomeu-González V, Cordero A, Tarazón E, Roselló E, Portolés M, Rivera M, Bertomeu-Martínez V., 2012
Morillas P, de H, Castillo J, Quiles J, Bertomeu-González V, Cordero A, Tarazón E, Roselló E, Portolés M, Rivera M, Bertomeu-Martínez V., 2012
Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway.
Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ., J. Cell. Physiol. 210(1), 2007
PMID: 17013806
Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ., J. Cell. Physiol. 210(1), 2007
PMID: 17013806
The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes.
Paas-Rozner M, Sela M, Mozes E., Proc. Natl. Acad. Sci. U.S.A. 98(22), 2001
PMID: 11606745
Paas-Rozner M, Sela M, Mozes E., Proc. Natl. Acad. Sci. U.S.A. 98(22), 2001
PMID: 11606745
Adrenomedullin in cultured human retinal pigment epithelial cells.
Udono T, Takahashi K, Nakayama M, Murakami O, Durlu YK, Tamai M, Shibahara S., Invest. Ophthalmol. Vis. Sci. 41(7), 2000
PMID: 10845623
Udono T, Takahashi K, Nakayama M, Murakami O, Durlu YK, Tamai M, Shibahara S., Invest. Ophthalmol. Vis. Sci. 41(7), 2000
PMID: 10845623
Plasma level of adrenomedullin is influenced by a single nucleotide polymorphism in the adiponectin gene.
Wong HK, Ong KL, Leung RY, Cheung TT, Xu A, Lam TH, Lam KS, Cheung BM., PLoS ONE 8(8), 2013
PMID: 23936408
Wong HK, Ong KL, Leung RY, Cheung TT, Xu A, Lam TH, Lam KS, Cheung BM., PLoS ONE 8(8), 2013
PMID: 23936408
Adiponectin reduces connective tissue growth factor in human hepatocytes which is already induced in non-fibrotic non-alcoholic steatohepatitis.
Walter R, Wanninger J, Bauer S, Eisinger K, Neumeier M, Weiss TS, Amann T, Hellerbrand C, Schaffler A, Scholmerich J, Buechler C., Exp. Mol. Pathol. 91(3), 2011
PMID: 21946149
Walter R, Wanninger J, Bauer S, Eisinger K, Neumeier M, Weiss TS, Amann T, Hellerbrand C, Schaffler A, Scholmerich J, Buechler C., Exp. Mol. Pathol. 91(3), 2011
PMID: 21946149
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells.
Wenger C, Ellenrieder V, Alber B, Lacher U, Menke A, Hameister H, Wilda M, Iwamura T, Beger HG, Adler G, Gress TM., Oncogene 18(4), 1999
PMID: 10023684
Wenger C, Ellenrieder V, Alber B, Lacher U, Menke A, Hameister H, Wilda M, Iwamura T, Beger HG, Adler G, Gress TM., Oncogene 18(4), 1999
PMID: 10023684
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
Tomita Y, Marchenko N, Erster S, Nemajerova A, Dehner A, Klein C, Pan H, Kessler H, Pancoska P, Moll UM., J. Biol. Chem. 281(13), 2006
PMID: 16443602
Tomita Y, Marchenko N, Erster S, Nemajerova A, Dehner A, Klein C, Pan H, Kessler H, Pancoska P, Moll UM., J. Biol. Chem. 281(13), 2006
PMID: 16443602
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC., Oncogene 9(6), 1994
PMID: 8183579
Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC., Oncogene 9(6), 1994
PMID: 8183579
Akt activation emulates Chk1 inhibition and Bcl2 overexpression and abrogates G2 cell cycle checkpoint by inhibiting BRCA1 foci.
Tonic I, Yu WN, Park Y, Chen CC, Hay N., J. Biol. Chem. 285(31), 2010
PMID: 20495005
Tonic I, Yu WN, Park Y, Chen CC, Hay N., J. Biol. Chem. 285(31), 2010
PMID: 20495005
Epidermal growth factor stimulates nuclear factor-κB activation and heme oxygenase-1 expression via c-Src, NADPH oxidase, PI3K, and Akt in human colon cancer cells.
Lien GS, Wu MS, Bien MY, Chen CH, Lin CH, Chen BC., PLoS ONE 9(8), 2014
PMID: 25122478
Lien GS, Wu MS, Bien MY, Chen CH, Lin CH, Chen BC., PLoS ONE 9(8), 2014
PMID: 25122478
Heme oxygenase-1/p21WAF1 mediates peroxisome proliferator-activated receptor-gamma signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells.
Li M, Li Z, Sun X, Yang L, Fang P, Liu Y, Li W, Xu J, Lu J, Xie M, Zhang D., FEBS J. 277(6), 2010
PMID: 20163460
Li M, Li Z, Sun X, Yang L, Fang P, Liu Y, Li W, Xu J, Lu J, Xie M, Zhang D., FEBS J. 277(6), 2010
PMID: 20163460
Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells.
Ackerman WE 4th, Zhang XL, Rovin BH, Kniss DA., Biol. Reprod. 73(3), 2005
PMID: 15843495
Ackerman WE 4th, Zhang XL, Rovin BH, Kniss DA., Biol. Reprod. 73(3), 2005
PMID: 15843495
Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes.
Sampey AV, Hutchinson P, Morand EF., Mediators Inflamm. 9(3-4), 2000
PMID: 11132768
Sampey AV, Hutchinson P, Morand EF., Mediators Inflamm. 9(3-4), 2000
PMID: 11132768
Induction of both cytosolic phospholipase A2 and prostaglandin H synthase-2 by interleukin-1 beta in WISH cells in inhibited by dexamethasone.
Xue S, Slater DM, Bennett PR, Myatt L., Prostaglandins 51(2), 1996
PMID: 8711133
Xue S, Slater DM, Bennett PR, Myatt L., Prostaglandins 51(2), 1996
PMID: 8711133
Prostaglandin E2 regulates the expression of connective tissue growth factor (CTGF/CCN2) in human osteoarthritic chondrocytes via the EP4 receptor.
Masuko K, Murata M, Yudoh K, Shimizu H, Beppu M, Nakamura H, Kato T., BMC Res Notes 3(), 2010
PMID: 20205862
Masuko K, Murata M, Yudoh K, Shimizu H, Beppu M, Nakamura H, Kato T., BMC Res Notes 3(), 2010
PMID: 20205862
Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.
Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Tsunematsu H, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Kubota S, Takigawa M, Tomimaru Y, Tomokuni A, Nagano H, Doki Y, Mori M, Hayashi N., J. Clin. Invest. 121(8), 2011
PMID: 21747166
Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Tsunematsu H, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Kubota S, Takigawa M, Tomimaru Y, Tomokuni A, Nagano H, Doki Y, Mori M, Hayashi N., J. Clin. Invest. 121(8), 2011
PMID: 21747166
Interleukin-10 induces macrophage apoptosis and expression of CD16 (FcgammaRIII) whose engagement blocks the cell death programme and facilitates differentiation.
Wang ZQ, Bapat AS, Rayanade RJ, Dagtas AS, Hoffmann MK., Immunology 102(3), 2001
PMID: 11298832
Wang ZQ, Bapat AS, Rayanade RJ, Dagtas AS, Hoffmann MK., Immunology 102(3), 2001
PMID: 11298832
Cytokine-modulated inhibition of neutrophil apoptosis at local site augments exudative neutrophil functions and reflects inflammatory response after surgery.
Matsuda T, Saito H, Fukatsu K, Han I, Inoue T, Furukawa S, Ikeda S, Hidemura A., Surgery 129(1), 2001
PMID: 11150036
Matsuda T, Saito H, Fukatsu K, Han I, Inoue T, Furukawa S, Ikeda S, Hidemura A., Surgery 129(1), 2001
PMID: 11150036
Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4.
Equils O, Lu D, Gatter M, Witkin SS, Bertolotto C, Arditi M, McGregor JA, Simmons CF, Hobel CJ., J. Immunol. 177(2), 2006
PMID: 16818785
Equils O, Lu D, Gatter M, Witkin SS, Bertolotto C, Arditi M, McGregor JA, Simmons CF, Hobel CJ., J. Immunol. 177(2), 2006
PMID: 16818785
Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal.
Tang SC, Lathia JD, Selvaraj PK, Jo DG, Mughal MR, Cheng A, Siler DA, Markesbery WR, Arumugam TV, Mattson MP., Exp. Neurol. 213(1), 2008
PMID: 18586243
Tang SC, Lathia JD, Selvaraj PK, Jo DG, Mughal MR, Cheng A, Siler DA, Markesbery WR, Arumugam TV, Mattson MP., Exp. Neurol. 213(1), 2008
PMID: 18586243
Expression and immune effect of toll-like receptor 4 in human trophoblast cells.
Deng F, Han F, Wu C., J. Huazhong Univ. Sci. Technol. Med. Sci. 29(3), 2009
PMID: 19513622
Deng F, Han F, Wu C., J. Huazhong Univ. Sci. Technol. Med. Sci. 29(3), 2009
PMID: 19513622
Arsenic trioxide induces apoptosis through a reactive oxygen species-dependent pathway and loss of mitochondrial membrane potential in HeLa cells.
Woo SH, Park IC, Park MJ, Lee HC, Lee SJ, Chun YJ, Lee SH, Hong SI, Rhee CH., Int. J. Oncol. 21(1), 2002
PMID: 12063550
Woo SH, Park IC, Park MJ, Lee HC, Lee SJ, Chun YJ, Lee SH, Hong SI, Rhee CH., Int. J. Oncol. 21(1), 2002
PMID: 12063550
Macrophages in tumor-draining lymph node with different characteristics induce T-cell apoptosis in patients with advanced stage-gastric cancer.
Takahashi A, Kono K, Ichihara F, Sugai H, Amemiya H, Iizuka H, Fujii H, Matsumoto Y., Int. J. Cancer 104(4), 2003
PMID: 12584734
Takahashi A, Kono K, Ichihara F, Sugai H, Amemiya H, Iizuka H, Fujii H, Matsumoto Y., Int. J. Cancer 104(4), 2003
PMID: 12584734
Evidence that de novo protein synthesis is dispensable for anti-apoptotic effects of NF-kappaB.
Kajino S, Suganuma M, Teranishi F, Takahashi N, Tetsuka T, Ohara H, Itoh M, Okamoto T., Oncogene 19(18), 2000
PMID: 10822373
Kajino S, Suganuma M, Teranishi F, Takahashi N, Tetsuka T, Ohara H, Itoh M, Okamoto T., Oncogene 19(18), 2000
PMID: 10822373
Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.
Kolenko V, Bloom T, Rayman P, Bukowski R, Hsi E, Finke J., J. Immunol. 163(2), 1999
PMID: 10395645
Kolenko V, Bloom T, Rayman P, Bukowski R, Hsi E, Finke J., J. Immunol. 163(2), 1999
PMID: 10395645
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.
Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW., Mol. Cell. Biol. 20(5), 2000
PMID: 10669740
Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW., Mol. Cell. Biol. 20(5), 2000
PMID: 10669740
Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis.
Francois F, Grimes ML., J. Neurochem. 73(4), 1999
PMID: 10501228
Francois F, Grimes ML., J. Neurochem. 73(4), 1999
PMID: 10501228
alpha-MSH decreases apoptosis in ischaemic acute renal failure in rats: possible mechanism of this beneficial effect.
Jo SK, Yun SY, Chang KH, Cha DR, Cho WY, Kim HK, Won NH., Nephrol. Dial. Transplant. 16(8), 2001
PMID: 11477159
Jo SK, Yun SY, Chang KH, Cha DR, Cho WY, Kim HK, Won NH., Nephrol. Dial. Transplant. 16(8), 2001
PMID: 11477159
Overexpression of the homeobox gene DLX-7 inhibits apoptosis by induced expression of intercellular adhesion molecule-1.
Shimamoto T, Ohyashiki K, Takeshita K., Exp. Hematol. 28(4), 2000
PMID: 10781901
Shimamoto T, Ohyashiki K, Takeshita K., Exp. Hematol. 28(4), 2000
PMID: 10781901
Cystatin C induces apoptosis and tyrosine hydroxylase gene expression through JNK-dependent pathway in neuronal cells.
Liang X, Nagai A, Terashima M, Sheikh AM, Shiota Y, Mitaki S, Kim SU, Yamaguchi S., Neurosci. Lett. 496(2), 2011
PMID: 21504781
Liang X, Nagai A, Terashima M, Sheikh AM, Shiota Y, Mitaki S, Kim SU, Yamaguchi S., Neurosci. Lett. 496(2), 2011
PMID: 21504781
AUTHOR UNKNOWN, 0
The role of the central nervous system in hypertension.
Wyss JM, Carlson SH., Curr. Hypertens. Rep. 1(3), 1999
PMID: 10981074
Wyss JM, Carlson SH., Curr. Hypertens. Rep. 1(3), 1999
PMID: 10981074
The central nervous system and inflammation in hypertension.
Marvar PJ, Lob H, Vinh A, Zarreen F, Harrison DG., Curr Opin Pharmacol 11(2), 2010
PMID: 21196131
Marvar PJ, Lob H, Vinh A, Zarreen F, Harrison DG., Curr Opin Pharmacol 11(2), 2010
PMID: 21196131
Hippocampal neurogenesis response: What can we expect from two different models of hypertension?
Pedroso D, Nunes AR, Diogo LN, Oudot C, Monteiro EC, Brenner C, Vieira HLA., Brain Res. 1646(), 2016
PMID: 27235865
Pedroso D, Nunes AR, Diogo LN, Oudot C, Monteiro EC, Brenner C, Vieira HLA., Brain Res. 1646(), 2016
PMID: 27235865
Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory.
Shih YH, Tsai SF, Huang SH, Chiang YT, Hughes MW, Wu SY, Lee CW, Yang TT, Kuo YM., Neuroscience 322(), 2016
PMID: 26921651
Shih YH, Tsai SF, Huang SH, Chiang YT, Hughes MW, Wu SY, Lee CW, Yang TT, Kuo YM., Neuroscience 322(), 2016
PMID: 26921651
P2X receptors in the cardiovascular system and their potential as therapeutic targets in disease.
Ralevic V., Curr. Med. Chem. 22(7), 2015
PMID: 25515516
Ralevic V., Curr. Med. Chem. 22(7), 2015
PMID: 25515516
Effect of acute and chronic hypertension on short- and long-term spatial and avoidance memory in male rats.
Ghavipanjeh GR, Alaei H, Khazaei M, Pourshanazari AA, Hoveida R., Pathophysiology 17(1), 2009
PMID: 19766467
Ghavipanjeh GR, Alaei H, Khazaei M, Pourshanazari AA, Hoveida R., Pathophysiology 17(1), 2009
PMID: 19766467
Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition.
Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJ., J. Cereb. Blood Flow Metab. 33(11), 2013
PMID: 23963364
Bink DI, Ritz K, Aronica E, van der Weerd L, Daemen MJ., J. Cereb. Blood Flow Metab. 33(11), 2013
PMID: 23963364
Chronic asthma results in cognitive dysfunction in immature mice.
Guo RB, Sun PL, Zhao AP, Gu J, Ding X, Qi J, Sun XL, Hu G., Exp. Neurol. 247(), 2013
PMID: 23639832
Guo RB, Sun PL, Zhao AP, Gu J, Ding X, Qi J, Sun XL, Hu G., Exp. Neurol. 247(), 2013
PMID: 23639832
AUTHOR UNKNOWN, 0
AUTHOR UNKNOWN, 0
Psychological factors in asthma.
Van Lieshout RJ, Macqueen G., Allergy Asthma Clin Immunol 4(1), 2008
PMID: 20525122
Van Lieshout RJ, Macqueen G., Allergy Asthma Clin Immunol 4(1), 2008
PMID: 20525122
Insulin as a humoral factor of energy supply for the biological function of locomotion
Titiov VN., 2005
Titiov VN., 2005
Apolipoprotein E polymorphism and LDL size in a biethnic population.
Haffner SM, Stern MP, Miettinen H, Robbins D, Howard BV., Arterioscler. Thromb. Vasc. Biol. 16(9), 1996
PMID: 8792773
Haffner SM, Stern MP, Miettinen H, Robbins D, Howard BV., Arterioscler. Thromb. Vasc. Biol. 16(9), 1996
PMID: 8792773
Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.
Zheng XL, Matsubara S, Diao C, Hollenberg MD, Wong NC., J. Biol. Chem. 276(17), 2001
PMID: 11278817
Zheng XL, Matsubara S, Diao C, Hollenberg MD, Wong NC., J. Biol. Chem. 276(17), 2001
PMID: 11278817
Apolipoproteins in human fetal colon: immunolocalization, biogenesis, and hormonal regulation.
Basque JR, Levy E, Beaulieu JF, Menard D., J. Cell. Biochem. 70(3), 1998
PMID: 9706873
Basque JR, Levy E, Beaulieu JF, Menard D., J. Cell. Biochem. 70(3), 1998
PMID: 9706873
Apolipoprotein A-I stimulates secretion of apolipoprotein E by foam cell macrophages.
Rees D, Sloane T, Jessup W, Dean RT, Kritharides L., J. Biol. Chem. 274(39), 1999
PMID: 10488140
Rees D, Sloane T, Jessup W, Dean RT, Kritharides L., J. Biol. Chem. 274(39), 1999
PMID: 10488140
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
Banerjee A, Wu ZS, Qian PX, Kang J, Liu DX, Zhu T, Lobie PE., PLoS ONE 7(11), 2012
PMID: 23185544
Banerjee A, Wu ZS, Qian PX, Kang J, Liu DX, Zhu T, Lobie PE., PLoS ONE 7(11), 2012
PMID: 23185544
Adiponectin promotes VEGF-A-dependent angiogenesis in human chondrosarcoma through PI3K, Akt, mTOR, and HIF-α pathway.
Lee HP, Lin CY, Shih JS, Fong YC, Wang SW, Li TM, Tang CH., Oncotarget 6(34), 2015
PMID: 26468982
Lee HP, Lin CY, Shih JS, Fong YC, Wang SW, Li TM, Tang CH., Oncotarget 6(34), 2015
PMID: 26468982
Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes.
Conde J, Scotece M, Lopez V, Gomez R, Lago F, Pino J, Gomez-Reino JJ, Gualillo O., PLoS ONE 7(12), 2012
PMID: 23285079
Conde J, Scotece M, Lopez V, Gomez R, Lago F, Pino J, Gomez-Reino JJ, Gualillo O., PLoS ONE 7(12), 2012
PMID: 23285079
Organizational effects of perinatal exposure to bisphenol-A and diethylstilbestrol on arcuate nucleus circuitry controlling food intake and energy expenditure in male and female CD-1 mice.
Mackay H, Patterson ZR, Khazall R, Patel S, Tsirlin D, Abizaid A., Endocrinology 154(4), 2013
PMID: 23493373
Mackay H, Patterson ZR, Khazall R, Patel S, Tsirlin D, Abizaid A., Endocrinology 154(4), 2013
PMID: 23493373
EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas.
Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S., J. Clin. Invest. 121(12), 2011
PMID: 22105169
Fukuoka H, Cooper O, Ben-Shlomo A, Mamelak A, Ren SG, Bruyette D, Melmed S., J. Clin. Invest. 121(12), 2011
PMID: 22105169
Connective tissue growth factor autocriny in human hepatocellular carcinoma: oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation.
Urtasun R, Latasa MU, Demartis MI, Balzani S, Goni S, Garcia-Irigoyen O, Elizalde M, Azcona M, Pascale RM, Feo F, Bioulac-Sage P, Balabaud C, Muntane J, Prieto J, Berasain C, Avila MA., Hepatology 54(6), 2011
PMID: 21800344
Urtasun R, Latasa MU, Demartis MI, Balzani S, Goni S, Garcia-Irigoyen O, Elizalde M, Azcona M, Pascale RM, Feo F, Bioulac-Sage P, Balabaud C, Muntane J, Prieto J, Berasain C, Avila MA., Hepatology 54(6), 2011
PMID: 21800344
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 29504915
PubMed | Europe PMC
Suchen in