Cytotoxic Compounds from Aloe megalacantha
Abdissa Ayana N, Gohlke S, Frese M, Sewald N (2017)
Molecules 22(7): 1136.
Zeitschriftenaufsatz
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Abstract / Bemerkung
Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound.
Stichworte
Asphodelaceae;
Aloe megalacantha;
roots;
quinone;
anthraquinone;
cytotoxicity
Erscheinungsjahr
2017
Zeitschriftentitel
Molecules
Band
22
Ausgabe
7
Art.-Nr.
1136
Urheberrecht / Lizenzen
ISSN
1420-3049
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
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https://pub.uni-bielefeld.de/record/2912699
Zitieren
Abdissa Ayana N, Gohlke S, Frese M, Sewald N. Cytotoxic Compounds from Aloe megalacantha. Molecules. 2017;22(7): 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., & Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7), 1136. doi:10.3390/molecules22071136
Abdissa Ayana, Negera, Gohlke, Sebastian, Frese, Marcel, and Sewald, Norbert. 2017. “Cytotoxic Compounds from Aloe megalacantha”. Molecules 22 (7): 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., and Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules 22:1136.
Abdissa Ayana, N., et al., 2017. Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7): 1136.
N. Abdissa Ayana, et al., “Cytotoxic Compounds from Aloe megalacantha”, Molecules, vol. 22, 2017, : 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., Sewald, N.: Cytotoxic Compounds from Aloe megalacantha. Molecules. 22, : 1136 (2017).
Abdissa Ayana, Negera, Gohlke, Sebastian, Frese, Marcel, and Sewald, Norbert. “Cytotoxic Compounds from Aloe megalacantha”. Molecules 22.7 (2017): 1136.
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2019-09-06T09:18:50Z
MD5 Prüfsumme
de0d165d8680dd011daca325dc42a5b8
Daten bereitgestellt von European Bioinformatics Institute (EBI)
5 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice.
Hintsa G, Sibhat GG, Karim A., Evid Based Complement Alternat Med 2019(), 2019
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Hintsa G, Sibhat GG, Karim A., Evid Based Complement Alternat Med 2019(), 2019
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Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model.
Hammeso WW, Emiru YK, Ayalew Getahun K, Kahaliw W., Evid Based Complement Alternat Med 2019(), 2019
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Hammeso WW, Emiru YK, Ayalew Getahun K, Kahaliw W., Evid Based Complement Alternat Med 2019(), 2019
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