Cytotoxic Compounds from Aloe megalacantha

Abdissa Ayana N, Gohlke S, Frese M, Sewald N (2017)
Molecules 22(7): 1136.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound.
Asphodelaceae; Aloe megalacantha; roots; quinone; anthraquinone; cytotoxicity
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Abdissa Ayana N, Gohlke S, Frese M, Sewald N. Cytotoxic Compounds from Aloe megalacantha. Molecules. 2017;22(7): 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., & Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7), 1136. doi:10.3390/molecules22071136
Abdissa Ayana, N., Gohlke, S., Frese, M., and Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules 22:1136.
Abdissa Ayana, N., et al., 2017. Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7): 1136.
N. Abdissa Ayana, et al., “Cytotoxic Compounds from Aloe megalacantha”, Molecules, vol. 22, 2017, : 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., Sewald, N.: Cytotoxic Compounds from Aloe megalacantha. Molecules. 22, : 1136 (2017).
Abdissa Ayana, Negera, Gohlke, Sebastian, Frese, Marcel, and Sewald, Norbert. “Cytotoxic Compounds from Aloe megalacantha”. Molecules 22.7 (2017): 1136.
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5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of Aloe megalacantha Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model.
Hammeso WW, Emiru YK, Ayalew Getahun K, Kahaliw W., Evid Based Complement Alternat Med 2019(), 2019
PMID: 31178917
Bioactive secondary metabolites from new endophytic fungus Curvularia. sp isolated from Rauwolfia macrophylla.
Kaaniche F, Hamed A, Abdel-Razek AS, Wibberg D, Abdissa N, El Euch IZ, Allouche N, Mellouli L, Shaaban M, Sewald N., PLoS One 14(6), 2019
PMID: 31247016
In vitro α-amylase inhibitory effect of TLC isolates of Aloe megalacantha baker and Aloe monticola Reynolds.
Tekulu GH, Araya EM, Mengesha HG., BMC Complement Altern Med 19(1), 2019
PMID: 31391018
Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy.
Salehi B, Albayrak S, Antolak H, Kręgiel D, Pawlikowska E, Sharifi-Rad M, Uprety Y, Tsouh Fokou PV, Yousef Z, Amiruddin Zakaria Z, Varoni EM, Sharopov F, Martins N, Iriti M, Sharifi-Rad J., Int J Mol Sci 19(9), 2018
PMID: 30235891

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