Cytotoxic Compounds from Aloe megalacantha

Abdissa Ayana N, Gohlke S, Frese M, Sewald N (2017)
Molecules 22(7): 1136.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Phytochemical investigation of the ethyl acetate extract of the roots of Aloe megalacantha led to the isolation of four new natural products—1,8-dimethoxynepodinol (1), aloesaponarin III (2), 10-O-methylchrysalodin (3) and methyl-26-O-feruloyl-oxyhexacosanate (4)—along with ten known compounds. All purified metabolites were characterized by NMR, mass spectrometric analyses and comparison with literature data. The isolates were evaluated for their cytotoxic activity against a human cervix carcinoma cell line KB-3-1 and some of them exhibited good activity, with aloesaponarin II (IC50 = 0.98 µM) being the most active compound.
Stichworte
Asphodelaceae; Aloe megalacantha; roots; quinone; anthraquinone; cytotoxicity
Erscheinungsjahr
2017
Zeitschriftentitel
Molecules
Band
22
Ausgabe
7
Art.-Nr.
1136
ISSN
1420-3049
Finanzierungs-Informationen
Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
Page URI
https://pub.uni-bielefeld.de/record/2912699

Zitieren

Abdissa Ayana N, Gohlke S, Frese M, Sewald N. Cytotoxic Compounds from Aloe megalacantha. Molecules. 2017;22(7): 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., & Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7), 1136. doi:10.3390/molecules22071136
Abdissa Ayana, N., Gohlke, S., Frese, M., and Sewald, N. (2017). Cytotoxic Compounds from Aloe megalacantha. Molecules 22:1136.
Abdissa Ayana, N., et al., 2017. Cytotoxic Compounds from Aloe megalacantha. Molecules, 22(7): 1136.
N. Abdissa Ayana, et al., “Cytotoxic Compounds from Aloe megalacantha”, Molecules, vol. 22, 2017, : 1136.
Abdissa Ayana, N., Gohlke, S., Frese, M., Sewald, N.: Cytotoxic Compounds from Aloe megalacantha. Molecules. 22, : 1136 (2017).
Abdissa Ayana, Negera, Gohlke, Sebastian, Frese, Marcel, and Sewald, Norbert. “Cytotoxic Compounds from Aloe megalacantha”. Molecules 22.7 (2017): 1136.
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2019-09-06T09:18:50Z
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