Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining

Steckling N, Tobollik M, Plaß D, Hornberg C, Ericson B, Fuller R, Bose-O'Reilly S (2017)
Annals of Global Health 83(2): 234-247.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Steckling, NadineUniBi; Tobollik, Myriam; Plaß, DietrichUniBi; Hornberg, ClaudiaUniBi; Ericson, Bret; Fuller, Richard; Bose-O'Reilly, Stephan
Abstract / Bemerkung
Background Artisanal small-scale gold mining (ASGM) is the world's largest anthropogenic source of mercury emission. Gold miners are highly exposed to metallic mercury and suffer occupational mercury intoxication. The global disease burden as a result of this exposure is largely unknown because the informal character of ASGM restricts the availability of reliable data. Objective To estimate the prevalence of occupational mercury intoxication and the disability-adjusted life years (DALYs) attributable to chronic metallic mercury vapor intoxication (CMMVI) among ASGM gold miners globally and in selected countries. Methods Estimates of the number of artisanal small-scale gold (ASG) miners were extracted from reviews supplemented by a literature search. Prevalence of moderate CMMVI among miners was determined by compiling a dataset of available studies that assessed frequency of intoxication in gold miners using a standardized diagnostic tool and biomonitoring data on mercury in urine. Severe cases of CMMVI were not included because it was assumed that these persons can no longer be employed as miners. Cases in workers' families and communities were not considered. Years lived with disability as a result of CMMVI among ASG miners were quantified by multiplying the number of prevalent cases of CMMVI by the appropriate disability weight. No deaths are expected to result from CMMVI and therefore years of life lost were not calculated. Disease burden was calculated by multiplying the prevalence rate with the number of miners for each country and the disability weight. Sensitivity analyses were performed using different assumptions on the number of miners and the intoxication prevalence rate. Findings Globally, 14-19 million workers are employed as ASG miners. Based on human biomonitoring data, between 25% and 33% of these miners—3.3-6.5 million miners globally—suffer from moderate CMMVI. The resulting global burden of disease is estimated to range from 1.22 (uncertainty interval [UI] 0.87-1.61) to 2.39 (UI 1.69-3.14) million DALYs. Conclusions This study presents the first global and country-based estimates of disease burden caused by mercury intoxication in ASGM. Data availability and quality limit the results, and the total disease burden is likely undercounted. Despite these limitations, the data clearly indicate that mercury intoxication in ASG miners is a major, largely neglected global health problem.
artisanal small-scale gold mining; burden of disease; disability-adjusted life year; global; DALY; mercury; mercury intoxication
Annals of Global Health
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Steckling N, Tobollik M, Plaß D, et al. Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining. Annals of Global Health. 2017;83(2):234-247.
Steckling, N., Tobollik, M., Plaß, D., Hornberg, C., Ericson, B., Fuller, R., & Bose-O'Reilly, S. (2017). Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining. Annals of Global Health, 83(2), 234-247. doi:10.1016/j.aogh.2016.12.005
Steckling, N., Tobollik, M., Plaß, D., Hornberg, C., Ericson, B., Fuller, R., and Bose-O'Reilly, S. (2017). Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining. Annals of Global Health 83, 234-247.
Steckling, N., et al., 2017. Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining. Annals of Global Health, 83(2), p 234-247.
N. Steckling, et al., “Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining”, Annals of Global Health, vol. 83, 2017, pp. 234-247.
Steckling, N., Tobollik, M., Plaß, D., Hornberg, C., Ericson, B., Fuller, R., Bose-O'Reilly, S.: Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining. Annals of Global Health. 83, 234-247 (2017).
Steckling, Nadine, Tobollik, Myriam, Plaß, Dietrich, Hornberg, Claudia, Ericson, Bret, Fuller, Richard, and Bose-O'Reilly, Stephan. “Global Burden of Disease of Mercury used in Artisanal Small-Scale Gold Mining”. Annals of Global Health 83.2 (2017): 234-247.
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5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

The Mercury Problem in Artisanal and Small-Scale Gold Mining.
Esdaile LJ, Chalker JM., Chemistry 24(27), 2018
PMID: 29314284
Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to S. schenckii sensu stricto Infection in Mice.
Batista-Duharte A, Téllez-Martínez D, Aparecida Jellmayer J, Leandro Portuondo Fuentes D, Campos Polesi M, Martins Baviera A, Zeppone Carlos I., J Fungi (Basel) 4(2), 2018
PMID: 29799450
Pollution and Global Health – An Agenda for Prevention.
Landrigan PJ, Fuller R, Hu H, Caravanos J, Cropper ML, Hanrahan D, Sandilya K, Chiles TC, Kumar P, Suk WA., Environ Health Perspect 126(8), 2018
PMID: 30118434

71 References

Daten bereitgestellt von Europe PubMed Central.




A review of mercury exposure among artisanal small-scale gold miners in developing countries.
Kristensen AK, Thomsen JF, Mikkelsen S., Int Arch Occup Environ Health 87(6), 2013
PMID: 23979147



Hentschel, 2002
Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador.
Harari R, Harari F, Gerhardsson L, Lundh T, Skerfving S, Stromberg U, Broberg K., Toxicol. Lett. 213(1), 2011
PMID: 21925580
Global health and environmental pollution.
Landrigan PJ, Fuller R., Int J Public Health 60(7), 2015
PMID: 26135237

The Mt. Diwata study on the Philippines 1999--assessing mercury intoxication of the population by small scale gold mining.
Drasch G, Bose-O'Reilly S, Beinhoff C, Roider G, Maydl S., Sci. Total Environ. 267(1-3), 2001
PMID: 11286210

Bose-O’Reilly, 2004

Rodrigues-Filho, 2004
Health assessment of artisanal gold miners in Indonesia.
Bose-O'Reilly S, Drasch G, Beinhoff C, Rodrigues-Filho S, Roider G, Lettmeier B, Maydl A, Maydl S, Siebert U., Sci. Total Environ. 408(4), 2009
PMID: 19945736
The burden of chronic mercury intoxication in artisanal small-scale gold mining in Zimbabwe: data availability and preliminary estimates.
Steckling N, Bose-O'Reilly S, Pinheiro P, Plass D, Shoko D, Drasch G, Bernaudat L, Siebert U, Hornberg C., Environ Health 13(), 2014
PMID: 25495641

Disability Weights for Chronic Mercury Intoxication Resulting from Gold Mining Activities: Results from an Online Pairwise Comparisons Survey.
Steckling N, Devleesschauwer B, Winkelnkemper J, Fischer F, Ericson B, Kramer A, Hornberg C, Fuller R, Plass D, Bose-O'Reilly S., Int J Environ Res Public Health 14(1), 2017
PMID: 28075395
Disease profile and health-related quality of life (HRQoL) using the EuroQol (EQ-5D + C) questionnaire for chronic metallic mercury vapor intoxication.
Steckling N, Plass D, Bose-O'Reilly S, Kobal AB, Kramer A, Hornberg C., Health Qual Life Outcomes 13(), 2015
PMID: 26654565
Review of disability weight studies: comparison of methodological choices and values.
Haagsma JA, Polinder S, Cassini A, Colzani E, Havelaar AH., Popul Health Metr 12(), 2014
PMID: 26019690
GBD 2010: design, definitions, and metrics.
Murray CJ, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, Naghavi M, Salomon JA, Shibuya K, Vos T, Wikler D, Lopez AD., Lancet 380(9859), 2012
PMID: 23245602
World emissions of mercury from artisanal and small scale gold mining
Telmer, 2009
An estimation of the artisanal small-scale production of gold in the world.
Seccatore J, Veiga M, Origliasso C, Marin T, De Tomi G., Sci. Total Environ. 496(), 2014
PMID: 24867677

Veiga, 2004
Health assessment of artisanal gold miners in Tanzania.
Bose-O'Reilly S, Drasch G, Beinhoff C, Tesha A, Drasch K, Roider G, Taylor H, Appleton D, Siebert U., Sci. Total Environ. 408(4), 2009
PMID: 19945738

Health risks of gold miners: a synoptic review.
Eisler R., Environ Geochem Health 25(3), 2003
PMID: 12971253

Schutzmeier, 2016
Assessment of Hg contamination and exposure to miners and schoolchildren at a small-scale gold mining and recovery operation in Thailand.
Umbangtalad S, Parkpian P, Visvanathan C, Delaune RD, Jugsujinda A., J Environ Sci Health A Tox Hazard Subst Environ Eng 42(14), 2007
PMID: 18074277
The price of gold: mercury exposure in the Amazonian rain forest.
Branches FJ, Erickson TB, Aks SE, Hryhorczuk DO., J. Toxicol. Clin. Toxicol. 31(2), 1993
PMID: 8492342
Mercury exposure in female artisanal small-scale gold miners (ASGM) in Mongolia: An analysis of human biomonitoring (HBM) data from 2008.
Steckling N, Boese-O'Reilly S, Gradel C, Gutschmidt K, Shinee E, Altangerel E, Badrakh B, Bonduush I, Surenjav U, Ferstl P, Roider G, Sakamoto M, Sepai O, Drasch G, Lettmeier B, Morton J, Jones K, Siebert U, Hornberg C., Sci. Total Environ. 409(5), 2010
PMID: 21183207
Mercury levels in urine and hair of children in an Andean gold-mining settlement
Counter, Int J Occupat Environ Health 11(), 2005
Neurocognitive screening of mercury-exposed children of Andean gold miners
Counter, Int J Occupat Environ Health 12(), 2006


Sinta, 2014
Informal and illegal mining and mercury pollution in Madre de Dios: A public health problema
Plenge, Acta Medica Peruana (), 2012
Mercury exposure and children's health.
Bose-O'Reilly S, McCarty KM, Steckling N, Lettmeier B., Curr Probl Pediatr Adolesc Health Care 40(8), 2010
PMID: 20816346
An assessment of Hg pollution in different goldmining areas, Amazon Brazil
Malm, Sci Total Environ 175(), 1995
Human exposure to mercury due to gold mining in the Tapajos River basin, Amazon, Brazil: speciation of mercury in human hair, blood and urine
Akagi, Water Air Soil Pollut 80(), 1995
Human exposure to mercury and the accumulation of methylmercury that is associated with gold mining in the Amazon Basin Brazil
Akagi, J Health Sci 46(), 2000
Fractional mercury levels in Brazilian gold refiners and miners.
Aks SE, Erickson T, Branches FJ, Naleway C, Chou HN, Levy P, Hryhorczuk D., J. Toxicol. Clin. Toxicol. 33(1), 1995
PMID: 7837306
Exposure to elemental mercury in urban workers and gold miners from the Tapajos Region, Para, Brazil
de, Bull Environ Contamin Toxicol 67(), 2001
Mercury exposures in informal gold miners and relatives in southern Peru
Hurtado, Int J Occupat Environ Health 12(), 2006
Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010.
Dooyema CA, Neri A, Lo YC, Durant J, Dargan PI, Swarthout T, Biya O, Gidado SO, Haladu S, Sani-Gwarzo N, Nguku PM, Akpan H, Idris S, Bashir AM, Brown MJ., Environ. Health Perspect. 120(4), 2011
PMID: 22186192

Mercury exposure among artisanal gold miners in Madre de Dios, Peru: a cross-sectional study.
Yard EE, Horton J, Schier JG, Caldwell K, Sanchez C, Lewis L, Gastanaga C., J Med Toxicol 8(4), 2012
PMID: 22926732
Mercury exposure in a low-income community in South Africa
Oosthuizen, South African Med J 100(), 2010
Mercury exposure of maroon workers in the small scale gold mining in Suriname.
de Kom JF, van der Voet GB, de Wolff FA., Environ. Res. 77(2), 1998
PMID: 9600801
Occupational exposure to airborne mercury during gold mining operations near El Callao, Venezuela.
Drake PL, Rojas M, Reh CM, Mueller CA, Jenkins FM., Int Arch Occup Environ Health 74(3), 2001
PMID: 11355295
Assessing mercury health effects in gold workers near El Callao, Venezuela.
Rojas M, Drake PL, Roberts SM., J. Occup. Environ. Med. 43(2), 2001
PMID: 11227634
Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010.
Salomon JA, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, Begum N, Shah R, Karyana M, Kosen S, Farje MR, Moncada G, Dutta A, Sazawal S, Dyer A, Seiler J, Aboyans V, Baker L, Baxter A, Benjamin EJ, Bhalla K, Bin Abdulhak A, Blyth F, Bourne R, Braithwaite T, Brooks P, Brugha TS, Bryan-Hancock C, Buchbinder R, Burney P, Calabria B, Chen H, Chugh SS, Cooley R, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, Davis A, Degenhardt L, Diaz-Torne C, Dorsey ER, Driscoll T, Edmond K, Elbaz A, Ezzati M, Feigin V, Ferri CP, Flaxman AD, Flood L, Fransen M, Fuse K, Gabbe BJ, Gillum RF, Haagsma J, Harrison JE, Havmoeller R, Hay RJ, Hel-Baqui A, Hoek HW, Hoffman H, Hogeland E, Hoy D, Jarvis D, Karthikeyan G, Knowlton LM, Lathlean T, Leasher JL, Lim SS, Lipshultz SE, Lopez AD, Lozano R, Lyons R, Malekzadeh R, Marcenes W, March L, Margolis DJ, McGill N, McGrath J, Mensah GA, Meyer AC, Michaud C, Moran A, Mori R, Murdoch ME, Naldi L, Newton CR, Norman R, Omer SB, Osborne R, Pearce N, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Pourmalek F, Prince M, Rehm JT, Remuzzi G, Richardson K, Room R, Saha S, Sampson U, Sanchez-Riera L, Segui-Gomez M, Shahraz S, Shibuya K, Singh D, Sliwa K, Smith E, Soerjomataram I, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Taylor HR, Tleyjeh IM, van der Werf MJ, Watson WL, Weatherall DJ, Weintraub R, Weisskopf MG, Whiteford H, Wilkinson JD, Woolf AD, Zheng ZJ, Murray CJ, Jonas JB., Lancet 380(9859), 2012
PMID: 23245605
Disability weights for the Global Burden of Disease 2013 study.
Salomon JA, Haagsma JA, Davis A, de Noordhout CM, Polinder S, Havelaar AH, Cassini A, Devleesschauwer B, Kretzschmar M, Speybroeck N, Murray CJ, Vos T., Lancet Glob Health 3(11), 2015
PMID: 26475018
Assessing disability weights based on the responses of 30,660 people from four European countries.
Haagsma JA, Maertens de Noordhout C, Polinder S, Vos T, Havelaar AH, Cassini A, Devleesschauwer B, Kretzschmar ME, Speybroeck N, Salomon JA., Popul Health Metr 13(), 2015
PMID: 26778920
A mortality study of men exposed to elemental mercury.
Cragle DL, Hollis DR, Qualters JR, Tankersley WG, Fry SA., J Occup Med 26(11), 1984
PMID: 6502285


Zimmer, 1984
Mercury as a serious health hazard for children in gold mining areas.
Bose-O'Reilly S, Lettmeier B, Gothe RM, Beinhoff C, Siebert U, Drasch G., Environ. Res. 107(1), 2008
PMID: 18321481
Human biomonitoring data from mercury exposed miners in six artisanal small-scale gold mining areas in Asia and Africa
Baeuml, Minerals 1(), 2011

Four decades of support for artisanal and small-scale mining in sub-Saharan Africa: a critical review
Hilson, Extractive Industries Soc 1(), 2014

Veiga, 0


Boungnaphalom, 2003

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