Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer

Roy D, Mondal S, Khurana A, Jung D-B, Hoffmann R, He X, Kalogera E, Dierks T, Hammond E, Dredge K, Shridhar V (2017)
SCIENTIFIC REPORTS 7(1): 41977.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Roy, Debarshi; Mondal, Susmita; Khurana, Ashwani; Jung, Deok-Beom; Hoffmann, Robert; He, Xiaoping; Kalogera, Eleftheria; Dierks, ThomasUniBi; Hammond, Edward; Dredge, Keith; Shridhar, Viji
Abstract / Bemerkung
Defective autophagy and deranged metabolic pathways are common in cancer; pharmacologic targeting of these two pathways could provide a viable therapeutic option. However, how these pathways are regulated by limited availability of growth factors is still unknown. Our study shows that HSulf-1 (endosulfatase), a known tumor suppressor which attenuates heparin sulfate binding growth factor signaling, also regulates interplay between autophagy and lipogenesis. Silencing of HSulf-1 in OV202 and TOV2223 cells (ovarian cancer cell lines) resulted in increased lipid droplets (LDs), reduced autophagic vacuoles (AVs) and less LC3B puncta. In contrast, HSulf-1 proficient cells exhibit more AVs and reduced LDs. Increased LDs in HSulf-1 depleted cells was associated with increased ERK mediated cPLA2S505 phosphorylation. Conversely, HSulf-1 expression in SKOV3 cells reduced the number of LDs and increased the number of AVs compared to vector controls. Furthermore, pharmacological (AACOCF3) and ShRNA mediated downregulation of cPLA2 resulted in reduced LDs, and increased autophagy. Finally, in vivo experiment using OV202 Sh1 derived xenograft show that AACOCF3 treatment effectively attenuated tumor growth and LD biogenesis. Collectively, these results show a reciprocal regulation of autophagy and lipid biogenesis by HSulf-1 in ovarian cancer.
Erscheinungsjahr
2017
Zeitschriftentitel
SCIENTIFIC REPORTS
Band
7
Ausgabe
1
Art.-Nr.
41977
ISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2909071

Zitieren

Roy D, Mondal S, Khurana A, et al. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS. 2017;7(1): 41977.
Roy, D., Mondal, S., Khurana, A., Jung, D. - B., Hoffmann, R., He, X., Kalogera, E., et al. (2017). Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS, 7(1), 41977. doi:10.1038/srep41977
Roy, Debarshi, Mondal, Susmita, Khurana, Ashwani, Jung, Deok-Beom, Hoffmann, Robert, He, Xiaoping, Kalogera, Eleftheria, et al. 2017. “Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer”. SCIENTIFIC REPORTS 7 (1): 41977.
Roy, D., Mondal, S., Khurana, A., Jung, D. - B., Hoffmann, R., He, X., Kalogera, E., Dierks, T., Hammond, E., Dredge, K., et al. (2017). Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS 7:41977.
Roy, D., et al., 2017. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS, 7(1): 41977.
D. Roy, et al., “Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer”, SCIENTIFIC REPORTS, vol. 7, 2017, : 41977.
Roy, D., Mondal, S., Khurana, A., Jung, D.-B., Hoffmann, R., He, X., Kalogera, E., Dierks, T., Hammond, E., Dredge, K., Shridhar, V.: Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS. 7, : 41977 (2017).
Roy, Debarshi, Mondal, Susmita, Khurana, Ashwani, Jung, Deok-Beom, Hoffmann, Robert, He, Xiaoping, Kalogera, Eleftheria, Dierks, Thomas, Hammond, Edward, Dredge, Keith, and Shridhar, Viji. “Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer”. SCIENTIFIC REPORTS 7.1 (2017): 41977.

2 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers.
Mondal S, Roy D, Sarkar Bhattacharya S, Jin L, Jung D, Zhang S, Kalogera E, Staub J, Wang Y, Xuyang W, Khurana A, Chien J, Telang S, Chesney J, Tapolsky G, Petras D, Shridhar V., Int J Cancer 144(1), 2019
PMID: 30226266
Lipid Storage and Autophagy in Melanoma Cancer Cells.
Giampietri C, Petrungaro S, Cordella M, Tabolacci C, Tomaipitinca L, Facchiano A, Eramo A, Filippini A, Facchiano F, Ziparo E., Int J Mol Sci 18(6), 2017
PMID: 28617309

72 References

Daten bereitgestellt von Europe PubMed Central.

Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids.
Cabodevilla AG, Sanchez-Caballero L, Nintou E, Boiadjieva VG, Picatoste F, Gubern A, Claro E., J. Biol. Chem. 288(39), 2013
PMID: 23940052
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clave C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Droge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fesus L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, Gonzalez-Estevez C, Gorski S, Gottlieb RA, Haussinger D, He YW, Heidenreich K, Hill JA, Hoyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jaattela M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovacs AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lopez-Otin C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Melendez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Munz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nurnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Talloczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcategui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL., Autophagy 4(2), 2007
PMID: 18188003
Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes.
Guijas C, Perez-Chacon G, Astudillo AM, Rubio JM, Gil-de-Gomez L, Balboa MA, Balsinde J., J. Lipid Res. 53(11), 2012
PMID: 22949356
Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2.
Gubern A, Barcelo-Torns M, Casas J, Barneda D, Masgrau R, Picatoste F, Balsinde J, Balboa MA, Claro E., J. Biol. Chem. 284(9), 2008
PMID: 19117952
Group IVA phospholipase A(2) deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.
Ishihara K, Kanai S, Tanaka K, Kawashita E, Akiba S., Biochem. Biophys. Res. Commun. 471(1), 2016
PMID: 26850849
SnapShot: Lipid Droplets.
Krahmer N, Guo Y, Farese RV Jr, Walther TC., Cell 139(5), 2009
PMID: 19945384
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Hardie DG., Nat. Rev. Mol. Cell Biol. 8(10), 2007
PMID: 17712357
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy.
Shteingauz A, Boyango I, Naroditsky I, Hammond E, Gruber M, Doweck I, Ilan N, Vlodavsky I., Cancer Res. 75(18), 2015
PMID: 26249176
Growth factor regulation of autophagy and cell survival in the absence of apoptosis.
Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB., Cell 120(2), 2005
PMID: 15680329
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.
Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF., Cell 140(1), 2010
PMID: 20079333
Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation.
Takahashi Y, Shinoda A, Furuya N, Harada E, Arimura N, Ichi I, Fujiwara Y, Inoue J, Sato R., PLoS ONE 8(5), 2013
PMID: 23734208
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.
Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM., J. Biol. Chem. 277(37), 2002
PMID: 12107176
Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance.
Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM., PLoS ONE 9(1), 2014
PMID: 24489859
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J., J. Neurosci. 31(5), 2011
PMID: 21289194
Autophagy regulates lipid metabolism.
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ., Nature 458(7242), 2009
PMID: 19339967
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E., Nat. Med. 17(11), 2011
PMID: 22037646
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development.
Baenke F, Peck B, Miess H, Schulze A., Dis Model Mech 6(6), 2013
PMID: 24203995
Lipid droplets in atherosclerotic fatty streaks of human aorta.
Lang PD, Insull W Jr., J. Clin. Invest. 49(8), 1970
PMID: 5431659
Autophagy: cellular and molecular mechanisms.
Glick D, Barth S, Macleod KF., J. Pathol. 221(1), 2010
PMID: 20225336
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells.
Zirath H, Frenzel A, Oliynyk G, Segerstrom L, Westermark UK, Larsson K, Munksgaard Persson M, Hultenby K, Lehtio J, Einvik C, Pahlman S, Kogner P, Jakobsson PJ, Henriksson MA., Proc. Natl. Acad. Sci. U.S.A. 110(25), 2013
PMID: 23733953
The lipid phenotype of breast cancer cells characterized by Raman microspectroscopy: towards a stratification of malignancy.
Nieva C, Marro M, Santana-Codina N, Rao S, Petrov D, Sierra A., PLoS ONE 7(10), 2012
PMID: 23082122
Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival.
Xu G, Jiang Y, Xiao Y, Liu XD, Yue F, Li W, Li X, He Y, Jiang X, Huang H, Chen Q, Jonasch E, Liu L., Oncotarget 7(5), 2016
PMID: 26701856
On the formation of lipid droplets in human adipocytes: the organization of the perilipin-vimentin cortex.
Heid H, Rickelt S, Zimbelmann R, Winter S, Schumacher H, Dorflinger Y, Kuhn C, Franke WW., PLoS ONE 9(2), 2014
PMID: 24587346
Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging.
Tirinato L, Liberale C, Di Franco S, Candeloro P, Benfante A, La Rocca R, Potze L, Marotta R, Ruffilli R, Rajamanickam VP, Malerba M, De Angelis F, Falqui A, Carbone E, Todaro M, Medema JP, Stassi G, Di Fabrizio E., Stem Cells 33(1), 2015
PMID: 25186497
Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy.
Artesi M, Kroonen J, Bredel M, Nguyen-Khac M, Deprez M, Schoysman L, Poulet C, Chakravarti A, Kim H, Scholtens D, Seute T, Rogister B, Bours V, Robe PA., Neuro-oncology 17(3), 2014
PMID: 25155356
Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites.
Pol A, Gross SP, Parton RG., J. Cell Biol. 204(5), 2014
PMID: 24590170
The role of lipid droplets in metabolic disease in rodents and humans.
Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG., J. Clin. Invest. 121(6), 2011
PMID: 21633178
Integrated genomic analyses of ovarian carcinoma.
Cancer Genome Atlas Research Network, Bell D, Berchuck A, Birrer M, Chien J, Cramer D, Dao F, Dhir R, DiSaia P, Gabra H, Glenn P, Godwin A, Gross J, Hartmann L, Huang M, Huntsman D, Iacocca M, Imielinski M, Kalloger S, Karlan B, Levine D, Mills G, Morrison C, Mutch D, Olvera N, Orsulic S, Park K, Petrelli N, Rabeno B, Rader J, Sikic B, Smith-McCune K, Sood A, Bowtell D, Penny R, Testa J, Chang K, Dinh H, Drummond J, Fowler G, Gunaratne P, Hawes A, Kovar C, Lewis L, Morgan M, Newsham I, Santibanez J, Reid J, Trevino L, Wu Y-, Wang M, Muzny D, Wheeler D, Gibbs R, Getz G, Lawrence M, Cibulskis K, Sivachenko A, Sougnez C, Voet D, Wilkinson J, Bloom T, Ardlie K, Fennell T, Baldwin J, Gabriel S, Lander E, Ding LL, Fulton R, Koboldt D, McLellan M, Wylie T, Walker J, O'Laughlin M, Dooling D, Fulton L, Abbott R, Dees N, Zhang Q, Kandoth C, Wendl M, Schierding W, Shen D, Harris C, Schmidt H, Kalicki J, Delehaunty K, Fronick C, Demeter R, Cook L, Wallis J, Lin L, Magrini V, Hodges J, Eldred J, Smith S, Pohl C, Vandin F, Raphael B, Weinstock G, Mardis E, Wilson R, Meyerson M, Winckler W, Getz G, Verhaak R, Carter S, Mermel C, Saksena G, Nguyen H, Onofrio R, Lawrence M, Hubbard D, Gupta S, Crenshaw A, Ramos A, Ardlie K, Chin L, Protopopov A, Zhang J, Kim T, Perna I, Xiao Y, Zhang H, Ren G, Sathiamoorthy N, Park R, Lee E, Park P, Kucherlapati R, Absher M, Waite L, Sherlock G, Brooks J, Li J, Xu J, Myers R, Laird PW, Cope L, Herman J, Shen H, Weisenberger D, Noushmehr H, Pan F, Triche T Jr, Berman B, Van Den Berg D, Buckley J, Baylin S, Spellman P, Purdom E, Neuvial P, Bengtsson H, Jakkula L, Durinck S, Han J, Dorton S, Marr H, Choi Y, Wang V, Wang N, Ngai J, Conboy J, Parvin B, Feiler H, Speed T, Gray J, Levine A, Socci N, Liang Y, Taylor B, Schultz N, Borsu L, Lash A, Brennan C, Viale A, Sander C, Ladanyi M, Hoadley K, Meng S, Du Y, Shi Y, Li L, Turman Y, Zang D, Helms E, Balu S, Zhou X, Wu J, Topal M, Hayes D, Perou C, Getz G, Voet D, Saksena G, Zhang J, Zhang H, Wu C, Shukla S, Cibulskis K, Lawrence M, Sivachenko A, Jing R, Park R, Liu Y, Park P, Noble M, Chin L, Carter H, Kim D, Karchin R, Spellman P, Purdom E, Neuvial P, Bengtsson H, Durinck S, Han J, Korkola J, Heiser L, Cho R, Hu Z, Parvin B, Speed T, Gray J, Schultz N, Cerami E, Taylor B, Olshen A, Reva B, Antipin Y, Shen R, Mankoo P, Sheridan R, Ciriello G, Chang W, Bernanke J, Borsu L, Levine D, Ladanyi M, Sander C, Haussler D, Benz C, Stuart J, Benz S, Sanborn J, Vaske C, Zhu J, Szeto C, Scott G, Yau C, Hoadley K, Du Y, Balu S, Hayes D, Perou C, Wilkerson M, Zhang N, Akbani R, Baggerly K, Yung W, Mills G, Weinstein J, Penny R, Shelton T, Grimm D, Hatfield M, Morris S, Yena P, Rhodes P, Sherman M, Paulauskis J, Millis S, Kahn A, Greene J, Sfeir R, Jensen M, Chen J, Whitmore J, Alonso S, Jordan J, Chu A, Zhang J, Barker A, Compton C, Eley G, Ferguson M, Fielding P, Gerhard D, Myles R, Schaefer C, Mills Shaw K, Vaught J, Vockley J, Good P, Guyer M, Ozenberger B, Peterson J, Thomson E., Nature 474(7353), 2011
PMID: 21720365
Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer.
He X, Khurana A, Roy D, Kaufmann S, Shridhar V., Int. J. Cancer 135(8), 2014
PMID: 24596063
HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer.
Mondal S, Roy D, Camacho-Pereira J, Khurana A, Chini E, Yang L, Baddour J, Stilles K, Padmabandu S, Leung S, Kalloger S, Gilks B, Lowe V, Dierks T, Hammond E, Dredge K, Nagrath D, Shridhar V., Oncotarget 6(32), 2015
PMID: 26378042
PPARγ maintains ERBB2-positive breast cancer stem cells.
Wang X, Sun Y, Wong J, Conklin DS., Oncogene 32(49), 2013
PMID: 23770845
Proline oxidase-adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation.
Lettieri Barbato D, Aquilano K, Baldelli S, Cannata SM, Bernardini S, Rotilio G, Ciriolo MR., Cell Death Differ. 21(1), 2013
PMID: 24096872
Cytosolic lipid droplets increase in size by microtubule-dependent complex formation.
Bostrom P, Rutberg M, Ericsson J, Holmdahl P, Andersson L, Frohman MA, Boren J, Olofsson SO., Arterioscler. Thromb. Vasc. Biol. 25(9), 2005
PMID: 16051877
The role of lipids in the control of autophagy.
Dall'Armi C, Devereaux KA, Di Paolo G., Curr. Biol. 23(1), 2013
PMID: 23305670
HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma.
Lai JP, Chien J, Strome SE, Staub J, Montoya DP, Greene EL, Smith DI, Roberts LR, Shridhar V., Oncogene 23(7), 2004
PMID: 14973553
Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.
Lai J, Chien J, Staub J, Avula R, Greene EL, Matthews TA, Smith DI, Kaufmann SH, Roberts LR, Shridhar V., J. Biol. Chem. 278(25), 2003
PMID: 12686563
Properties of the Group IV phospholipase A2 family.
Ghosh M, Tucker DE, Burchett SA, Leslie CC., Prog. Lipid Res. 45(6), 2006
PMID: 16814865
Autophagic proteolysis of long-lived proteins in nonliver cells.
Roberts EA, Deretic V., Methods Mol. Biol. 445(), 2008
PMID: 18425445
Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth.
Khurana A, Roy D, Kalogera E, Mondal S, Wen X, He X, Dowdy S, Shridhar V., Oncotarget 6(34), 2015
PMID: 26497553
Group IVA phospholipase A2 is necessary for the biogenesis of lipid droplets.
Gubern A, Casas J, Barcelo-Torns M, Barneda D, de la Rosa X, Masgrau R, Picatoste F, Balsinde J, Balboa MA, Claro E., J. Biol. Chem. 283(41), 2008
PMID: 18632668
Epigenetic regulation of autophagy by the methyltransferase G9a.
Artal-Martinez de Narvajas A, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujanda L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD., Mol. Cell. Biol. 33(20), 2013
PMID: 23918802
How to interpret LC3 immunoblotting.
Mizushima N, Yoshimori T., Autophagy 3(6), 2007
PMID: 17611390
Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance.
Staub J, Chien J, Pan Y, Qian X, Narita K, Aletti G, Scheerer M, Roberts LR, Molina J, Shridhar V., Oncogene 26(34), 2007
PMID: 17310998
Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer.
Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung DB, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V., Cancer Metab 2(), 2014
PMID: 25225614
Autophagy in malignant transformation and cancer progression.
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G., EMBO J. 34(7), 2015
PMID: 25712477
Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes.
Subramanian V, Rothenberg A, Gomez C, Cohen AW, Garcia A, Bhattacharyya S, Shapiro L, Dolios G, Wang R, Lisanti MP, Brasaemle DL., J. Biol. Chem. 279(40), 2004
PMID: 15292255
Lipid droplets in inflammation and cancer.
Bozza PT, Viola JP., Prostaglandins Leukot. Essent. Fatty Acids 82(4-6), 2010
PMID: 20206487
PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples.
Winterhoff B, Freyer L, Hammond E, Giri S, Mondal S, Roy D, Teoman A, Mullany SA, Hoffmann R, von Bismarck A, Chien J, Block MS, Millward M, Bampton D, Dredge K, Shridhar V., Eur. J. Cancer 51(7), 2015
PMID: 25754234
Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis.
Straub BK, Herpel E, Singer S, Zimbelmann R, Breuhahn K, Macher-Goeppinger S, Warth A, Lehmann-Koch J, Longerich T, Heid H, Schirmacher P., Mod. Pathol. 23(3), 2010
PMID: 20081801
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.
Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A., Oncogene 24(43), 2005
PMID: 16007182
Lipophagy: connecting autophagy and lipid metabolism.
Singh R, Cuervo AM., Int J Cell Biol 2012(), 2012
PMID: 22536247
Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization.
Skinner JR, Shew TM, Schwartz DM, Tzekov A, Lepus CM, Abumrad NA, Wolins NE., J. Biol. Chem. 284(45), 2009
PMID: 19748893
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
Qiu B, Ackerman D, Sanchez DJ, Li B, Ochocki JD, Grazioli A, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC., Cancer Discov 5(6), 2015
PMID: 25829424
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 28169314
PubMed | Europe PMC

Suchen in

Google Scholar