Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer

Roy D, Mondal S, Khurana A, Jung D-B, Hoffmann R, He X, Kalogera E, Dierks T, Hammond E, Dredge K, Shridhar V (2017)
SCIENTIFIC REPORTS 7: 41977.

Zeitschriftenaufsatz | Veröffentlicht| Englisch
 
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Autor/in
Roy, Debarshi; Mondal, Susmita; Khurana, Ashwani; Jung, Deok-Beom; Hoffmann, Robert; He, Xiaoping; Kalogera, Eleftheria; Dierks, ThomasUniBi; Hammond, Edward; Dredge, Keith; Shridhar, Viji
Abstract / Bemerkung
Defective autophagy and deranged metabolic pathways are common in cancer; pharmacologic targeting of these two pathways could provide a viable therapeutic option. However, how these pathways are regulated by limited availability of growth factors is still unknown. Our study shows that HSulf-1 (endosulfatase), a known tumor suppressor which attenuates heparin sulfate binding growth factor signaling, also regulates interplay between autophagy and lipogenesis. Silencing of HSulf-1 in OV202 and TOV2223 cells (ovarian cancer cell lines) resulted in increased lipid droplets (LDs), reduced autophagic vacuoles (AVs) and less LC3B puncta. In contrast, HSulf-1 proficient cells exhibit more AVs and reduced LDs. Increased LDs in HSulf-1 depleted cells was associated with increased ERK mediated cPLA2S505 phosphorylation. Conversely, HSulf-1 expression in SKOV3 cells reduced the number of LDs and increased the number of AVs compared to vector controls. Furthermore, pharmacological (AACOCF3) and ShRNA mediated downregulation of cPLA2 resulted in reduced LDs, and increased autophagy. Finally, in vivo experiment using OV202 Sh1 derived xenograft show that AACOCF3 treatment effectively attenuated tumor growth and LD biogenesis. Collectively, these results show a reciprocal regulation of autophagy and lipid biogenesis by HSulf-1 in ovarian cancer.
Erscheinungsjahr
2017
Zeitschriftentitel
SCIENTIFIC REPORTS
Band
7
Art.-Nr.
41977
ISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2909071

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Roy D, Mondal S, Khurana A, et al. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS. 2017;7: 41977.
Roy, D., Mondal, S., Khurana, A., Jung, D. - B., Hoffmann, R., He, X., Kalogera, E., et al. (2017). Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS, 7, 41977. doi:10.1038/srep41977
Roy, D., Mondal, S., Khurana, A., Jung, D. - B., Hoffmann, R., He, X., Kalogera, E., Dierks, T., Hammond, E., Dredge, K., et al. (2017). Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS 7:41977.
Roy, D., et al., 2017. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS, 7: 41977.
D. Roy, et al., “Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer”, SCIENTIFIC REPORTS, vol. 7, 2017, : 41977.
Roy, D., Mondal, S., Khurana, A., Jung, D.-B., Hoffmann, R., He, X., Kalogera, E., Dierks, T., Hammond, E., Dredge, K., Shridhar, V.: Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. SCIENTIFIC REPORTS. 7, : 41977 (2017).
Roy, Debarshi, Mondal, Susmita, Khurana, Ashwani, Jung, Deok-Beom, Hoffmann, Robert, He, Xiaoping, Kalogera, Eleftheria, Dierks, Thomas, Hammond, Edward, Dredge, Keith, and Shridhar, Viji. “Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer”. SCIENTIFIC REPORTS 7 (2017): 41977.

2 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers.
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