A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

Lopes MW, Leal RB, Guarnieri R, Schwarzbold ML, Hoeller A, Diaz AP, Boos GL, Lin K, Linhares MN, Nunes JC, Quevedo J, et al. (2016)
TRANSLATIONAL PSYCHIATRY 6: e986.

Zeitschriftenaufsatz | Veröffentlicht| Englisch
 
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Autor/in
Lopes, M. W.; Leal, R. B.; Guarnieri, R.; Schwarzbold, M. L.; Hoeller, A.; Diaz, A. P.; Boos, G. L.; Lin, K.; Linhares, M. N.; Nunes, J. C.; Quevedo, J.; Bortolotto, Z. A.
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Abstract / Bemerkung
Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment has been paralleled by the high incidence of acute and chronic neuropsychiatric side effects, which reinforces the brain sensitivity for GC. Synapses can be bi-directionally modifiable via potentiation (long-term potentiation, LTP) or depotentiation (long-term depression, LTD) of synaptic transmission efficacy, and the phosphorylation state of Ser831 and Ser845 sites, in the GluA1 subunit of the glutamate AMPA receptors, are a critical event for these synaptic neuroplasticity events. Through a quasi-randomized controlled study, we show that a single high dexamethasone dose significantly reduces in a dose-dependent manner the levels of GluA1-Ser831 phosphorylation in the amygdala resected during surgery for temporal lobe epilepsy. This is the first report demonstrating GC effects on key markers of synaptic neuroplasticity in the human limbic system. The results contribute to understanding how GC affects the human brain under physiologic and pharmacologic conditions.
Erscheinungsjahr
2016
Zeitschriftentitel
TRANSLATIONAL PSYCHIATRY
Band
6
Art.-Nr.
e986
ISSN
2158-3188
Page URI
https://pub.uni-bielefeld.de/record/2908831

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Lopes MW, Leal RB, Guarnieri R, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY. 2016;6: e986.
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., et al. (2016). A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY, 6, e986. doi:10.1038/tp.2016.251
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., Lin, K., Linhares, M. N., Nunes, J. C., et al. (2016). A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY 6:e986.
Lopes, M.W., et al., 2016. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY, 6: e986.
M.W. Lopes, et al., “A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system”, TRANSLATIONAL PSYCHIATRY, vol. 6, 2016, : e986.
Lopes, M.W., Leal, R.B., Guarnieri, R., Schwarzbold, M.L., Hoeller, A., Diaz, A.P., Boos, G.L., Lin, K., Linhares, M.N., Nunes, J.C., Quevedo, J., Bortolotto, Z.A., Markowitsch, H.J., Lightman, S.L., Walz, R.: A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. TRANSLATIONAL PSYCHIATRY. 6, : e986 (2016).
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., Lin, K., Linhares, M. N., Nunes, J. C., Quevedo, J., Bortolotto, Z. A., Markowitsch, Hans J., Lightman, S. L., and Walz, R. “A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system”. TRANSLATIONAL PSYCHIATRY 6 (2016): e986.

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