Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes
Demond H, Trapphoff T, Dankert D, Heiligentag M, Gruemmer R, Horsthemke B, Eichenlaub-Ritter U (2016)
PLOS ONE 11(9): e0162722.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Demond, Hannah;
Trapphoff, Tom;
Dankert, Deborah;
Heiligentag, Martyna;
Gruemmer, Ruth;
Horsthemke, Bernhard;
Eichenlaub-Ritter, UrsulaUniBi
Abstract / Bemerkung
Delayed ovulation and delayed fertilization can lead to reduced developmental competence of the oocyte. In contrast to the consequences of postovulatory aging of the oocyte, hardly anything is known about the molecular processes occurring during oocyte maturation if ovulation is delayed (preovulatory aging). We investigated several aspects of oocyte maturation in two models of preovulatory aging: an in vitro follicle culture and an in vivo mouse model in which ovulation was postponed using the GnRH antagonist cetrorelix. Both models showed significantly reduced oocyte maturation rates after aging. Furthermore, in vitro preovulatory aging deregulated the protein abundance of the maternal effect genes Smarca4 and Nlrp5, decreased the levels of histone H3K9 trimethylation and caused major deterioration of chromosome alignment and spindle conformation. Protein abundance of YBX2, an important regulator of mRNA stability, storage and recruitment in the oocyte, was not affected by in vitro aging. In contrast, in vivo preovulatory aging led to reduction in Ybx2 transcript and YBX2 protein abundance. Taken together, preovulatory aging seems to affect various processes in the oocyte, which could explain the low maturation rates and the previously described failures in fertilization and embryonic development.
Erscheinungsjahr
2016
Zeitschriftentitel
PLOS ONE
Band
11
Ausgabe
9
Art.-Nr.
e0162722
Urheberrecht / Lizenzen
ISSN
1932-6203
Page URI
https://pub.uni-bielefeld.de/record/2906182
Zitieren
Demond H, Trapphoff T, Dankert D, et al. Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. PLOS ONE. 2016;11(9): e0162722.
Demond, H., Trapphoff, T., Dankert, D., Heiligentag, M., Gruemmer, R., Horsthemke, B., & Eichenlaub-Ritter, U. (2016). Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. PLOS ONE, 11(9), e0162722. doi:10.1371/journal.pone.0162722
Demond, Hannah, Trapphoff, Tom, Dankert, Deborah, Heiligentag, Martyna, Gruemmer, Ruth, Horsthemke, Bernhard, and Eichenlaub-Ritter, Ursula. 2016. “Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes”. PLOS ONE 11 (9): e0162722.
Demond, H., Trapphoff, T., Dankert, D., Heiligentag, M., Gruemmer, R., Horsthemke, B., and Eichenlaub-Ritter, U. (2016). Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. PLOS ONE 11:e0162722.
Demond, H., et al., 2016. Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. PLOS ONE, 11(9): e0162722.
H. Demond, et al., “Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes”, PLOS ONE, vol. 11, 2016, : e0162722.
Demond, H., Trapphoff, T., Dankert, D., Heiligentag, M., Gruemmer, R., Horsthemke, B., Eichenlaub-Ritter, U.: Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes. PLOS ONE. 11, : e0162722 (2016).
Demond, Hannah, Trapphoff, Tom, Dankert, Deborah, Heiligentag, Martyna, Gruemmer, Ruth, Horsthemke, Bernhard, and Eichenlaub-Ritter, Ursula. “Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes”. PLOS ONE 11.9 (2016): e0162722.
3 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression.
Nevoral J, Landsmann L, Stiavnicka M, Hosek P, Moravec J, Prokesova S, Rimnacova H, Koutna E, Klein P, Hoskova K, Zalmanova T, Fenclova T, Petr J, Kralickova M., J Anim Sci Biotechnol 10(), 2019
PMID: 31413827
Nevoral J, Landsmann L, Stiavnicka M, Hosek P, Moravec J, Prokesova S, Rimnacova H, Koutna E, Klein P, Hoskova K, Zalmanova T, Fenclova T, Petr J, Kralickova M., J Anim Sci Biotechnol 10(), 2019
PMID: 31413827
Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring.
Begemann M, Rezwan FI, Beygo J, Docherty LE, Kolarova J, Schroeder C, Buiting K, Chokkalingam K, Degenhardt F, Wakeling EL, Kleinle S, González Fassrainer D, Oehl-Jaschkowitz B, Turner CLS, Patalan M, Gizewska M, Binder G, Bich Ngoc CT, Chi Dung V, Mehta SG, Baynam G, Hamilton-Shield JP, Aljareh S, Lokulo-Sodipe O, Horton R, Siebert R, Elbracht M, Temple IK, Eggermann T, Mackay DJG., J Med Genet 55(7), 2018
PMID: 29574422
Begemann M, Rezwan FI, Beygo J, Docherty LE, Kolarova J, Schroeder C, Buiting K, Chokkalingam K, Degenhardt F, Wakeling EL, Kleinle S, González Fassrainer D, Oehl-Jaschkowitz B, Turner CLS, Patalan M, Gizewska M, Binder G, Bich Ngoc CT, Chi Dung V, Mehta SG, Baynam G, Hamilton-Shield JP, Aljareh S, Lokulo-Sodipe O, Horton R, Siebert R, Elbracht M, Temple IK, Eggermann T, Mackay DJG., J Med Genet 55(7), 2018
PMID: 29574422
Maternal RNA regulates Aurora C kinase during mouse oocyte maturation in a translation-independent fashion.
Balboula AZ, Blengini CS, Gentilello AS, Takahashi M, Schindler K., Biol Reprod 96(6), 2017
PMID: 28575288
Balboula AZ, Blengini CS, Gentilello AS, Takahashi M, Schindler K., Biol Reprod 96(6), 2017
PMID: 28575288
50 References
Daten bereitgestellt von Europe PubMed Central.
Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review.
Al-Inany HG, Abou-Setta AM, Aboulghar M., Reprod. Biomed. Online 14(5), 2007
PMID: 17509210
Al-Inany HG, Abou-Setta AM, Aboulghar M., Reprod. Biomed. Online 14(5), 2007
PMID: 17509210
Expression of MSY2 in mouse oocytes and preimplantation embryos.
Yu J, Hecht NB, Schultz RM., Biol. Reprod. 65(4), 2001
PMID: 11566752
Yu J, Hecht NB, Schultz RM., Biol. Reprod. 65(4), 2001
PMID: 11566752
DNA integrity, growth pattern, spindle formation, chromosomal constitution and imprinting patterns of mouse oocytes from vitrified pre-antral follicles.
Trapphoff T, El Hajj N, Zechner U, Haaf T, Eichenlaub-Ritter U., Hum. Reprod. 25(12), 2010
PMID: 20940142
Trapphoff T, El Hajj N, Zechner U, Haaf T, Eichenlaub-Ritter U., Hum. Reprod. 25(12), 2010
PMID: 20940142
Culture environment modulates maturation and metabolism of human oocytes.
Roberts R, Franks S, Hardy K., Hum. Reprod. 17(11), 2002
PMID: 12407055
Roberts R, Franks S, Hardy K., Hum. Reprod. 17(11), 2002
PMID: 12407055
Mater, a maternal effect gene required for early embryonic development in mice.
Tong ZB, Gold L, Pfeifer KE, Dorward H, Lee E, Bondy CA, Dean J, Nelson LM., Nat. Genet. 26(3), 2000
PMID: 11062459
Tong ZB, Gold L, Pfeifer KE, Dorward H, Lee E, Bondy CA, Dean J, Nelson LM., Nat. Genet. 26(3), 2000
PMID: 11062459
Vitrification at the pre-antral stage transiently alters inner mitochondrial membrane potential but proteome of in vitro grown and matured mouse oocytes appears unaffected.
Demant M, Trapphoff T, Frohlich T, Arnold GJ, Eichenlaub-Ritter U., Hum. Reprod. 27(4), 2012
PMID: 22258663
Demant M, Trapphoff T, Frohlich T, Arnold GJ, Eichenlaub-Ritter U., Hum. Reprod. 27(4), 2012
PMID: 22258663
Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome.
Medvedev S, Pan H, Schultz RM., Biol. Reprod. 85(3), 2011
PMID: 21613634
Medvedev S, Pan H, Schultz RM., Biol. Reprod. 85(3), 2011
PMID: 21613634
The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.
Yu XJ, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang ZB, Zheng P, Zhu MS, Wang H, Sun QY, Dean J, Li L., Nat Commun 5(), 2014
PMID: 25208553
Yu XJ, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang ZB, Zheng P, Zhu MS, Wang H, Sun QY, Dean J, Li L., Nat Commun 5(), 2014
PMID: 25208553
Maternal Setdb1 Is Required for Meiotic Progression and Preimplantation Development in Mouse.
Kim J, Zhao H, Dan J, Kim S, Hardikar S, Hollowell D, Lin K, Lu Y, Takata Y, Shen J, Chen T., PLoS Genet. 12(4), 2016
PMID: 27070551
Kim J, Zhao H, Dan J, Kim S, Hardikar S, Hollowell D, Lin K, Lu Y, Takata Y, Shen J, Chen T., PLoS Genet. 12(4), 2016
PMID: 27070551
A subcortical maternal complex essential for preimplantation mouse embryogenesis.
Li L, Baibakov B, Dean J., Dev. Cell 15(3), 2008
PMID: 18804437
Li L, Baibakov B, Dean J., Dev. Cell 15(3), 2008
PMID: 18804437
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Frohlich T, Arnold GJ, Grummer R, Horsthemke B, Eichenlaub-Ritter U., Hum. Reprod. 31(1), 2015
PMID: 26577303
Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Frohlich T, Arnold GJ, Grummer R, Horsthemke B, Eichenlaub-Ritter U., Hum. Reprod. 31(1), 2015
PMID: 26577303
Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility.
Yang J, Medvedev S, Yu J, Tang LC, Agno JE, Matzuk MM, Schultz RM, Hecht NB., Proc. Natl. Acad. Sci. U.S.A. 102(16), 2005
PMID: 15824319
Yang J, Medvedev S, Yu J, Tang LC, Agno JE, Matzuk MM, Schultz RM, Hecht NB., Proc. Natl. Acad. Sci. U.S.A. 102(16), 2005
PMID: 15824319
Identification of a human subcortical maternal complex.
Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L., Mol. Hum. Reprod. 21(4), 2014
PMID: 25542835
Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L., Mol. Hum. Reprod. 21(4), 2014
PMID: 25542835
Chronic exposure to a low concentration of bisphenol A during follicle culture affects the epigenetic status of germinal vesicles and metaphase II oocytes.
Trapphoff T, Heiligentag M, El Hajj N, Haaf T, Eichenlaub-Ritter U., Fertil. Steril. 100(6), 2013
PMID: 24034936
Trapphoff T, Heiligentag M, El Hajj N, Haaf T, Eichenlaub-Ritter U., Fertil. Steril. 100(6), 2013
PMID: 24034936
Aging changes the chromatin configuration and histone methylation of mouse oocytes at germinal vesicle stage.
Manosalva I, Gonzalez A., Theriogenology 74(9), 2010
PMID: 20728928
Manosalva I, Gonzalez A., Theriogenology 74(9), 2010
PMID: 20728928
Post-transcriptional control of gene expression during mouse oogenesis.
Clarke HJ., Results Probl Cell Differ 55(), 2012
PMID: 22918798
Clarke HJ., Results Probl Cell Differ 55(), 2012
PMID: 22918798
Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer.
Dean W, Santos F, Reik W., Semin. Cell Dev. Biol. 14(1), 2003
PMID: 12524012
Dean W, Santos F, Reik W., Semin. Cell Dev. Biol. 14(1), 2003
PMID: 12524012
Post-transcriptional and post-translational regulation during mouse oocyte maturation.
Kang MK, Han SJ., BMB Rep 44(3), 2011
PMID: 21429291
Kang MK, Han SJ., BMB Rep 44(3), 2011
PMID: 21429291
Maternal control of early mouse development.
Li L, Zheng P, Dean J., Development 137(6), 2010
PMID: 20179092
Li L, Zheng P, Dean J., Development 137(6), 2010
PMID: 20179092
CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation.
Medvedev S, Yang J, Hecht NB, Schultz RM., Dev. Biol. 321(1), 2008
PMID: 18606161
Medvedev S, Yang J, Hecht NB, Schultz RM., Dev. Biol. 321(1), 2008
PMID: 18606161
Transcriptional control of mitosis: deregulation and cancer.
Nath S, Ghatak D, Das P, Roychoudhury S., Front Endocrinol (Lausanne) 6(), 2015
PMID: 25999914
Nath S, Ghatak D, Das P, Roychoudhury S., Front Endocrinol (Lausanne) 6(), 2015
PMID: 25999914
NLRP5 mediates mitochondrial function in mouse oocytes and embryos.
Fernandes R, Tsuda C, Perumalsamy AL, Naranian T, Chong J, Acton BM, Tong ZB, Nelson LM, Jurisicova A., Biol. Reprod. 86(5), 2012
PMID: 22357545
Fernandes R, Tsuda C, Perumalsamy AL, Naranian T, Chong J, Acton BM, Tong ZB, Nelson LM, Jurisicova A., Biol. Reprod. 86(5), 2012
PMID: 22357545
Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation.
Smitz J, Dolmans MM, Donnez J, Fortune JE, Hovatta O, Jewgenow K, Picton HM, Plancha C, Shea LD, Stouffer RL, Telfer EE, Woodruff TK, Zelinski MB., Hum. Reprod. Update 16(4), 2010
PMID: 20124287
Smitz J, Dolmans MM, Donnez J, Fortune JE, Hovatta O, Jewgenow K, Picton HM, Plancha C, Shea LD, Stouffer RL, Telfer EE, Woodruff TK, Zelinski MB., Hum. Reprod. Update 16(4), 2010
PMID: 20124287
Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice.
Lu YQ, He XC, Zheng P., Mol. Hum. Reprod. 22(4), 2016
PMID: 26769260
Lu YQ, He XC, Zheng P., Mol. Hum. Reprod. 22(4), 2016
PMID: 26769260
Switching between Epigenetic States at Pericentromeric Heterochromatin.
Dejardin J., Trends Genet. 31(11), 2015
PMID: 26431676
Dejardin J., Trends Genet. 31(11), 2015
PMID: 26431676
Follicle culture in reproductive toxicology: a tool for in-vitro testing of ovarian function?
Cortvrindt RG, Smitz JE., Hum. Reprod. Update 8(3), 2002
PMID: 12078835
Cortvrindt RG, Smitz JE., Hum. Reprod. Update 8(3), 2002
PMID: 12078835
The maternal to zygotic transition in mammals.
Li L, Lu X, Dean J., Mol. Aspects Med. 34(5), 2013
PMID: 23352575
Li L, Lu X, Dean J., Mol. Aspects Med. 34(5), 2013
PMID: 23352575
Preovulatory overripeness of the oocyte as a cause of ovarian dysfunction in the human female.
Smits LJ, Jongbloet PH, Zielhuis GA., Med. Hypotheses 45(5), 1995
PMID: 8748083
Smits LJ, Jongbloet PH, Zielhuis GA., Med. Hypotheses 45(5), 1995
PMID: 8748083
BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation.
Carey TS, Cao Z, Choi I, Ganguly A, Wilson CA, Paul S, Knott JG., Mol. Cell. Biol. 35(24), 2015
PMID: 26416882
Carey TS, Cao Z, Choi I, Ganguly A, Wilson CA, Paul S, Knott JG., Mol. Cell. Biol. 35(24), 2015
PMID: 26416882
GnRH antagonists are safer than agonists: an update of a Cochrane review.
Al-Inany HG, Youssef MA, Aboulghar M, Broekmans F, Sterrenburg M, Smit J, Abou-Setta AM., Hum. Reprod. Update 17(4), 2011
PMID: 21646384
Al-Inany HG, Youssef MA, Aboulghar M, Broekmans F, Sterrenburg M, Smit J, Abou-Setta AM., Hum. Reprod. Update 17(4), 2011
PMID: 21646384
Maternal BRG1 regulates zygotic genome activation in the mouse.
Bultman SJ, Gebuhr TC, Pan H, Svoboda P, Schultz RM, Magnuson T., Genes Dev. 20(13), 2006
PMID: 16818606
Bultman SJ, Gebuhr TC, Pan H, Svoboda P, Schultz RM, Magnuson T., Genes Dev. 20(13), 2006
PMID: 16818606
Translational control in oocyte development.
Richter JD, Lasko P., Cold Spring Harb Perspect Biol 3(9), 2011
PMID: 21690213
Richter JD, Lasko P., Cold Spring Harb Perspect Biol 3(9), 2011
PMID: 21690213
Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes.
Vogt E, Kipp A, Eichenlaub-Ritter U., Reprod. Biomed. Online 19(3), 2009
PMID: 19778480
Vogt E, Kipp A, Eichenlaub-Ritter U., Reprod. Biomed. Online 19(3), 2009
PMID: 19778480
Pre- and postovulatory aging of murine oocytes affect the transcript level and poly(A) tail length of maternal effect genes.
Dankert D, Demond H, Trapphoff T, Heiligentag M, Rademacher K, Eichenlaub-Ritter U, Horsthemke B, Grummer R., PLoS ONE 9(10), 2014
PMID: 25271735
Dankert D, Demond H, Trapphoff T, Heiligentag M, Rademacher K, Eichenlaub-Ritter U, Horsthemke B, Grummer R., PLoS ONE 9(10), 2014
PMID: 25271735
Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignment.
van den Berg IM, Eleveld C, van der Hoeven M, Birnie E, Steegers EA, Galjaard RJ, Laven JS, van Doorninck JH., Hum. Reprod. 26(5), 2011
PMID: 21349858
van den Berg IM, Eleveld C, van der Hoeven M, Birnie E, Steegers EA, Galjaard RJ, Laven JS, van Doorninck JH., Hum. Reprod. 26(5), 2011
PMID: 21349858
Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte.
Yang F, Baumann C, Viveiros MM, De La Fuente R., Int. J. Dev. Biol. 56(10-12), 2012
PMID: 23417411
Yang F, Baumann C, Viveiros MM, De La Fuente R., Int. J. Dev. Biol. 56(10-12), 2012
PMID: 23417411
The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos.
Eymery A, Liu Z, Ozonov EA, Stadler MB, Peters AH., Development 143(15), 2016
PMID: 27317807
Eymery A, Liu Z, Ozonov EA, Stadler MB, Peters AH., Development 143(15), 2016
PMID: 27317807
Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence.
Adriaens I, Cortvrindt R, Smitz J., Hum. Reprod. 19(2), 2004
PMID: 14747188
Adriaens I, Cortvrindt R, Smitz J., Hum. Reprod. 19(2), 2004
PMID: 14747188
Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte.
Han L, Ge J, Zhang L, Ma R, Hou X, Li B, Moley K, Wang Q., Sci Rep 5(), 2015
PMID: 26481302
Han L, Ge J, Zhang L, Ma R, Hou X, Li B, Moley K, Wang Q., Sci Rep 5(), 2015
PMID: 26481302
Alterations in epigenetic modifications during oocyte growth in mice.
Kageyama S, Liu H, Kaneko N, Ooga M, Nagata M, Aoki F., Reproduction 133(1), 2007
PMID: 17244735
Kageyama S, Liu H, Kaneko N, Ooga M, Nagata M, Aoki F., Reproduction 133(1), 2007
PMID: 17244735
The role of MATER in endoplasmic reticulum distribution and calcium homeostasis in mouse oocytes.
Kim B, Zhang X, Kan R, Cohen R, Mukai C, Travis AJ, Coonrod SA., Dev. Biol. 386(2), 2013
PMID: 24374158
Kim B, Zhang X, Kan R, Cohen R, Mukai C, Travis AJ, Coonrod SA., Dev. Biol. 386(2), 2013
PMID: 24374158
Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos.
Ohsugi M, Zheng P, Baibakov B, Li L, Dean J., Development 135(2), 2007
PMID: 18057100
Ohsugi M, Zheng P, Baibakov B, Li L, Dean J., Development 135(2), 2007
PMID: 18057100
Hormone-induced delayed ovulation affects early embryonic development.
Bittner AK, Horsthemke B, Winterhager E, Grummer R., Fertil. Steril. 95(7), 2011
PMID: 21474126
Bittner AK, Horsthemke B, Winterhager E, Grummer R., Fertil. Steril. 95(7), 2011
PMID: 21474126
Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications.
van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends WM, Laven JS, Peters AH, Baart EB., Nat Commun 5(), 2014
PMID: 25519718
van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends WM, Laven JS, Peters AH, Baart EB., Nat Commun 5(), 2014
PMID: 25519718
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T., Cell 107(3), 2001
PMID: 11701123
Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T., Cell 107(3), 2001
PMID: 11701123
Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes.
Sun F, Betzendahl I, Shen Y, Cortvrindt R, Smitz J, Eichenlaub-Ritter U., Mutagenesis 19(1), 2004
PMID: 14681309
Sun F, Betzendahl I, Shen Y, Cortvrindt R, Smitz J, Eichenlaub-Ritter U., Mutagenesis 19(1), 2004
PMID: 14681309
RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein.
Yu J, Hecht NB, Schultz RM., Biol. Reprod. 67(4), 2002
PMID: 12297523
Yu J, Hecht NB, Schultz RM., Biol. Reprod. 67(4), 2002
PMID: 12297523
In vitro follicle growth under non-attachment conditions and decreased FSH levels reduces Lhcgr expression in cumulus cells and promotes oocyte developmental competence.
Sanchez F, Romero S, Albuz FK, Smitz J., J. Assist. Reprod. Genet. 29(2), 2011
PMID: 22190081
Sanchez F, Romero S, Albuz FK, Smitz J., J. Assist. Reprod. Genet. 29(2), 2011
PMID: 22190081
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 27611906
PubMed | Europe PMC
Suchen in
Google Scholar