Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)

Razakarivony AA, Lenta Ndjakou B, Andriamihaja B, Michalek C, Razanamahefa B, Razafimahefa DR, Rakotondramanga MF, Randrianasolo R, Lannang AM, Randriamiaramisaina R, Boyom FF, et al. (2016)
Zeitschrift für Naturforschung B 71(4): 297-303.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Razakarivony, Andrianambinina A.UniBi; Lenta Ndjakou, BrunoUniBi; Andriamihaja, Bakolinirina; Michalek, CarmelaUniBi; Razanamahefa, Bakonirina; Razafimahefa, Dorothee R.; Rakotondramanga, Maonja Finaritra; Randrianasolo, Rivoarison; Lannang, Alain MeliUniBi ; Randriamiaramisaina, Ralinandrianina; Boyom, Fekam F.; Rosenthal, Philip J.
Alle
Abstract / Bemerkung
A new gentisic acid derivative named micronyc acid (1) and a new 1,4-benzoquinone derivative named micronone (2) have been isolated from the root of Micronychia tsiramiramy together with the known compounds gallic acid (3), methyl gallate (4), moronic acid (5), masticadienolic acid (6), and masticadienediol (7). The structures of 1 and 2 were established using MS and NMR. Compound 1 was tested for antiplasmodial activity in vitro against the chloroquine-resistant strain Plasmodium falciparum W2 and displayed moderate antiplasmodial activity in vitro with an IC50 value of 25.6 mu m. Compounds 1 and its acetyl derivative 1a were also tested for their cytotoxicity against the human cervix carcinoma cell line KB-3-1 and still showed moderate activity.
Stichworte
antiplasmodial activity; cytotoxicity; micronone; micronyc acid; Micronychia tsiramiramy; Plasmodium falciparum
Erscheinungsjahr
2016
Zeitschriftentitel
Zeitschrift für Naturforschung B
Band
71
Ausgabe
4
Seite(n)
297-303
ISSN
0932-0776
eISSN
1865-7117
Page URI
https://pub.uni-bielefeld.de/record/2904122

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Razakarivony AA, Lenta Ndjakou B, Andriamihaja B, et al. Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). Zeitschrift für Naturforschung B. 2016;71(4):297-303.
Razakarivony, A. A., Lenta Ndjakou, B., Andriamihaja, B., Michalek, C., Razanamahefa, B., Razafimahefa, D. R., Rakotondramanga, M. F., et al. (2016). Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). Zeitschrift für Naturforschung B, 71(4), 297-303. doi:10.1515/znb-2015-0188
Razakarivony, A. A., Lenta Ndjakou, B., Andriamihaja, B., Michalek, C., Razanamahefa, B., Razafimahefa, D. R., Rakotondramanga, M. F., Randrianasolo, R., Lannang, A. M., Randriamiaramisaina, R., et al. (2016). Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). Zeitschrift für Naturforschung B 71, 297-303.
Razakarivony, A.A., et al., 2016. Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). Zeitschrift für Naturforschung B, 71(4), p 297-303.
A.A. Razakarivony, et al., “Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)”, Zeitschrift für Naturforschung B, vol. 71, 2016, pp. 297-303.
Razakarivony, A.A., Lenta Ndjakou, B., Andriamihaja, B., Michalek, C., Razanamahefa, B., Razafimahefa, D.R., Rakotondramanga, M.F., Randrianasolo, R., Lannang, A.M., Randriamiaramisaina, R., Boyom, F.F., Rosenthal, P.J., Sewald, N.: Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae). Zeitschrift für Naturforschung B. 71, 297-303 (2016).
Razakarivony, Andrianambinina A., Lenta Ndjakou, Bruno, Andriamihaja, Bakolinirina, Michalek, Carmela, Razanamahefa, Bakonirina, Razafimahefa, Dorothee R., Rakotondramanga, Maonja Finaritra, Randrianasolo, Rivoarison, Lannang, Alain Meli, Randriamiaramisaina, Ralinandrianina, Boyom, Fekam F., Rosenthal, Philip J., and Sewald, Norbert. “Long-chain alkyl-substituted gentisic acid and benzoquinone derivatives from the root of Micronychia tsiramiramy (Anacardiaceae)”. Zeitschrift für Naturforschung B 71.4 (2016): 297-303.

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