Lipid peroxidation causes endosomal antigen release for cross-presentation
Dingjan I, Verboogen DRJ, Paardekooper LM, Revelo NH, Sittig SP, Visser LJ, Fischer von Mollard G, Henriet SSV, Figdor CG, ter Beest M, van den Bogaart G (2016)
SCIENTIFIC REPORTS 6(1): 22064.
Zeitschriftenaufsatz
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Autor*in
Dingjan, Ilse;
Verboogen, Danielle R. J.;
Paardekooper, Laurent M.;
Revelo, Natalia H.;
Sittig, Simone P.;
Visser, Linda J.;
Fischer von Mollard, GabrieleUniBi ;
Henriet, Stefanie S. V.;
Figdor, Carl G.;
ter Beest, Martin;
van den Bogaart, Geert
Einrichtung
Abstract / Bemerkung
Dendritic cells (DCs) present foreign antigen in major histocompatibility complex (MHC) class I molecules to cytotoxic T cells in a process called cross-presentation. An important step in this process is the release of antigen from the lumen of endosomes into the cytosol, but the mechanism of this step is still unclear. In this study, we show that reactive oxygen species (ROS) produced by the NADPH-oxidase complex NOX2 cause lipid peroxidation, a membrane disrupting chain-reaction, which in turn results in antigen leakage from endosomes. Antigen leakage and cross-presentation were inhibited by blocking ROS production or scavenging radicals and induced when using a ROS-generating photosensitizer. Endosomal antigen release was impaired in DCs from chronic granulomatous disease (CGD) patients with dysfunctional NOX2. Thus, NOX2 induces antigen release from endosomes for cross-presentation by direct oxidation of endosomal lipids. This constitutes a new cellular function for ROS in regulating immune responses against pathogens and cancer.
Erscheinungsjahr
2016
Zeitschriftentitel
SCIENTIFIC REPORTS
Band
6
Ausgabe
1
Art.-Nr.
22064
ISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2901574
Zitieren
Dingjan I, Verboogen DRJ, Paardekooper LM, et al. Lipid peroxidation causes endosomal antigen release for cross-presentation. SCIENTIFIC REPORTS. 2016;6(1): 22064.
Dingjan, I., Verboogen, D. R. J., Paardekooper, L. M., Revelo, N. H., Sittig, S. P., Visser, L. J., Fischer von Mollard, G., et al. (2016). Lipid peroxidation causes endosomal antigen release for cross-presentation. SCIENTIFIC REPORTS, 6(1), 22064. doi:10.1038/srep22064
Dingjan, Ilse, Verboogen, Danielle R. J., Paardekooper, Laurent M., Revelo, Natalia H., Sittig, Simone P., Visser, Linda J., Fischer von Mollard, Gabriele, et al. 2016. “Lipid peroxidation causes endosomal antigen release for cross-presentation”. SCIENTIFIC REPORTS 6 (1): 22064.
Dingjan, I., Verboogen, D. R. J., Paardekooper, L. M., Revelo, N. H., Sittig, S. P., Visser, L. J., Fischer von Mollard, G., Henriet, S. S. V., Figdor, C. G., ter Beest, M., et al. (2016). Lipid peroxidation causes endosomal antigen release for cross-presentation. SCIENTIFIC REPORTS 6:22064.
Dingjan, I., et al., 2016. Lipid peroxidation causes endosomal antigen release for cross-presentation. SCIENTIFIC REPORTS, 6(1): 22064.
I. Dingjan, et al., “Lipid peroxidation causes endosomal antigen release for cross-presentation”, SCIENTIFIC REPORTS, vol. 6, 2016, : 22064.
Dingjan, I., Verboogen, D.R.J., Paardekooper, L.M., Revelo, N.H., Sittig, S.P., Visser, L.J., Fischer von Mollard, G., Henriet, S.S.V., Figdor, C.G., ter Beest, M., van den Bogaart, G.: Lipid peroxidation causes endosomal antigen release for cross-presentation. SCIENTIFIC REPORTS. 6, : 22064 (2016).
Dingjan, Ilse, Verboogen, Danielle R. J., Paardekooper, Laurent M., Revelo, Natalia H., Sittig, Simone P., Visser, Linda J., Fischer von Mollard, Gabriele, Henriet, Stefanie S. V., Figdor, Carl G., ter Beest, Martin, and van den Bogaart, Geert. “Lipid peroxidation causes endosomal antigen release for cross-presentation”. SCIENTIFIC REPORTS 6.1 (2016): 22064.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
25 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes.
Baranov MV, Revelo NH, Verboogen DRJ, Ter Beest M, van den Bogaart G., Small GTPases 10(4), 2019
PMID: 28489960
Baranov MV, Revelo NH, Verboogen DRJ, Ter Beest M, van den Bogaart G., Small GTPases 10(4), 2019
PMID: 28489960
The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation.
Baranov MV, Bianchi F, Schirmacher A, van Aart MAC, Maassen S, Muntjewerff EM, Dingjan I, Ter Beest M, Verdoes M, Keyser SGL, Bertozzi CR, Diederichsen U, van den Bogaart G., iScience 11(), 2019
PMID: 30612035
Baranov MV, Bianchi F, Schirmacher A, van Aart MAC, Maassen S, Muntjewerff EM, Dingjan I, Ter Beest M, Verdoes M, Keyser SGL, Bertozzi CR, Diederichsen U, van den Bogaart G., iScience 11(), 2019
PMID: 30612035
Oxygen in the tumor microenvironment: effects on dendritic cell function.
Paardekooper LM, Vos W, van den Bogaart G., Oncotarget 10(8), 2019
PMID: 30783517
Paardekooper LM, Vos W, van den Bogaart G., Oncotarget 10(8), 2019
PMID: 30783517
Regulation of Antigen Export to the Cytosol During Cross-Presentation.
Gros M, Amigorena S., Front Immunol 10(), 2019
PMID: 30745902
Gros M, Amigorena S., Front Immunol 10(), 2019
PMID: 30745902
Variations in the Phagosomal Environment of Human Neutrophils and Mononuclear Phagocyte Subsets.
Foote JR, Patel AA, Yona S, Segal AW., Front Immunol 10(), 2019
PMID: 30881356
Foote JR, Patel AA, Yona S, Segal AW., Front Immunol 10(), 2019
PMID: 30881356
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells.
Schulze J, Rentzsch M, Kim D, Bellmann L, Stoitzner P, Rademacher C., Biochemistry 58(21), 2019
PMID: 31062587
Schulze J, Rentzsch M, Kim D, Bellmann L, Stoitzner P, Rademacher C., Biochemistry 58(21), 2019
PMID: 31062587
Human Monocyte-Derived Dendritic Cells Produce Millimolar Concentrations of ROS in Phagosomes Per Second.
Paardekooper LM, Dingjan I, Linders PTA, Staal AHJ, Cristescu SM, Verberk WCEP, van den Bogaart G., Front Immunol 10(), 2019
PMID: 31191556
Paardekooper LM, Dingjan I, Linders PTA, Staal AHJ, Cristescu SM, Verberk WCEP, van den Bogaart G., Front Immunol 10(), 2019
PMID: 31191556
Regulation of the Cell Biology of Antigen Cross-Presentation.
Blander JM., Annu Rev Immunol 36(), 2018
PMID: 29490164
Blander JM., Annu Rev Immunol 36(), 2018
PMID: 29490164
Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules.
Verboogen DRJ, Ter Beest M, Honigmann A, van den Bogaart G., FEBS Lett 592(9), 2018
PMID: 29570778
Verboogen DRJ, Ter Beest M, Honigmann A, van den Bogaart G., FEBS Lett 592(9), 2018
PMID: 29570778
Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I.
Horrevorts SK, Duinkerken S, Bloem K, Secades P, Kalay H, Musters RJ, van Vliet SJ, García-Vallejo JJ, van Kooyk Y., Front Immunol 9(), 2018
PMID: 29963041
Horrevorts SK, Duinkerken S, Bloem K, Secades P, Kalay H, Musters RJ, van Vliet SJ, García-Vallejo JJ, van Kooyk Y., Front Immunol 9(), 2018
PMID: 29963041
Current Concepts of Antigen Cross-Presentation.
Embgenbroich M, Burgdorf S., Front Immunol 9(), 2018
PMID: 30061897
Embgenbroich M, Burgdorf S., Front Immunol 9(), 2018
PMID: 30061897
A novel probe to assess cytosolic entry of exogenous proteins.
Lu Q, Grotzke JE, Cresswell P., Nat Commun 9(1), 2018
PMID: 30082832
Lu Q, Grotzke JE, Cresswell P., Nat Commun 9(1), 2018
PMID: 30082832
Humulus japonicus Extracts Protect Against Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Rats.
Bae J, Min YS, Nam Y, Lee HS, Sohn UD., J Med Food 21(10), 2018
PMID: 30334699
Bae J, Min YS, Nam Y, Lee HS, Sohn UD., J Med Food 21(10), 2018
PMID: 30334699
Adjuvants Enhancing Cross-Presentation by Dendritic Cells: The Key to More Effective Vaccines?
Ho NI, Huis In 't Veld LGM, Raaijmakers TK, Adema GJ., Front Immunol 9(), 2018
PMID: 30619259
Ho NI, Huis In 't Veld LGM, Raaijmakers TK, Adema GJ., Front Immunol 9(), 2018
PMID: 30619259
The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.
Cruz FM, Colbert JD, Merino E, Kriegsman BA, Rock KL., Annu Rev Immunol 35(), 2017
PMID: 28125356
Cruz FM, Colbert JD, Merino E, Kriegsman BA, Rock KL., Annu Rev Immunol 35(), 2017
PMID: 28125356
Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Dingjan I, Linders PT, van den Bekerom L, Baranov MV, Halder P, Ter Beest M, van den Bogaart G., J Cell Sci 130(7), 2017
PMID: 28202687
Dingjan I, Linders PT, van den Bekerom L, Baranov MV, Halder P, Ter Beest M, van den Bogaart G., J Cell Sci 130(7), 2017
PMID: 28202687
Membrane Oxidation in Cell Delivery and Cell Killing Applications.
Wang TY, Libardo MDJ, Angeles-Boza AM, Pellois JP., ACS Chem Biol 12(5), 2017
PMID: 28355059
Wang TY, Libardo MDJ, Angeles-Boza AM, Pellois JP., ACS Chem Biol 12(5), 2017
PMID: 28355059
How Does Membrane Oxidation Affect Cell Delivery and Cell Killing?
Libardo MDJ, Wang TY, Pellois JP, Angeles-Boza AM., Trends Biotechnol 35(8), 2017
PMID: 28460718
Libardo MDJ, Wang TY, Pellois JP, Angeles-Boza AM., Trends Biotechnol 35(8), 2017
PMID: 28460718
The ongoing saga of the mechanism(s) of MHC class I-restricted cross-presentation.
Grotzke JE, Sengupta D, Lu Q, Cresswell P., Curr Opin Immunol 46(), 2017
PMID: 28528219
Grotzke JE, Sengupta D, Lu Q, Cresswell P., Curr Opin Immunol 46(), 2017
PMID: 28528219
Fluorescence Lifetime Imaging Microscopy reveals rerouting of SNARE trafficking driving dendritic cell activation.
Verboogen DRJ, González Mancha N, Ter Beest M, van den Bogaart G., Elife 6(), 2017
PMID: 28524818
Verboogen DRJ, González Mancha N, Ter Beest M, van den Bogaart G., Elife 6(), 2017
PMID: 28524818
VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release.
Dingjan I, Paardekooper LM, Verboogen DRJ, von Mollard GF, Ter Beest M, van den Bogaart G., Eur J Cell Biol 96(7), 2017
PMID: 28688576
Dingjan I, Paardekooper LM, Verboogen DRJ, von Mollard GF, Ter Beest M, van den Bogaart G., Eur J Cell Biol 96(7), 2017
PMID: 28688576
Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.
Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C., Proc Natl Acad Sci U S A 114(29), 2017
PMID: 28679634
Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C., Proc Natl Acad Sci U S A 114(29), 2017
PMID: 28679634
Ethylene, an early marker of systemic inflammation in humans.
Paardekooper LM, van den Bogaart G, Kox M, Dingjan I, Neerincx AH, Bendix MB, Beest MT, Harren FJM, Risby T, Pickkers P, Marczin N, Cristescu SM., Sci Rep 7(1), 2017
PMID: 28761087
Paardekooper LM, van den Bogaart G, Kox M, Dingjan I, Neerincx AH, Bendix MB, Beest MT, Harren FJM, Risby T, Pickkers P, Marczin N, Cristescu SM., Sci Rep 7(1), 2017
PMID: 28761087
Nanoparticles: augmenting tumor antigen presentation for vaccine and immunotherapy treatments of cancer.
Chesson CB, Zloza A., Nanomedicine (Lond) 12(23), 2017
PMID: 29098928
Chesson CB, Zloza A., Nanomedicine (Lond) 12(23), 2017
PMID: 29098928
SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis.
Baranov MV, Revelo NH, Dingjan I, Maraspini R, Ter Beest M, Honigmann A, van den Bogaart G., Cell Rep 17(6), 2016
PMID: 27806292
Baranov MV, Revelo NH, Dingjan I, Maraspini R, Ter Beest M, Honigmann A, van den Bogaart G., Cell Rep 17(6), 2016
PMID: 27806292
65 References
Daten bereitgestellt von Europe PubMed Central.
Cross-presentation by dendritic cells.
Joffre OP, Segura E, Savina A, Amigorena S., Nat. Rev. Immunol. 12(8), 2012
PMID: 22790179
Joffre OP, Segura E, Savina A, Amigorena S., Nat. Rev. Immunol. 12(8), 2012
PMID: 22790179
An updated view of the intracellular mechanisms regulating cross-presentation.
Nair-Gupta P, Blander JM., Front Immunol 4(), 2013
PMID: 24319447
Nair-Gupta P, Blander JM., Front Immunol 4(), 2013
PMID: 24319447
The known unknowns of antigen processing and presentation.
Vyas JM, Van der Veen AG, Ploegh HL., Nat. Rev. Immunol. 8(8), 2008
PMID: 18641646
Vyas JM, Van der Veen AG, Ploegh HL., Nat. Rev. Immunol. 8(8), 2008
PMID: 18641646
Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.
Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A., Cell 147(6), 2011
PMID: 22153078
Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A., Cell 147(6), 2011
PMID: 22153078
Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells.
Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A., J. Exp. Med. 206(2), 2009
PMID: 19153244
Goldszmid RS, Coppens I, Lev A, Caspar P, Mellman I, Sher A., J. Exp. Med. 206(2), 2009
PMID: 19153244
A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells.
Ackerman AL, Giodini A, Cresswell P., Immunity 25(4), 2006
PMID: 17027300
Ackerman AL, Giodini A, Cresswell P., Immunity 25(4), 2006
PMID: 17027300
Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells.
Imai J, Hasegawa H, Maruya M, Koyasu S, Yahara I., Int. Immunol. 17(1), 2004
PMID: 15546887
Imai J, Hasegawa H, Maruya M, Koyasu S, Yahara I., Int. Immunol. 17(1), 2004
PMID: 15546887
The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.
Zehner M, Marschall AL, Bos E, Schloetel JG, Kreer C, Fehrenschild D, Limmer A, Ossendorp F, Lang T, Koster AJ, Dubel S, Burgdorf S., Immunity 42(5), 2015
PMID: 25979419
Zehner M, Marschall AL, Bos E, Schloetel JG, Kreer C, Fehrenschild D, Limmer A, Ossendorp F, Lang T, Koster AJ, Dubel S, Burgdorf S., Immunity 42(5), 2015
PMID: 25979419
Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.
Reis e Sousa C, Germain RN., J. Exp. Med. 182(3), 1995
PMID: 7650490
Reis e Sousa C, Germain RN., J. Exp. Med. 182(3), 1995
PMID: 7650490
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.
Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S., Nat. Cell Biol. 9(4), 2007
PMID: 17351642
Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S., Nat. Cell Biol. 9(4), 2007
PMID: 17351642
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.
Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC, Lennon-Dumenil AM, Seabra MC, Raposo G, Amigorena S., Cell 126(1), 2006
PMID: 16839887
Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC, Lennon-Dumenil AM, Seabra MC, Raposo G, Amigorena S., Cell 126(1), 2006
PMID: 16839887
Reactive oxygen species production in the phagosome: impact on antigen presentation in dendritic cells
AUTHOR UNKNOWN, 2013
AUTHOR UNKNOWN, 2013
NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.
Mantegazza AR, Savina A, Vermeulen M, Perez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S., Blood 112(12), 2008
PMID: 18682599
Mantegazza AR, Savina A, Vermeulen M, Perez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S., Blood 112(12), 2008
PMID: 18682599
Redirecting soluble antigen for MHC class I cross-presentation during phagocytosis.
Hari A, Ganguly A, Mu L, Davis SP, Stenner MD, Lam R, Munro F, Namet I, Alghamdi E, Furstenhaupt T, Dong W, Detampel P, Shen LJ, Amrein MW, Yates RM, Shi Y., Eur. J. Immunol. 45(2), 2014
PMID: 25378230
Hari A, Ganguly A, Mu L, Davis SP, Stenner MD, Lam R, Munro F, Namet I, Alghamdi E, Furstenhaupt T, Dong W, Detampel P, Shen LJ, Amrein MW, Yates RM, Shi Y., Eur. J. Immunol. 45(2), 2014
PMID: 25378230
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.
Bedard K, Krause KH., Physiol. Rev. 87(1), 2007
PMID: 17237347
Bedard K, Krause KH., Physiol. Rev. 87(1), 2007
PMID: 17237347
Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner.
Rybicka JM, Balce DR, Chaudhuri S, Allan ER, Yates RM., EMBO J. 31(4), 2011
PMID: 22157818
Rybicka JM, Balce DR, Chaudhuri S, Allan ER, Yates RM., EMBO J. 31(4), 2011
PMID: 22157818
NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing.
Allan ER, Tailor P, Balce DR, Pirzadeh P, McKenna NT, Renaux B, Warren AL, Jirik FR, Yates RM., J. Immunol. 192(11), 2014
PMID: 24778444
Allan ER, Tailor P, Balce DR, Pirzadeh P, McKenna NT, Renaux B, Warren AL, Jirik FR, Yates RM., J. Immunol. 192(11), 2014
PMID: 24778444
Lipid hydroperoxide generation, turnover, and effector action in biological systems.
Girotti AW., J. Lipid Res. 39(8), 1998
PMID: 9717713
Girotti AW., J. Lipid Res. 39(8), 1998
PMID: 9717713
Solubility of gases in human red blood cell ghosts.
Power GG, Stegall H., J Appl Physiol 29(2), 1970
PMID: 5428886
Power GG, Stegall H., J Appl Physiol 29(2), 1970
PMID: 5428886
Massive oxidation of phospholipid membranes leads to pore creation and bilayer disintegration
AUTHOR UNKNOWN, 2010
AUTHOR UNKNOWN, 2010
Relation of lipid peroxidation to loss of cations trapped in liposomes.
Leibowitz ME, Johnson MC., J. Lipid Res. 12(6), 1971
PMID: 5124531
Leibowitz ME, Johnson MC., J. Lipid Res. 12(6), 1971
PMID: 5124531
Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study.
Wong-Ekkabut J, Xu Z, Triampo W, Tang IM, Tieleman DP, Monticelli L., Biophys. J. 93(12), 2007
PMID: 17766354
Wong-Ekkabut J, Xu Z, Triampo W, Tang IM, Tieleman DP, Monticelli L., Biophys. J. 93(12), 2007
PMID: 17766354
Breaking down the barriers: siRNA delivery and endosome escape.
Dominska M, Dykxhoorn DM., J. Cell. Sci. 123(Pt 8), 2010
PMID: 20356929
Dominska M, Dykxhoorn DM., J. Cell. Sci. 123(Pt 8), 2010
PMID: 20356929
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol.
Berg K, Selbo PK, Prasmickaite L, Tjelle TE, Sandvig K, Moan J, Gaudernack G, Fodstad O, Kjolsrud S, Anholt H, Rodal GH, Rodal SK, Hogset A., Cancer Res. 59(6), 1999
PMID: 10096543
Berg K, Selbo PK, Prasmickaite L, Tjelle TE, Sandvig K, Moan J, Gaudernack G, Fodstad O, Kjolsrud S, Anholt H, Rodal GH, Rodal SK, Hogset A., Cancer Res. 59(6), 1999
PMID: 10096543
Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape
AUTHOR UNKNOWN, 2009
AUTHOR UNKNOWN, 2009
Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules.
Selbo PK, Weyergang A, Hogset A, Norum OJ, Berstad MB, Vikdal M, Berg K., J Control Release 148(1), 2010
PMID: 20600406
Selbo PK, Weyergang A, Hogset A, Norum OJ, Berstad MB, Vikdal M, Berg K., J Control Release 148(1), 2010
PMID: 20600406
Introduction of soluble protein into the class I pathway of antigen processing and presentation.
Moore MW, Carbone FR, Bevan MJ., Cell 54(6), 1988
PMID: 3261634
Moore MW, Carbone FR, Bevan MJ., Cell 54(6), 1988
PMID: 3261634
Mycobacterial infection of macrophages results in membrane-permeable phagosomes.
Teitelbaum R, Cammer M, Maitland ML, Freitag NE, Condeelis J, Bloom BR., Proc. Natl. Acad. Sci. U.S.A. 96(26), 1999
PMID: 10611360
Teitelbaum R, Cammer M, Maitland ML, Freitag NE, Condeelis J, Bloom BR., Proc. Natl. Acad. Sci. U.S.A. 96(26), 1999
PMID: 10611360
Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2.
Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI., Circ. Res. 104(2), 2008
PMID: 19096031
Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI., Circ. Res. 104(2), 2008
PMID: 19096031
Lipopolysaccharide-sensitive H+current in dendritic cells
AUTHOR UNKNOWN, 2012
AUTHOR UNKNOWN, 2012
Optimization of the C11-BODIPY(581/591) dye for the determination of lipid oxidation in Chlamydomonas reinhardtii by flow cytometry.
Cheloni G, Slaveykova VI., Cytometry A 83(10), 2013
PMID: 23943236
Cheloni G, Slaveykova VI., Cytometry A 83(10), 2013
PMID: 23943236
The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems.
Cross AR, Segal AW., Biochim. Biophys. Acta 1657(1), 2004
PMID: 15238208
Cross AR, Segal AW., Biochim. Biophys. Acta 1657(1), 2004
PMID: 15238208
Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome.
Windsor K, Genaro-Mattos TC, Kim HY, Liu W, Tallman KA, Miyamoto S, Korade Z, Porter NA., J. Lipid Res. 54(10), 2013
PMID: 23828810
Windsor K, Genaro-Mattos TC, Kim HY, Liu W, Tallman KA, Miyamoto S, Korade Z, Porter NA., J. Lipid Res. 54(10), 2013
PMID: 23828810
Promotion of plasma membrane repair by vitamin E.
Howard AC, McNeil AK, McNeil PL., Nat Commun 2(), 2011
PMID: 22186893
Howard AC, McNeil AK, McNeil PL., Nat Commun 2(), 2011
PMID: 22186893
Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset.
Lin ML, Zhan Y, Proietto AI, Prato S, Wu L, Heath WR, Villadangos JA, Lew AM., Proc. Natl. Acad. Sci. U.S.A. 105(8), 2008
PMID: 18272486
Lin ML, Zhan Y, Proietto AI, Prato S, Wu L, Heath WR, Villadangos JA, Lew AM., Proc. Natl. Acad. Sci. U.S.A. 105(8), 2008
PMID: 18272486
Tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time.
Ray K, Bobard A, Danckaert A, Paz-Haftel I, Clair C, Ehsani S, Tang C, Sansonetti P, Tran GV, Enninga J., Cell. Microbiol. 12(4), 2010
PMID: 20070313
Ray K, Bobard A, Danckaert A, Paz-Haftel I, Clair C, Ehsani S, Tang C, Sansonetti P, Tran GV, Enninga J., Cell. Microbiol. 12(4), 2010
PMID: 20070313
Galectin-3, a marker for vacuole lysis by invasive pathogens.
Paz I, Sachse M, Dupont N, Mounier J, Cederfur C, Enninga J, Leffler H, Poirier F, Prevost MC, Lafont F, Sansonetti P., Cell. Microbiol. 12(4), 2009
PMID: 19951367
Paz I, Sachse M, Dupont N, Mounier J, Cederfur C, Enninga J, Leffler H, Poirier F, Prevost MC, Lafont F, Sansonetti P., Cell. Microbiol. 12(4), 2009
PMID: 19951367
Efficient intracellular delivery of native proteins.
D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H, Geijsen N., Cell 161(3), 2015
PMID: 25910214
D'Astolfo DS, Pagliero RJ, Pras A, Karthaus WR, Clevers H, Prasad V, Lebbink RJ, Rehmann H, Geijsen N., Cell 161(3), 2015
PMID: 25910214
Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation.
Rosalia RA, Quakkelaar ED, Redeker A, Khan S, Camps M, Drijfhout JW, Silva AL, Jiskoot W, van Hall T, van Veelen PA, Janssen G, Franken K, Cruz LJ, Tromp A, Oostendorp J, van der Burg SH, Ossendorp F, Melief CJ., Eur. J. Immunol. 43(10), 2013
PMID: 23836147
Rosalia RA, Quakkelaar ED, Redeker A, Khan S, Camps M, Drijfhout JW, Silva AL, Jiskoot W, van Hall T, van Veelen PA, Janssen G, Franken K, Cruz LJ, Tromp A, Oostendorp J, van der Burg SH, Ossendorp F, Melief CJ., Eur. J. Immunol. 43(10), 2013
PMID: 23836147
Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets.
Tel J, Schreibelt G, Sittig SP, Mathan TS, Buschow SI, Cruz LJ, Lambeck AJ, Figdor CG, de Vries IJ., Blood 121(3), 2012
PMID: 23212525
Tel J, Schreibelt G, Sittig SP, Mathan TS, Buschow SI, Cruz LJ, Lambeck AJ, Figdor CG, de Vries IJ., Blood 121(3), 2012
PMID: 23212525
Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8.
Matheoud D, Moradin N, Bellemare-Pelletier A, Shio MT, Hong WJ, Olivier M, Gagnon E, Desjardins M, Descoteaux A., Cell Host Microbe 14(1), 2013
PMID: 23870310
Matheoud D, Moradin N, Bellemare-Pelletier A, Shio MT, Hong WJ, Olivier M, Gagnon E, Desjardins M, Descoteaux A., Cell Host Microbe 14(1), 2013
PMID: 23870310
Proteasome-independent major histocompatibility complex class I cross-presentation mediated by papaya mosaic virus-like particles leads to expansion of specific human T cells.
Leclerc D, Beauseigle D, Denis J, Morin H, Pare C, Lamarre A, Lapointe R., J. Virol. 81(3), 2006
PMID: 17121795
Leclerc D, Beauseigle D, Denis J, Morin H, Pare C, Lamarre A, Lapointe R., J. Virol. 81(3), 2006
PMID: 17121795
A genetically encoded photosensitizer.
Bulina ME, Chudakov DM, Britanova OV, Yanushevich YG, Staroverov DB, Chepurnykh TV, Merzlyak EM, Shkrob MA, Lukyanov S, Lukyanov KA., Nat. Biotechnol. 24(1), 2005
PMID: 16369538
Bulina ME, Chudakov DM, Britanova OV, Yanushevich YG, Staroverov DB, Chepurnykh TV, Merzlyak EM, Shkrob MA, Lukyanov S, Lukyanov KA., Nat. Biotechnol. 24(1), 2005
PMID: 16369538
Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system.
Vogel R, Al-Daccak R, Drews O, Alonzeau J, Mester G, Charron D, Stevanovic S, Mallet J., Mol Ther Nucleic Acids 2(), 2013
PMID: 23403517
Vogel R, Al-Daccak R, Drews O, Alonzeau J, Mester G, Charron D, Stevanovic S, Mallet J., Mol Ther Nucleic Acids 2(), 2013
PMID: 23403517
Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation.
Chapiro J, Claverol S, Piette F, Ma W, Stroobant V, Guillaume B, Gairin JE, Morel S, Burlet-Schiltz O, Monsarrat B, Boon T, Van den Eynde BJ., J. Immunol. 176(2), 2006
PMID: 16393993
Chapiro J, Claverol S, Piette F, Ma W, Stroobant V, Guillaume B, Gairin JE, Morel S, Burlet-Schiltz O, Monsarrat B, Boon T, Van den Eynde BJ., J. Immunol. 176(2), 2006
PMID: 16393993
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.
Brandes M, Willimann K, Bioley G, Levy N, Eberl M, Luo M, Tampe R, Levy F, Romero P, Moser B., Proc. Natl. Acad. Sci. U.S.A. 106(7), 2009
PMID: 19171897
Brandes M, Willimann K, Bioley G, Levy N, Eberl M, Luo M, Tampe R, Levy F, Romero P, Moser B., Proc. Natl. Acad. Sci. U.S.A. 106(7), 2009
PMID: 19171897
CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease.
De Luca A, Iannitti RG, Bozza S, Beau R, Casagrande A, D'Angelo C, Moretti S, Cunha C, Giovannini G, Massi-Benedetti C, Carvalho A, Boon L, Latge JP, Romani L., J. Clin. Invest. 122(5), 2012
PMID: 22523066
De Luca A, Iannitti RG, Bozza S, Beau R, Casagrande A, D'Angelo C, Moretti S, Cunha C, Giovannini G, Massi-Benedetti C, Carvalho A, Boon L, Latge JP, Romani L., J. Clin. Invest. 122(5), 2012
PMID: 22523066
Inflammatory manifestations in chronic granulomatous disease (CGD).
Rosenzweig SD., J. Clin. Immunol. 28 Suppl 1(), 2008
PMID: 18193341
Rosenzweig SD., J. Clin. Immunol. 28 Suppl 1(), 2008
PMID: 18193341
Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress.
Wang X, Ke Z, Chen G, Xu M, Bower KA, Frank JA, Zhang Z, Shi X, Luo J., PLoS ONE 7(5), 2012
PMID: 22662267
Wang X, Ke Z, Chen G, Xu M, Bower KA, Frank JA, Zhang Z, Shi X, Luo J., PLoS ONE 7(5), 2012
PMID: 22662267
Regulation of apoptosis-associated lysosomal membrane permeabilization.
Johansson AC, Appelqvist H, Nilsson C, Kagedal K, Roberg K, Ollinger K., Apoptosis 15(5), 2010
PMID: 20077016
Johansson AC, Appelqvist H, Nilsson C, Kagedal K, Roberg K, Ollinger K., Apoptosis 15(5), 2010
PMID: 20077016
Lysosomal labilization.
Terman A, Kurz T, Gustafsson B, Brunk UT., IUBMB Life 58(9), 2006
PMID: 17002981
Terman A, Kurz T, Gustafsson B, Brunk UT., IUBMB Life 58(9), 2006
PMID: 17002981
Neutrophils efficiently cross-prime naive T cells in vivo.
Beauvillain C, Delneste Y, Scotet M, Peres A, Gascan H, Guermonprez P, Barnaba V, Jeannin P., Blood 110(8), 2007
PMID: 17562875
Beauvillain C, Delneste Y, Scotet M, Peres A, Gascan H, Guermonprez P, Barnaba V, Jeannin P., Blood 110(8), 2007
PMID: 17562875
Replication of Cryptococcus neoformans in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm.
Tucker SC, Casadevall A., Proc. Natl. Acad. Sci. U.S.A. 99(5), 2002
PMID: 11880650
Tucker SC, Casadevall A., Proc. Natl. Acad. Sci. U.S.A. 99(5), 2002
PMID: 11880650
Alternative pathways for MHC class I presentation: a new function for autophagy.
Chemali M, Radtke K, Desjardins M, English L., Cell. Mol. Life Sci. 68(9), 2011
PMID: 21390546
Chemali M, Radtke K, Desjardins M, English L., Cell. Mol. Life Sci. 68(9), 2011
PMID: 21390546
Activation of antibacterial autophagy by NADPH oxidases.
Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH., Proc. Natl. Acad. Sci. U.S.A. 106(15), 2009
PMID: 19339495
Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH., Proc. Natl. Acad. Sci. U.S.A. 106(15), 2009
PMID: 19339495
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.
Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, Munz C., J. Cell Biol. 203(5), 2013
PMID: 24322427
Romao S, Gasser N, Becker AC, Guhl B, Bajagic M, Vanoaica D, Ziegler U, Roesler J, Dengjel J, Reichenbach J, Munz C., J. Cell Biol. 203(5), 2013
PMID: 24322427
The tumor microenvironment: characterization, redox considerations, and novel approaches for reactive oxygen species-targeted gene therapy
AUTHOR UNKNOWN, 2013
AUTHOR UNKNOWN, 2013
Hydrogen peroxide as second messenger in lymphocyte activation.
Reth M., Nat. Immunol. 3(12), 2002
PMID: 12447370
Reth M., Nat. Immunol. 3(12), 2002
PMID: 12447370
Generation and function of reactive oxygen species in dendritic cells during antigen presentation.
Matsue H, Edelbaum D, Shalhevet D, Mizumoto N, Yang C, Mummert ME, Oeda J, Masayasu H, Takashima A., J. Immunol. 171(6), 2003
PMID: 12960326
Matsue H, Edelbaum D, Shalhevet D, Mizumoto N, Yang C, Mummert ME, Oeda J, Masayasu H, Takashima A., J. Immunol. 171(6), 2003
PMID: 12960326
Phenotypical and functional characterization of clinical grade dendritic cells.
de Vries IJ, Eggert AA, Scharenborg NM, Vissers JL, Lesterhuis WJ, Boerman OC, Punt CJ, Adema GJ, Figdor CG., J. Immunother. 25(5), 2002
PMID: 12218781
de Vries IJ, Eggert AA, Scharenborg NM, Vissers JL, Lesterhuis WJ, Boerman OC, Punt CJ, Adema GJ, Figdor CG., J. Immunother. 25(5), 2002
PMID: 12218781
Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease.
Henriet SS, Jans J, Simonetti E, Kwon-Chung KJ, Rijs AJ, Hermans PW, Holland SM, de Jonge MI, Warris A., J. Infect. Dis. 207(12), 2013
PMID: 23482646
Henriet SS, Jans J, Simonetti E, Kwon-Chung KJ, Rijs AJ, Hermans PW, Holland SM, de Jonge MI, Warris A., J. Infect. Dis. 207(12), 2013
PMID: 23482646
Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens.
Karttunen J, Sanderson S, Shastri N., Proc. Natl. Acad. Sci. U.S.A. 89(13), 1992
PMID: 1378619
Karttunen J, Sanderson S, Shastri N., Proc. Natl. Acad. Sci. U.S.A. 89(13), 1992
PMID: 1378619
Podosomes of dendritic cells facilitate antigen sampling.
Baranov M, Ter Beest M, Reinieren-Beeren I, Cambi A, Figdor CG, van den Bogaart G., J. Cell. Sci. 127(Pt 5), 2014
PMID: 24424029
Baranov M, Ter Beest M, Reinieren-Beeren I, Cambi A, Figdor CG, van den Bogaart G., J. Cell. Sci. 127(Pt 5), 2014
PMID: 24424029
Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.
Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J., Nat. Biotechnol. 33(8), 2015
PMID: 26192320
Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J., Nat. Biotechnol. 33(8), 2015
PMID: 26192320
Flexible and sensitive method to functionally validate tumor-specific receptors via activation of NFAT.
Schaft N, Lankiewicz B, Gratama JW, Bolhuis RL, Debets R., J. Immunol. Methods 280(1-2), 2003
PMID: 12972184
Schaft N, Lankiewicz B, Gratama JW, Bolhuis RL, Debets R., J. Immunol. Methods 280(1-2), 2003
PMID: 12972184
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